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Protein

Vesicle-associated membrane protein 5

Gene

Vamp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • exocytosis Source: GO_Central
  • Golgi to plasma membrane protein transport Source: MGI
  • skeletal muscle tissue development Source: MGI
  • vesicle fusion Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 5
Short name:
VAMP-5
Alternative name(s):
Myobrevin
Gene namesi
Name:Vamp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1858622. Vamp5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7272CytoplasmicSequence analysisAdd
BLAST
Transmembranei73 – 9321Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini94 – 1029VesicularSequence analysis

GO - Cellular componenti

  • cell surface Source: MGI
  • cytoplasmic vesicle membrane Source: BHF-UCL
  • extracellular exosome Source: MGI
  • Golgi apparatus Source: UniProtKB-SubCell
  • integral component of organelle membrane Source: BHF-UCL
  • integral component of plasma membrane Source: MGI
  • intercalated disc Source: BHF-UCL
  • late endosome Source: BHF-UCL
  • perinuclear region of cytoplasm Source: BHF-UCL
  • plasma membrane Source: MGI
  • SNARE complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 102102Vesicle-associated membrane protein 5PRO_0000206734Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411PhosphoserineCombined sources
Modified residuei48 – 481PhosphoserineBy similarity
Modified residuei49 – 491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z2P8.
PaxDbiQ9Z2P8.
PRIDEiQ9Z2P8.
TopDownProteomicsiQ9Z2P8.

PTM databases

iPTMnetiQ9Z2P8.
PhosphoSiteiQ9Z2P8.
SwissPalmiQ9Z2P8.

Expressioni

Tissue specificityi

Preferentially expressed in the skeletal muscle and heart, detected at lower levels in several other tissues but not in the brain.

Inductioni

During myogenesis.

Gene expression databases

BgeeiENSMUSG00000073002.
CleanExiMM_VAMP5.
ExpressionAtlasiQ9Z2P8. baseline and differential.
GenevisibleiQ9Z2P8. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9Z2P8. 1 interaction.
STRINGi10090.ENSMUSP00000073852.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2P8.
SMRiQ9Z2P8. Positions 4-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 6561v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0860. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00730000111371.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiQ9Z2P8.
KOiK08514.
OMAiKRWENIR.
OrthoDBiEOG091G0ZXR.
PhylomeDBiQ9Z2P8.
TreeFamiTF313666.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2P8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKELKQCQ QQADEVTEIM LNNFDKVLER HGKLAELEQR SDQLLDMSSA
60 70 80 90 100
FSKTTKTLAQ QKRWENIRCR VYLGLAVAVG LLIILIVLLV VFLPSGGDSS

KP
Length:102
Mass (Da):11,416
Last modified:May 1, 1999 - v1
Checksum:i37707734244C5DC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035643 mRNA. Translation: AAC95282.1.
CCDSiCCDS39513.1.
RefSeqiNP_001074211.1. NM_001080742.2.
NP_058568.1. NM_016872.4.
UniGeneiMm.440321.

Genome annotation databases

EnsembliENSMUST00000074231; ENSMUSP00000073852; ENSMUSG00000073002.
ENSMUST00000101285; ENSMUSP00000098843; ENSMUSG00000073002.
ENSMUST00000192869; ENSMUSP00000141824; ENSMUSG00000102671.
ENSMUST00000195019; ENSMUSP00000141851; ENSMUSG00000102671.
GeneIDi53620.
KEGGimmu:53620.
UCSCiuc009cil.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035643 mRNA. Translation: AAC95282.1.
CCDSiCCDS39513.1.
RefSeqiNP_001074211.1. NM_001080742.2.
NP_058568.1. NM_016872.4.
UniGeneiMm.440321.

3D structure databases

ProteinModelPortaliQ9Z2P8.
SMRiQ9Z2P8. Positions 4-64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2P8. 1 interaction.
STRINGi10090.ENSMUSP00000073852.

PTM databases

iPTMnetiQ9Z2P8.
PhosphoSiteiQ9Z2P8.
SwissPalmiQ9Z2P8.

Proteomic databases

MaxQBiQ9Z2P8.
PaxDbiQ9Z2P8.
PRIDEiQ9Z2P8.
TopDownProteomicsiQ9Z2P8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074231; ENSMUSP00000073852; ENSMUSG00000073002.
ENSMUST00000101285; ENSMUSP00000098843; ENSMUSG00000073002.
ENSMUST00000192869; ENSMUSP00000141824; ENSMUSG00000102671.
ENSMUST00000195019; ENSMUSP00000141851; ENSMUSG00000102671.
GeneIDi53620.
KEGGimmu:53620.
UCSCiuc009cil.2. mouse.

Organism-specific databases

CTDi10791.
MGIiMGI:1858622. Vamp5.

Phylogenomic databases

eggNOGiKOG0860. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00730000111371.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiQ9Z2P8.
KOiK08514.
OMAiKRWENIR.
OrthoDBiEOG091G0ZXR.
PhylomeDBiQ9Z2P8.
TreeFamiTF313666.

Miscellaneous databases

PROiQ9Z2P8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073002.
CleanExiMM_VAMP5.
ExpressionAtlasiQ9Z2P8. baseline and differential.
GenevisibleiQ9Z2P8. MM.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVAMP5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.