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Q9Z2Q3

- HYAL2_RAT

UniProt

Q9Z2Q3 - HYAL2_RAT

Protein

Hyaluronidase-2

Gene

Hyal2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R By similarity.By similarity

    Catalytic activityi

    Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei135 – 1351Proton donorBy similarity

    GO - Molecular functioni

    1. hyaluronic acid binding Source: UniProtKB
    2. hyaluronoglucuronidase activity Source: UniProtKB
    3. hyalurononglucosaminidase activity Source: UniProtKB
    4. protein binding Source: RGD
    5. receptor signaling protein tyrosine kinase inhibitor activity Source: UniProtKB
    6. virus receptor activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cartilage development Source: UniProtKB
    3. cellular response to fibroblast growth factor stimulus Source: UniProtKB
    4. cellular response to interleukin-1 Source: UniProtKB
    5. cellular response to transforming growth factor beta stimulus Source: UniProtKB
    6. cellular response to UV-B Source: UniProtKB
    7. fusion of virus membrane with host plasma membrane Source: UniProtKB
    8. glycosaminoglycan catabolic process Source: UniProtKB
    9. hyaluronan catabolic process Source: UniProtKB
    10. kidney development Source: UniProtKB
    11. monocyte activation Source: UniProtKB
    12. negative regulation of cell growth Source: UniProtKB
    13. negative regulation of fibroblast migration Source: UniProtKB
    14. negative regulation of MAP kinase activity Source: UniProtKB
    15. negative regulation of protein kinase B signaling Source: UniProtKB
    16. negative regulation of protein tyrosine kinase activity Source: UniProtKB
    17. positive regulation of inflammatory response Source: UniProtKB
    18. positive regulation of interleukin-6 secretion Source: UniProtKB
    19. positive regulation of interleukin-8 secretion Source: UniProtKB
    20. positive regulation of urine volume Source: UniProtKB
    21. renal water absorption Source: UniProtKB
    22. response to reactive oxygen species Source: UniProtKB
    23. response to virus Source: UniProtKB
    24. transformation of host cell by virus Source: RGD
    25. viral entry into host cell Source: RGD

    Keywords - Molecular functioni

    Glycosidase, Hydrolase, Receptor

    Protein family/group databases

    CAZyiGH56. Glycoside Hydrolase Family 56.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronidase-2 (EC:3.2.1.35)
    Short name:
    Hyal-2
    Alternative name(s):
    Hyaluronoglucosaminidase-2
    Gene namesi
    Name:Hyal2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620321. Hyal2.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of plasma membrane Source: UniProtKB
    2. apical plasma membrane Source: UniProtKB
    3. cytoplasmic membrane-bounded vesicle Source: UniProtKB
    4. cytoplasmic vesicle Source: UniProtKB
    5. cytosol Source: UniProtKB
    6. endocytic vesicle Source: UniProtKB
    7. Golgi membrane Source: UniProtKB
    8. lysosome Source: UniProtKB
    9. membrane raft Source: UniProtKB
    10. microvillus Source: UniProtKB
    11. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 448428Hyaluronidase-2PRO_0000012103Add
    BLAST
    Propeptidei449 – 47325Removed in mature formSequence AnalysisPRO_0000012104Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 340By similarity
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi211 ↔ 227By similarity
    Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi365 ↔ 376By similarity
    Disulfide bondi370 ↔ 427By similarity
    Disulfide bondi429 ↔ 438By similarity
    Lipidationi448 – 4481GPI-anchor amidated aspartateSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ9Z2Q3.
    PRIDEiQ9Z2Q3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9Z2Q3.

    Interactioni

    Subunit structurei

    Interacts with MST1R.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2Q3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini361 – 43979EGF-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 56 family.Curated
    Contains 1 EGF-like domain.Curated

    Keywords - Domaini

    EGF-like domain, Signal

    Phylogenomic databases

    eggNOGiNOG77606.
    HOGENOMiHOG000015133.
    HOVERGENiHBG052053.
    InParanoidiQ9Z2Q3.
    PhylomeDBiQ9Z2Q3.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    [Graphical view]
    PANTHERiPTHR11769. PTHR11769. 1 hit.
    PfamiPF01630. Glyco_hydro_56. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
    PRINTSiPR00846. GLHYDRLASE56.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z2Q3-1 [UniParc]FASTAAdd to Basket

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    MRAGLGPIIT LALVLEVAWA SELKPTAPPI FTGRPFVVAW NVPTQECAPR    50
    HKVPLDLRAF DVEATPNEGF FNQNITTFYY DRLGLYPRFD AAGMSVHGGV 100
    PQNGSLCAHL PMLKEAVERY IQTQEPAGLA VIDWEEWRPV WVRNWQEKDV 150
    YRQSSRQLVA SRHPDWPSDR IVKQAQYEFE FAARQFMLNT LRYVKAVRPQ 200
    HLWGFYLFPD CYNHDYVQNW DSYTGRCPDV EVAQNDQLAW LWAENTALFP 250
    SVYLDKTLAS SKHSRNFVSF RVQEALRVAH THHANHALPV YVFTRPTYTR 300
    RLTELNQMDL ISTIGESAAL GSAGVIFWGD SVYASSMENC QNLKKYLTQT 350
    LVPYIVNVSW ATQYCSWTQC HGHGRCVRRN PSASTFLHLS PSSFRLVPGR 400
    TPSEPQLRPE GELSEDDLSY LQMHFRCHCY LGWGGEQCQW NHKRAAGDAS 450
    RAWAGAHLAS LLGLVAMTLT WTL 473
    Length:473
    Mass (Da):53,999
    Last modified:May 1, 1999 - v1
    Checksum:i46B90A2F260B0CE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034218 mRNA. Translation: AAD01980.1.
    UniGeneiRn.8278.

    Genome annotation databases

    UCSCiRGD:620321. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034218 mRNA. Translation: AAD01980.1 .
    UniGenei Rn.8278.

    3D structure databases

    ProteinModelPortali Q9Z2Q3.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH56. Glycoside Hydrolase Family 56.

    Proteomic databases

    PaxDbi Q9Z2Q3.
    PRIDEi Q9Z2Q3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:620321. rat.

    Organism-specific databases

    RGDi 620321. Hyal2.

    Phylogenomic databases

    eggNOGi NOG77606.
    HOGENOMi HOG000015133.
    HOVERGENi HBG052053.
    InParanoidi Q9Z2Q3.
    PhylomeDBi Q9Z2Q3.

    Miscellaneous databases

    PROi Q9Z2Q3.

    Gene expression databases

    Genevestigatori Q9Z2Q3.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    [Graphical view ]
    PANTHERi PTHR11769. PTHR11769. 1 hit.
    Pfami PF01630. Glyco_hydro_56. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
    PRINTSi PR00846. GLHYDRLASE56.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of the cDNA for a rat hyaluronidase."
      Boel P., Mertens-Strijthagen J., Flamion B.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHYAL2_RAT
    AccessioniPrimary (citable) accession number: Q9Z2Q3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3