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Protein

Cytokine receptor-like factor 3

Gene

Crlf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the negative regulation of cell cycle progression.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor-like factor 3
Alternative name(s):
Cytokine receptor-like molecule 9
Short name:
CREME-9
Cytokine receptor-related factor 4
Gene namesi
Name:Crlf3
Synonyms:Creme9, Cytor4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1860086 Crlf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889371 – 442Cytokine receptor-like factor 3Add BLAST442

Proteomic databases

EPDiQ9Z2L7
PaxDbiQ9Z2L7
PeptideAtlasiQ9Z2L7
PRIDEiQ9Z2L7

PTM databases

PhosphoSitePlusiQ9Z2L7

Expressioni

Gene expression databases

BgeeiENSMUSG00000017561
CleanExiMM_CRLF3
ExpressionAtlasiQ9Z2L7 baseline and differential
GenevisibleiQ9Z2L7 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9Z2L7, 3 interactors
MINTiQ9Z2L7
STRINGi10090.ENSMUSP00000060028

Structurei

3D structure databases

ProteinModelPortaliQ9Z2L7
SMRiQ9Z2L7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 274Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST94

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili10 – 46Sequence analysisAdd BLAST37

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II83 Eukaryota
ENOG4110NSY LUCA
GeneTreeiENSGT00390000014117
HOGENOMiHOG000111973
HOVERGENiHBG054457
InParanoidiQ9Z2L7
OMAiDYRLQYR
OrthoDBiEOG091G0GM2
PhylomeDBiQ9Z2L7
TreeFamiTF328682

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z2L7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGAMEPEPE VLLQEARENV EAAQSYRREL GQRLQGLREA QRQIKESASQ
60 70 80 90 100
TRDVLKQHFS DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE
110 120 130 140 150
HGVNTADDLV REGEIAILGG IEEESDKLWN FTKKASHIQL DSLPEVPLLV
160 170 180 190 200
DVPCLSAQLD DSILNIVKDH IFKHGTVASR PPVQIEELIE KPGGIIVRWC
210 220 230 240 250
KVDDDFTAQD YRLQFRKCTA NHFEDVYVGS ETEFIVLHID PNVDYQFRVC
260 270 280 290 300
ARGDGRQEWS PWSVPQTGHS TLVPHEWTTG FEGYSLSSRR NIALRNDAES
310 320 330 340 350
SGVLYSSAPT YFCGQTLTFR VETVGQPDRR DSIGVCAERQ NGYESLQRDQ
360 370 380 390 400
AVCISTNGAV FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TSNSHEGGNA
410 420 430 440
KLRVTISSNN REVVFDWLLE QACGPLYFGC SFFYPGWKVL VF
Length:442
Mass (Da):49,559
Last modified:May 1, 1999 - v1
Checksum:i537CBBE507DFA3E6
GO
Isoform 2 (identifier: Q9Z2L7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-344: VETVGQPDRRDSIGVCAERQNGYE → CSLCQWKRNDQSVACSYLWLHCHI
     345-442: Missing.

Note: No experimental confirmation available.
Show »
Length:344
Mass (Da):39,153
Checksum:iAFB8C65DDB9284BC
GO

Sequence cautioni

The sequence CAI24764 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025847321 – 344VETVG…QNGYE → CSLCQWKRNDQSVACSYLWL HCHI in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_025848345 – 442Missing in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046060 mRNA Translation: AAD02423.1
AK037880 mRNA Translation: BAC29888.1
AK137528 mRNA Translation: BAE23396.1
AK146798 mRNA Translation: BAE27440.1
AL591113 Genomic DNA Translation: CAI24762.1
AL591113 Genomic DNA Translation: CAI24763.1
AL591113 Genomic DNA Translation: CAI24764.1 Sequence problems.
BC004780 mRNA Translation: AAH04780.1
AF120152 mRNA Translation: AAD31759.1
CCDSiCCDS25126.1 [Q9Z2L7-1]
CCDS70260.1 [Q9Z2L7-2]
RefSeqiNP_001264035.1, NM_001277106.1 [Q9Z2L7-2]
NP_061246.1, NM_018776.2 [Q9Z2L7-1]
UniGeneiMm.272093

Genome annotation databases

EnsembliENSMUST00000061283; ENSMUSP00000060028; ENSMUSG00000017561 [Q9Z2L7-1]
ENSMUST00000103233; ENSMUSP00000099523; ENSMUSG00000017561 [Q9Z2L7-2]
GeneIDi54394
KEGGimmu:54394
UCSCiuc007kld.2 mouse [Q9Z2L7-1]
uc011yaq.2 mouse [Q9Z2L7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCRLF3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2L7
Secondary accession number(s): Q5SYK6, Q91W21, Q9R262
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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