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Q9Z2L7

- CRLF3_MOUSE

UniProt

Q9Z2L7 - CRLF3_MOUSE

Protein

Cytokine receptor-like factor 3

Gene

Crlf3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    May play a role in the negative regulation of cell cycle progression.By similarity

    GO - Biological processi

    1. G1/S transition of mitotic cell cycle Source: UniProtKB
    2. negative regulation of cell growth Source: UniProtKB
    3. positive regulation of cell cycle arrest Source: UniProtKB
    4. positive regulation of JAK-STAT cascade Source: UniProtKB
    5. positive regulation of transcription, DNA-templated Source: UniProtKB
    6. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytokine receptor-like factor 3
    Alternative name(s):
    Cytokine receptor-like molecule 9
    Short name:
    CREME-9
    Cytokine receptor-related factor 4
    Gene namesi
    Name:Crlf3
    Synonyms:Creme9, Cytor4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1860086. Crlf3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Cytokine receptor-like factor 3PRO_0000288937Add
    BLAST

    Proteomic databases

    MaxQBiQ9Z2L7.
    PaxDbiQ9Z2L7.
    PRIDEiQ9Z2L7.

    PTM databases

    PhosphoSiteiQ9Z2L7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Z2L7.
    BgeeiQ9Z2L7.
    CleanExiMM_CRLF3.
    GenevestigatoriQ9Z2L7.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9Z2L7. 3 interactions.
    MINTiMINT-1748451.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2L7.
    SMRiQ9Z2L7. Positions 177-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini181 – 27494Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili10 – 4637Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG71415.
    GeneTreeiENSGT00390000014117.
    HOGENOMiHOG000111973.
    HOVERGENiHBG054457.
    InParanoidiQ9Z2L7.
    OMAiTNNNEGG.
    OrthoDBiEOG74TWZJ.
    PhylomeDBiQ9Z2L7.
    TreeFamiTF328682.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS50853. FN3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Z2L7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKGAMEPEPE VLLQEARENV EAAQSYRREL GQRLQGLREA QRQIKESASQ    50
    TRDVLKQHFS DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE 100
    HGVNTADDLV REGEIAILGG IEEESDKLWN FTKKASHIQL DSLPEVPLLV 150
    DVPCLSAQLD DSILNIVKDH IFKHGTVASR PPVQIEELIE KPGGIIVRWC 200
    KVDDDFTAQD YRLQFRKCTA NHFEDVYVGS ETEFIVLHID PNVDYQFRVC 250
    ARGDGRQEWS PWSVPQTGHS TLVPHEWTTG FEGYSLSSRR NIALRNDAES 300
    SGVLYSSAPT YFCGQTLTFR VETVGQPDRR DSIGVCAERQ NGYESLQRDQ 350
    AVCISTNGAV FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TSNSHEGGNA 400
    KLRVTISSNN REVVFDWLLE QACGPLYFGC SFFYPGWKVL VF 442
    Length:442
    Mass (Da):49,559
    Last modified:May 1, 1999 - v1
    Checksum:i537CBBE507DFA3E6
    GO
    Isoform 2 (identifier: Q9Z2L7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         321-344: VETVGQPDRRDSIGVCAERQNGYE → CSLCQWKRNDQSVACSYLWLHCHI
         345-442: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:344
    Mass (Da):39,153
    Checksum:iAFB8C65DDB9284BC
    GO

    Sequence cautioni

    The sequence CAI24764.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei321 – 34424VETVG…QNGYE → CSLCQWKRNDQSVACSYLWL HCHI in isoform 2. 1 PublicationVSP_025847Add
    BLAST
    Alternative sequencei345 – 44298Missing in isoform 2. 1 PublicationVSP_025848Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF046060 mRNA. Translation: AAD02423.1.
    AK037880 mRNA. Translation: BAC29888.1.
    AK137528 mRNA. Translation: BAE23396.1.
    AK146798 mRNA. Translation: BAE27440.1.
    AL591113 Genomic DNA. Translation: CAI24762.1.
    AL591113 Genomic DNA. Translation: CAI24763.1.
    AL591113 Genomic DNA. Translation: CAI24764.1. Sequence problems.
    BC004780 mRNA. Translation: AAH04780.1.
    AF120152 mRNA. Translation: AAD31759.1.
    CCDSiCCDS25126.1. [Q9Z2L7-1]
    CCDS70260.1. [Q9Z2L7-2]
    RefSeqiNP_001264035.1. NM_001277106.1. [Q9Z2L7-2]
    NP_061246.1. NM_018776.2. [Q9Z2L7-1]
    UniGeneiMm.272093.

    Genome annotation databases

    EnsembliENSMUST00000061283; ENSMUSP00000060028; ENSMUSG00000017561. [Q9Z2L7-1]
    ENSMUST00000103233; ENSMUSP00000099523; ENSMUSG00000017561. [Q9Z2L7-2]
    GeneIDi54394.
    KEGGimmu:54394.
    UCSCiuc007kld.1. mouse. [Q9Z2L7-1]
    uc011yaq.1. mouse. [Q9Z2L7-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF046060 mRNA. Translation: AAD02423.1 .
    AK037880 mRNA. Translation: BAC29888.1 .
    AK137528 mRNA. Translation: BAE23396.1 .
    AK146798 mRNA. Translation: BAE27440.1 .
    AL591113 Genomic DNA. Translation: CAI24762.1 .
    AL591113 Genomic DNA. Translation: CAI24763.1 .
    AL591113 Genomic DNA. Translation: CAI24764.1 . Sequence problems.
    BC004780 mRNA. Translation: AAH04780.1 .
    AF120152 mRNA. Translation: AAD31759.1 .
    CCDSi CCDS25126.1. [Q9Z2L7-1 ]
    CCDS70260.1. [Q9Z2L7-2 ]
    RefSeqi NP_001264035.1. NM_001277106.1. [Q9Z2L7-2 ]
    NP_061246.1. NM_018776.2. [Q9Z2L7-1 ]
    UniGenei Mm.272093.

    3D structure databases

    ProteinModelPortali Q9Z2L7.
    SMRi Q9Z2L7. Positions 177-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9Z2L7. 3 interactions.
    MINTi MINT-1748451.

    PTM databases

    PhosphoSitei Q9Z2L7.

    Proteomic databases

    MaxQBi Q9Z2L7.
    PaxDbi Q9Z2L7.
    PRIDEi Q9Z2L7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061283 ; ENSMUSP00000060028 ; ENSMUSG00000017561 . [Q9Z2L7-1 ]
    ENSMUST00000103233 ; ENSMUSP00000099523 ; ENSMUSG00000017561 . [Q9Z2L7-2 ]
    GeneIDi 54394.
    KEGGi mmu:54394.
    UCSCi uc007kld.1. mouse. [Q9Z2L7-1 ]
    uc011yaq.1. mouse. [Q9Z2L7-2 ]

    Organism-specific databases

    CTDi 51379.
    MGIi MGI:1860086. Crlf3.

    Phylogenomic databases

    eggNOGi NOG71415.
    GeneTreei ENSGT00390000014117.
    HOGENOMi HOG000111973.
    HOVERGENi HBG054457.
    InParanoidi Q9Z2L7.
    OMAi TNNNEGG.
    OrthoDBi EOG74TWZJ.
    PhylomeDBi Q9Z2L7.
    TreeFami TF328682.

    Miscellaneous databases

    NextBioi 311244.
    PROi Q9Z2L7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z2L7.
    Bgeei Q9Z2L7.
    CleanExi MM_CRLF3.
    Genevestigatori Q9Z2L7.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS50853. FN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An extended gap penalty scheme for profiles results in the discovery of a novel cytokine receptor related transcript in an EST database."
      Farrah T., Adams R., Kho C.-J., Yamagiwa T.M., Madden K.L., Whitmore T., Jelmberg A., Pownder T., Lofton-Day C.E., Lok S.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Bone, Liver and Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: NMRI.
      Tissue: Mammary tumor.
    5. "Cloning of a novel cytokine receptor-like molecule."
      Maeda M., Nomura H.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-442 (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiCRLF3_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z2L7
    Secondary accession number(s): Q5SYK6, Q91W21, Q9R262
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3