Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphomannomutase 2

Gene

Pmm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81NucleophileBy similarity
Active sitei10 – 101Proton donor/acceptorSequence Analysis
Binding sitei17 – 171SubstrateBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei130 – 1301SubstrateBy similarity
Binding sitei137 – 1371SubstrateBy similarity
Binding sitei175 – 1751SubstrateBy similarity
Binding sitei177 – 1771SubstrateBy similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. mannose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiREACT_198715. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase 2 (EC:5.4.2.8)
Short name:
PMM 2
Gene namesi
Name:Pmm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1859214. Pmm2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. neuronal cell body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 242241Phosphomannomutase 2PRO_0000199696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei145 – 1451N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Z2M7.
PaxDbiQ9Z2M7.
PRIDEiQ9Z2M7.

2D gel databases

REPRODUCTION-2DPAGEQ9Z2M7.

PTM databases

PhosphoSiteiQ9Z2M7.

Expressioni

Gene expression databases

BgeeiQ9Z2M7.
CleanExiMM_PMM2.
ExpressionAtlasiQ9Z2M7. baseline and differential.
GenevestigatoriQ9Z2M7.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ9Z2M7. 1 interaction.
MINTiMINT-4108105.
STRINGi10090.ENSMUSP00000023396.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2M7.
SMRiQ9Z2M7. Positions 4-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiCOG0561.
GeneTreeiENSGT00390000002918.
HOGENOMiHOG000181843.
HOVERGENiHBG009971.
InParanoidiQ9Z2M7.
KOiK17497.
OMAiQEERLEF.
OrthoDBiEOG773XH0.
PhylomeDBiQ9Z2M7.
TreeFamiTF300874.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z2M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLCLFDMD GTLTAPRQKI TEEMDGFLQK LRQKTKIGVV GGSDFEKLQE
60 70 80 90 100
QLGNDVVEKY DYVFPENGLV AYKDGKLLCK QNIQGHLGED VIQDLINYCL
110 120 130 140 150
SYIANIKLPK KRGTFIEFRN GMLNVSPIGR SCSQEERIEF YELDKKEHIR
160 170 180 190 200
QKFVADLRKE FAGKGLTFSI GGQISIDVFP EGWDKRYCLR HLEHAGYKTI
210 220 230 240
YFFGDKTMPG GNDHEIFTDP RTVGYTVTAP EDTRRICEGL FP
Length:242
Mass (Da):27,657
Last modified:May 1, 1999 - v1
Checksum:i065CD3C322AE724C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043514 mRNA. Translation: AAD02276.1.
BC046325 mRNA. Translation: AAH46325.1.
CCDSiCCDS27941.1.
RefSeqiNP_058577.1. NM_016881.2.
UniGeneiMm.9699.

Genome annotation databases

EnsembliENSMUST00000023396; ENSMUSP00000023396; ENSMUSG00000022711.
GeneIDi54128.
KEGGimmu:54128.
UCSCiuc007ycr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043514 mRNA. Translation: AAD02276.1.
BC046325 mRNA. Translation: AAH46325.1.
CCDSiCCDS27941.1.
RefSeqiNP_058577.1. NM_016881.2.
UniGeneiMm.9699.

3D structure databases

ProteinModelPortaliQ9Z2M7.
SMRiQ9Z2M7. Positions 4-241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2M7. 1 interaction.
MINTiMINT-4108105.
STRINGi10090.ENSMUSP00000023396.

PTM databases

PhosphoSiteiQ9Z2M7.

2D gel databases

REPRODUCTION-2DPAGEQ9Z2M7.

Proteomic databases

MaxQBiQ9Z2M7.
PaxDbiQ9Z2M7.
PRIDEiQ9Z2M7.

Protocols and materials databases

DNASUi54128.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023396; ENSMUSP00000023396; ENSMUSG00000022711.
GeneIDi54128.
KEGGimmu:54128.
UCSCiuc007ycr.1. mouse.

Organism-specific databases

CTDi5373.
MGIiMGI:1859214. Pmm2.

Phylogenomic databases

eggNOGiCOG0561.
GeneTreeiENSGT00390000002918.
HOGENOMiHOG000181843.
HOVERGENiHBG009971.
InParanoidiQ9Z2M7.
KOiK17497.
OMAiQEERLEF.
OrthoDBiEOG773XH0.
PhylomeDBiQ9Z2M7.
TreeFamiTF300874.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.
ReactomeiREACT_198715. Synthesis of GDP-mannose.

Miscellaneous databases

ChiTaRSiPmm2. mouse.
NextBioi310929.
PROiQ9Z2M7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z2M7.
CleanExiMM_PMM2.
ExpressionAtlasiQ9Z2M7. baseline and differential.
GenevestigatoriQ9Z2M7.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and localization of two mouse phosphomannomutase genes, Pmm1 and Pmm2."
    Heykants L., Schollen E., Grunewald S., Matthijs G.
    Gene 270:53-59(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-145, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiPMM2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: March 4, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.