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Protein

Ubiquitin-like protein 3

Gene

Ubl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein 3
Alternative name(s):
Membrane-anchored ubiquitin-fold protein
Short name:
MUB
Short name:
MmMUB
Protein HCG-1
Gene namesi
Name:Ubl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1344373. Ubl3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 114114Ubiquitin-like protein 3PRO_0000114863Add
BLAST
Propeptidei115 – 1173Removed in mature formCuratedPRO_0000248184

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi113 – 1131S-palmitoyl cysteine1 Publication
Modified residuei114 – 1141Cysteine methyl esterCurated
Lipidationi114 – 1141S-geranylgeranyl cysteine1 Publication

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

EPDiQ9Z2M6.
MaxQBiQ9Z2M6.
PaxDbiQ9Z2M6.
PRIDEiQ9Z2M6.

PTM databases

iPTMnetiQ9Z2M6.
PhosphoSiteiQ9Z2M6.
SwissPalmiQ9Z2M6.

Expressioni

Gene expression databases

BgeeiQ9Z2M6.
CleanExiMM_UBL3.
GenevisibleiQ9Z2M6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078303.

Structurei

Secondary structure

1
117
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 159Combined sources
Beta strandi17 – 193Combined sources
Beta strandi21 – 266Combined sources
Helixi32 – 4110Combined sources
Beta strandi42 – 443Combined sources
Turni55 – 573Combined sources
Beta strandi58 – 625Combined sources
Beta strandi65 – 673Combined sources
Turni73 – 775Combined sources
Beta strandi83 – 908Combined sources
Beta strandi95 – 973Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WGHNMR-A1-103[»]
ProteinModelPortaliQ9Z2M6.
SMRiQ9Z2M6. Positions 2-117.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z2M6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 8879Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IVZB. Eukaryota.
ENOG4111N2D. LUCA.
GeneTreeiENSGT00390000004952.
HOGENOMiHOG000253908.
HOVERGENiHBG054980.
InParanoidiQ9Z2M6.
OMAiMHLVTRE.
OrthoDBiEOG7KSXBW.
PhylomeDBiQ9Z2M6.
TreeFamiTF314489.

Family and domain databases

InterProiIPR017000. MUB.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PIRSFiPIRSF032572. MUB. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z2M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHVPADMI NLRLILVSGK TKEFLFSPND SASDIAKHVY DNWPMDWEEE
60 70 80 90 100
QVSSPNILRL IYQGRFLHGN VTLGALKLPF GKTTVMHLVA RETLPEPNSQ
110
GQRNREKTGE SNCCVIL
Length:117
Mass (Da):13,180
Last modified:May 1, 1999 - v1
Checksum:i2EB3A5102AD06F2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044222 mRNA. Translation: AAD02324.1.
AK145952 mRNA. Translation: BAE26780.1.
BC024507 mRNA. Translation: AAH24507.1.
BC025595 mRNA. Translation: AAH25595.1.
BC043729 mRNA. Translation: AAH43729.1.
CCDSiCCDS39403.1.
RefSeqiNP_036038.1. NM_011908.2.
XP_006504895.1. XM_006504832.2.
UniGeneiMm.21846.
Mm.488617.

Genome annotation databases

EnsembliENSMUST00000079324; ENSMUSP00000078303; ENSMUSG00000001687.
ENSMUST00000164904; ENSMUSP00000131049; ENSMUSG00000001687.
ENSMUST00000201595; ENSMUSP00000144073; ENSMUSG00000001687.
GeneIDi24109.
KEGGimmu:24109.
UCSCiuc009aou.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044222 mRNA. Translation: AAD02324.1.
AK145952 mRNA. Translation: BAE26780.1.
BC024507 mRNA. Translation: AAH24507.1.
BC025595 mRNA. Translation: AAH25595.1.
BC043729 mRNA. Translation: AAH43729.1.
CCDSiCCDS39403.1.
RefSeqiNP_036038.1. NM_011908.2.
XP_006504895.1. XM_006504832.2.
UniGeneiMm.21846.
Mm.488617.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WGHNMR-A1-103[»]
ProteinModelPortaliQ9Z2M6.
SMRiQ9Z2M6. Positions 2-117.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078303.

PTM databases

iPTMnetiQ9Z2M6.
PhosphoSiteiQ9Z2M6.
SwissPalmiQ9Z2M6.

Proteomic databases

EPDiQ9Z2M6.
MaxQBiQ9Z2M6.
PaxDbiQ9Z2M6.
PRIDEiQ9Z2M6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079324; ENSMUSP00000078303; ENSMUSG00000001687.
ENSMUST00000164904; ENSMUSP00000131049; ENSMUSG00000001687.
ENSMUST00000201595; ENSMUSP00000144073; ENSMUSG00000001687.
GeneIDi24109.
KEGGimmu:24109.
UCSCiuc009aou.1. mouse.

Organism-specific databases

CTDi5412.
MGIiMGI:1344373. Ubl3.

Phylogenomic databases

eggNOGiENOG410IVZB. Eukaryota.
ENOG4111N2D. LUCA.
GeneTreeiENSGT00390000004952.
HOGENOMiHOG000253908.
HOVERGENiHBG054980.
InParanoidiQ9Z2M6.
OMAiMHLVTRE.
OrthoDBiEOG7KSXBW.
PhylomeDBiQ9Z2M6.
TreeFamiTF314489.

Miscellaneous databases

ChiTaRSiUbl3. mouse.
EvolutionaryTraceiQ9Z2M6.
PROiQ9Z2M6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z2M6.
CleanExiMM_UBL3.
GenevisibleiQ9Z2M6. MM.

Family and domain databases

InterProiIPR017000. MUB.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PIRSFiPIRSF032572. MUB. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene."
    Chadwick B.P., Kidd T., Sgouros J., Ish-Horowicz D., Frischauf A.-M.
    Gene 233:189-195(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Mammary tumor.
  4. "MUBS: a family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation."
    Downes B.P., Saracco S.A., Lee S.S., Crowell D.N., Vierstra R.D.
    J. Biol. Chem. 281:27145-27157(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE, ISOPRENYLATION AT CYS-114 IN VITRO.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney and Testis.
  6. "Solution structure of mouse ubiquitin-like 3 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-103.

Entry informationi

Entry nameiUBL3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2M6
Secondary accession number(s): A4FTW0, Q3UKM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.