Reviewed, UniProtKB/Swiss-Prot Q9Z2I7 (SVOP_RAT)

Names and origin

Protein names

Recommended name:
    Synaptic vesicle 2-related protein
      Short name=SV2-related protein

Gene names

Name:

Svop

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Multi-pass membrane protein.
Tissue specificity	Detected in brain (at protein level). Detected in brain, in synaptic layers of the cerebellum, hippocampus and cerebral cortex. Ref.1
Sequence similarities	Belongs to the major facilitator superfamily.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse
Domain	Transmembrane
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	ion transport Inferred from electronic annotation. Source: InterPro transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synaptic vesicle Ref.1 Inferred from direct assay. Source: HGNC
Molecular function	ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 548	548	Synaptic vesicle 2-related protein		PRO_0000279455
Regions
	Topological domain	1 – 87	87	Cytoplasmic Potential
	Transmembrane	88 – 108	21	Potential
	Topological domain	109 – 122	14	Vesicular Potential
	Transmembrane	123 – 143	21	Potential
	Topological domain	144 – 156	13	Cytoplasmic Potential
	Transmembrane	157 – 177	21	Potential
	Topological domain	178 – 180	3	Vesicular Potential
	Transmembrane	181 – 201	21	Potential
	Topological domain	202 – 209	8	Cytoplasmic Potential
	Transmembrane	210 – 230	21	Potential
	Topological domain	231 – 238	8	Vesicular Potential
	Transmembrane	239 – 259	21	Potential
	Topological domain	260 – 316	57	Cytoplasmic Potential
	Transmembrane	317 – 337	21	Potential
	Topological domain	338 – 373	36	Vesicular Potential
	Transmembrane	374 – 394	21	Potential
	Topological domain	395 – 401	7	Cytoplasmic Potential
	Transmembrane	402 – 422	21	Potential
	Topological domain	423 – 424	2	Vesicular Potential
	Transmembrane	425 – 445	21	Potential
	Topological domain	446 – 457	12	Cytoplasmic Potential
	Transmembrane	458 – 478	21	Potential
	Topological domain	479 – 489	11	Vesicular Potential
	Transmembrane	490 – 510	21	Potential
	Topological domain	511 – 548	38	Cytoplasmic Potential
Amino acid modifications
	Modified residue	25	1	Phosphoserine By similarity
	Modified residue	31	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9Z2I7-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 19AD8475B7579496	FASTA	548	60,804
	10 20 30 40 50 60 MEEDLFQLRQ LPVVKFRRTG ESARSEDDAA SGEHDVQIEG VRVGLEAVEL DDGAAVPKEF 70 80 90 100 110 120 ANPTDDTFMV EDAVEAIGFG RFQWKLSVLT GLAWMADAME MMILSILAPQ LHCEWRLPSW 130 140 150 160 170 180 QVALLTSVVF IGMMSSSTLW GNISDQYGRK TGLKISVFWT LYYGILSAFA PVYSWILVLR 190 200 210 220 230 240 GLVGFGIGGV PQSVTLYAEF LPMKARAKCI LLIEVFWAIG TVFEVLLAVF VMPSLGWRWL 250 260 270 280 290 300 LLLSAAPLLV FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE 310 320 330 340 350 360 DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI SSRKKAVEAK 370 380 390 400 410 420 CSLACEYLSK EDYMDLLWTT LSEFPGVLVT LWVIDRLGRK KTMALCFVIF SLCSLLLFIC 430 440 450 460 470 480 IGRNVLTLLL FIARAFISGG FQAAYVYTPE VYPTATRALG LGTCSGMARV GALITPFIAQ 490 500 510 520 530 540 VMLESSVYLT LAVYSGCCLL AALASCFLPI ETKGRALQES SHREWGQEMV GRGTNSTGVP RSNSGSQE

References

[1]

"SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles." Janz R., Hofmann K., Suedhof T.C. J. Neurosci. 18:9269-9281(1998) [PubMed: 9801366] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF060173 mRNA. Translation: AAC78627.1.
IPI	IPI00951585.
RefSeq	NP_599231.2.
UniGene	Rn.162148
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Z2I7.
Genome annotation databases
Ensembl	ENSRNOT00000066407; ENSRNOP00000060331; ENSRNOG00000000693; Rattus norvegicus. [Genome view]
GeneID	171442.
KEGG	rno:171442.
UCSC	NM_134404. rat.
Organism-specific databases
CTD	171442.
RGD	620277. Svop.
Phylogenomic databases
HOVERGEN	Q9Z2I7.
Gene expression databases
Genevestigator	Q9Z2I7.
Family and domain databases
InterPro	IPR011701. MFS_1. IPR016196. MFS_general_subst_transpt. IPR004749. Orgcat_transp. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00898. 2A0119. 1 hit.
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	622360.

Entry information

Entry name

SVOP_RAT

Accession

Primary (citable) accession number: Q9Z2I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	May 1, 1999
Last modified:	November 24, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)