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Protein

Synaptic vesicle glycoprotein 2C

Gene

Sv2c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.
Receptor for the botulinium neurotoxin type A/BOTA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2C
Short name:
Synaptic vesicle protein 2C
Gene namesi
Name:Sv2c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi619718. Sv2c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 154154CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Topological domaini176 – 19116ExtracellularSequence analysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Topological domaini213 – 22614CytoplasmicSequence analysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence analysisAdd
BLAST
Topological domaini248 – 2481ExtracellularSequence analysis
Transmembranei249 – 26921HelicalSequence analysisAdd
BLAST
Topological domaini270 – 28011CytoplasmicSequence analysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST
Topological domaini302 – 32019ExtracellularSequence analysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence analysisAdd
BLAST
Topological domaini342 – 43796CytoplasmicSequence analysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence analysisAdd
BLAST
Topological domaini459 – 578120ExtracellularSequence analysisAdd
BLAST
Transmembranei579 – 59921HelicalSequence analysisAdd
BLAST
Topological domaini600 – 60910CytoplasmicSequence analysis
Transmembranei610 – 63021HelicalSequence analysisAdd
BLAST
Topological domaini631 – 6366ExtracellularSequence analysis
Transmembranei637 – 65721HelicalSequence analysisAdd
BLAST
Topological domaini658 – 67013CytoplasmicSequence analysisAdd
BLAST
Transmembranei671 – 69323HelicalSequence analysisAdd
BLAST
Topological domaini694 – 6974ExtracellularSequence analysis
Transmembranei698 – 71619HelicalSequence analysisAdd
BLAST
Topological domaini717 – 72711CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • synaptic vesicle Source: RGD
  • synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Synaptic vesicle glycoprotein 2CPRO_0000239773Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence analysis
Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence analysis
Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence analysis
Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence analysis
Glycosylationi565 – 5651N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Z2I6.
PRIDEiQ9Z2I6.

PTM databases

iPTMnetiQ9Z2I6.
PhosphoSiteiQ9Z2I6.

Expressioni

Tissue specificityi

Expressed at high levels in very few brain areas including the striatum, midbrain and hindbrain, and in the olfactory bulb. Expressed at lower levels in cerebrum, hippocampus and cerebellum (at protein level). Mainly expressed in brain; also detected in lung, liver, kidney.2 Publications

Gene expression databases

GenevisibleiQ9Z2I6. RN.

Interactioni

Subunit structurei

Interacts with SYT1 in a calcium-dependent manner.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
botAP1084512EBI-8178859,EBI-8178893From a different organism.

Protein-protein interaction databases

IntActiQ9Z2I6. 1 interaction.
MINTiMINT-1795475.
STRINGi10116.ENSRNOP00000024459.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2I6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5757Interaction with SYT1Add
BLAST
Regioni529 – 56638BOTA-bindingAdd
BLAST

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRID. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ9Z2I6.
KOiK06258.
OMAiDFEPYKF.
OrthoDBiEOG74TWZ1.
PhylomeDBiQ9Z2I6.
TreeFamiTF324824.

Family and domain databases

InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSYKDRTS LMKGAKDIAK EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ
60 70 80 90 100
DEDDDDDYYP PGETYSGEAN DDEGSSEATE GHDEEDEIYE GEYQGIPSTN
110 120 130 140 150
QGKDSIVSVG QPKGDEYKDR RELESERRAD EEELAQQYEL IIQECGHGRF
160 170 180 190 200
QWALFFVLGM ALMADGVEVF VVGFVLPSAE TDLCIPNSGS GWLGSIVYLG
210 220 230 240 250
MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG YGFFLLCRLL
260 270 280 290 300
SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI
310 320 330 340 350
IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV
360 370 380 390 400
GKHDEAWMIL KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG
410 420 430 440 450
TWYRRCFVRI RTELYGIWLT FMRCFNYPVR ENTIKLTIVW FTLSFGYYGL
460 470 480 490 500
SVWFPDVIKH LQSDEYALLT RNVQKDKYAN FSINFTMENQ VHTGMEYDNG
510 520 530 540 550
RFLGVKFKSV TFKDSVFKSC TFDDVTSVNT YFKNCTFIDT LFENTDFEPY
560 570 580 590 600
KFIDSEFQNC SFLHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS
610 620 630 640 650
ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA
660 670 680 690 700
WNSLDVVTVE LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKAIP
710 720
ILLASTVLVC GGLVGLRLPD TRTQVLM
Length:727
Mass (Da):82,249
Last modified:May 1, 1999 - v1
Checksum:i4C154C69341D8DB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060174 mRNA. Translation: AAC78628.1.
RefSeqiNP_113781.1. NM_031593.1.
UniGeneiRn.161757.

Genome annotation databases

EnsembliENSRNOT00000024459; ENSRNOP00000024459; ENSRNOG00000018094.
GeneIDi29643.
KEGGirno:29643.
UCSCiRGD:619718. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060174 mRNA. Translation: AAC78628.1.
RefSeqiNP_113781.1. NM_031593.1.
UniGeneiRn.161757.

3D structure databases

ProteinModelPortaliQ9Z2I6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2I6. 1 interaction.
MINTiMINT-1795475.
STRINGi10116.ENSRNOP00000024459.

PTM databases

iPTMnetiQ9Z2I6.
PhosphoSiteiQ9Z2I6.

Proteomic databases

PaxDbiQ9Z2I6.
PRIDEiQ9Z2I6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024459; ENSRNOP00000024459; ENSRNOG00000018094.
GeneIDi29643.
KEGGirno:29643.
UCSCiRGD:619718. rat.

Organism-specific databases

CTDi22987.
RGDi619718. Sv2c.

Phylogenomic databases

eggNOGiENOG410IRID. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ9Z2I6.
KOiK06258.
OMAiDFEPYKF.
OrthoDBiEOG74TWZ1.
PhylomeDBiQ9Z2I6.
TreeFamiTF324824.

Miscellaneous databases

PROiQ9Z2I6.

Gene expression databases

GenevisibleiQ9Z2I6. RN.

Family and domain databases

InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles."
    Janz R., Hofmann K., Suedhof T.C.
    J. Neurosci. 18:9269-9281(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family."
    Janz R., Suedhof T.C.
    Neuroscience 94:1279-1290(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  3. "SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment."
    Iezzi M., Theander S., Janz R., Loze C., Wollheim C.B.
    J. Cell Sci. 118:5647-5660(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. Cited for: FUNCTION, INTERACTION WITH SYT1.
  5. "SV2 is the protein receptor for botulinum neurotoxin A."
    Dong M., Yeh F., Tepp W.H., Dean C., Johnson E.A., Janz R., Chapman E.R.
    Science 312:592-596(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A BOTA RECEPTOR.

Entry informationi

Entry nameiSV2C_RAT
AccessioniPrimary (citable) accession number: Q9Z2I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.