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Protein

Peroxisomal 2,4-dienoyl-CoA reductase

Gene

Decr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

Catalytic activityi

Trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60SubstrateBy similarity1
Binding sitei86NADPBy similarity1
Binding sitei88SubstrateBy similarity1
Binding sitei118SubstrateBy similarity1
Binding sitei182NADPBy similarity1
Binding sitei219SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi35 – 40NADPBy similarity6
Nucleotide bindingi60 – 64NADPBy similarity5
Nucleotide bindingi208 – 214NADPBy similarity7

GO - Molecular functioni

  • 2,4-dienoyl-CoA reductase (NADPH) activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandNADP

Chemistry databases

SwissLipidsiSLP:000001051.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal 2,4-dienoyl-CoA reductase (EC:1.3.1.34)
Alternative name(s):
2,4-dienoyl-CoA reductase 2
DCR-AKL
pVI-AKL
Gene namesi
Name:Decr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi71002. Decr2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545621 – 292Peroxisomal 2,4-dienoyl-CoA reductaseAdd BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151N6-acetyllysineBy similarity1
Modified residuei287PhosphoserineBy similarity1
Modified residuei291N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9Z2M4.
PRIDEiQ9Z2M4.

PTM databases

iPTMnetiQ9Z2M4.
PhosphoSitePlusiQ9Z2M4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000050424.
ExpressionAtlasiQ9Z2M4. baseline and differential.
GenevisibleiQ9Z2M4. RN.

Interactioni

Subunit structurei

Monomer, dimer and oligomer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027518.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2M4.
SMRiQ9Z2M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 128Substrate bindingBy similarity3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi290 – 292Microbody targeting signal3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00440000033742.
HOVERGENiHBG100327.
InParanoidiQ9Z2M4.
KOiK13237.
OMAiNKTEMAH.

Family and domain databases

InterProiView protein in InterPro
IPR036291. NAD(P)-bd_dom_sf.
IPR002347. SDR_fam.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z2M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQQPPDVEE DDCLSEYHHL FCPDLLQDKV AFITGGGSGI GFRIAEIFMR
60 70 80 90 100
HGCHTVIVSR SLPRVSEAAK KLVAATGKRC LPLSMDVRVP PAVMAAVDQA
110 120 130 140 150
LKEFGKIDIL INCAAGNFLC PASALSFNAF KTVVDIDTLG TFNVSRVLYE
160 170 180 190 200
KFFRDHGGVI VNITATLSMR GQVLQLHAGA AKAAVDAMTR HLAVEWGPQN
210 220 230 240 250
IRVNSLAPGA ISGTEGLRRL GGPKASSKFK YLSSPIPRLG TKTEIAHSVL
260 270 280 290
YLASPLASYV SGIVLVVDGG SWMTLPNDIG RLLEFESSSA KL
Length:292
Mass (Da):31,292
Last modified:May 1, 1999 - v1
Checksum:iB969DC35647DD844
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044574 mRNA. Translation: AAD02333.1.
BC070959 mRNA. Translation: AAH70959.1.
RefSeqiNP_741993.1. NM_171996.3.
XP_006246086.1. XM_006246024.3.
UniGeneiRn.144598.

Genome annotation databases

EnsembliENSRNOT00000027518; ENSRNOP00000027518; ENSRNOG00000050424.
GeneIDi64461.
KEGGirno:64461.
UCSCiRGD:71002. rat.

Similar proteinsi

Entry informationi

Entry nameiDECR2_RAT
AccessioniPrimary (citable) accession number: Q9Z2M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families