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Q9Z2M7

- PMM2_MOUSE

UniProt

Q9Z2M7 - PMM2_MOUSE

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Protein

Phosphomannomutase 2

Gene

Pmm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81NucleophileBy similarity
Active sitei10 – 101Proton donor/acceptorSequence Analysis
Binding sitei17 – 171SubstrateBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei130 – 1301SubstrateBy similarity
Binding sitei137 – 1371SubstrateBy similarity
Binding sitei175 – 1751SubstrateBy similarity
Binding sitei177 – 1771SubstrateBy similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. mannose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiREACT_198715. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase 2 (EC:5.4.2.8)
Short name:
PMM 2
Gene namesi
Name:Pmm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1859214. Pmm2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular vesicular exosome Source: Ensembl
  3. neuronal cell body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Phosphomannomutase 2PRO_0000199696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei145 – 1451N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Z2M7.
PaxDbiQ9Z2M7.
PRIDEiQ9Z2M7.

2D gel databases

REPRODUCTION-2DPAGEQ9Z2M7.

PTM databases

PhosphoSiteiQ9Z2M7.

Expressioni

Gene expression databases

BgeeiQ9Z2M7.
CleanExiMM_PMM2.
ExpressionAtlasiQ9Z2M7. baseline and differential.
GenevestigatoriQ9Z2M7.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ9Z2M7. 1 interaction.
MINTiMINT-4108105.
STRINGi10090.ENSMUSP00000023396.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2M7.
SMRiQ9Z2M7. Positions 4-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiCOG0561.
GeneTreeiENSGT00390000002918.
HOGENOMiHOG000181843.
HOVERGENiHBG009971.
InParanoidiQ9Z2M7.
KOiK17497.
OMAiTYCLQHV.
OrthoDBiEOG773XH0.
PhylomeDBiQ9Z2M7.
TreeFamiTF300874.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z2M7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATLCLFDMD GTLTAPRQKI TEEMDGFLQK LRQKTKIGVV GGSDFEKLQE
60 70 80 90 100
QLGNDVVEKY DYVFPENGLV AYKDGKLLCK QNIQGHLGED VIQDLINYCL
110 120 130 140 150
SYIANIKLPK KRGTFIEFRN GMLNVSPIGR SCSQEERIEF YELDKKEHIR
160 170 180 190 200
QKFVADLRKE FAGKGLTFSI GGQISIDVFP EGWDKRYCLR HLEHAGYKTI
210 220 230 240
YFFGDKTMPG GNDHEIFTDP RTVGYTVTAP EDTRRICEGL FP
Length:242
Mass (Da):27,657
Last modified:May 1, 1999 - v1
Checksum:i065CD3C322AE724C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043514 mRNA. Translation: AAD02276.1.
BC046325 mRNA. Translation: AAH46325.1.
CCDSiCCDS27941.1.
RefSeqiNP_058577.1. NM_016881.2.
UniGeneiMm.9699.

Genome annotation databases

EnsembliENSMUST00000023396; ENSMUSP00000023396; ENSMUSG00000022711.
GeneIDi54128.
KEGGimmu:54128.
UCSCiuc007ycr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043514 mRNA. Translation: AAD02276.1 .
BC046325 mRNA. Translation: AAH46325.1 .
CCDSi CCDS27941.1.
RefSeqi NP_058577.1. NM_016881.2.
UniGenei Mm.9699.

3D structure databases

ProteinModelPortali Q9Z2M7.
SMRi Q9Z2M7. Positions 4-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9Z2M7. 1 interaction.
MINTi MINT-4108105.
STRINGi 10090.ENSMUSP00000023396.

PTM databases

PhosphoSitei Q9Z2M7.

2D gel databases

REPRODUCTION-2DPAGE Q9Z2M7.

Proteomic databases

MaxQBi Q9Z2M7.
PaxDbi Q9Z2M7.
PRIDEi Q9Z2M7.

Protocols and materials databases

DNASUi 54128.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023396 ; ENSMUSP00000023396 ; ENSMUSG00000022711 .
GeneIDi 54128.
KEGGi mmu:54128.
UCSCi uc007ycr.1. mouse.

Organism-specific databases

CTDi 5373.
MGIi MGI:1859214. Pmm2.

Phylogenomic databases

eggNOGi COG0561.
GeneTreei ENSGT00390000002918.
HOGENOMi HOG000181843.
HOVERGENi HBG009971.
InParanoidi Q9Z2M7.
KOi K17497.
OMAi TYCLQHV.
OrthoDBi EOG773XH0.
PhylomeDBi Q9Z2M7.
TreeFami TF300874.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00424 .
Reactomei REACT_198715. Synthesis of GDP-mannose.

Miscellaneous databases

ChiTaRSi Pmm2. mouse.
NextBioi 310929.
PROi Q9Z2M7.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z2M7.
CleanExi MM_PMM2.
ExpressionAtlasi Q9Z2M7. baseline and differential.
Genevestigatori Q9Z2M7.

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view ]
PANTHERi PTHR10466. PTHR10466. 1 hit.
Pfami PF03332. PMM. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and localization of two mouse phosphomannomutase genes, Pmm1 and Pmm2."
    Heykants L., Schollen E., Grunewald S., Matthijs G.
    Gene 270:53-59(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-145, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiPMM2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3