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Q9Z2Q6

- SEPT5_MOUSE

UniProt

Q9Z2Q6 - SEPT5_MOUSE

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Protein

Septin-5

Gene

Sept5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). Involved in cytokinesis (Potential). May play a role in platelet secretion.By similarity1 PublicationCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851GTPBy similarity
Binding sitei111 – 1111GTP; via amide nitrogenBy similarity
Binding sitei248 – 2481GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei263 – 2631GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi51 – 588GTPBy similarity
Nucleotide bindingi190 – 1989GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. regulation of exocytosis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-5
Alternative name(s):
Cell division control-related protein 1
Short name:
CDCrel-1
Peanut-like protein 1
Gene namesi
Name:Sept5
Synonyms:Pnutl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1195461. Sept5.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. axon terminus Source: MGI
  2. cell cortex Source: MGI
  3. plasma membrane Source: UniProtKB
  4. septin complex Source: InterPro
  5. synapse Source: MGI
  6. synaptic vesicle Source: UniProtKB
  7. terminal bouton Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Mice have a normal life-span and show no apparent abnormalities, including synaptic properties and hippocampal neuron growth. In platelets, hyperresponsive degranulation phenotype.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Septin-5PRO_0000173523Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei225 – 2251Phosphoserine1 Publication
Modified residuei327 – 3271Phosphoserine1 Publication
Modified residuei336 – 3361Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z2Q6.
PaxDbiQ9Z2Q6.
PRIDEiQ9Z2Q6.

PTM databases

PhosphoSiteiQ9Z2Q6.

Expressioni

Developmental stagei

Detected at 17 dpc in the brain. Expression increases during postnatal life and reaches a plateau at approximately P10 (at protein level).1 Publication

Gene expression databases

BgeeiQ9Z2Q6.
CleanExiMM_SEPT5.
ExpressionAtlasiQ9Z2Q6. baseline and differential.
GenevestigatoriQ9Z2Q6.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPT2 and SEPT5. Interaction with SEPT4 not detected. In platelets, associated with a complex containing STX4 (By similarity). Interacts with PARK2. This interaction leads to SEPT5 ubiquitination and degradation.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PARK2O602602EBI-772125,EBI-716346From a different organism.

Protein-protein interaction databases

BioGridi202285. 4 interactions.
IntActiQ9Z2Q6. 5 interactions.
MINTiMINT-4134165.
STRINGi10090.ENSMUSP00000094750.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2Q6.
SMRiQ9Z2Q6. Positions 41-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 314274Septin-type GAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili338 – 36932Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5019.
GeneTreeiENSGT00760000118899.
HOVERGENiHBG065093.
InParanoidiQ9Z2Q6.
KOiK04557.
OMAiAVNNSEC.
OrthoDBiEOG79KPF0.
TreeFamiTF101079.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2Q6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTGLRYKSK LATPEDKQDI DKQYVGFATL PNQVHRKSVK KGFDFTLMVA
60 70 80 90 100
GESGLGKSTL VHSLFLTDLY KDRKLLSAEE RINQTVEILK HTVDIEEKGV
110 120 130 140 150
KLKLTIVDTP GFGDAVNNSE CWKPITDYVD QQFEQYFRDE SGLNRKNIQD
160 170 180 190 200
NRVHCCLYFI SPFGHGLRPV DVGFMKALHE KVNIVPLIAK ADCLVPSEIR
210 220 230 240 250
KLKDRIREEI DKFGIHVYQF PECDSDEDED FKQQDRELKE SAPFAVIGSN
260 270 280 290 300
TVVEAKGQRV RGRLYPWGIV EVENQAHCDF VKLRNMLIRT HMHDLKDVTC
310 320 330 340 350
DVHYENYRAH CIQQMTSKLT QDSRMESPIP ILPLPTPDAE TEKLIRMKDE
360
ELRRMQEMLQ KMKQQMQDQ
Length:369
Mass (Da):42,748
Last modified:December 6, 2005 - v2
Checksum:iD58468DBA9ADE626
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134700 mRNA. Translation: BAE22248.1.
BC059848 mRNA. Translation: AAH59848.1.
BC141073 mRNA. Translation: AAI41074.1.
BC145331 mRNA. Translation: AAI45332.1.
AF033350 mRNA. Translation: AAC83974.1.
CCDSiCCDS57021.1.
RefSeqiNP_998779.2. NM_213614.2.
UniGeneiMm.20365.

Genome annotation databases

EnsembliENSMUST00000096987; ENSMUSP00000094750; ENSMUSG00000072214.
GeneIDi18951.
KEGGimmu:18951.
UCSCiuc007yoj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK134700 mRNA. Translation: BAE22248.1 .
BC059848 mRNA. Translation: AAH59848.1 .
BC141073 mRNA. Translation: AAI41074.1 .
BC145331 mRNA. Translation: AAI45332.1 .
AF033350 mRNA. Translation: AAC83974.1 .
CCDSi CCDS57021.1.
RefSeqi NP_998779.2. NM_213614.2.
UniGenei Mm.20365.

3D structure databases

ProteinModelPortali Q9Z2Q6.
SMRi Q9Z2Q6. Positions 41-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202285. 4 interactions.
IntActi Q9Z2Q6. 5 interactions.
MINTi MINT-4134165.
STRINGi 10090.ENSMUSP00000094750.

PTM databases

PhosphoSitei Q9Z2Q6.

Proteomic databases

MaxQBi Q9Z2Q6.
PaxDbi Q9Z2Q6.
PRIDEi Q9Z2Q6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000096987 ; ENSMUSP00000094750 ; ENSMUSG00000072214 .
GeneIDi 18951.
KEGGi mmu:18951.
UCSCi uc007yoj.1. mouse.

Organism-specific databases

CTDi 5413.
MGIi MGI:1195461. Sept5.

Phylogenomic databases

eggNOGi COG5019.
GeneTreei ENSGT00760000118899.
HOVERGENi HBG065093.
InParanoidi Q9Z2Q6.
KOi K04557.
OMAi AVNNSEC.
OrthoDBi EOG79KPF0.
TreeFami TF101079.

Miscellaneous databases

NextBioi 295300.
PROi Q9Z2Q6.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z2Q6.
CleanExi MM_SEPT5.
ExpressionAtlasi Q9Z2Q6. baseline and differential.
Genevestigatori Q9Z2Q6.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000038. Cell_div_GTP-bd.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view ]
PANTHERi PTHR18884. PTHR18884. 1 hit.
Pfami PF00735. Septin. 1 hit.
[Graphical view ]
PIRSFi PIRSF006698. Septin. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51719. G_SEPTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Medulla oblongata.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "CDCREL-1, a septin deleted in DiGeorge Syndrome, is expressed in the developing brain and cartilage primordia in mouse embryogenesis."
    Botta A., Lindsay E.A., Jurecic V., Zieger B., Ware J., Baldini A.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-369.
    Strain: C57BL/6.
    Tissue: Brain, Cartilage and Skin.
  4. Lubec G., Klug S., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 23-36; 58-71; 82-90; 182-190; 240-256; 264-282 AND 297-308, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain and Hippocampus.
  5. "Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1."
    Zhang Y., Gao J., Chung K.K.K., Huang H., Dawson V.L., Dawson T.M.
    Proc. Natl. Acad. Sci. U.S.A. 97:13354-13359(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PARK2, UBIQUITIN-MEDIATED DEGRADATION.
  6. "The septin CDCrel-1 is dispensable for normal development and neurotransmitter release."
    Peng X.-R., Jia Z., Zhang Y., Ware J., Trimble W.S.
    Mol. Cell. Biol. 22:378-387(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SEPT2 AND SEPT7, LACK OF INTERACTION WITH SEPT4, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  7. Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327 AND THR-336, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  9. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSEPT5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2Q6
Secondary accession number(s): B2RUC5, Q3UYG4, Q6PB74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3