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Protein

Calcium/calmodulin-dependent protein kinase II inhibitor 2

Gene

Camk2n2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca2+/calmodulin on CAMK2.2 Publications

GO - Molecular functioni

  • calcium-dependent protein kinase inhibitor activity Source: RGD
  • protein kinase binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase II inhibitor 2
Alternative name(s):
CaM-KII inhibitory protein
Short name:
CaM-KIIN
CaM-KIINbeta
Gene namesi
Name:Camk2n2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi708411. Camk2n2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7979Calcium/calmodulin-dependent protein kinase II inhibitor 2PRO_0000327268Add
BLAST

Proteomic databases

PaxDbiQ9Z2N6.
PRIDEiQ9Z2N6.

Expressioni

Tissue specificityi

Expressed in forebrain, hippocampus, midbrain, cerebellum, and testis. Expressed in forebrain, hippocampus, midbrain, and cerebellum (at protein level). In the cortex expressed more in laminae II and III than in laminae IV-VI. Expressed within the pyramidal layer of the hippocampus and granular layer of the dentate gyrus as well as in the olfactory bulb. Diffusely expressed within the caudate-putamen and globus pallidus. Diffusely expressed throughout regions of the midbrain. In cerebellum, expressed within the Purkinje and granular layer. Stronger expressed in the cerebellum. Highly expressed in frontal cortex, hippocampus, olfactory bulb, caudate-putamen and cerebellum exhibit (at protein level).2 Publications

Gene expression databases

GenevisibleiQ9Z2N6. RN.

Interactioni

Subunit structurei

Interacts with CAMK2A and CAMK2B in the presence of Ca2+/calmodulin or after autophosphorylation.2 Publications

GO - Molecular functioni

  • protein kinase binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054937.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 6927Inhibitory domainAdd
BLAST

Domaini

The inhibitory domain blocks CAMK2 binding to GRIN2B.

Sequence similaritiesi

Belongs to the CAMK2N family.Curated

Phylogenomic databases

eggNOGiENOG410J0NK. Eukaryota.
ENOG411202V. LUCA.
GeneTreeiENSGT00390000004940.
HOVERGENiHBG104926.
InParanoidiQ9Z2N6.
OMAiLQDTNTF.
OrthoDBiEOG7TF7CN.
PhylomeDBiQ9Z2N6.

Family and domain databases

InterProiIPR026779. Camk2n.
[Graphical view]
PANTHERiPTHR31007. PTHR31007. 1 hit.
PfamiPF15170. CaM-KIIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEILPYGED KMGRFGADPE GSDLSFSCRL QDTNSFFAGN QAKRPPKLGQ
60 70
IGRAKRVVIE DDRIDDVLKG MGEKPPSGV
Length:79
Mass (Da):8,628
Last modified:May 1, 1999 - v1
Checksum:iB34820F5D6417CF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041854 mRNA. Translation: AAD02202.1.
RefSeqiNP_067710.1. NM_021678.1.
UniGeneiRn.42880.

Genome annotation databases

EnsembliENSRNOT00000058131; ENSRNOP00000054937; ENSRNOG00000038184.
GeneIDi59314.
KEGGirno:59314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041854 mRNA. Translation: AAD02202.1.
RefSeqiNP_067710.1. NM_021678.1.
UniGeneiRn.42880.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054937.

Proteomic databases

PaxDbiQ9Z2N6.
PRIDEiQ9Z2N6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000058131; ENSRNOP00000054937; ENSRNOG00000038184.
GeneIDi59314.
KEGGirno:59314.

Organism-specific databases

CTDi94032.
RGDi708411. Camk2n2.

Phylogenomic databases

eggNOGiENOG410J0NK. Eukaryota.
ENOG411202V. LUCA.
GeneTreeiENSGT00390000004940.
HOVERGENiHBG104926.
InParanoidiQ9Z2N6.
OMAiLQDTNTF.
OrthoDBiEOG7TF7CN.
PhylomeDBiQ9Z2N6.

Miscellaneous databases

PROiQ9Z2N6.

Gene expression databases

GenevisibleiQ9Z2N6. RN.

Family and domain databases

InterProiIPR026779. Camk2n.
[Graphical view]
PANTHERiPTHR31007. PTHR31007. 1 hit.
PfamiPF15170. CaM-KIIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of a calmodulin kinase II inhibitor protein in brain."
    Chang B.H., Mukherji S., Soderling T.R.
    Proc. Natl. Acad. Sci. U.S.A. 95:10890-10895(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CAMK2A AND CAMK2B, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Calcium/calmodulin-dependent protein kinase II inhibitor protein: localization of isoforms in rat brain."
    Chang B.H., Mukherji S., Soderling T.R.
    Neuroscience 102:767-777(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CAMK2B, TISSUE SPECIFICITY.
  3. Cited for: FUNCTION.

Entry informationi

Entry nameiCK2N2_RAT
AccessioniPrimary (citable) accession number: Q9Z2N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.