Unreviewed, UniProtKB/TrEMBL Q9Z2P2 (Q9Z2P2_MOUSE)

Names and origin

Protein names

Submitted name:
    Sulfonylurea receptor-1 EMBL AAC72292.1

Gene names

Name:	Abcc8 MGI 1352629
Synonyms:	SUR-1 EMBL AAC72292.1

Organism

Mus musculus (Mouse) EMBL AAC72292.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	899 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter superfamily.

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000684V4 Nucleotide-binding
Molecular function	Receptor EMBL AAC72292.1
Gene Ontology (GO)
Biological process	negative regulation of insulin secretion Inferred from electronic annotation. Source: Compara positive regulation of potassium ion transport Inferred from electronic annotation. Source: Compara potassium ion transport Inferred from electronic annotation. Source: InterPro response to drug Inferred from electronic annotation. Source: Compara response to insulin stimulus Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara response to pH Inferred from electronic annotation. Source: Compara response to zinc ion Inferred from electronic annotation. Source: Compara transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	ATP-sensitive potassium channel complex Inferred from electronic annotation. Source: Compara sarcolemma Inferred from electronic annotation. Source: Compara synaptic vesicle membrane Inferred from electronic annotation. Source: Compara
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro potassium channel activity Inferred from electronic annotation. Source: Compara sulfonylurea receptor activity Inferred from electronic annotation. Source: InterPro syntaxin binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	899	1	EMBL AAC72292.1

Sequences

	Sequence		Length	Mass (Da)
	Q9Z2P2-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 278FF6625FDA1B25	FASTA	899	101,088
	10 20 30 40 50 60 MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG WGSQSSKVHI 70 80 90 100 110 120 HHSTWLHFPG HNLRWILTFM LLFVLVCEIA EGILSDGVTE SRHLHLYMPA GMAFMAAITS 130 140 150 160 170 180 VVYYHNIETS NFPKLLIALL IYWTLAFITK TIKFVKFYDH AISFSQLRFC LTGLLVILYG 190 200 210 220 230 240 MLLLVEINVI RVRRYIFFKT PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA 250 260 270 280 290 300 HRKPIDLRAI GKLPIAMRAL TNYQRLCAAF DAQARKDRQS QQGARAIWRA LCHAFGRRLV 310 320 330 340 350 360 LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE FLGNAYVLAV 370 380 390 400 410 420 LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM HLSTSNLSMG EMTAGQICNL 430 440 450 460 470 480 VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI LLYYILGVSA LIGAAVIILL APVQYFVATK 490 500 510 520 530 540 LSQAQRSTLE YSNERLKQTN EMLRGIKLLK LYAWENIFCS RVEMTRRKEM TSLRAFAVYT 550 560 570 580 590 600 SISIFMNTAI PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST 610 620 630 640 650 660 VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR PAREEVRDLL 670 680 690 700 710 720 GPLQRLTPSM DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT IRIPRGQLTM IVGQVGCGKS 730 740 750 760 770 780 SLLLATLGEM QRVSGAVFWN SSLPDSEGED PSNPERETAA DSDARSRGPV AYASQKPWLL 790 800 810 820 830 840 NATVEENITF ESPFNKQRYK MVIEACSLQP DIDILPHGDQ TQIGERGINL SGGQRQRISV 850 860 870 880 890 ARALYQHTNV VFLDDPFSAL DVHLSDHLMQ AGILELLRDD KRTVVLVTHK LQYLPHADW

References

[1]	"Expression of sulphonylurea receptor protein in mouse kidney." Beesley A.H., Qureshi I.Z., Giesberts A.N., Parker A.J., White S.J. Pflugers Arch. 438:1-7(1999) [PubMed: 10370080] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129/Sv EMBL AAC72292.1.
[2]	"Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose." Shiota C., Larsson O., Shelton K.D., Shiota M., Efanov A.M., Hoy M., Lindner J., Kooptiwut S., Juntti-Berggren L., Gromada J., Berggren P.O., Magnuson M.A. J. Biol. Chem. 277:37176-37183(2002) [PubMed: 12149271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129/Sv EMBL AAC72292.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF037295 , AF037274, AF037275, AF037276, AF037277, AF037278, AF037279, AF037280, AF037281, AF037282, AF037283, AF037284, AF037285, AF037286, AF037287, AF037288, AF037289, AF037290, AF037291, AF037292, AF037293, AF037294 Genomic DNA. Translation: AAC72292.1.
IPI	IPI00624726.
UniGene	Mm.259076
3D structure databases
HSSP	HSSP built from PDB template 1R0W based on UniProtKB P26361.
SMR	Q9Z2P2. Positions 285-899.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Z2P2.
PTM databases
PhosphoSite	Q9Z2P2.
Genome annotation databases
Ensembl	ENSMUST00000033123; ENSMUSP00000033123; ENSMUSG00000040136; Mus musculus. [Genome view]
Organism-specific databases
MGI	MGI:1352629. Abcc8.
Phylogenomic databases
HOVERGEN	Q9Z2P2.
InParanoid	Q9Z2P2.
Gene expression databases
ArrayExpress	Q9Z2P2.
Bgee	Q9Z2P2.
Genevestigator	Q9Z2P2.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. IPR000388. Sulphorea_rcpt_N. IPR000844. Surea_rcpt_1_N. [Graphical view]
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
PRINTS	PR01093. SULFNYLUR1. PR01092. SULFNYLUREAR.
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

Q9Z2P2_MOUSE

Accession

Primary (citable) accession number: Q9Z2P2

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1999
Last sequence update:	May 1, 1999
Last modified:	February 9, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)