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Unreviewed, UniProtKB/TrEMBL Q9Z2P2 (Q9Z2P2_MOUSE)

Last modified February 9, 2010. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Sulfonylurea receptor-1 EMBL AAC72292.1
Gene names
Name: Abcc8 MGI 1352629
Synonyms: SUR-1 EMBL AAC72292.1
OrganismMus musculus (Mouse) EMBL AAC72292.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length899 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter superfamily.

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Ontologies

Keywords
   LigandATP-binding RuleBase RU000684V4
Nucleotide-binding
   Molecular functionReceptor EMBL AAC72292.1
Gene Ontology (GO)
   Biological processnegative regulation of insulin secretion

Inferred from electronic annotation. Source: Compara

positive regulation of potassium ion transport

Inferred from electronic annotation. Source: Compara

potassium ion transport

Inferred from electronic annotation. Source: InterPro

response to drug

Inferred from electronic annotation. Source: Compara

response to insulin stimulus

Inferred from electronic annotation. Source: Compara

response to lipopolysaccharide

Inferred from electronic annotation. Source: Compara

response to pH

Inferred from electronic annotation. Source: Compara

response to zinc ion

Inferred from electronic annotation. Source: Compara

transmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular componentATP-sensitive potassium channel complex

Inferred from electronic annotation. Source: Compara

sarcolemma

Inferred from electronic annotation. Source: Compara

synaptic vesicle membrane

Inferred from electronic annotation. Source: Compara

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity, coupled to transmembrane movement of substances

Inferred from electronic annotation. Source: InterPro

potassium channel activity

Inferred from electronic annotation. Source: Compara

sulfonylurea receptor activity

Inferred from electronic annotation. Source: InterPro

syntaxin binding

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue8991 EMBL AAC72292.1

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Sequences

Sequence LengthMass (Da)Tools
Q9Z2P2-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 278FF6625FDA1B25

FASTA899101,088
        10         20         30         40         50         60 
MPLAFCGTEN HSAAYRVDQG VLNNGCFVDA LNVVPHVFLL FITFPILFIG WGSQSSKVHI 

        70         80         90        100        110        120 
HHSTWLHFPG HNLRWILTFM LLFVLVCEIA EGILSDGVTE SRHLHLYMPA GMAFMAAITS 

       130        140        150        160        170        180 
VVYYHNIETS NFPKLLIALL IYWTLAFITK TIKFVKFYDH AISFSQLRFC LTGLLVILYG 

       190        200        210        220        230        240 
MLLLVEINVI RVRRYIFFKT PREVKPPEDL QDLGVRFLQP FVNLLSKGTY WWMNAFIKTA 

       250        260        270        280        290        300 
HRKPIDLRAI GKLPIAMRAL TNYQRLCAAF DAQARKDRQS QQGARAIWRA LCHAFGRRLV 

       310        320        330        340        350        360 
LSSTFRILAD LLGFAGPLCI FGIVDHLGKE NHVFQPKTQF LGVYFVSSQE FLGNAYVLAV 

       370        380        390        400        410        420 
LLFLALLLQR TFLQASYYVA IETGINLRGA IQTKIYNKIM HLSTSNLSMG EMTAGQICNL 

       430        440        450        460        470        480 
VAIDTNQLMW FFFLCPNLWA MPVQIIVGVI LLYYILGVSA LIGAAVIILL APVQYFVATK 

       490        500        510        520        530        540 
LSQAQRSTLE YSNERLKQTN EMLRGIKLLK LYAWENIFCS RVEMTRRKEM TSLRAFAVYT 

       550        560        570        580        590        600 
SISIFMNTAI PIAAVLITFV GHVSFFKESD FSPSVAFASL SLFHILVTPL FLLSSVVRST 

       610        620        630        640        650        660 
VKALVSVQKL SEFLSSAEIR EEQCAPREPA PQGQAGKYQA VPLKVVNRKR PAREEVRDLL 

       670        680        690        700        710        720 
GPLQRLTPSM DGDADNFCVQ IIGGFFTWTP DGIPTLSNIT IRIPRGQLTM IVGQVGCGKS 

       730        740        750        760        770        780 
SLLLATLGEM QRVSGAVFWN SSLPDSEGED PSNPERETAA DSDARSRGPV AYASQKPWLL 

       790        800        810        820        830        840 
NATVEENITF ESPFNKQRYK MVIEACSLQP DIDILPHGDQ TQIGERGINL SGGQRQRISV 

       850        860        870        880        890 
ARALYQHTNV VFLDDPFSAL DVHLSDHLMQ AGILELLRDD KRTVVLVTHK LQYLPHADW

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References

[1]"Expression of sulphonylurea receptor protein in mouse kidney."
Beesley A.H., Qureshi I.Z., Giesberts A.N., Parker A.J., White S.J.
Pflugers Arch. 438:1-7(1999) [PubMed: 10370080] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/Sv EMBL AAC72292.1.
[2]"Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose."
Shiota C., Larsson O., Shelton K.D., Shiota M., Efanov A.M., Hoy M., Lindner J., Kooptiwut S., Juntti-Berggren L., Gromada J., Berggren P.O., Magnuson M.A.
J. Biol. Chem. 277:37176-37183(2002) [PubMed: 12149271] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/Sv EMBL AAC72292.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF037295 expand/collapse EMBL AC list , AF037274, AF037275, AF037276, AF037277, AF037278, AF037279, AF037280, AF037281, AF037282, AF037283, AF037284, AF037285, AF037286, AF037287, AF037288, AF037289, AF037290, AF037291, AF037292, AF037293, AF037294 Genomic DNA. Translation: AAC72292.1.
IPIIPI00624726.
UniGeneMm.259076

3D structure databases

HSSPHSSP built from PDB template 1R0W based on UniProtKB P26361.
SMRQ9Z2P2. Positions 285-899.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9Z2P2.

PTM databases

PhosphoSiteQ9Z2P2.

Genome annotation databases

EnsemblENSMUST00000033123; ENSMUSP00000033123; ENSMUSG00000040136; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:1352629. Abcc8.

Phylogenomic databases

HOVERGENQ9Z2P2.
InParanoidQ9Z2P2.

Gene expression databases

ArrayExpressQ9Z2P2.
BgeeQ9Z2P2.
GenevestigatorQ9Z2P2.

Family and domain databases

InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR003593. ATPase_AAA+_core.
IPR000388. Sulphorea_rcpt_N.
IPR000844. Surea_rcpt_1_N.
[Graphical view]
PfamPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
PRINTSPR01093. SULFNYLUR1.
PR01092. SULFNYLUREAR.
SMARTSM00382. AAA. 1 hit.
[Graphical view]
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameQ9Z2P2_MOUSE
AccessionPrimary (citable) accession number: Q9Z2P2
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: February 9, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information