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Protein

Vesicle-associated membrane protein 5

Gene

Vamp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 5
Short name:
VAMP-5
Alternative name(s):
Myobrevin
Gene namesi
Name:Vamp5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620419. Vamp5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7272CytoplasmicSequence analysisAdd
BLAST
Transmembranei73 – 9321Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini94 – 1029VesicularSequence analysis

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: RGD
  • SNARE complex Source: GO_Central
  • trans-Golgi network Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 102102Vesicle-associated membrane protein 5PRO_0000206735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411PhosphoserineBy similarity
Modified residuei48 – 481PhosphoserineBy similarity
Modified residuei49 – 491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z2J5.
PRIDEiQ9Z2J5.

PTM databases

iPTMnetiQ9Z2J5.

Expressioni

Inductioni

During myogenesis.

Gene expression databases

GenevisibleiQ9Z2J5. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016984.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2J5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 6561v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0860. Eukaryota.
COG5143. LUCA.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiQ9Z2J5.
KOiK08514.
OMAiKRWENIR.
OrthoDBiEOG7Q5HHH.
PhylomeDBiQ9Z2J5.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKELERCQ RQADQVTEIM LNNFDKVLER DGKLSELQQR SDQLLDMSSA
60 70 80 90 100
FSKTTKTLAQ QKRWENIRCR VYLGLAVAGG LLLILVVLLV IFLPSGEDSS

KP
Length:102
Mass (Da):11,495
Last modified:May 1, 1999 - v1
Checksum:i6AC37413597236BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054826 mRNA. Translation: AAC97474.1.
RefSeqiNP_446007.1. NM_053555.1.
UniGeneiRn.22616.

Genome annotation databases

GeneIDi89818.
KEGGirno:89818.
UCSCiRGD:620419. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054826 mRNA. Translation: AAC97474.1.
RefSeqiNP_446007.1. NM_053555.1.
UniGeneiRn.22616.

3D structure databases

ProteinModelPortaliQ9Z2J5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016984.

PTM databases

iPTMnetiQ9Z2J5.

Proteomic databases

PaxDbiQ9Z2J5.
PRIDEiQ9Z2J5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi89818.
KEGGirno:89818.
UCSCiRGD:620419. rat.

Organism-specific databases

CTDi10791.
RGDi620419. Vamp5.

Phylogenomic databases

eggNOGiKOG0860. Eukaryota.
COG5143. LUCA.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
InParanoidiQ9Z2J5.
KOiK08514.
OMAiKRWENIR.
OrthoDBiEOG7Q5HHH.
PhylomeDBiQ9Z2J5.

Miscellaneous databases

PROiQ9Z2J5.

Gene expression databases

GenevisibleiQ9Z2J5. RN.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel synaptobrevin/VAMP homologous protein (VAMP5) is increased during in vitro myogenesis and present in the plasma membrane."
    Zeng Q., Subramaniam V.N., Wong S.H., Tang B.L., Parton R.G., Rea S., James D.E., Hong W.
    Mol. Biol. Cell 9:2423-2437(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiVAMP5_RAT
AccessioniPrimary (citable) accession number: Q9Z2J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.