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Protein

Cytokine receptor-like factor 3

Gene

Crlf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the negative regulation of cell cycle progression.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor-like factor 3
Alternative name(s):
Cytokine receptor-like molecule 9
Short name:
CREME-9
Cytokine receptor-related factor 4
Gene namesi
Name:Crlf3
Synonyms:Creme9, Cytor4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1860086. Crlf3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889371 – 442Cytokine receptor-like factor 3Add BLAST442

Proteomic databases

EPDiQ9Z2L7.
PaxDbiQ9Z2L7.
PeptideAtlasiQ9Z2L7.
PRIDEiQ9Z2L7.

PTM databases

PhosphoSitePlusiQ9Z2L7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000017561.
CleanExiMM_CRLF3.
ExpressionAtlasiQ9Z2L7. baseline and differential.
GenevisibleiQ9Z2L7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9Z2L7. 3 interactors.
MINTiMINT-1748451.
STRINGi10090.ENSMUSP00000060028.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2L7.
SMRiQ9Z2L7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 274Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST94

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili10 – 46Sequence analysisAdd BLAST37

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II83. Eukaryota.
ENOG4110NSY. LUCA.
GeneTreeiENSGT00390000014117.
HOGENOMiHOG000111973.
HOVERGENiHBG054457.
InParanoidiQ9Z2L7.
OMAiDYRLQYR.
OrthoDBiEOG091G0GM2.
PhylomeDBiQ9Z2L7.
TreeFamiTF328682.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z2L7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGAMEPEPE VLLQEARENV EAAQSYRREL GQRLQGLREA QRQIKESASQ
60 70 80 90 100
TRDVLKQHFS DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE
110 120 130 140 150
HGVNTADDLV REGEIAILGG IEEESDKLWN FTKKASHIQL DSLPEVPLLV
160 170 180 190 200
DVPCLSAQLD DSILNIVKDH IFKHGTVASR PPVQIEELIE KPGGIIVRWC
210 220 230 240 250
KVDDDFTAQD YRLQFRKCTA NHFEDVYVGS ETEFIVLHID PNVDYQFRVC
260 270 280 290 300
ARGDGRQEWS PWSVPQTGHS TLVPHEWTTG FEGYSLSSRR NIALRNDAES
310 320 330 340 350
SGVLYSSAPT YFCGQTLTFR VETVGQPDRR DSIGVCAERQ NGYESLQRDQ
360 370 380 390 400
AVCISTNGAV FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TSNSHEGGNA
410 420 430 440
KLRVTISSNN REVVFDWLLE QACGPLYFGC SFFYPGWKVL VF
Length:442
Mass (Da):49,559
Last modified:May 1, 1999 - v1
Checksum:i537CBBE507DFA3E6
GO
Isoform 2 (identifier: Q9Z2L7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-344: VETVGQPDRRDSIGVCAERQNGYE → CSLCQWKRNDQSVACSYLWLHCHI
     345-442: Missing.

Note: No experimental confirmation available.
Show »
Length:344
Mass (Da):39,153
Checksum:iAFB8C65DDB9284BC
GO

Sequence cautioni

The sequence CAI24764 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025847321 – 344VETVG…QNGYE → CSLCQWKRNDQSVACSYLWL HCHI in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_025848345 – 442Missing in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046060 mRNA. Translation: AAD02423.1.
AK037880 mRNA. Translation: BAC29888.1.
AK137528 mRNA. Translation: BAE23396.1.
AK146798 mRNA. Translation: BAE27440.1.
AL591113 Genomic DNA. Translation: CAI24762.1.
AL591113 Genomic DNA. Translation: CAI24763.1.
AL591113 Genomic DNA. Translation: CAI24764.1. Sequence problems.
BC004780 mRNA. Translation: AAH04780.1.
AF120152 mRNA. Translation: AAD31759.1.
CCDSiCCDS25126.1. [Q9Z2L7-1]
CCDS70260.1. [Q9Z2L7-2]
RefSeqiNP_001264035.1. NM_001277106.1. [Q9Z2L7-2]
NP_061246.1. NM_018776.2. [Q9Z2L7-1]
UniGeneiMm.272093.

Genome annotation databases

EnsembliENSMUST00000061283; ENSMUSP00000060028; ENSMUSG00000017561. [Q9Z2L7-1]
ENSMUST00000103233; ENSMUSP00000099523; ENSMUSG00000017561. [Q9Z2L7-2]
GeneIDi54394.
KEGGimmu:54394.
UCSCiuc007kld.2. mouse. [Q9Z2L7-1]
uc011yaq.2. mouse. [Q9Z2L7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046060 mRNA. Translation: AAD02423.1.
AK037880 mRNA. Translation: BAC29888.1.
AK137528 mRNA. Translation: BAE23396.1.
AK146798 mRNA. Translation: BAE27440.1.
AL591113 Genomic DNA. Translation: CAI24762.1.
AL591113 Genomic DNA. Translation: CAI24763.1.
AL591113 Genomic DNA. Translation: CAI24764.1. Sequence problems.
BC004780 mRNA. Translation: AAH04780.1.
AF120152 mRNA. Translation: AAD31759.1.
CCDSiCCDS25126.1. [Q9Z2L7-1]
CCDS70260.1. [Q9Z2L7-2]
RefSeqiNP_001264035.1. NM_001277106.1. [Q9Z2L7-2]
NP_061246.1. NM_018776.2. [Q9Z2L7-1]
UniGeneiMm.272093.

3D structure databases

ProteinModelPortaliQ9Z2L7.
SMRiQ9Z2L7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2L7. 3 interactors.
MINTiMINT-1748451.
STRINGi10090.ENSMUSP00000060028.

PTM databases

PhosphoSitePlusiQ9Z2L7.

Proteomic databases

EPDiQ9Z2L7.
PaxDbiQ9Z2L7.
PeptideAtlasiQ9Z2L7.
PRIDEiQ9Z2L7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061283; ENSMUSP00000060028; ENSMUSG00000017561. [Q9Z2L7-1]
ENSMUST00000103233; ENSMUSP00000099523; ENSMUSG00000017561. [Q9Z2L7-2]
GeneIDi54394.
KEGGimmu:54394.
UCSCiuc007kld.2. mouse. [Q9Z2L7-1]
uc011yaq.2. mouse. [Q9Z2L7-2]

Organism-specific databases

CTDi51379.
MGIiMGI:1860086. Crlf3.

Phylogenomic databases

eggNOGiENOG410II83. Eukaryota.
ENOG4110NSY. LUCA.
GeneTreeiENSGT00390000014117.
HOGENOMiHOG000111973.
HOVERGENiHBG054457.
InParanoidiQ9Z2L7.
OMAiDYRLQYR.
OrthoDBiEOG091G0GM2.
PhylomeDBiQ9Z2L7.
TreeFamiTF328682.

Miscellaneous databases

PROiQ9Z2L7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017561.
CleanExiMM_CRLF3.
ExpressionAtlasiQ9Z2L7. baseline and differential.
GenevisibleiQ9Z2L7. MM.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRLF3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2L7
Secondary accession number(s): Q5SYK6, Q91W21, Q9R262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.