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Q9Z2L7 (CRLF3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytokine receptor-like factor 3
Alternative name(s):
Cytokine receptor-like molecule 9
Short name=CREME-9
Cytokine receptor-related factor 4
Gene names
Name:Crlf3
Synonyms:Creme9, Cytor4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in the negative regulation of cell cycle progression By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the cytokine receptor-like factor 3 family.

Contains 1 fibronectin type-III domain.

Sequence caution

The sequence CAI24764.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Z2L7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Z2L7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     321-344: VETVGQPDRRDSIGVCAERQNGYE → CSLCQWKRNDQSVACSYLWLHCHI
     345-442: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Cytokine receptor-like factor 3
PRO_0000288937

Regions

Domain181 – 27494Fibronectin type-III
Coiled coil10 – 4637 Potential

Natural variations

Alternative sequence321 – 34424VETVG…QNGYE → CSLCQWKRNDQSVACSYLWL HCHI in isoform 2.
VSP_025847
Alternative sequence345 – 44298Missing in isoform 2.
VSP_025848

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 537CBBE507DFA3E6

FASTA44249,559
        10         20         30         40         50         60 
MKGAMEPEPE VLLQEARENV EAAQSYRREL GQRLQGLREA QRQIKESASQ TRDVLKQHFS 

        70         80         90        100        110        120 
DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE HGVNTADDLV REGEIAILGG 

       130        140        150        160        170        180 
IEEESDKLWN FTKKASHIQL DSLPEVPLLV DVPCLSAQLD DSILNIVKDH IFKHGTVASR 

       190        200        210        220        230        240 
PPVQIEELIE KPGGIIVRWC KVDDDFTAQD YRLQFRKCTA NHFEDVYVGS ETEFIVLHID 

       250        260        270        280        290        300 
PNVDYQFRVC ARGDGRQEWS PWSVPQTGHS TLVPHEWTTG FEGYSLSSRR NIALRNDAES 

       310        320        330        340        350        360 
SGVLYSSAPT YFCGQTLTFR VETVGQPDRR DSIGVCAERQ NGYESLQRDQ AVCISTNGAV 

       370        380        390        400        410        420 
FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TSNSHEGGNA KLRVTISSNN REVVFDWLLE 

       430        440 
QACGPLYFGC SFFYPGWKVL VF 

« Hide

Isoform 2 [UniParc].

Checksum: AFB8C65DDB9284BC
Show »

FASTA34439,153

References

« Hide 'large scale' references
[1]"An extended gap penalty scheme for profiles results in the discovery of a novel cytokine receptor related transcript in an EST database."
Farrah T., Adams R., Kho C.-J., Yamagiwa T.M., Madden K.L., Whitmore T., Jelmberg A., Pownder T., Lofton-Day C.E., Lok S.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Bone, Liver and Thymus.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: NMRI.
Tissue: Mammary tumor.
[5]"Cloning of a novel cytokine receptor-like molecule."
Maeda M., Nomura H.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-442 (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF046060 mRNA. Translation: AAD02423.1.
AK037880 mRNA. Translation: BAC29888.1.
AK137528 mRNA. Translation: BAE23396.1.
AK146798 mRNA. Translation: BAE27440.1.
AL591113 Genomic DNA. Translation: CAI24762.1.
AL591113 Genomic DNA. Translation: CAI24763.1.
AL591113 Genomic DNA. Translation: CAI24764.1. Sequence problems.
BC004780 mRNA. Translation: AAH04780.1.
AF120152 mRNA. Translation: AAD31759.1.
CCDSCCDS25126.1. [Q9Z2L7-1]
CCDS70260.1. [Q9Z2L7-2]
RefSeqNP_001264035.1. NM_001277106.1. [Q9Z2L7-2]
NP_061246.1. NM_018776.2. [Q9Z2L7-1]
UniGeneMm.272093.

3D structure databases

ProteinModelPortalQ9Z2L7.
SMRQ9Z2L7. Positions 177-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9Z2L7. 3 interactions.
MINTMINT-1748451.

PTM databases

PhosphoSiteQ9Z2L7.

Proteomic databases

MaxQBQ9Z2L7.
PaxDbQ9Z2L7.
PRIDEQ9Z2L7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000061283; ENSMUSP00000060028; ENSMUSG00000017561. [Q9Z2L7-1]
ENSMUST00000103233; ENSMUSP00000099523; ENSMUSG00000017561. [Q9Z2L7-2]
GeneID54394.
KEGGmmu:54394.
UCSCuc007kld.1. mouse. [Q9Z2L7-1]
uc011yaq.1. mouse. [Q9Z2L7-2]

Organism-specific databases

CTD51379.
MGIMGI:1860086. Crlf3.

Phylogenomic databases

eggNOGNOG71415.
GeneTreeENSGT00390000014117.
HOGENOMHOG000111973.
HOVERGENHBG054457.
InParanoidQ9Z2L7.
OMATNNNEGG.
OrthoDBEOG74TWZJ.
PhylomeDBQ9Z2L7.
TreeFamTF328682.

Gene expression databases

ArrayExpressQ9Z2L7.
BgeeQ9Z2L7.
CleanExMM_CRLF3.
GenevestigatorQ9Z2L7.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
PROSITEPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311244.
PROQ9Z2L7.
SOURCESearch...

Entry information

Entry nameCRLF3_MOUSE
AccessionPrimary (citable) accession number: Q9Z2L7
Secondary accession number(s): Q5SYK6, Q91W21, Q9R262
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot