Q9Z2M7 (PMM2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphomannomutase 2
Short name=PMM 2
EC=5.4.2.8

Gene names

Name:

Pmm2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.
Catalytic activity	Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the eukaryotic PMM family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	GDP-mannose biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway mannose biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from direct assay PubMed 16115222. Source: MGI neuronal cell body Inferred from direct assay PubMed 16115222. Source: MGI
Molecular_function	phosphomannomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Phosphomannomutase 2		PRO_0000199696
Sites
	Active site	8	1	Nucleophile By similarity
	Active site	10	1	By similarity
	Active site	43	1	By similarity
	Active site	185	1	By similarity
	Binding site	17	1	Substrate By similarity
	Binding site	119	1	Substrate By similarity
	Binding site	130	1	Substrate By similarity
	Binding site	137	1	Substrate By similarity
	Binding site	175	1	Substrate By similarity
	Binding site	177	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z2M7 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 065CD3C322AE724C	FASTA	242	27,657
	10 20 30 40 50 60 MATLCLFDMD GTLTAPRQKI TEEMDGFLQK LRQKTKIGVV GGSDFEKLQE QLGNDVVEKY 70 80 90 100 110 120 DYVFPENGLV AYKDGKLLCK QNIQGHLGED VIQDLINYCL SYIANIKLPK KRGTFIEFRN 130 140 150 160 170 180 GMLNVSPIGR SCSQEERIEF YELDKKEHIR QKFVADLRKE FAGKGLTFSI GGQISIDVFP 190 200 210 220 230 240 EGWDKRYCLR HLEHAGYKTI YFFGDKTMPG GNDHEIFTDP RTVGYTVTAP EDTRRICEGL FP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and localization of two mouse phosphomannomutase genes, Pmm1 and Pmm2." Heykants L., Schollen E., Grunewald S., Matthijs G. Gene 270:53-59(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF043514 mRNA. Translation: AAD02276.1. BC046325 mRNA. Translation: AAH46325.1.
IPI	IPI00131228.
RefSeq	NP_058577.1. NM_016881.2.
UniGene	Mm.9699.
3D structure databases
ProteinModelPortal	Q9Z2M7.
SMR	Q9Z2M7. Positions 4-241.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4108105.
STRING	10090.ENSMUSP00000023396.
PTM databases
PhosphoSite	Q9Z2M7.
2D gel databases
REPRODUCTION-2DPAGE	Q9Z2M7.
Proteomic databases
PaxDb	Q9Z2M7.
PRIDE	Q9Z2M7.
Protocols and materials databases
DNASU	54128.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023396; ENSMUSP00000023396; ENSMUSG00000022711.
GeneID	54128.
KEGG	mmu:54128.
UCSC	uc007ycr.1. mouse.
Organism-specific databases
CTD	5373.
MGI	MGI:1859214. Pmm2.
Phylogenomic databases
eggNOG	COG0561.
GeneTree	ENSGT00390000002918.
HOGENOM	HOG000181843.
HOVERGEN	HBG009971.
InParanoid	Q9Z2M7.
KO	K01840.
OMA	EFERYDK.
OrthoDB	EOG4894NB.
Enzyme and pathway databases
UniPathway	UPA00126; UER00424.
Gene expression databases
ArrayExpress	Q9Z2M7.
Bgee	Q9Z2M7.
CleanEx	MM_PMM2.
Genevestigator	Q9Z2M7.
GermOnline	ENSMUSG00000022711. Mus musculus.
Family and domain databases
Gene3D	3.40.50.1000. 2 hits.
InterPro	IPR023214. HAD-like_dom. IPR006379. HAD-SF_hydro_IIB. IPR005002. PMM. [Graphical view]
PANTHER	PTHR10466. PTHR10466. 1 hit.
Pfam	PF03332. PMM. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	PMM2. mouse.
NextBio	310929.
SOURCE	Search...

Entry information

Entry name

PMM2_MOUSE

Accession

Primary (citable) accession number: Q9Z2M7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	May 1, 1999
Last modified:	May 29, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program