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Protein

Phosphomannomutase 2

Gene

Pmm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Mannose-6-phosphate isomerase (Mpi), Mannose-6-phosphate isomerase (Mpi), Mannose-6-phosphate isomerase (Mpi)
  2. Phosphomannomutase 1 (Pmm1), Phosphomannomutase (Pmm2), Phosphomannomutase, Phosphomannomutase (Pmm2), Phosphomannomutase (Pmm1), Phosphomannomutase (Pmm2), Phosphomannomutase (Pmm1), Phosphomannomutase (Pmm2), Phosphomannomutase 2 (Pmm2)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei8NucleophileBy similarity1
Active sitei10Proton donor/acceptorSequence analysis1
Binding sitei17SubstrateBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei130SubstrateBy similarity1
Binding sitei137SubstrateBy similarity1
Binding sitei175SubstrateBy similarity1
Binding sitei177SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

ReactomeiR-MMU-446205. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase 2 (EC:5.4.2.8)
Short name:
PMM 2
Gene namesi
Name:Pmm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1859214. Pmm2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: GO_Central
  • extracellular exosome Source: MGI
  • neuronal cell body Source: MGI

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001996961 – 242Phosphomannomutase 2Add BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei145N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Z2M7.
MaxQBiQ9Z2M7.
PaxDbiQ9Z2M7.
PRIDEiQ9Z2M7.

2D gel databases

REPRODUCTION-2DPAGEQ9Z2M7.

PTM databases

iPTMnetiQ9Z2M7.
PhosphoSitePlusiQ9Z2M7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022711.
CleanExiMM_PMM2.
ExpressionAtlasiQ9Z2M7. baseline and differential.
GenevisibleiQ9Z2M7. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ9Z2M7. 1 interactor.
MINTiMINT-4108105.
STRINGi10090.ENSMUSP00000023396.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2M7.
SMRiQ9Z2M7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiKOG3189. Eukaryota.
COG0561. LUCA.
GeneTreeiENSGT00390000002918.
HOGENOMiHOG000181843.
HOVERGENiHBG009971.
InParanoidiQ9Z2M7.
KOiK17497.
OMAiITKEMDG.
OrthoDBiEOG09040HEM.
PhylomeDBiQ9Z2M7.
TreeFamiTF300874.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiView protein in InterPro
IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiView protein in Pfam
PF03332. PMM. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z2M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLCLFDMD GTLTAPRQKI TEEMDGFLQK LRQKTKIGVV GGSDFEKLQE
60 70 80 90 100
QLGNDVVEKY DYVFPENGLV AYKDGKLLCK QNIQGHLGED VIQDLINYCL
110 120 130 140 150
SYIANIKLPK KRGTFIEFRN GMLNVSPIGR SCSQEERIEF YELDKKEHIR
160 170 180 190 200
QKFVADLRKE FAGKGLTFSI GGQISIDVFP EGWDKRYCLR HLEHAGYKTI
210 220 230 240
YFFGDKTMPG GNDHEIFTDP RTVGYTVTAP EDTRRICEGL FP
Length:242
Mass (Da):27,657
Last modified:May 1, 1999 - v1
Checksum:i065CD3C322AE724C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043514 mRNA. Translation: AAD02276.1.
BC046325 mRNA. Translation: AAH46325.1.
CCDSiCCDS27941.1.
RefSeqiNP_058577.1. NM_016881.2.
UniGeneiMm.9699.

Genome annotation databases

EnsembliENSMUST00000023396; ENSMUSP00000023396; ENSMUSG00000022711.
GeneIDi54128.
KEGGimmu:54128.
UCSCiuc007ycr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043514 mRNA. Translation: AAD02276.1.
BC046325 mRNA. Translation: AAH46325.1.
CCDSiCCDS27941.1.
RefSeqiNP_058577.1. NM_016881.2.
UniGeneiMm.9699.

3D structure databases

ProteinModelPortaliQ9Z2M7.
SMRiQ9Z2M7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2M7. 1 interactor.
MINTiMINT-4108105.
STRINGi10090.ENSMUSP00000023396.

PTM databases

iPTMnetiQ9Z2M7.
PhosphoSitePlusiQ9Z2M7.

2D gel databases

REPRODUCTION-2DPAGEQ9Z2M7.

Proteomic databases

EPDiQ9Z2M7.
MaxQBiQ9Z2M7.
PaxDbiQ9Z2M7.
PRIDEiQ9Z2M7.

Protocols and materials databases

DNASUi54128.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023396; ENSMUSP00000023396; ENSMUSG00000022711.
GeneIDi54128.
KEGGimmu:54128.
UCSCiuc007ycr.1. mouse.

Organism-specific databases

CTDi5373.
MGIiMGI:1859214. Pmm2.

Phylogenomic databases

eggNOGiKOG3189. Eukaryota.
COG0561. LUCA.
GeneTreeiENSGT00390000002918.
HOGENOMiHOG000181843.
HOVERGENiHBG009971.
InParanoidiQ9Z2M7.
KOiK17497.
OMAiITKEMDG.
OrthoDBiEOG09040HEM.
PhylomeDBiQ9Z2M7.
TreeFamiTF300874.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.
ReactomeiR-MMU-446205. Synthesis of GDP-mannose.

Miscellaneous databases

ChiTaRSiPmm2. mouse.
PROiQ9Z2M7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022711.
CleanExiMM_PMM2.
ExpressionAtlasiQ9Z2M7. baseline and differential.
GenevisibleiQ9Z2M7. MM.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiView protein in InterPro
IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiView protein in Pfam
PF03332. PMM. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPMM2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: February 15, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.