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Q9Z2Q3

- HYAL2_RAT

UniProt

Q9Z2Q3 - HYAL2_RAT

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Protein

Hyaluronidase-2

Gene

Hyal2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity).By similarity

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351Proton donorBy similarity

GO - Molecular functioni

  1. hyaluronic acid binding Source: UniProtKB
  2. hyaluronoglucuronidase activity Source: UniProtKB
  3. hyalurononglucosaminidase activity Source: UniProtKB
  4. receptor signaling protein tyrosine kinase inhibitor activity Source: UniProtKB
  5. virus receptor activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cartilage development Source: UniProtKB
  3. cellular response to fibroblast growth factor stimulus Source: UniProtKB
  4. cellular response to interleukin-1 Source: UniProtKB
  5. cellular response to transforming growth factor beta stimulus Source: UniProtKB
  6. cellular response to UV-B Source: UniProtKB
  7. fusion of virus membrane with host plasma membrane Source: UniProtKB
  8. glycosaminoglycan catabolic process Source: UniProtKB
  9. hyaluronan catabolic process Source: UniProtKB
  10. kidney development Source: UniProtKB
  11. monocyte activation Source: UniProtKB
  12. negative regulation of cell growth Source: UniProtKB
  13. negative regulation of fibroblast migration Source: UniProtKB
  14. negative regulation of MAP kinase activity Source: UniProtKB
  15. negative regulation of protein kinase B signaling Source: UniProtKB
  16. negative regulation of protein tyrosine kinase activity Source: UniProtKB
  17. positive regulation of inflammatory response Source: UniProtKB
  18. positive regulation of interleukin-6 secretion Source: UniProtKB
  19. positive regulation of interleukin-8 secretion Source: UniProtKB
  20. positive regulation of urine volume Source: UniProtKB
  21. renal water absorption Source: UniProtKB
  22. response to reactive oxygen species Source: UniProtKB
  23. response to virus Source: UniProtKB
  24. transformation of host cell by virus Source: RGD
  25. viral entry into host cell Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Receptor

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-2 (EC:3.2.1.35)
Short name:
Hyal-2
Alternative name(s):
Hyaluronoglucosaminidase-2
Gene namesi
Name:Hyal2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620321. Hyal2.

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of plasma membrane Source: UniProtKB
  2. apical plasma membrane Source: UniProtKB
  3. cytoplasmic membrane-bounded vesicle Source: UniProtKB
  4. cytoplasmic vesicle Source: UniProtKB
  5. cytosol Source: UniProtKB
  6. endocytic vesicle Source: UniProtKB
  7. Golgi membrane Source: UniProtKB
  8. lysosome Source: UniProtKB
  9. membrane raft Source: UniProtKB
  10. microvillus Source: UniProtKB
  11. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 448428Hyaluronidase-2PRO_0000012103Add
BLAST
Propeptidei449 – 47325Removed in mature formSequence AnalysisPRO_0000012104Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 340By similarity
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi211 ↔ 227By similarity
Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi365 ↔ 376By similarity
Disulfide bondi370 ↔ 427By similarity
Disulfide bondi429 ↔ 438By similarity
Lipidationi448 – 4481GPI-anchor amidated aspartateSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9Z2Q3.
PRIDEiQ9Z2Q3.

Expressioni

Gene expression databases

GenevestigatoriQ9Z2Q3.

Interactioni

Subunit structurei

Interacts with MST1R.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9Z2Q3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini361 – 43979EGF-likeAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG77606.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ9Z2Q3.
PhylomeDBiQ9Z2Q3.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z2Q3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRAGLGPIIT LALVLEVAWA SELKPTAPPI FTGRPFVVAW NVPTQECAPR
60 70 80 90 100
HKVPLDLRAF DVEATPNEGF FNQNITTFYY DRLGLYPRFD AAGMSVHGGV
110 120 130 140 150
PQNGSLCAHL PMLKEAVERY IQTQEPAGLA VIDWEEWRPV WVRNWQEKDV
160 170 180 190 200
YRQSSRQLVA SRHPDWPSDR IVKQAQYEFE FAARQFMLNT LRYVKAVRPQ
210 220 230 240 250
HLWGFYLFPD CYNHDYVQNW DSYTGRCPDV EVAQNDQLAW LWAENTALFP
260 270 280 290 300
SVYLDKTLAS SKHSRNFVSF RVQEALRVAH THHANHALPV YVFTRPTYTR
310 320 330 340 350
RLTELNQMDL ISTIGESAAL GSAGVIFWGD SVYASSMENC QNLKKYLTQT
360 370 380 390 400
LVPYIVNVSW ATQYCSWTQC HGHGRCVRRN PSASTFLHLS PSSFRLVPGR
410 420 430 440 450
TPSEPQLRPE GELSEDDLSY LQMHFRCHCY LGWGGEQCQW NHKRAAGDAS
460 470
RAWAGAHLAS LLGLVAMTLT WTL
Length:473
Mass (Da):53,999
Last modified:May 1, 1999 - v1
Checksum:i46B90A2F260B0CE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034218 mRNA. Translation: AAD01980.1.
UniGeneiRn.8278.

Genome annotation databases

UCSCiRGD:620321. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034218 mRNA. Translation: AAD01980.1 .
UniGenei Rn.8278.

3D structure databases

ProteinModelPortali Q9Z2Q3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH56. Glycoside Hydrolase Family 56.

Proteomic databases

PaxDbi Q9Z2Q3.
PRIDEi Q9Z2Q3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:620321. rat.

Organism-specific databases

RGDi 620321. Hyal2.

Phylogenomic databases

eggNOGi NOG77606.
HOGENOMi HOG000015133.
HOVERGENi HBG052053.
InParanoidi Q9Z2Q3.
PhylomeDBi Q9Z2Q3.

Miscellaneous databases

PROi Q9Z2Q3.

Gene expression databases

Genevestigatori Q9Z2Q3.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
PRINTSi PR00846. GLHYDRLASE56.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of the cDNA for a rat hyaluronidase."
    Boel P., Mertens-Strijthagen J., Flamion B.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHYAL2_RAT
AccessioniPrimary (citable) accession number: Q9Z2Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3