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Protein

Tumor necrosis factor ligand superfamily member 4

Gene

Tnfsf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production (By similarity).By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • tumor necrosis factor receptor binding Source: Ensembl
  • tumor necrosis factor receptor superfamily binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-RNO-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 4
Alternative name(s):
OX40 ligand
Short name:
OX40L
CD_antigen: CD252
Gene namesi
Name:Tnfsf4
Synonyms:Ox40l, Txgp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi619816. Tnfsf4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini49 – 199ExtracellularSequence analysisAdd BLAST151

GO - Cellular componenti

  • cell surface Source: RGD
  • extracellular space Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854961 – 199Tumor necrosis factor ligand superfamily member 4Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70 ↔ 163By similarity
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 184By similarity
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z2P3.
PRIDEiQ9Z2P3.

Expressioni

Tissue specificityi

Detected in T-cell lines, but not in a macrophage cell line.

Gene expression databases

BgeeiENSRNOG00000002968.
ExpressionAtlasiQ9Z2P3. baseline and differential.
GenevisibleiQ9Z2P3. RN.

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • tumor necrosis factor receptor binding Source: Ensembl
  • tumor necrosis factor receptor superfamily binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003969.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2P3.
SMRiQ9Z2P3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0GG. Eukaryota.
ENOG41119SD. LUCA.
GeneTreeiENSGT00390000015127.
HOGENOMiHOG000076309.
HOVERGENiHBG056457.
InParanoidiQ9Z2P3.
KOiK05469.
OMAiMEGVQPL.
OrthoDBiEOG091G0OEG.
PhylomeDBiQ9Z2P3.
TreeFamiTF336384.

Family and domain databases

InterProiView protein in InterPro
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
SMARTiView protein in SMART
SM00207. TNF. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS00251. TNF_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z2P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGEGVQPPD ENLENGSRPR FKWKKVLRLV VSGIKAAGLL LCVVYVCLQF
60 70 80 90 100
SSSPAKDSPI QRLRAPVTGC EGGRLFIGTS KNEYETMEVQ NNSVIINCDG
110 120 130 140 150
LYLIHLKGSF FQEVKINLHF RKDRSPIFVP MLNNGQRVVF TVVTSLAFKD
160 170 180 190
EVYLTVNASD TLCEHLQIND GELIIVQLTP NGYCAPERPY SSTVNQVPL
Length:199
Mass (Da):22,190
Last modified:May 1, 1999 - v1
Checksum:i0032C901CC62B0FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037067 mRNA. Translation: AAC67236.1.
PIRiJE0351.
RefSeqiNP_446004.1. NM_053552.1.
UniGeneiRn.30043.

Genome annotation databases

EnsembliENSRNOT00000003969; ENSRNOP00000003969; ENSRNOG00000002968.
GeneIDi89814.
KEGGirno:89814.
UCSCiRGD:619816. rat.

Similar proteinsi

Entry informationi

Entry nameiTNFL4_RAT
AccessioniPrimary (citable) accession number: Q9Z2P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 1999
Last modified: August 30, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families