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Reviewed, UniProtKB/Swiss-Prot Q9Z2M2 (ADH1_GEOAT)

Last modified November 4, 2008. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1
Alternative name(s):
    Alcohol dehydrogenase A subunit
Gene names
Name: ADH1
OrganismGeomys attwateri (Attwater's pocket gopher) (Geomys bursarius attwateri)
Taxonomic identifier72447 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Geomyidae › Geomys

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Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD(+) = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

CytoplasmBy similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.

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Ontologies

Keywords

   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionalcohol dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 375374Alcohol dehydrogenase 1
PRO_0000254949

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding681Zinc 1; catalytic By similarity
Metal binding981Zinc 2 By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1121Zinc 2 By similarity
Metal binding1751Zinc 1; catalytic By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9Z2M2-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 6A01A35C159C1122

FASTA37539,841
        10         20         30         40         50         60 
MSTAGKVIKC RAAVLWEKNK PFSIEEVEVA PPKAYEVRIK IVATGICRSD DHVVNGSIIT 

        70         80         90        100        110        120 
PLPAILGHEA GGIVESIGEG VTTVKPGDKV IPLFVPQCGK CRACKHPESN LCTHGDLGRA 

       130        140        150        160        170        180 
QGTLMDGTSR FTCKGKPIHH FLGVTTFSEY TVVSEISVTK IDAASPLEKV CLIGCGFSTG 

       190        200        210        220        230        240 
YGSAVKVGKV ARGSICACVW SGRVGLSAII GCKAAGAARI IAVDINKDKF AKAKELGATE 

       250        260        270        280        290        300 
CVNPQDYDKP IYEVLQEMTD GGVDFSFEVI GRLDTKVSAL MCCQESHGVS VIVGVPPNAQ 

       310        320        330        340        350        360 
SLTIDPKVLL SGRSWKGAVF GGYKGKDDVP KLVADFMAKK FPLEPLITNV FPLAKINEGF 

       370 
DLLRAGKSIR TVLTF

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References

[1]"Nucleotide polymorphism at the alcohol dehydrogenase locus of pocket gophers, genus Geomys."
Bradley R.D., Adkins R.M., Honeycutt R.L., McDonald J.H.
Mol. Biol. Evol. 15:709-717(1998) [PubMed: 9615452] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

AF044730 mRNA. Translation: AAC98959.1.

3D structure databases

HSSPHSSP built from PDB template 1HEU based on UniProtKB P00327.
SMRQ9Z2M2. Positions 1-374, 2-375.
ModBaseSearch...

Phylogenomic databases

HOVERGENQ9Z2M2.

Family and domain databases

InterProIPR013154. AlcDHase_GroES-like.
IPR002085. AlcDHase_SF_Zn.
IPR013149. AlcDHase_Zn-bd.
IPR002328. AlcDHase_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

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Entry information

Entry nameADH1_GEOAT
AccessionPrimary (citable) accession number: Q9Z2M2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 23, 2007
Last modified: November 4, 2008
This is version 44 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents