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Q9Z2M7 (PMM2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphomannomutase 2

Short name=PMM 2
EC=5.4.2.8
Gene names
Name:Pmm2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activity

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the eukaryotic PMM family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionIsomerase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGDP-mannose biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

mannose biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 16115222. Source: MGI

neuronal cell body

Inferred from direct assay PubMed 16115222. Source: MGI

   Molecular_functionphosphomannomutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242Phosphomannomutase 2
PRO_0000199696

Sites

Active site81Nucleophile By similarity
Active site101Proton donor/acceptor Potential
Binding site171Substrate By similarity
Binding site1191Substrate By similarity
Binding site1301Substrate By similarity
Binding site1371Substrate By similarity
Binding site1751Substrate By similarity
Binding site1771Substrate By similarity

Amino acid modifications

Modified residue1451N6-acetyllysine Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9Z2M7 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 065CD3C322AE724C

FASTA24227,657
        10         20         30         40         50         60 
MATLCLFDMD GTLTAPRQKI TEEMDGFLQK LRQKTKIGVV GGSDFEKLQE QLGNDVVEKY 

        70         80         90        100        110        120 
DYVFPENGLV AYKDGKLLCK QNIQGHLGED VIQDLINYCL SYIANIKLPK KRGTFIEFRN 

       130        140        150        160        170        180 
GMLNVSPIGR SCSQEERIEF YELDKKEHIR QKFVADLRKE FAGKGLTFSI GGQISIDVFP 

       190        200        210        220        230        240 
EGWDKRYCLR HLEHAGYKTI YFFGDKTMPG GNDHEIFTDP RTVGYTVTAP EDTRRICEGL 


FP 

« Hide

References

« Hide 'large scale' references
[1]"Identification and localization of two mouse phosphomannomutase genes, Pmm1 and Pmm2."
Heykants L., Schollen E., Grunewald S., Matthijs G.
Gene 270:53-59(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
[3]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-145, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF043514 mRNA. Translation: AAD02276.1.
BC046325 mRNA. Translation: AAH46325.1.
RefSeqNP_058577.1. NM_016881.2.
UniGeneMm.9699.

3D structure databases

ProteinModelPortalQ9Z2M7.
SMRQ9Z2M7. Positions 4-241.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9Z2M7. 1 interaction.
MINTMINT-4108105.
STRING10090.ENSMUSP00000023396.

PTM databases

PhosphoSiteQ9Z2M7.

2D gel databases

REPRODUCTION-2DPAGEQ9Z2M7.

Proteomic databases

PaxDbQ9Z2M7.
PRIDEQ9Z2M7.

Protocols and materials databases

DNASU54128.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023396; ENSMUSP00000023396; ENSMUSG00000022711.
GeneID54128.
KEGGmmu:54128.
UCSCuc007ycr.1. mouse.

Organism-specific databases

CTD5373.
MGIMGI:1859214. Pmm2.

Phylogenomic databases

eggNOGCOG0561.
GeneTreeENSGT00390000002918.
HOGENOMHOG000181843.
HOVERGENHBG009971.
InParanoidQ9Z2M7.
KOK17497.
OMATYCLQHV.
OrthoDBEOG773XH0.
PhylomeDBQ9Z2M7.
TreeFamTF300874.

Enzyme and pathway databases

UniPathwayUPA00126; UER00424.

Gene expression databases

ArrayExpressQ9Z2M7.
BgeeQ9Z2M7.
CleanExMM_PMM2.
GenevestigatorQ9Z2M7.

Family and domain databases

Gene3D3.40.50.1000. 2 hits.
InterProIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERPTHR10466. PTHR10466. 1 hit.
PfamPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetSearch...

Other

ChiTaRSPMM2. mouse.
NextBio310929.
PROQ9Z2M7.
SOURCESearch...

Entry information

Entry namePMM2_MOUSE
AccessionPrimary (citable) accession number: Q9Z2M7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot