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Q9Z2J0

- S23A1_MOUSE

UniProt

Q9Z2J0 - S23A1_MOUSE

Protein

Solute carrier family 23 member 1

Gene

Slc23a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (19 Oct 2002)
      Previous versions | rss
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    Functioni

    Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate By similarity.By similarity

    GO - Molecular functioni

    1. dehydroascorbic acid transporter activity Source: UniProtKB
    2. L-ascorbate:sodium symporter activity Source: Ensembl
    3. L-ascorbic acid transporter activity Source: UniProtKB
    4. sodium-dependent L-ascorbate transmembrane transporter activity Source: UniProtKB
    5. sodium ion transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. brain development Source: UniProtKB
    2. dehydroascorbic acid transport Source: UniProtKB
    3. L-ascorbic acid transport Source: UniProtKB
    4. lung development Source: UniProtKB
    5. response to toxic substance Source: UniProtKB
    6. sodium ion transport Source: UniProtKB
    7. transepithelial L-ascorbic acid transport Source: UniProtKB
    8. vitamin transmembrane transport Source: GOC

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_215258. Vitamin C (ascorbate) metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 23 member 1
    Alternative name(s):
    Na(+)/L-ascorbic acid transporter 1
    Sodium-dependent vitamin C transporter 1
    Yolk sac permease-like molecule 3
    Gene namesi
    Name:Slc23a1
    Synonyms:Svct1, Yspl3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1341903. Slc23a1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. basal plasma membrane Source: UniProtKB
    3. brush border Source: Ensembl
    4. cytoplasm Source: UniProtKB
    5. integral component of membrane Source: UniProtKB-KW
    6. intracellular organelle Source: UniProtKB
    7. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 605605Solute carrier family 23 member 1PRO_0000165976Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Modified residuei603 – 6031Phosphothreonine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Z2J0.
    PaxDbiQ9Z2J0.
    PRIDEiQ9Z2J0.

    PTM databases

    PhosphoSiteiQ9Z2J0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Z2J0.
    BgeeiQ9Z2J0.
    GenevestigatoriQ9Z2J0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2J0.
    SMRiQ9Z2J0. Positions 42-477.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5959CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini81 – 888ExtracellularSequence Analysis
    Topological domaini110 – 1101CytoplasmicSequence Analysis
    Topological domaini132 – 16635ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini188 – 21427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini233 – 2364ExtracellularSequence Analysis
    Topological domaini251 – 2577ExtracellularSequence Analysis
    Topological domaini279 – 31941CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini341 – 36525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini387 – 40923CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini431 – 4333ExtracellularSequence Analysis
    Topological domaini455 – 46410CytoplasmicSequence Analysis
    Topological domaini486 – 49712ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini519 – 60587CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei237 – 25014HelicalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei215 – 23218HelicalSequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei320 – 34021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei366 – 38621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei410 – 43021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei434 – 45421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei498 – 51821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2233.
    GeneTreeiENSGT00390000015686.
    HOGENOMiHOG000038201.
    HOVERGENiHBG056256.
    InParanoidiQ9Z2J0.
    KOiK14611.
    OMAiTRDRQAP.
    OrthoDBiEOG7R56RZ.
    PhylomeDBiQ9Z2J0.
    TreeFamiTF313272.

    Family and domain databases

    InterProiIPR006043. Xant/urac/vitC.
    [Graphical view]
    PANTHERiPTHR11119. PTHR11119. 1 hit.
    PfamiPF00860. Xan_ur_permease. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z2J0-1 [UniParc]FASTAAdd to Basket

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    MKTPEDPGSP KQHEVVDSAG TSTRDRQAPL PTEPKFDMLY KIEDVPPWYL    50
    CILLGFQHYL TCFSGTIAVP FLLAEALCVG RDQHMVSQLI GTIFTCVGIT 100
    TLIQTTVGIR LPLFQASAFA FLVPAKSILA LERWKCPSEE EIYGNWSMPL 150
    NTSHIWHPRI REVQGAIMVS SMVEVVIGLM GLPGALLSYI GPLTVTPTVS 200
    LIGLSVFQAA GDRAGSHWGI SACSILLIVL FSQYLRNLTF LLPVYRWGKG 250
    LTLFRVQIFK MFPIVLAIMT VWLLCYVLTL TDVLPADPTV YGFQARTDAR 300
    GDIMAISPWI RIPYPCQWGL PTVTVAAVLG MFSATLAGII ESIGDYYACA 350
    RLAGAPPPPV HAINRGIFTE GICCIIAGLL GTGNGSTSSS PNIGVLGITK 400
    VGSRRVVQYG AGIMLILGAI GKFTALFASL PDPILGGMFC TLFGMITAVG 450
    LSNLQFVDMN SSRNLFVLGF SMFFGLTLPN YLDSNPGAIN TGIPEVDQIL 500
    TVLLTTEMFV GGCLAFILDN TVPGSPEERG LIQWKAGAHA NSETSASLKS 550
    YDFPFGMGMV KRTTFFRYIP ICPVFRGFSK KTQNQPPVLE DTPDNIETGS 600
    VCTKV 605
    Length:605
    Mass (Da):65,554
    Last modified:October 19, 2002 - v2
    Checksum:iA3F64CB42DA1CFF5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti205 – 2051S → Y in AAC78805. (PubMed:9804989)Curated
    Sequence conflicti223 – 2231C → R in BAC39457. (PubMed:16141072)Curated
    Sequence conflicti540 – 5412AN → PH in BAC39457. (PubMed:16141072)Curated
    Sequence conflicti579 – 5791S → F in BAC39457. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058318 mRNA. Translation: AAC78805.1.
    AK085499 mRNA. Translation: BAC39457.1.
    AK143959 mRNA. Translation: BAE25631.1.
    AK165439 mRNA. Translation: BAE38187.1.
    BC013528 mRNA. Translation: AAH13528.1.
    CCDSiCCDS29144.1.
    RefSeqiNP_035527.3. NM_011397.4.
    UniGeneiMm.22702.

    Genome annotation databases

    EnsembliENSMUST00000025212; ENSMUSP00000025212; ENSMUSG00000024354.
    GeneIDi20522.
    KEGGimmu:20522.
    UCSCiuc008eml.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058318 mRNA. Translation: AAC78805.1 .
    AK085499 mRNA. Translation: BAC39457.1 .
    AK143959 mRNA. Translation: BAE25631.1 .
    AK165439 mRNA. Translation: BAE38187.1 .
    BC013528 mRNA. Translation: AAH13528.1 .
    CCDSi CCDS29144.1.
    RefSeqi NP_035527.3. NM_011397.4.
    UniGenei Mm.22702.

    3D structure databases

    ProteinModelPortali Q9Z2J0.
    SMRi Q9Z2J0. Positions 42-477.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9Z2J0.

    Proteomic databases

    MaxQBi Q9Z2J0.
    PaxDbi Q9Z2J0.
    PRIDEi Q9Z2J0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025212 ; ENSMUSP00000025212 ; ENSMUSG00000024354 .
    GeneIDi 20522.
    KEGGi mmu:20522.
    UCSCi uc008eml.2. mouse.

    Organism-specific databases

    CTDi 9963.
    MGIi MGI:1341903. Slc23a1.

    Phylogenomic databases

    eggNOGi COG2233.
    GeneTreei ENSGT00390000015686.
    HOGENOMi HOG000038201.
    HOVERGENi HBG056256.
    InParanoidi Q9Z2J0.
    KOi K14611.
    OMAi TRDRQAP.
    OrthoDBi EOG7R56RZ.
    PhylomeDBi Q9Z2J0.
    TreeFami TF313272.

    Enzyme and pathway databases

    Reactomei REACT_215258. Vitamin C (ascorbate) metabolism.

    Miscellaneous databases

    ChiTaRSi SLC23A1. mouse.
    NextBioi 298751.
    PROi Q9Z2J0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z2J0.
    Bgeei Q9Z2J0.
    Genevestigatori Q9Z2J0.

    Family and domain databases

    InterProi IPR006043. Xant/urac/vitC.
    [Graphical view ]
    PANTHERi PTHR11119. PTHR11119. 1 hit.
    Pfami PF00860. Xan_ur_permease. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters."
      Faaland C.A., Race J.E., Ricken G., Warner F.J., Williams W.J., Holtzman E.J.
      Biochim. Biophys. Acta 1442:353-360(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-603, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiS23A1_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z2J0
    Secondary accession number(s): Q3TNA2, Q8C3M2, Q91WR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: October 19, 2002
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3