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Protein

Synaptic vesicle 2-related protein

Gene

Svop

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle 2-related protein
Short name:
SV2-related protein
Gene namesi
Name:Svop
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi620277. Svop.

Subcellular locationi

  • Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8787CytoplasmicSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Topological domaini109 – 12214VesicularSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Topological domaini144 – 15613CytoplasmicSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Topological domaini178 – 1803VesicularSequence analysis
Transmembranei181 – 20121HelicalSequence analysisAdd
BLAST
Topological domaini202 – 2098CytoplasmicSequence analysis
Transmembranei210 – 23021HelicalSequence analysisAdd
BLAST
Topological domaini231 – 2388VesicularSequence analysis
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Topological domaini260 – 31657CytoplasmicSequence analysisAdd
BLAST
Transmembranei317 – 33721HelicalSequence analysisAdd
BLAST
Topological domaini338 – 37336VesicularSequence analysisAdd
BLAST
Transmembranei374 – 39421HelicalSequence analysisAdd
BLAST
Topological domaini395 – 4017CytoplasmicSequence analysis
Transmembranei402 – 42221HelicalSequence analysisAdd
BLAST
Topological domaini423 – 4242VesicularSequence analysis
Transmembranei425 – 44521HelicalSequence analysisAdd
BLAST
Topological domaini446 – 45712CytoplasmicSequence analysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence analysisAdd
BLAST
Topological domaini479 – 48911VesicularSequence analysisAdd
BLAST
Transmembranei490 – 51021HelicalSequence analysisAdd
BLAST
Topological domaini511 – 54838CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • synaptic vesicle Source: HGNC
  • synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Synaptic vesicle 2-related proteinPRO_0000279455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251PhosphoserineCombined sources
Modified residuei31 – 311PhosphoserineCombined sources
Modified residuei542 – 5421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9Z2I7.

PTM databases

iPTMnetiQ9Z2I7.

Expressioni

Tissue specificityi

Detected in brain (at protein level). Detected in brain, in synaptic layers of the cerebellum, hippocampus and cerebral cortex.1 Publication

Gene expression databases

ExpressionAtlasiQ9Z2I7. baseline and differential.
GenevisibleiQ9Z2I7. RN.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2I7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074384.
HOGENOMiHOG000114543.
HOVERGENiHBG057057.
InParanoidiQ9Z2I7.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR004749. Orgcat_transp/SVOP.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEDLFQLRQ LPVVKFRRTG ESARSEDDAA SGEHDVQIEG VRVGLEAVEL
60 70 80 90 100
DDGAAVPKEF ANPTDDTFMV EDAVEAIGFG RFQWKLSVLT GLAWMADAME
110 120 130 140 150
MMILSILAPQ LHCEWRLPSW QVALLTSVVF IGMMSSSTLW GNISDQYGRK
160 170 180 190 200
TGLKISVFWT LYYGILSAFA PVYSWILVLR GLVGFGIGGV PQSVTLYAEF
210 220 230 240 250
LPMKARAKCI LLIEVFWAIG TVFEVLLAVF VMPSLGWRWL LLLSAAPLLV
260 270 280 290 300
FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE
310 320 330 340 350
DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI
360 370 380 390 400
SSRKKAVEAK CSLACEYLSK EDYMDLLWTT LSEFPGVLVT LWVIDRLGRK
410 420 430 440 450
KTMALCFVIF SLCSLLLFIC IGRNVLTLLL FIARAFISGG FQAAYVYTPE
460 470 480 490 500
VYPTATRALG LGTCSGMARV GALITPFIAQ VMLESSVYLT LAVYSGCCLL
510 520 530 540
AALASCFLPI ETKGRALQES SHREWGQEMV GRGTNSTGVP RSNSGSQE
Length:548
Mass (Da):60,804
Last modified:May 1, 1999 - v1
Checksum:i19AD8475B7579496
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060173 mRNA. Translation: AAC78627.1.
RefSeqiNP_599231.2. NM_134404.2.
XP_008767537.1. XM_008769315.1.
UniGeneiRn.162148.

Genome annotation databases

EnsembliENSRNOT00000000874; ENSRNOP00000000874; ENSRNOG00000000693.
GeneIDi171442.
KEGGirno:171442.
UCSCiRGD:620277. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060173 mRNA. Translation: AAC78627.1.
RefSeqiNP_599231.2. NM_134404.2.
XP_008767537.1. XM_008769315.1.
UniGeneiRn.162148.

3D structure databases

ProteinModelPortaliQ9Z2I7.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9Z2I7.

Proteomic databases

PRIDEiQ9Z2I7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000874; ENSRNOP00000000874; ENSRNOG00000000693.
GeneIDi171442.
KEGGirno:171442.
UCSCiRGD:620277. rat.

Organism-specific databases

CTDi55530.
RGDi620277. Svop.

Phylogenomic databases

GeneTreeiENSGT00550000074384.
HOGENOMiHOG000114543.
HOVERGENiHBG057057.
InParanoidiQ9Z2I7.

Miscellaneous databases

PROiQ9Z2I7.

Gene expression databases

ExpressionAtlasiQ9Z2I7. baseline and differential.
GenevisibleiQ9Z2I7. RN.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR004749. Orgcat_transp/SVOP.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles."
    Janz R., Hofmann K., Suedhof T.C.
    J. Neurosci. 18:9269-9281(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25 AND SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSVOP_RAT
AccessioniPrimary (citable) accession number: Q9Z2I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.