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Protein

Synaptosomal-associated protein 29

Gene

Snap29

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Cilium biogenesis/degradation, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptosomal-associated protein 29By similarity
Short name:
SNAP-29By similarity
Alternative name(s):
Golgi SNARE of 32 kDa
Short name:
Gs32
Soluble 29 kDa NSF attachment protein
Vesicle-membrane fusion protein SNAP-29
Gene namesi
Name:Snap29By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620225. Snap29.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Synaptosomal-associated protein 29PRO_0000213603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771PhosphoserineBy similarity
Modified residuei78 – 781PhosphoserineBy similarity
Modified residuei114 – 1141PhosphoserineBy similarity
Modified residuei163 – 1631PhosphoserineBy similarity
Modified residuei181 – 1811PhosphoserineBy similarity
Modified residuei203 – 2031PhosphoserineBy similarity
Modified residuei209 – 2091PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z2P6.
PRIDEiQ9Z2P6.

PTM databases

iPTMnetiQ9Z2P6.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Interactioni

Subunit structurei

Forms a SNARE complex, composed of VAMP8, SNAP29 and STX17, involved in fusion of autophagosome with lysosome (By similarity). Interacts with multiple syntaxins including STX6 (PubMed:9880331).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Ehd1Q641Z62EBI-492883,EBI-492911
Ehd4Q9EQP22EBI-492883,EBI-491022From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9Z2P6. 4 interactions.
MINTiMINT-1542515.
STRINGi10116.ENSRNOP00000002550.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini195 – 25763t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SNAP-25 family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3065. Eukaryota.
ENOG410Y3Y0. LUCA.
HOGENOMiHOG000046806.
HOVERGENiHBG057045.
InParanoidiQ9Z2P6.
PhylomeDBiQ9Z2P6.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
SMARTiSM00397. t_SNARE. 2 hits.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGYPKSYNP FDDDVEDEDT RPAPWKDARD LPDGPDPPID RQQYLRQEVL
60 70 80 90 100
RGPSATAAST SRSLFLMYES EKIGVASSEE LVRQRGVLEH TEKMVDKMDQ
110 120 130 140 150
DLKMSQKHIN SIKSVFGGFI NYFKSKPVEP PPEQNGSIVP QPSSRLKEAI
160 170 180 190 200
NTSKDQESKY QASHPNLRRL HDAELDSVPA STVNTEVYPK NSSLRAYHQK
210 220 230 240 250
IDSNLDELSV GLGRLKDIAL GMQTEIEEQD DILDRLTTKV DKLDVNIKST

EKKVRQL
Length:257
Mass (Da):29,071
Last modified:May 1, 1999 - v1
Checksum:i9B9BC1A351CB1A3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035822 mRNA. Translation: AAC72291.1.
UniGeneiRn.17902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035822 mRNA. Translation: AAC72291.1.
UniGeneiRn.17902.

3D structure databases

ProteinModelPortaliQ9Z2P6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2P6. 4 interactions.
MINTiMINT-1542515.
STRINGi10116.ENSRNOP00000002550.

PTM databases

iPTMnetiQ9Z2P6.

Proteomic databases

PaxDbiQ9Z2P6.
PRIDEiQ9Z2P6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi620225. Snap29.

Phylogenomic databases

eggNOGiKOG3065. Eukaryota.
ENOG410Y3Y0. LUCA.
HOGENOMiHOG000046806.
HOVERGENiHBG057045.
InParanoidiQ9Z2P6.
PhylomeDBiQ9Z2P6.

Miscellaneous databases

PROiQ9Z2P6.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
SMARTiSM00397. t_SNARE. 2 hits.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6."
    Wong S.H., Xu Y., Zhang T., Griffiths G., Lowe S.L., Subramaniam V.N., Seow K.T., Hong W.
    Mol. Biol. Cell 10:119-134(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH STX6, TISSUE SPECIFICITY.
  2. Lubec G., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 170-190 AND 201-235, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.

Entry informationi

Entry nameiSNP29_RAT
AccessioniPrimary (citable) accession number: Q9Z2P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.