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Protein

Synaptic vesicle glycoprotein 2C

Gene

Sv2c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.2 Publications
(Microbial infection) Receptor for the botulinium neurotoxin type A/BOTA.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processNeurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2C
Short name:
Synaptic vesicle protein 2C
Gene namesi
Name:Sv2c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi619718 Sv2c

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 154CytoplasmicSequence analysisAdd BLAST154
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 191ExtracellularSequence analysisAdd BLAST16
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 226CytoplasmicSequence analysisAdd BLAST14
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248ExtracellularSequence analysis1
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 280CytoplasmicSequence analysisAdd BLAST11
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 320ExtracellularSequence analysisAdd BLAST19
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 437CytoplasmicSequence analysisAdd BLAST96
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 578ExtracellularSequence analysisAdd BLAST120
Transmembranei579 – 599HelicalSequence analysisAdd BLAST21
Topological domaini600 – 609CytoplasmicSequence analysis10
Transmembranei610 – 630HelicalSequence analysisAdd BLAST21
Topological domaini631 – 636ExtracellularSequence analysis6
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Topological domaini658 – 670CytoplasmicSequence analysisAdd BLAST13
Transmembranei671 – 693HelicalSequence analysisAdd BLAST23
Topological domaini694 – 697ExtracellularSequence analysis4
Transmembranei698 – 716HelicalSequence analysisAdd BLAST19
Topological domaini717 – 727CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi559N → A: Loss of one glycosylation site. No effect on botulinium neurotoxin type A/BOTA binding, but reduces the uptake of botulinium neurotoxin type A/BOTA. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397731 – 727Synaptic vesicle glycoprotein 2CAdd BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineBy similarity1
Modified residuei76PhosphoserineBy similarity1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei466PhosphotyrosineBy similarity1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi534N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi559N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi565N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.3 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Z2I6
PRIDEiQ9Z2I6

PTM databases

iPTMnetiQ9Z2I6
PhosphoSitePlusiQ9Z2I6

Expressioni

Tissue specificityi

Expressed at high levels in very few brain areas including the striatum, midbrain and hindbrain, and in the olfactory bulb. Expressed at lower levels in cerebrum, hippocampus and cerebellum (at protein level). Mainly expressed in brain; also detected in lung, liver, kidney.2 Publications

Gene expression databases

BgeeiENSRNOG00000018094
GenevisibleiQ9Z2I6 RN

Interactioni

Subunit structurei

Interacts with SYT1 in a calcium-dependent manner.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
botAP1084512EBI-8178859,EBI-8178893From Clostridium botulinum.

Protein-protein interaction databases

IntActiQ9Z2I6, 1 interactor
MINTiQ9Z2I6
STRINGi10116.ENSRNOP00000024459

Structurei

Secondary structure

1727
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi478 – 480Combined sources3
Beta strandi488 – 494Combined sources7
Beta strandi496 – 499Combined sources4
Beta strandi501 – 504Combined sources4
Beta strandi506 – 509Combined sources4
Beta strandi511 – 514Combined sources4
Beta strandi516 – 519Combined sources4
Beta strandi521 – 524Combined sources4
Beta strandi526 – 529Combined sources4
Beta strandi531 – 534Combined sources4
Beta strandi536 – 539Combined sources4
Beta strandi541 – 545Combined sources5
Helixi549 – 551Combined sources3
Beta strandi552 – 554Combined sources3
Beta strandi556 – 562Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JMCX-ray2.64B/D/F/H455-577[»]
ProteinModelPortaliQ9Z2I6
SMRiQ9Z2I6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 57Interaction with SYT11 PublicationAdd BLAST57
Regioni519 – 566BOTA-binding1 PublicationAdd BLAST48

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRID Eukaryota
ENOG410YQME LUCA
GeneTreeiENSGT00550000074384
HOGENOMiHOG000065727
HOVERGENiHBG053967
InParanoidiQ9Z2I6
KOiK06258
OMAiFMRCFNY
OrthoDBiEOG091G02NC
PhylomeDBiQ9Z2I6
TreeFamiTF324824

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR001646 5peptide_repeat
IPR011701 MFS
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
IPR022308 SV2
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PF13599 Pentapeptide_4, 1 hit
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR01299 synapt_SV2, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSYKDRTS LMKGAKDIAK EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ
60 70 80 90 100
DEDDDDDYYP PGETYSGEAN DDEGSSEATE GHDEEDEIYE GEYQGIPSTN
110 120 130 140 150
QGKDSIVSVG QPKGDEYKDR RELESERRAD EEELAQQYEL IIQECGHGRF
160 170 180 190 200
QWALFFVLGM ALMADGVEVF VVGFVLPSAE TDLCIPNSGS GWLGSIVYLG
210 220 230 240 250
MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG YGFFLLCRLL
260 270 280 290 300
SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI
310 320 330 340 350
IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV
360 370 380 390 400
GKHDEAWMIL KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG
410 420 430 440 450
TWYRRCFVRI RTELYGIWLT FMRCFNYPVR ENTIKLTIVW FTLSFGYYGL
460 470 480 490 500
SVWFPDVIKH LQSDEYALLT RNVQKDKYAN FSINFTMENQ VHTGMEYDNG
510 520 530 540 550
RFLGVKFKSV TFKDSVFKSC TFDDVTSVNT YFKNCTFIDT LFENTDFEPY
560 570 580 590 600
KFIDSEFQNC SFLHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS
610 620 630 640 650
ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA
660 670 680 690 700
WNSLDVVTVE LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKAIP
710 720
ILLASTVLVC GGLVGLRLPD TRTQVLM
Length:727
Mass (Da):82,249
Last modified:May 1, 1999 - v1
Checksum:i4C154C69341D8DB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060174 mRNA Translation: AAC78628.1
RefSeqiNP_113781.1, NM_031593.1
XP_017446285.1, XM_017590796.1
UniGeneiRn.161757

Genome annotation databases

EnsembliENSRNOT00000024459; ENSRNOP00000024459; ENSRNOG00000018094
GeneIDi29643
KEGGirno:29643
UCSCiRGD:619718 rat

Similar proteinsi

Entry informationi

Entry nameiSV2C_RAT
AccessioniPrimary (citable) accession number: Q9Z2I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 1, 1999
Last modified: February 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health