Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9Z2I7 (SVOP_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptic vesicle 2-related protein
Short name=SV2-related protein
Gene names
Name:Svop
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Detected in brain (at protein level). Detected in brain, in synaptic layers of the cerebellum, hippocampus and cerebral cortex. Ref.1

Sequence similarities

Belongs to the major facilitator superfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 548548Synaptic vesicle 2-related protein
PRO_0000279455

Regions

Topological domain1 – 8787Cytoplasmic Potential
Transmembrane88 – 10821Helical; Potential
Topological domain109 – 12214Vesicular Potential
Transmembrane123 – 14321Helical; Potential
Topological domain144 – 15613Cytoplasmic Potential
Transmembrane157 – 17721Helical; Potential
Topological domain178 – 1803Vesicular Potential
Transmembrane181 – 20121Helical; Potential
Topological domain202 – 2098Cytoplasmic Potential
Transmembrane210 – 23021Helical; Potential
Topological domain231 – 2388Vesicular Potential
Transmembrane239 – 25921Helical; Potential
Topological domain260 – 31657Cytoplasmic Potential
Transmembrane317 – 33721Helical; Potential
Topological domain338 – 37336Vesicular Potential
Transmembrane374 – 39421Helical; Potential
Topological domain395 – 4017Cytoplasmic Potential
Transmembrane402 – 42221Helical; Potential
Topological domain423 – 4242Vesicular Potential
Transmembrane425 – 44521Helical; Potential
Topological domain446 – 45712Cytoplasmic Potential
Transmembrane458 – 47821Helical; Potential
Topological domain479 – 48911Vesicular Potential
Transmembrane490 – 51021Helical; Potential
Topological domain511 – 54838Cytoplasmic Potential

Amino acid modifications

Modified residue251Phosphoserine By similarity
Modified residue311Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z2I7 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 19AD8475B7579496

FASTA54860,804
        10         20         30         40         50         60 
MEEDLFQLRQ LPVVKFRRTG ESARSEDDAA SGEHDVQIEG VRVGLEAVEL DDGAAVPKEF 

        70         80         90        100        110        120 
ANPTDDTFMV EDAVEAIGFG RFQWKLSVLT GLAWMADAME MMILSILAPQ LHCEWRLPSW 

       130        140        150        160        170        180 
QVALLTSVVF IGMMSSSTLW GNISDQYGRK TGLKISVFWT LYYGILSAFA PVYSWILVLR 

       190        200        210        220        230        240 
GLVGFGIGGV PQSVTLYAEF LPMKARAKCI LLIEVFWAIG TVFEVLLAVF VMPSLGWRWL 

       250        260        270        280        290        300 
LLLSAAPLLV FAVLCFWLPE SARYDVLSGN QEKAIATLKR IATENGAPMP LGKLIISRQE 

       310        320        330        340        350        360 
DRGKMRDLFT PHFRWTTLLL WFIWFSNAFS YYGLVLLTTE LFQAGDVCSI SSRKKAVEAK 

       370        380        390        400        410        420 
CSLACEYLSK EDYMDLLWTT LSEFPGVLVT LWVIDRLGRK KTMALCFVIF SLCSLLLFIC 

       430        440        450        460        470        480 
IGRNVLTLLL FIARAFISGG FQAAYVYTPE VYPTATRALG LGTCSGMARV GALITPFIAQ 

       490        500        510        520        530        540 
VMLESSVYLT LAVYSGCCLL AALASCFLPI ETKGRALQES SHREWGQEMV GRGTNSTGVP 


RSNSGSQE

« Hide

References

[1]"SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles."
Janz R., Hofmann K., Suedhof T.C.
J. Neurosci. 18:9269-9281(1998) [PubMed: 9801366] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF060173 mRNA. Translation: AAC78627.1.
IPIIPI00951585.
RefSeqNP_599231.2. NM_134404.2.
UniGeneRn.162148.

3D structure databases

ProteinModelPortalQ9Z2I7.
ModBaseSearch...

Proteomic databases

PRIDEQ9Z2I7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID171442.
KEGGrno:171442.
UCSCNM_134404. rat.

Organism-specific databases

CTD55530.
RGD620277. Svop.

Phylogenomic databases

eggNOGroNOG12492.
GeneTreeENSGT00550000074384.
HOVERGENHBG057057.

Gene expression databases

GenevestigatorQ9Z2I7.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR00898. 2A0119. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio622360.

Entry information

Entry nameSVOP_RAT
AccessionPrimary (citable) accession number: Q9Z2I7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: May 1, 1999
Last modified: September 21, 2011
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents