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Protein

Death effector domain-containing protein

Gene

Dedd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Death effector domain-containing protein
Alternative name(s):
Death effector domain-containing testicular molecule
Gene namesi
Name:Dedd
Synonyms:Deft
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi620050 Dedd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912761 – 318Death effector domain-containing proteinAdd BLAST318

Post-translational modificationi

Exists predominantly in a mono- or diubiquitinated form.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9Z2K0
PRIDEiQ9Z2K0

Expressioni

Tissue specificityi

Widely expressed with highest levels in testis. Within the testis, highly expressed in germ cells but not expressed in Sertoli cells.1 Publication

Developmental stagei

First detected in 20-day-old animals. Reaches a peak at 30 days.1 Publication

Gene expression databases

BgeeiENSRNOG00000003779
GenevisibleiQ9Z2K0 RN

Interactioni

Subunit structurei

Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005147

Structurei

3D structure databases

ProteinModelPortaliQ9Z2K0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 103DEDPROSITE-ProRule annotationAdd BLAST79

Phylogenomic databases

eggNOGiENOG410IFFJ Eukaryota
ENOG410Z8U6 LUCA
GeneTreeiENSGT00390000008714
HOGENOMiHOG000049120
HOVERGENiHBG007220
InParanoidiQ9Z2K0
OMAiCPDPVDK
OrthoDBiEOG091G07VX
PhylomeDBiQ9Z2K0
TreeFamiTF331807

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR001875 DED_dom
PfamiView protein in Pfam
PF01335 DED, 1 hit
SMARTiView protein in SMART
SM00031 DED, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50168 DED, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLKRRASQ VWPEERVEQE HGLYSLHRMF DIVGTHLTHR DVRVLSFLFV
60 70 80 90 100
DVIDDHERGL IRNGRDFLLA LERQGRCDES NFRQVLQLLR IITRHDLLPY
110 120 130 140 150
VTLKKRRAVC PDLVDKYLEE TSIRYVTPRA LSDPEPRPPQ PSKTVPPHYP
160 170 180 190 200
VVCCPTSGSQ MCSKRPARGR TTLGSQRKRR KSVTPDPKEK QTCDIRLRVR
210 220 230 240 250
AEYCQHETAL QGNVFSNKQD PLERQFERFN QANTILKSRD LGSIICDIKF
260 270 280 290 300
SELTYLDAFW RDYINGSLLE ALKGVFITDS LKQAVGHEAI KLLVNVDEED
310
YELGRQKLLR NLMLQALP
Length:318
Mass (Da):36,847
Last modified:May 1, 1999 - v1
Checksum:iB8751791F66A03DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053362 mRNA Translation: AAC80287.1
RefSeqiNP_113988.1, NM_031800.1
XP_006250331.1, XM_006250269.3
XP_006250334.1, XM_006250272.3
XP_006250336.1, XM_006250274.3
XP_017454431.1, XM_017598942.1
XP_017454432.1, XM_017598943.1
XP_017454433.1, XM_017598944.1
XP_017454434.1, XM_017598945.1
XP_017454435.1, XM_017598946.1
UniGeneiRn.203286

Genome annotation databases

EnsembliENSRNOT00000005147; ENSRNOP00000005147; ENSRNOG00000003779
GeneIDi83631
KEGGirno:83631
UCSCiRGD:620050 rat

Similar proteinsi

Entry informationi

Entry nameiDEDD_RAT
AccessioniPrimary (citable) accession number: Q9Z2K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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