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Q9Z2M7

- PMM2_MOUSE

UniProt

Q9Z2M7 - PMM2_MOUSE

Protein

Phosphomannomutase 2

Gene

Pmm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei8 – 81NucleophileBy similarity
    Active sitei10 – 101Proton donor/acceptorSequence Analysis
    Binding sitei17 – 171SubstrateBy similarity
    Binding sitei119 – 1191SubstrateBy similarity
    Binding sitei130 – 1301SubstrateBy similarity
    Binding sitei137 – 1371SubstrateBy similarity
    Binding sitei175 – 1751SubstrateBy similarity
    Binding sitei177 – 1771SubstrateBy similarity

    GO - Molecular functioni

    1. phosphomannomutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    2. mannose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    ReactomeiREACT_198715. Synthesis of GDP-mannose.
    UniPathwayiUPA00126; UER00424.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase 2 (EC:5.4.2.8)
    Short name:
    PMM 2
    Gene namesi
    Name:Pmm2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1859214. Pmm2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. neuronal cell body Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 242242Phosphomannomutase 2PRO_0000199696Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei145 – 1451N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9Z2M7.
    PaxDbiQ9Z2M7.
    PRIDEiQ9Z2M7.

    2D gel databases

    REPRODUCTION-2DPAGEQ9Z2M7.

    PTM databases

    PhosphoSiteiQ9Z2M7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Z2M7.
    BgeeiQ9Z2M7.
    CleanExiMM_PMM2.
    GenevestigatoriQ9Z2M7.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ9Z2M7. 1 interaction.
    MINTiMINT-4108105.
    STRINGi10090.ENSMUSP00000023396.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2M7.
    SMRiQ9Z2M7. Positions 4-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic PMM family.Curated

    Phylogenomic databases

    eggNOGiCOG0561.
    GeneTreeiENSGT00390000002918.
    HOGENOMiHOG000181843.
    HOVERGENiHBG009971.
    InParanoidiQ9Z2M7.
    KOiK17497.
    OMAiTYCLQHV.
    OrthoDBiEOG773XH0.
    PhylomeDBiQ9Z2M7.
    TreeFamiTF300874.

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    InterProiIPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view]
    PANTHERiPTHR10466. PTHR10466. 1 hit.
    PfamiPF03332. PMM. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Z2M7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATLCLFDMD GTLTAPRQKI TEEMDGFLQK LRQKTKIGVV GGSDFEKLQE    50
    QLGNDVVEKY DYVFPENGLV AYKDGKLLCK QNIQGHLGED VIQDLINYCL 100
    SYIANIKLPK KRGTFIEFRN GMLNVSPIGR SCSQEERIEF YELDKKEHIR 150
    QKFVADLRKE FAGKGLTFSI GGQISIDVFP EGWDKRYCLR HLEHAGYKTI 200
    YFFGDKTMPG GNDHEIFTDP RTVGYTVTAP EDTRRICEGL FP 242
    Length:242
    Mass (Da):27,657
    Last modified:May 1, 1999 - v1
    Checksum:i065CD3C322AE724C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043514 mRNA. Translation: AAD02276.1.
    BC046325 mRNA. Translation: AAH46325.1.
    CCDSiCCDS27941.1.
    RefSeqiNP_058577.1. NM_016881.2.
    UniGeneiMm.9699.

    Genome annotation databases

    EnsembliENSMUST00000023396; ENSMUSP00000023396; ENSMUSG00000022711.
    GeneIDi54128.
    KEGGimmu:54128.
    UCSCiuc007ycr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043514 mRNA. Translation: AAD02276.1 .
    BC046325 mRNA. Translation: AAH46325.1 .
    CCDSi CCDS27941.1.
    RefSeqi NP_058577.1. NM_016881.2.
    UniGenei Mm.9699.

    3D structure databases

    ProteinModelPortali Q9Z2M7.
    SMRi Q9Z2M7. Positions 4-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9Z2M7. 1 interaction.
    MINTi MINT-4108105.
    STRINGi 10090.ENSMUSP00000023396.

    PTM databases

    PhosphoSitei Q9Z2M7.

    2D gel databases

    REPRODUCTION-2DPAGE Q9Z2M7.

    Proteomic databases

    MaxQBi Q9Z2M7.
    PaxDbi Q9Z2M7.
    PRIDEi Q9Z2M7.

    Protocols and materials databases

    DNASUi 54128.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023396 ; ENSMUSP00000023396 ; ENSMUSG00000022711 .
    GeneIDi 54128.
    KEGGi mmu:54128.
    UCSCi uc007ycr.1. mouse.

    Organism-specific databases

    CTDi 5373.
    MGIi MGI:1859214. Pmm2.

    Phylogenomic databases

    eggNOGi COG0561.
    GeneTreei ENSGT00390000002918.
    HOGENOMi HOG000181843.
    HOVERGENi HBG009971.
    InParanoidi Q9Z2M7.
    KOi K17497.
    OMAi TYCLQHV.
    OrthoDBi EOG773XH0.
    PhylomeDBi Q9Z2M7.
    TreeFami TF300874.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00424 .
    Reactomei REACT_198715. Synthesis of GDP-mannose.

    Miscellaneous databases

    ChiTaRSi PMM2. mouse.
    NextBioi 310929.
    PROi Q9Z2M7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z2M7.
    Bgeei Q9Z2M7.
    CleanExi MM_PMM2.
    Genevestigatori Q9Z2M7.

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    InterProi IPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view ]
    PANTHERi PTHR10466. PTHR10466. 1 hit.
    Pfami PF03332. PMM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and localization of two mouse phosphomannomutase genes, Pmm1 and Pmm2."
      Heykants L., Schollen E., Grunewald S., Matthijs G.
      Gene 270:53-59(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-145, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiPMM2_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z2M7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3