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Protein

Peroxisomal 2,4-dienoyl-CoA reductase

Gene

Decr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

Catalytic activityi

Trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601SubstrateBy similarity
Binding sitei86 – 861NADPBy similarity
Binding sitei88 – 881SubstrateBy similarity
Binding sitei118 – 1181SubstrateBy similarity
Binding sitei182 – 1821NADPBy similarity
Binding sitei219 – 2191SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 406NADPBy similarity
Nucleotide bindingi60 – 645NADPBy similarity
Nucleotide bindingi208 – 2147NADPBy similarity

GO - Molecular functioni

  • 2,4-dienoyl-CoA reductase (NADPH) activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NADP

Chemistry

SwissLipidsiSLP:000001051.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal 2,4-dienoyl-CoA reductase (EC:1.3.1.34)
Alternative name(s):
2,4-dienoyl-CoA reductase 2
DCR-AKL
pVI-AKL
Gene namesi
Name:Decr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi71002. Decr2.

Subcellular locationi

  • Peroxisome 1 Publication

GO - Cellular componenti

  • peroxisomal membrane Source: UniProtKB
  • peroxisome Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 292291Peroxisomal 2,4-dienoyl-CoA reductasePRO_0000054562Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511N6-acetyllysineBy similarity
Modified residuei291 – 2911N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9Z2M4.
PRIDEiQ9Z2M4.

PTM databases

iPTMnetiQ9Z2M4.

Expressioni

Gene expression databases

ExpressionAtlasiQ9Z2M4. baseline and differential.
GenevisibleiQ9Z2M4. RN.

Interactioni

Subunit structurei

Monomer, dimer and oligomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027518.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni126 – 1283Substrate bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi290 – 2923Microbody targeting signal

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00440000033742.
HOVERGENiHBG100327.
InParanoidiQ9Z2M4.
KOiK13237.
OMAiDDTEGMR.
OrthoDBiEOG789CBR.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z2M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQQPPDVEE DDCLSEYHHL FCPDLLQDKV AFITGGGSGI GFRIAEIFMR
60 70 80 90 100
HGCHTVIVSR SLPRVSEAAK KLVAATGKRC LPLSMDVRVP PAVMAAVDQA
110 120 130 140 150
LKEFGKIDIL INCAAGNFLC PASALSFNAF KTVVDIDTLG TFNVSRVLYE
160 170 180 190 200
KFFRDHGGVI VNITATLSMR GQVLQLHAGA AKAAVDAMTR HLAVEWGPQN
210 220 230 240 250
IRVNSLAPGA ISGTEGLRRL GGPKASSKFK YLSSPIPRLG TKTEIAHSVL
260 270 280 290
YLASPLASYV SGIVLVVDGG SWMTLPNDIG RLLEFESSSA KL
Length:292
Mass (Da):31,292
Last modified:May 1, 1999 - v1
Checksum:iB969DC35647DD844
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044574 mRNA. Translation: AAD02333.1.
BC070959 mRNA. Translation: AAH70959.1.
RefSeqiNP_741993.1. NM_171996.3.
XP_006246086.1. XM_006246024.2.
UniGeneiRn.144598.

Genome annotation databases

EnsembliENSRNOT00000027518; ENSRNOP00000027518; ENSRNOG00000050424.
GeneIDi64461.
KEGGirno:64461.
UCSCiRGD:71002. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044574 mRNA. Translation: AAD02333.1.
BC070959 mRNA. Translation: AAH70959.1.
RefSeqiNP_741993.1. NM_171996.3.
XP_006246086.1. XM_006246024.2.
UniGeneiRn.144598.

3D structure databases

ProteinModelPortaliQ9Z2M4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027518.

Chemistry

SwissLipidsiSLP:000001051.

PTM databases

iPTMnetiQ9Z2M4.

Proteomic databases

PaxDbiQ9Z2M4.
PRIDEiQ9Z2M4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027518; ENSRNOP00000027518; ENSRNOG00000050424.
GeneIDi64461.
KEGGirno:64461.
UCSCiRGD:71002. rat.

Organism-specific databases

CTDi26063.
RGDi71002. Decr2.

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00440000033742.
HOVERGENiHBG100327.
InParanoidiQ9Z2M4.
KOiK13237.
OMAiDDTEGMR.
OrthoDBiEOG789CBR.

Miscellaneous databases

NextBioi613208.
PROiQ9Z2M4.

Gene expression databases

ExpressionAtlasiQ9Z2M4. baseline and differential.
GenevisibleiQ9Z2M4. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase."
    Fransen M., Van Veldhoven P.P., Subramani S.
    Biochem. J. 340:561-568(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ENZYME ACTIVITY, SUBCELLULAR LOCATION.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiDECR2_RAT
AccessioniPrimary (citable) accession number: Q9Z2M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.