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Q9Z2I6 (SV2C_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Synaptic vesicle glycoprotein 2C
Short name=Synaptic vesicle protein 2C
Gene names
Name:Sv2c
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length727 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. Ref.3 Ref.4 Ref.5

Receptor for the botulinium neurotoxin type A/BOTA. Ref.3 Ref.4 Ref.5

Subunit structure

Interacts with SYT1 in a calcium-dependent manner. Ref.4

Subcellular location

Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Multi-pass membrane protein. Note: Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas. Ref.2 Ref.3

Tissue specificity

Expressed at high levels in very few brain areas including the striatum, midbrain and hindbrain, and in the olfactory bulb. Expressed at lower levels in cerebrum, hippocampus and cerebellum (at protein level). Mainly expressed in brain; also detected in lung, liver, kidney. Ref.1 Ref.2

Post-translational modification

N-glycosylated. Ref.1 Ref.2

Sequence similarities

Belongs to the major facilitator superfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 727727Synaptic vesicle glycoprotein 2C
PRO_0000239773

Regions

Topological domain1 – 154154Cytoplasmic Potential
Transmembrane155 – 17521Helical; Potential
Topological domain176 – 19116Extracellular Potential
Transmembrane192 – 21221Helical; Potential
Topological domain213 – 22614Cytoplasmic Potential
Transmembrane227 – 24721Helical; Potential
Topological domain2481Extracellular Potential
Transmembrane249 – 26921Helical; Potential
Topological domain270 – 28011Cytoplasmic Potential
Transmembrane281 – 30121Helical; Potential
Topological domain302 – 32019Extracellular Potential
Transmembrane321 – 34121Helical; Potential
Topological domain342 – 43796Cytoplasmic Potential
Transmembrane438 – 45821Helical; Potential
Topological domain459 – 578120Extracellular Potential
Transmembrane579 – 59921Helical; Potential
Topological domain600 – 60910Cytoplasmic Potential
Transmembrane610 – 63021Helical; Potential
Topological domain631 – 6366Extracellular Potential
Transmembrane637 – 65721Helical; Potential
Topological domain658 – 67013Cytoplasmic Potential
Transmembrane671 – 69323Helical; Potential
Topological domain694 – 6974Extracellular Potential
Transmembrane698 – 71619Helical; Potential
Topological domain717 – 72711Cytoplasmic Potential
Region1 – 5757Interaction with SYT1
Region529 – 56638BOTA-binding

Amino acid modifications

Glycosylation4801N-linked (GlcNAc...) Potential
Glycosylation4841N-linked (GlcNAc...) Potential
Glycosylation5341N-linked (GlcNAc...) Potential
Glycosylation5591N-linked (GlcNAc...) Potential
Glycosylation5651N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9Z2I6 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 4C154C69341D8DB7

FASTA72782,249
        10         20         30         40         50         60 
MEDSYKDRTS LMKGAKDIAK EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ DEDDDDDYYP 

        70         80         90        100        110        120 
PGETYSGEAN DDEGSSEATE GHDEEDEIYE GEYQGIPSTN QGKDSIVSVG QPKGDEYKDR 

       130        140        150        160        170        180 
RELESERRAD EEELAQQYEL IIQECGHGRF QWALFFVLGM ALMADGVEVF VVGFVLPSAE 

       190        200        210        220        230        240 
TDLCIPNSGS GWLGSIVYLG MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG 

       250        260        270        280        290        300 
YGFFLLCRLL SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI 

       310        320        330        340        350        360 
IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV GKHDEAWMIL 

       370        380        390        400        410        420 
KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG TWYRRCFVRI RTELYGIWLT 

       430        440        450        460        470        480 
FMRCFNYPVR ENTIKLTIVW FTLSFGYYGL SVWFPDVIKH LQSDEYALLT RNVQKDKYAN 

       490        500        510        520        530        540 
FSINFTMENQ VHTGMEYDNG RFLGVKFKSV TFKDSVFKSC TFDDVTSVNT YFKNCTFIDT 

       550        560        570        580        590        600 
LFENTDFEPY KFIDSEFQNC SFLHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS 

       610        620        630        640        650        660 
ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA WNSLDVVTVE 

       670        680        690        700        710        720 
LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKAIP ILLASTVLVC GGLVGLRLPD 


TRTQVLM

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References

[1]"SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles."
Janz R., Hofmann K., Suedhof T.C.
J. Neurosci. 18:9269-9281(1998) [PubMed: 9801366] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION, TISSUE SPECIFICITY.
Tissue: Brain.
[2]"SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family."
Janz R., Suedhof T.C.
Neuroscience 94:1279-1290(1999) [PubMed: 10625067] [Abstract]
Cited for: GLYCOSYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[3]"SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment."
Iezzi M., Theander S., Janz R., Loze C., Wollheim C.B.
J. Cell Sci. 118:5647-5660(2005) [PubMed: 16306227] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"SV2A and SV2C contain a unique synaptotagmin-binding site."
Schivell A.E., Mochida S., Kensel-Hammes P., Custer K.L., Bajjalieh S.M.
Mol. Cell. Neurosci. 29:56-64(2005) [PubMed: 15866046] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SYT1.
[5]"SV2 is the protein receptor for botulinum neurotoxin A."
Dong M., Yeh F., Tepp W.H., Dean C., Johnson E.A., Janz R., Chapman E.R.
Science 312:592-596(2006) [PubMed: 16543415] [Abstract]
Cited for: FUNCTION AS A BOTA RECEPTOR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF060174 mRNA. Translation: AAC78628.1.
IPIIPI00209910.
RefSeqNP_113781.1. NM_031593.1.
UniGeneRn.161757.

3D structure databases

ProteinModelPortalQ9Z2I6.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-1795475.
STRINGQ9Z2I6.

PTM databases

PhosphoSiteQ9Z2I6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000024459; ENSRNOP00000024459; ENSRNOG00000018094.
GeneID29643.
KEGGrno:29643.
UCSCNM_031593. rat.

Organism-specific databases

CTD22987.
RGD619718. Sv2c.

Phylogenomic databases

eggNOGroNOG07549.
GeneTreeENSGT00550000074384.
HOVERGENHBG053967.
InParanoidQ9Z2I6.
OrthoDBEOG4HHP1V.

Gene expression databases

ArrayExpressQ9Z2I6.
GenevestigatorQ9Z2I6.
GermOnlineENSRNOG00000018094. Rattus norvegicus.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2_chordata.
[Graphical view]
KOK06258.
PfamPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR01299. Synapt_SV2. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609906.

Entry information

Entry nameSV2C_RAT
AccessionPrimary (citable) accession number: Q9Z2I6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 1, 1999
Last modified: November 16, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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