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Protein

Tumor necrosis factor ligand superfamily member 4

Gene

Tnfsf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production (By similarity).By similarity

GO - Molecular functioni

  • tumor necrosis factor receptor superfamily binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-RNO-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 4
Alternative name(s):
OX40 ligand
Short name:
OX40L
CD_antigen: CD252
Gene namesi
Name:Tnfsf4
Synonyms:Ox40l, Txgp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi619816. Tnfsf4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525CytoplasmicSequence analysisAdd
BLAST
Transmembranei26 – 4823Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini49 – 199151ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: RGD
  • extracellular space Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Tumor necrosis factor ligand superfamily member 4PRO_0000185496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 163By similarity
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence analysis
Disulfide bondi98 ↔ 184By similarity
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Z2P3.
PRIDEiQ9Z2P3.

Expressioni

Tissue specificityi

Detected in T-cell lines, but not in a macrophage cell line.

Gene expression databases

GenevisibleiQ9Z2P3. RN.

Interactioni

Subunit structurei

Homotrimer.Curated

GO - Molecular functioni

  • tumor necrosis factor receptor superfamily binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003969.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2P3.
SMRiQ9Z2P3. Positions 57-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0GG. Eukaryota.
ENOG41119SD. LUCA.
GeneTreeiENSGT00390000015127.
HOGENOMiHOG000076309.
HOVERGENiHBG056457.
InParanoidiQ9Z2P3.
KOiK05469.
OMAiMEGVQPL.
OrthoDBiEOG74BJVD.
PhylomeDBiQ9Z2P3.
TreeFamiTF336384.

Family and domain databases

InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGEGVQPPD ENLENGSRPR FKWKKVLRLV VSGIKAAGLL LCVVYVCLQF
60 70 80 90 100
SSSPAKDSPI QRLRAPVTGC EGGRLFIGTS KNEYETMEVQ NNSVIINCDG
110 120 130 140 150
LYLIHLKGSF FQEVKINLHF RKDRSPIFVP MLNNGQRVVF TVVTSLAFKD
160 170 180 190
EVYLTVNASD TLCEHLQIND GELIIVQLTP NGYCAPERPY SSTVNQVPL
Length:199
Mass (Da):22,190
Last modified:May 1, 1999 - v1
Checksum:i0032C901CC62B0FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037067 mRNA. Translation: AAC67236.1.
PIRiJE0351.
RefSeqiNP_446004.1. NM_053552.1.
UniGeneiRn.30043.

Genome annotation databases

EnsembliENSRNOT00000003969; ENSRNOP00000003969; ENSRNOG00000002968.
GeneIDi89814.
KEGGirno:89814.
UCSCiRGD:619816. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037067 mRNA. Translation: AAC67236.1.
PIRiJE0351.
RefSeqiNP_446004.1. NM_053552.1.
UniGeneiRn.30043.

3D structure databases

ProteinModelPortaliQ9Z2P3.
SMRiQ9Z2P3. Positions 57-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003969.

Proteomic databases

PaxDbiQ9Z2P3.
PRIDEiQ9Z2P3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003969; ENSRNOP00000003969; ENSRNOG00000002968.
GeneIDi89814.
KEGGirno:89814.
UCSCiRGD:619816. rat.

Organism-specific databases

CTDi7292.
RGDi619816. Tnfsf4.

Phylogenomic databases

eggNOGiENOG410J0GG. Eukaryota.
ENOG41119SD. LUCA.
GeneTreeiENSGT00390000015127.
HOGENOMiHOG000076309.
HOVERGENiHBG056457.
InParanoidiQ9Z2P3.
KOiK05469.
OMAiMEGVQPL.
OrthoDBiEOG74BJVD.
PhylomeDBiQ9Z2P3.
TreeFamiTF336384.

Enzyme and pathway databases

ReactomeiR-RNO-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

PROiQ9Z2P3.

Gene expression databases

GenevisibleiQ9Z2P3. RN.

Family and domain databases

InterProiIPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of rat OX40 ligand by molecular cloning."
    Akiba H., Atsuta M., Yagita H., Okumura K.
    Biochem. Biophys. Res. Commun. 251:131-136(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: T-cell lymphoma.

Entry informationi

Entry nameiTNFL4_RAT
AccessioniPrimary (citable) accession number: Q9Z2P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.