Q9Z2K1 (K1C16_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type I cytoskeletal 16

Alternative name(s):
Cytokeratin-16
Short name=CK-16
Keratin-16
Short name=K16

Gene names

Name:	Krt16
Synonyms:	Krt1-16

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Heterodimer of a type I and a type II keratin. KRT16 associates with KRT6 isomers. Interacts with TCHP By similarity. Interacts with TRADD. Ref.2
Miscellaneous	There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intermediate filament cytoskeleton organization Inferred from direct assay PubMed 12445204. Source: MGI
Cellular_component	intermediate filament Inferred from direct assay PubMed 12445204. Source: MGI
Molecular_function	structural constituent of cytoskeleton Inferred from direct assay PubMed 12445204. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Keratin, type I cytoskeletal 16		PRO_0000063663
Regions
	Region	1 – 112	112	Head
	Region	113 – 420	308	Rod
	Region	113 – 148	36	Coil 1A
	Region	149 – 166	18	Linker 1
	Region	167 – 258	92	Coil 1B
	Region	259 – 281	23	Linker 12
	Region	282 – 420	139	Coil 2
	Region	421 – 469	49	Tail

Sequences

	Sequence		Length	Mass (Da)
	Q9Z2K1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 13B8028CF28B64D5	FASTA	469	51,606
	10 20 30 40 50 60 MATCSRQFTS SSSMKGSCGI GGGSSRMSSI LAGGSCRAPS TCGGMSVTSS RFSSGGVCGI 70 80 90 100 110 120 GGGYGGSFSS SSFGGGLGSG FGGRFDGFGG GFGAGLGGGL GGGIGDGLLV GSEKVTMQNL 130 140 150 160 170 180 NDRLATYLDK VRALEEANRD LEVKIRDWYQ RQRPTEIKDY SPYFKTIEDL KSKIIIATQE 190 200 210 220 230 240 NAQFTLQIDN ARLAADDFRT KYENELFLRQ SVEGDINGLR KVLDELTLSR ADLEMQIENL 250 260 270 280 290 300 REELAFLKKN HEEEMLALRG QTGGDVNVEM DAAPGVDLSR ILNEMRDQYE QMAEKNRRDV 310 320 330 340 350 360 EAWFLRKTEE LNKEVASNSD LIQSNRSEVA ELRRVFQGLE IELQSQLSMK ASLENSLEET 370 380 390 400 410 420 KGRYCMQLSQ IQGLISSVEE QLAQLRCEME QQSQEYNILL DVKTRLEQEI ATYRRLLDGE 430 440 450 460 NIHSSSQHSS GQSYSSREVF SSSSRQPRSI LKEQGSTSFS QSQSQSSRD

References

[1]	"cDNA cloning, expression, and assembly characteristics of mouse keratin 16." Porter R.M., Hutcheson A.M., Rugg E.L., Quinlan R.A., Lane E.B. J. Biol. Chem. 273:32265-32272(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[2]	"Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion." Tong X., Coulombe P.A. Genes Dev. 20:1353-1364(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TRADD.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF053235 mRNA. Translation: AAC79424.1.
IPI	IPI00874585.
RefSeq	NP_032496.1. NM_008470.1.
UniGene	Mm.422799.
3D structure databases
ProteinModelPortal	Q9Z2K1.
SMR	Q9Z2K1. Positions 163-261, 330-419.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Z2K1. 1 interaction.
STRING	10090.ENSMUSP00000099415.
PTM databases
PhosphoSite	Q9Z2K1.
Proteomic databases
PaxDb	Q9Z2K1.
PRIDE	Q9Z2K1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000007280; ENSMUSP00000007280; ENSMUSG00000053797.
GeneID	16666.
KEGG	mmu:16666.
Organism-specific databases
CTD	3868.
MGI	MGI:96690. Krt16.
Phylogenomic databases
eggNOG	NOG148784.
GeneTree	ENSGT00610000085921.
HOVERGEN	HBG013015.
KO	K07604.
OMA	NSELIQS.
OrthoDB	EOG483D4W.
Gene expression databases
ArrayExpress	Q9Z2K1.
Bgee	Q9Z2K1.
CleanEx	MM_KRT16.
Genevestigator	Q9Z2K1.
GermOnline	ENSMUSG00000053797. Mus musculus.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	290379.
SOURCE	Search...

Entry information

Entry name

K1C16_MOUSE

Accession

Primary (citable) accession number: Q9Z2K1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program