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Protein

Solute carrier family 23 member 1

Gene

Slc23a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • brain development Source: UniProtKB
  • dehydroascorbic acid transport Source: UniProtKB
  • L-ascorbic acid transmembrane transport Source: UniProtKB
  • lung development Source: UniProtKB
  • response to toxic substance Source: UniProtKB
  • sodium ion transport Source: UniProtKB
  • transepithelial L-ascorbic acid transport Source: UniProtKB

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-196836 Vitamin C (ascorbate) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 1
Alternative name(s):
Na(+)/L-ascorbic acid transporter 1
Sodium-dependent vitamin C transporter 1
Yolk sac permease-like molecule 3
Gene namesi
Name:Slc23a1
Synonyms:Svct1, Yspl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1341903 Slc23a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 59CytoplasmicSequence analysisAdd BLAST59
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 88ExtracellularSequence analysis8
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110CytoplasmicSequence analysis1
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 166ExtracellularSequence analysisAdd BLAST35
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 214CytoplasmicSequence analysisAdd BLAST27
Transmembranei215 – 232HelicalSequence analysisAdd BLAST18
Topological domaini233 – 236ExtracellularSequence analysis4
Intramembranei237 – 250HelicalSequence analysisAdd BLAST14
Topological domaini251 – 257ExtracellularSequence analysis7
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 319CytoplasmicSequence analysisAdd BLAST41
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 365ExtracellularSequence analysisAdd BLAST25
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Topological domaini387 – 409CytoplasmicSequence analysisAdd BLAST23
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Topological domaini431 – 433ExtracellularSequence analysis3
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Topological domaini455 – 464CytoplasmicSequence analysis10
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Topological domaini486 – 497ExtracellularSequence analysisAdd BLAST12
Transmembranei498 – 518HelicalSequence analysisAdd BLAST21
Topological domaini519 – 605CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659761 – 605Solute carrier family 23 member 1Add BLAST605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei598PhosphothreonineCombined sources1
Modified residuei600PhosphoserineCombined sources1
Modified residuei603PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Z2J0
PaxDbiQ9Z2J0
PRIDEiQ9Z2J0

PTM databases

iPTMnetiQ9Z2J0
PhosphoSitePlusiQ9Z2J0
SwissPalmiQ9Z2J0

Expressioni

Gene expression databases

BgeeiENSMUSG00000024354
ExpressionAtlasiQ9Z2J0 baseline and differential
GenevisibleiQ9Z2J0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025212

Structurei

3D structure databases

ProteinModelPortaliQ9Z2J0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1292 Eukaryota
COG2233 LUCA
GeneTreeiENSGT00390000015686
HOGENOMiHOG000038201
HOVERGENiHBG056256
InParanoidiQ9Z2J0
KOiK14611
OMAiITPVFSR
OrthoDBiEOG091G063Y
PhylomeDBiQ9Z2J0
TreeFamiTF313272

Family and domain databases

InterProiView protein in InterPro
IPR029954 SLC23A1
IPR006043 Xant/urac/vitC
PANTHERiPTHR11119:SF21 PTHR11119:SF21, 1 hit
PfamiView protein in Pfam
PF00860 Xan_ur_permease, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTPEDPGSP KQHEVVDSAG TSTRDRQAPL PTEPKFDMLY KIEDVPPWYL
60 70 80 90 100
CILLGFQHYL TCFSGTIAVP FLLAEALCVG RDQHMVSQLI GTIFTCVGIT
110 120 130 140 150
TLIQTTVGIR LPLFQASAFA FLVPAKSILA LERWKCPSEE EIYGNWSMPL
160 170 180 190 200
NTSHIWHPRI REVQGAIMVS SMVEVVIGLM GLPGALLSYI GPLTVTPTVS
210 220 230 240 250
LIGLSVFQAA GDRAGSHWGI SACSILLIVL FSQYLRNLTF LLPVYRWGKG
260 270 280 290 300
LTLFRVQIFK MFPIVLAIMT VWLLCYVLTL TDVLPADPTV YGFQARTDAR
310 320 330 340 350
GDIMAISPWI RIPYPCQWGL PTVTVAAVLG MFSATLAGII ESIGDYYACA
360 370 380 390 400
RLAGAPPPPV HAINRGIFTE GICCIIAGLL GTGNGSTSSS PNIGVLGITK
410 420 430 440 450
VGSRRVVQYG AGIMLILGAI GKFTALFASL PDPILGGMFC TLFGMITAVG
460 470 480 490 500
LSNLQFVDMN SSRNLFVLGF SMFFGLTLPN YLDSNPGAIN TGIPEVDQIL
510 520 530 540 550
TVLLTTEMFV GGCLAFILDN TVPGSPEERG LIQWKAGAHA NSETSASLKS
560 570 580 590 600
YDFPFGMGMV KRTTFFRYIP ICPVFRGFSK KTQNQPPVLE DTPDNIETGS

VCTKV
Length:605
Mass (Da):65,554
Last modified:October 19, 2002 - v2
Checksum:iA3F64CB42DA1CFF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205S → Y in AAC78805 (PubMed:9804989).Curated1
Sequence conflicti223C → R in BAC39457 (PubMed:16141072).Curated1
Sequence conflicti540 – 541AN → PH in BAC39457 (PubMed:16141072).Curated2
Sequence conflicti579S → F in BAC39457 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058318 mRNA Translation: AAC78805.1
AK085499 mRNA Translation: BAC39457.1
AK143959 mRNA Translation: BAE25631.1
AK165439 mRNA Translation: BAE38187.1
BC013528 mRNA Translation: AAH13528.1
CCDSiCCDS29144.1
RefSeqiNP_035527.3, NM_011397.4
XP_017173340.1, XM_017317851.1
UniGeneiMm.22702

Genome annotation databases

EnsembliENSMUST00000025212; ENSMUSP00000025212; ENSMUSG00000024354
GeneIDi20522
KEGGimmu:20522
UCSCiuc008eml.2 mouse

Similar proteinsi

Entry informationi

Entry nameiS23A1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2J0
Secondary accession number(s): Q3TNA2, Q8C3M2, Q91WR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: May 23, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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