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Protein

Solute carrier family 23 member 1

Gene

Slc23a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • brain development Source: UniProtKB
  • dehydroascorbic acid transport Source: UniProtKB
  • L-ascorbic acid transport Source: UniProtKB
  • lung development Source: UniProtKB
  • response to toxic substance Source: UniProtKB
  • sodium ion transport Source: UniProtKB
  • transepithelial L-ascorbic acid transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-196836. Vitamin C (ascorbate) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 1
Alternative name(s):
Na(+)/L-ascorbic acid transporter 1
Sodium-dependent vitamin C transporter 1
Yolk sac permease-like molecule 3
Gene namesi
Name:Slc23a1
Synonyms:Svct1, Yspl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1341903. Slc23a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 59CytoplasmicSequence analysisAdd BLAST59
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 88ExtracellularSequence analysis8
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110CytoplasmicSequence analysis1
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 166ExtracellularSequence analysisAdd BLAST35
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 214CytoplasmicSequence analysisAdd BLAST27
Transmembranei215 – 232HelicalSequence analysisAdd BLAST18
Topological domaini233 – 236ExtracellularSequence analysis4
Intramembranei237 – 250HelicalSequence analysisAdd BLAST14
Topological domaini251 – 257ExtracellularSequence analysis7
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 319CytoplasmicSequence analysisAdd BLAST41
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 365ExtracellularSequence analysisAdd BLAST25
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Topological domaini387 – 409CytoplasmicSequence analysisAdd BLAST23
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Topological domaini431 – 433ExtracellularSequence analysis3
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Topological domaini455 – 464CytoplasmicSequence analysis10
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Topological domaini486 – 497ExtracellularSequence analysisAdd BLAST12
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21
Topological domaini519 – 605CytoplasmicSequence analysisAdd BLAST87

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • basal plasma membrane Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • intracellular organelle Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659761 – 605Solute carrier family 23 member 1Add BLAST605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1
Modified residuei598PhosphothreonineCombined sources1
Modified residuei600PhosphoserineCombined sources1
Modified residuei603PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z2J0.
PaxDbiQ9Z2J0.
PRIDEiQ9Z2J0.

PTM databases

iPTMnetiQ9Z2J0.
PhosphoSitePlusiQ9Z2J0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024354.
ExpressionAtlasiQ9Z2J0. baseline and differential.
GenevisibleiQ9Z2J0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025212.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2J0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9Z2J0.
KOiK14611.
OMAiSAPWFRM.
OrthoDBiEOG091G063Y.
PhylomeDBiQ9Z2J0.
TreeFamiTF313272.

Family and domain databases

InterProiIPR029954. SLC23A1.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF21. PTHR11119:SF21. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTPEDPGSP KQHEVVDSAG TSTRDRQAPL PTEPKFDMLY KIEDVPPWYL
60 70 80 90 100
CILLGFQHYL TCFSGTIAVP FLLAEALCVG RDQHMVSQLI GTIFTCVGIT
110 120 130 140 150
TLIQTTVGIR LPLFQASAFA FLVPAKSILA LERWKCPSEE EIYGNWSMPL
160 170 180 190 200
NTSHIWHPRI REVQGAIMVS SMVEVVIGLM GLPGALLSYI GPLTVTPTVS
210 220 230 240 250
LIGLSVFQAA GDRAGSHWGI SACSILLIVL FSQYLRNLTF LLPVYRWGKG
260 270 280 290 300
LTLFRVQIFK MFPIVLAIMT VWLLCYVLTL TDVLPADPTV YGFQARTDAR
310 320 330 340 350
GDIMAISPWI RIPYPCQWGL PTVTVAAVLG MFSATLAGII ESIGDYYACA
360 370 380 390 400
RLAGAPPPPV HAINRGIFTE GICCIIAGLL GTGNGSTSSS PNIGVLGITK
410 420 430 440 450
VGSRRVVQYG AGIMLILGAI GKFTALFASL PDPILGGMFC TLFGMITAVG
460 470 480 490 500
LSNLQFVDMN SSRNLFVLGF SMFFGLTLPN YLDSNPGAIN TGIPEVDQIL
510 520 530 540 550
TVLLTTEMFV GGCLAFILDN TVPGSPEERG LIQWKAGAHA NSETSASLKS
560 570 580 590 600
YDFPFGMGMV KRTTFFRYIP ICPVFRGFSK KTQNQPPVLE DTPDNIETGS

VCTKV
Length:605
Mass (Da):65,554
Last modified:October 19, 2002 - v2
Checksum:iA3F64CB42DA1CFF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205S → Y in AAC78805 (PubMed:9804989).Curated1
Sequence conflicti223C → R in BAC39457 (PubMed:16141072).Curated1
Sequence conflicti540 – 541AN → PH in BAC39457 (PubMed:16141072).Curated2
Sequence conflicti579S → F in BAC39457 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058318 mRNA. Translation: AAC78805.1.
AK085499 mRNA. Translation: BAC39457.1.
AK143959 mRNA. Translation: BAE25631.1.
AK165439 mRNA. Translation: BAE38187.1.
BC013528 mRNA. Translation: AAH13528.1.
CCDSiCCDS29144.1.
RefSeqiNP_035527.3. NM_011397.4.
XP_017173340.1. XM_017317851.1.
UniGeneiMm.22702.

Genome annotation databases

EnsembliENSMUST00000025212; ENSMUSP00000025212; ENSMUSG00000024354.
GeneIDi20522.
KEGGimmu:20522.
UCSCiuc008eml.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058318 mRNA. Translation: AAC78805.1.
AK085499 mRNA. Translation: BAC39457.1.
AK143959 mRNA. Translation: BAE25631.1.
AK165439 mRNA. Translation: BAE38187.1.
BC013528 mRNA. Translation: AAH13528.1.
CCDSiCCDS29144.1.
RefSeqiNP_035527.3. NM_011397.4.
XP_017173340.1. XM_017317851.1.
UniGeneiMm.22702.

3D structure databases

ProteinModelPortaliQ9Z2J0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025212.

PTM databases

iPTMnetiQ9Z2J0.
PhosphoSitePlusiQ9Z2J0.

Proteomic databases

MaxQBiQ9Z2J0.
PaxDbiQ9Z2J0.
PRIDEiQ9Z2J0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025212; ENSMUSP00000025212; ENSMUSG00000024354.
GeneIDi20522.
KEGGimmu:20522.
UCSCiuc008eml.2. mouse.

Organism-specific databases

CTDi9963.
MGIiMGI:1341903. Slc23a1.

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9Z2J0.
KOiK14611.
OMAiSAPWFRM.
OrthoDBiEOG091G063Y.
PhylomeDBiQ9Z2J0.
TreeFamiTF313272.

Enzyme and pathway databases

ReactomeiR-MMU-196836. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

ChiTaRSiSlc23a1. mouse.
PROiQ9Z2J0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024354.
ExpressionAtlasiQ9Z2J0. baseline and differential.
GenevisibleiQ9Z2J0. MM.

Family and domain databases

InterProiIPR029954. SLC23A1.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF21. PTHR11119:SF21. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS23A1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2J0
Secondary accession number(s): Q3TNA2, Q8C3M2, Q91WR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.