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Q9Z2Q6

- SEPT5_MOUSE

UniProt

Q9Z2Q6 - SEPT5_MOUSE

Protein

Septin-5

Gene

Sept5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Filament-forming cytoskeletal GTPase By similarity. Involved in cytokinesis Potential. May play a role in platelet secretion.By similarity1 PublicationCurated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei85 – 851GTPBy similarity
    Binding sitei111 – 1111GTP; via amide nitrogenBy similarity
    Binding sitei248 – 2481GTP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei263 – 2631GTPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi51 – 588GTPBy similarity
    Nucleotide bindingi190 – 1989GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. regulation of exocytosis Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Septin-5
    Alternative name(s):
    Cell division control-related protein 1
    Short name:
    CDCrel-1
    Peanut-like protein 1
    Gene namesi
    Name:Sept5
    Synonyms:Pnutl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1195461. Sept5.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. axon terminus Source: MGI
    2. cell cortex Source: MGI
    3. plasma membrane Source: UniProtKB
    4. septin complex Source: InterPro
    5. synapse Source: MGI
    6. synaptic vesicle Source: UniProtKB
    7. terminal bouton Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Disruption phenotypei

    Mice have a normal life-span and show no apparent abnormalities, including synaptic properties and hippocampal neuron growth. In platelets, hyperresponsive degranulation phenotype.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Septin-5PRO_0000173523Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei225 – 2251Phosphoserine1 Publication
    Modified residuei327 – 3271Phosphoserine1 Publication
    Modified residuei336 – 3361Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Z2Q6.
    PaxDbiQ9Z2Q6.
    PRIDEiQ9Z2Q6.

    PTM databases

    PhosphoSiteiQ9Z2Q6.

    Expressioni

    Developmental stagei

    Detected at 17 dpc in the brain. Expression increases during postnatal life and reaches a plateau at approximately P10 (at protein level).1 Publication

    Gene expression databases

    BgeeiQ9Z2Q6.
    CleanExiMM_SEPT5.
    GenevestigatoriQ9Z2Q6.

    Interactioni

    Subunit structurei

    Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation By similarity. Interacts with SEPT2 and SEPT5. Interaction with SEPT4 not detected. In platelets, associated with a complex containing STX4 By similarity. Interacts with PARK2. This interaction leads to SEPT5 ubiquitination and degradation.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PARK2O602602EBI-772125,EBI-716346From a different organism.

    Protein-protein interaction databases

    BioGridi202285. 4 interactions.
    IntActiQ9Z2Q6. 5 interactions.
    MINTiMINT-4134165.
    STRINGi10090.ENSMUSP00000094750.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2Q6.
    SMRiQ9Z2Q6. Positions 41-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 314274Septin-type GAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili338 – 36932Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5019.
    GeneTreeiENSGT00620000087649.
    HOVERGENiHBG065093.
    InParanoidiB2RUC5.
    KOiK04557.
    OMAiAVNNSEC.
    OrthoDBiEOG79KPF0.
    TreeFamiTF101079.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR000038. Cell_div_GTP-bd.
    IPR027417. P-loop_NTPase.
    IPR016491. Septin.
    [Graphical view]
    PANTHERiPTHR18884. PTHR18884. 1 hit.
    PfamiPF00735. Septin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006698. Septin. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51719. G_SEPTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z2Q6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTGLRYKSK LATPEDKQDI DKQYVGFATL PNQVHRKSVK KGFDFTLMVA    50
    GESGLGKSTL VHSLFLTDLY KDRKLLSAEE RINQTVEILK HTVDIEEKGV 100
    KLKLTIVDTP GFGDAVNNSE CWKPITDYVD QQFEQYFRDE SGLNRKNIQD 150
    NRVHCCLYFI SPFGHGLRPV DVGFMKALHE KVNIVPLIAK ADCLVPSEIR 200
    KLKDRIREEI DKFGIHVYQF PECDSDEDED FKQQDRELKE SAPFAVIGSN 250
    TVVEAKGQRV RGRLYPWGIV EVENQAHCDF VKLRNMLIRT HMHDLKDVTC 300
    DVHYENYRAH CIQQMTSKLT QDSRMESPIP ILPLPTPDAE TEKLIRMKDE 350
    ELRRMQEMLQ KMKQQMQDQ 369
    Length:369
    Mass (Da):42,748
    Last modified:December 6, 2005 - v2
    Checksum:iD58468DBA9ADE626
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK134700 mRNA. Translation: BAE22248.1.
    BC059848 mRNA. Translation: AAH59848.1.
    BC141073 mRNA. Translation: AAI41074.1.
    BC145331 mRNA. Translation: AAI45332.1.
    AF033350 mRNA. Translation: AAC83974.1.
    CCDSiCCDS57021.1.
    RefSeqiNP_998779.2. NM_213614.2.
    UniGeneiMm.20365.

    Genome annotation databases

    EnsembliENSMUST00000096987; ENSMUSP00000094750; ENSMUSG00000072214.
    GeneIDi18951.
    KEGGimmu:18951.
    UCSCiuc007yoj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK134700 mRNA. Translation: BAE22248.1 .
    BC059848 mRNA. Translation: AAH59848.1 .
    BC141073 mRNA. Translation: AAI41074.1 .
    BC145331 mRNA. Translation: AAI45332.1 .
    AF033350 mRNA. Translation: AAC83974.1 .
    CCDSi CCDS57021.1.
    RefSeqi NP_998779.2. NM_213614.2.
    UniGenei Mm.20365.

    3D structure databases

    ProteinModelPortali Q9Z2Q6.
    SMRi Q9Z2Q6. Positions 41-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202285. 4 interactions.
    IntActi Q9Z2Q6. 5 interactions.
    MINTi MINT-4134165.
    STRINGi 10090.ENSMUSP00000094750.

    PTM databases

    PhosphoSitei Q9Z2Q6.

    Proteomic databases

    MaxQBi Q9Z2Q6.
    PaxDbi Q9Z2Q6.
    PRIDEi Q9Z2Q6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000096987 ; ENSMUSP00000094750 ; ENSMUSG00000072214 .
    GeneIDi 18951.
    KEGGi mmu:18951.
    UCSCi uc007yoj.1. mouse.

    Organism-specific databases

    CTDi 5413.
    MGIi MGI:1195461. Sept5.

    Phylogenomic databases

    eggNOGi COG5019.
    GeneTreei ENSGT00620000087649.
    HOVERGENi HBG065093.
    InParanoidi B2RUC5.
    KOi K04557.
    OMAi AVNNSEC.
    OrthoDBi EOG79KPF0.
    TreeFami TF101079.

    Miscellaneous databases

    NextBioi 295300.
    PROi Q9Z2Q6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z2Q6.
    CleanExi MM_SEPT5.
    Genevestigatori Q9Z2Q6.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR000038. Cell_div_GTP-bd.
    IPR027417. P-loop_NTPase.
    IPR016491. Septin.
    [Graphical view ]
    PANTHERi PTHR18884. PTHR18884. 1 hit.
    Pfami PF00735. Septin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006698. Septin. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51719. G_SEPTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Medulla oblongata.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "CDCREL-1, a septin deleted in DiGeorge Syndrome, is expressed in the developing brain and cartilage primordia in mouse embryogenesis."
      Botta A., Lindsay E.A., Jurecic V., Zieger B., Ware J., Baldini A.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-369.
      Strain: C57BL/6.
      Tissue: Brain, Cartilage and Skin.
    4. Lubec G., Klug S., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 23-36; 58-71; 82-90; 182-190; 240-256; 264-282 AND 297-308, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain and Hippocampus.
    5. "Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1."
      Zhang Y., Gao J., Chung K.K.K., Huang H., Dawson V.L., Dawson T.M.
      Proc. Natl. Acad. Sci. U.S.A. 97:13354-13359(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PARK2, UBIQUITIN-MEDIATED DEGRADATION.
    6. "The septin CDCrel-1 is dispensable for normal development and neurotransmitter release."
      Peng X.-R., Jia Z., Zhang Y., Ware J., Trimble W.S.
      Mol. Cell. Biol. 22:378-387(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SEPT2 AND SEPT7, LACK OF INTERACTION WITH SEPT4, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    7. Cited for: DISRUPTION PHENOTYPE, FUNCTION.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327 AND THR-336, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    9. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiSEPT5_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z2Q6
    Secondary accession number(s): B2RUC5, Q3UYG4, Q6PB74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3