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Protein

Regulator of cell cycle RGCC

Gene

Rgcc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein kinase activator activity Source: GO_Central
  • protein kinase binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of cell cycle RGCC
Alternative name(s):
Response gene to complement 32 protein
Short name:
RGC-32
Gene namesi
Name:Rgcc
Synonyms:Rgc32
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi619721. Rgcc.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: Ensembl
  • cytoplasm Source: BHF-UCL
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002747031 – 137Regulator of cell cycle RGCCAdd BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphoserineBy similarity1
Modified residuei69PhosphoserineBy similarity1
Modified residuei71PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei91PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei111Phosphothreonine; by CDK1By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z2P4.
PRIDEiQ9Z2P4.

PTM databases

iPTMnetiQ9Z2P4.
PhosphoSitePlusiQ9Z2P4.

Expressioni

Tissue specificityi

Detected in kidney, heart, brain, lung, skin, spleen and thymus.1 Publication

Inductioni

Up-regulated in oligodendrocytes in response to complement activation.1 Publication

Gene expression databases

BgeeiENSRNOG00000042960.
GenevisibleiQ9Z2P4. RN.

Interactioni

Subunit structurei

Interacts with PLK1 (By similarity). Interacts with CDK1. Interacts with SMAD3 (By similarity).By similarity

GO - Molecular functioni

  • protein kinase binding Source: BHF-UCL

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060481.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 26Ala-richAdd BLAST16
Compositional biasi64 – 108Ser/Thr-richAdd BLAST45

Phylogenomic databases

eggNOGiENOG410J12H. Eukaryota.
ENOG4111Y7V. LUCA.
GeneTreeiENSGT00390000011709.
HOVERGENiHBG060999.
InParanoidiQ9Z2P4.
OMAiFRYDEHL.
OrthoDBiEOG091G1849.
PhylomeDBiQ9Z2P4.

Family and domain databases

InterProiIPR029252. RGCC.
[Graphical view]
PfamiPF15151. RGCC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPSTQSSP AAVAAAAPAM DSAAAADLTD VLCEFDAVLA DFASPFHERH
60 70 80 90 100
FHYEEHLERM KRRSSASVSD SSGFSDSESA DSLYRDSFTF SDEKLNSPTD
110 120 130
STPALLSSAV TPRKAKLGDT KELEDFIADL DRTLASM
Length:137
Mass (Da):14,766
Last modified:May 1, 1999 - v1
Checksum:i0CBE742C5FDC544C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036548 mRNA. Translation: AAC68839.1.
RefSeqiNP_446460.1. NM_054008.1.
UniGeneiRn.3504.

Genome annotation databases

EnsembliENSRNOT00000068216; ENSRNOP00000060481; ENSRNOG00000042960.
GeneIDi117183.
KEGGirno:117183.
UCSCiRGD:619721. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036548 mRNA. Translation: AAC68839.1.
RefSeqiNP_446460.1. NM_054008.1.
UniGeneiRn.3504.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060481.

PTM databases

iPTMnetiQ9Z2P4.
PhosphoSitePlusiQ9Z2P4.

Proteomic databases

PaxDbiQ9Z2P4.
PRIDEiQ9Z2P4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000068216; ENSRNOP00000060481; ENSRNOG00000042960.
GeneIDi117183.
KEGGirno:117183.
UCSCiRGD:619721. rat.

Organism-specific databases

CTDi28984.
RGDi619721. Rgcc.

Phylogenomic databases

eggNOGiENOG410J12H. Eukaryota.
ENOG4111Y7V. LUCA.
GeneTreeiENSGT00390000011709.
HOVERGENiHBG060999.
InParanoidiQ9Z2P4.
OMAiFRYDEHL.
OrthoDBiEOG091G1849.
PhylomeDBiQ9Z2P4.

Miscellaneous databases

PROiQ9Z2P4.

Gene expression databases

BgeeiENSRNOG00000042960.
GenevisibleiQ9Z2P4. RN.

Family and domain databases

InterProiIPR029252. RGCC.
[Graphical view]
PfamiPF15151. RGCC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGCC_RAT
AccessioniPrimary (citable) accession number: Q9Z2P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.