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Protein

Death effector domain-containing protein

Gene

Dedd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Death effector domain-containing protein
Alternative name(s):
Death effector domain-containing testicular molecule
Gene namesi
Name:Dedd
Synonyms:Deft
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi620050. Dedd.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleusnucleolus By similarity

  • Note: Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli. Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Death effector domain-containing proteinPRO_0000191276Add
BLAST

Post-translational modificationi

Exists predominantly in a mono- or diubiquitinated form.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9Z2K0.
PRIDEiQ9Z2K0.

Expressioni

Tissue specificityi

Widely expressed with highest levels in testis. Within the testis, highly expressed in germ cells but not expressed in Sertoli cells.1 Publication

Developmental stagei

First detected in 20-day-old animals. Reaches a peak at 30 days.1 Publication

Gene expression databases

GenevisibleiQ9Z2K0. RN.

Interactioni

Subunit structurei

Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005147.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2K0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 10379DEDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DED (death effector) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFFJ. Eukaryota.
ENOG410Z8U6. LUCA.
GeneTreeiENSGT00390000008714.
HOGENOMiHOG000049120.
HOVERGENiHBG007220.
InParanoidiQ9Z2K0.
OMAiCQHESAL.
OrthoDBiEOG7BCNBW.
PhylomeDBiQ9Z2K0.
TreeFamiTF331807.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR001875. DED_dom.
[Graphical view]
PfamiPF01335. DED. 1 hit.
[Graphical view]
SMARTiSM00031. DED. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50168. DED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLKRRASQ VWPEERVEQE HGLYSLHRMF DIVGTHLTHR DVRVLSFLFV
60 70 80 90 100
DVIDDHERGL IRNGRDFLLA LERQGRCDES NFRQVLQLLR IITRHDLLPY
110 120 130 140 150
VTLKKRRAVC PDLVDKYLEE TSIRYVTPRA LSDPEPRPPQ PSKTVPPHYP
160 170 180 190 200
VVCCPTSGSQ MCSKRPARGR TTLGSQRKRR KSVTPDPKEK QTCDIRLRVR
210 220 230 240 250
AEYCQHETAL QGNVFSNKQD PLERQFERFN QANTILKSRD LGSIICDIKF
260 270 280 290 300
SELTYLDAFW RDYINGSLLE ALKGVFITDS LKQAVGHEAI KLLVNVDEED
310
YELGRQKLLR NLMLQALP
Length:318
Mass (Da):36,847
Last modified:May 1, 1999 - v1
Checksum:iB8751791F66A03DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053362 mRNA. Translation: AAC80287.1.
RefSeqiNP_113988.1. NM_031800.1.
XP_006250331.1. XM_006250269.2.
XP_006250332.1. XM_006250270.2.
XP_006250334.1. XM_006250272.2.
XP_006250335.1. XM_006250273.2.
XP_006250336.1. XM_006250274.2.
UniGeneiRn.203286.

Genome annotation databases

EnsembliENSRNOT00000005147; ENSRNOP00000005147; ENSRNOG00000003779.
GeneIDi83631.
KEGGirno:83631.
UCSCiRGD:620050. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053362 mRNA. Translation: AAC80287.1.
RefSeqiNP_113988.1. NM_031800.1.
XP_006250331.1. XM_006250269.2.
XP_006250332.1. XM_006250270.2.
XP_006250334.1. XM_006250272.2.
XP_006250335.1. XM_006250273.2.
XP_006250336.1. XM_006250274.2.
UniGeneiRn.203286.

3D structure databases

ProteinModelPortaliQ9Z2K0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005147.

Proteomic databases

PaxDbiQ9Z2K0.
PRIDEiQ9Z2K0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005147; ENSRNOP00000005147; ENSRNOG00000003779.
GeneIDi83631.
KEGGirno:83631.
UCSCiRGD:620050. rat.

Organism-specific databases

CTDi9191.
RGDi620050. Dedd.

Phylogenomic databases

eggNOGiENOG410IFFJ. Eukaryota.
ENOG410Z8U6. LUCA.
GeneTreeiENSGT00390000008714.
HOGENOMiHOG000049120.
HOVERGENiHBG007220.
InParanoidiQ9Z2K0.
OMAiCQHESAL.
OrthoDBiEOG7BCNBW.
PhylomeDBiQ9Z2K0.
TreeFamiTF331807.

Miscellaneous databases

PROiQ9Z2K0.

Gene expression databases

GenevisibleiQ9Z2K0. RN.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR001875. DED_dom.
[Graphical view]
PfamiPF01335. DED. 1 hit.
[Graphical view]
SMARTiSM00031. DED. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50168. DED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells."
    Leo C.P., Hsu S.Y., McGee E.A., Salanova M., Hsueh A.J.W.
    Endocrinology 139:4839-4848(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Testis.

Entry informationi

Entry nameiDEDD_RAT
AccessioniPrimary (citable) accession number: Q9Z2K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.