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Q9Z2L7

- CRLF3_MOUSE

UniProt

Q9Z2L7 - CRLF3_MOUSE

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Protein

Cytokine receptor-like factor 3

Gene

Crlf3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in the negative regulation of cell cycle progression.By similarity

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: UniProtKB
  2. negative regulation of cell growth Source: UniProtKB
  3. positive regulation of cell cycle arrest Source: UniProtKB
  4. positive regulation of JAK-STAT cascade Source: UniProtKB
  5. positive regulation of transcription, DNA-templated Source: UniProtKB
  6. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor-like factor 3
Alternative name(s):
Cytokine receptor-like molecule 9
Short name:
CREME-9
Cytokine receptor-related factor 4
Gene namesi
Name:Crlf3
Synonyms:Creme9, Cytor4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1860086. Crlf3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Cytokine receptor-like factor 3PRO_0000288937Add
BLAST

Proteomic databases

MaxQBiQ9Z2L7.
PaxDbiQ9Z2L7.
PRIDEiQ9Z2L7.

PTM databases

PhosphoSiteiQ9Z2L7.

Expressioni

Gene expression databases

BgeeiQ9Z2L7.
CleanExiMM_CRLF3.
ExpressionAtlasiQ9Z2L7. baseline and differential.
GenevestigatoriQ9Z2L7.

Interactioni

Protein-protein interaction databases

IntActiQ9Z2L7. 3 interactions.
MINTiMINT-1748451.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2L7.
SMRiQ9Z2L7. Positions 175-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini181 – 27494Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili10 – 4637Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG71415.
GeneTreeiENSGT00390000014117.
HOGENOMiHOG000111973.
HOVERGENiHBG054457.
InParanoidiQ9Z2L7.
OMAiTNNNEGG.
OrthoDBiEOG74TWZJ.
PhylomeDBiQ9Z2L7.
TreeFamiTF328682.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Z2L7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGAMEPEPE VLLQEARENV EAAQSYRREL GQRLQGLREA QRQIKESASQ
60 70 80 90 100
TRDVLKQHFS DLKGTLGKLL DERLVTLLQE VDTIEQETIK PLDDCQKLIE
110 120 130 140 150
HGVNTADDLV REGEIAILGG IEEESDKLWN FTKKASHIQL DSLPEVPLLV
160 170 180 190 200
DVPCLSAQLD DSILNIVKDH IFKHGTVASR PPVQIEELIE KPGGIIVRWC
210 220 230 240 250
KVDDDFTAQD YRLQFRKCTA NHFEDVYVGS ETEFIVLHID PNVDYQFRVC
260 270 280 290 300
ARGDGRQEWS PWSVPQTGHS TLVPHEWTTG FEGYSLSSRR NIALRNDAES
310 320 330 340 350
SGVLYSSAPT YFCGQTLTFR VETVGQPDRR DSIGVCAERQ NGYESLQRDQ
360 370 380 390 400
AVCISTNGAV FVNGKEMTNQ LPAVTSGSTV TFDIEAVTLG TSNSHEGGNA
410 420 430 440
KLRVTISSNN REVVFDWLLE QACGPLYFGC SFFYPGWKVL VF
Length:442
Mass (Da):49,559
Last modified:May 1, 1999 - v1
Checksum:i537CBBE507DFA3E6
GO
Isoform 2 (identifier: Q9Z2L7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-344: VETVGQPDRRDSIGVCAERQNGYE → CSLCQWKRNDQSVACSYLWLHCHI
     345-442: Missing.

Note: No experimental confirmation available.

Show »
Length:344
Mass (Da):39,153
Checksum:iAFB8C65DDB9284BC
GO

Sequence cautioni

The sequence CAI24764.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei321 – 34424VETVG…QNGYE → CSLCQWKRNDQSVACSYLWL HCHI in isoform 2. 1 PublicationVSP_025847Add
BLAST
Alternative sequencei345 – 44298Missing in isoform 2. 1 PublicationVSP_025848Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF046060 mRNA. Translation: AAD02423.1.
AK037880 mRNA. Translation: BAC29888.1.
AK137528 mRNA. Translation: BAE23396.1.
AK146798 mRNA. Translation: BAE27440.1.
AL591113 Genomic DNA. Translation: CAI24762.1.
AL591113 Genomic DNA. Translation: CAI24763.1.
AL591113 Genomic DNA. Translation: CAI24764.1. Sequence problems.
BC004780 mRNA. Translation: AAH04780.1.
AF120152 mRNA. Translation: AAD31759.1.
CCDSiCCDS25126.1. [Q9Z2L7-1]
CCDS70260.1. [Q9Z2L7-2]
RefSeqiNP_001264035.1. NM_001277106.1. [Q9Z2L7-2]
NP_061246.1. NM_018776.2. [Q9Z2L7-1]
UniGeneiMm.272093.

Genome annotation databases

EnsembliENSMUST00000061283; ENSMUSP00000060028; ENSMUSG00000017561. [Q9Z2L7-1]
ENSMUST00000103233; ENSMUSP00000099523; ENSMUSG00000017561. [Q9Z2L7-2]
GeneIDi54394.
KEGGimmu:54394.
UCSCiuc007kld.1. mouse. [Q9Z2L7-1]
uc011yaq.1. mouse. [Q9Z2L7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF046060 mRNA. Translation: AAD02423.1 .
AK037880 mRNA. Translation: BAC29888.1 .
AK137528 mRNA. Translation: BAE23396.1 .
AK146798 mRNA. Translation: BAE27440.1 .
AL591113 Genomic DNA. Translation: CAI24762.1 .
AL591113 Genomic DNA. Translation: CAI24763.1 .
AL591113 Genomic DNA. Translation: CAI24764.1 . Sequence problems.
BC004780 mRNA. Translation: AAH04780.1 .
AF120152 mRNA. Translation: AAD31759.1 .
CCDSi CCDS25126.1. [Q9Z2L7-1 ]
CCDS70260.1. [Q9Z2L7-2 ]
RefSeqi NP_001264035.1. NM_001277106.1. [Q9Z2L7-2 ]
NP_061246.1. NM_018776.2. [Q9Z2L7-1 ]
UniGenei Mm.272093.

3D structure databases

ProteinModelPortali Q9Z2L7.
SMRi Q9Z2L7. Positions 175-266.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9Z2L7. 3 interactions.
MINTi MINT-1748451.

PTM databases

PhosphoSitei Q9Z2L7.

Proteomic databases

MaxQBi Q9Z2L7.
PaxDbi Q9Z2L7.
PRIDEi Q9Z2L7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061283 ; ENSMUSP00000060028 ; ENSMUSG00000017561 . [Q9Z2L7-1 ]
ENSMUST00000103233 ; ENSMUSP00000099523 ; ENSMUSG00000017561 . [Q9Z2L7-2 ]
GeneIDi 54394.
KEGGi mmu:54394.
UCSCi uc007kld.1. mouse. [Q9Z2L7-1 ]
uc011yaq.1. mouse. [Q9Z2L7-2 ]

Organism-specific databases

CTDi 51379.
MGIi MGI:1860086. Crlf3.

Phylogenomic databases

eggNOGi NOG71415.
GeneTreei ENSGT00390000014117.
HOGENOMi HOG000111973.
HOVERGENi HBG054457.
InParanoidi Q9Z2L7.
OMAi TNNNEGG.
OrthoDBi EOG74TWZJ.
PhylomeDBi Q9Z2L7.
TreeFami TF328682.

Miscellaneous databases

NextBioi 311244.
PROi Q9Z2L7.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z2L7.
CleanExi MM_CRLF3.
ExpressionAtlasi Q9Z2L7. baseline and differential.
Genevestigatori Q9Z2L7.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS50853. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An extended gap penalty scheme for profiles results in the discovery of a novel cytokine receptor related transcript in an EST database."
    Farrah T., Adams R., Kho C.-J., Yamagiwa T.M., Madden K.L., Whitmore T., Jelmberg A., Pownder T., Lofton-Day C.E., Lok S.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Bone, Liver and Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: NMRI.
    Tissue: Mammary tumor.
  5. "Cloning of a novel cytokine receptor-like molecule."
    Maeda M., Nomura H.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-442 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiCRLF3_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2L7
Secondary accession number(s): Q5SYK6, Q91W21, Q9R262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3