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Protein

Synaptic vesicle glycoprotein 2C

Gene

Sv2c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.
Receptor for the botulinium neurotoxin type A/BOTA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2C
Short name:
Synaptic vesicle protein 2C
Gene namesi
Name:Sv2c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi619718. Sv2c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 154CytoplasmicSequence analysisAdd BLAST154
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 191ExtracellularSequence analysisAdd BLAST16
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 226CytoplasmicSequence analysisAdd BLAST14
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248ExtracellularSequence analysis1
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 280CytoplasmicSequence analysisAdd BLAST11
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 320ExtracellularSequence analysisAdd BLAST19
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 437CytoplasmicSequence analysisAdd BLAST96
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 578ExtracellularSequence analysisAdd BLAST120
Transmembranei579 – 599HelicalSequence analysisAdd BLAST21
Topological domaini600 – 609CytoplasmicSequence analysis10
Transmembranei610 – 630HelicalSequence analysisAdd BLAST21
Topological domaini631 – 636ExtracellularSequence analysis6
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Topological domaini658 – 670CytoplasmicSequence analysisAdd BLAST13
Transmembranei671 – 693HelicalSequence analysisAdd BLAST23
Topological domaini694 – 697ExtracellularSequence analysis4
Transmembranei698 – 716HelicalSequence analysisAdd BLAST19
Topological domaini717 – 727CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397731 – 727Synaptic vesicle glycoprotein 2CAdd BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi480N-linked (GlcNAc...)Sequence analysis1
Glycosylationi484N-linked (GlcNAc...)Sequence analysis1
Glycosylationi534N-linked (GlcNAc...)Sequence analysis1
Glycosylationi559N-linked (GlcNAc...)Sequence analysis1
Glycosylationi565N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Z2I6.
PRIDEiQ9Z2I6.

PTM databases

iPTMnetiQ9Z2I6.
PhosphoSitePlusiQ9Z2I6.

Expressioni

Tissue specificityi

Expressed at high levels in very few brain areas including the striatum, midbrain and hindbrain, and in the olfactory bulb. Expressed at lower levels in cerebrum, hippocampus and cerebellum (at protein level). Mainly expressed in brain; also detected in lung, liver, kidney.2 Publications

Gene expression databases

BgeeiENSRNOG00000018094.
GenevisibleiQ9Z2I6. RN.

Interactioni

Subunit structurei

Interacts with SYT1 in a calcium-dependent manner.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
botAP1084512EBI-8178859,EBI-8178893From a different organism.

Protein-protein interaction databases

IntActiQ9Z2I6. 1 interactor.
MINTiMINT-1795475.
STRINGi10116.ENSRNOP00000024459.

Structurei

Secondary structure

1727
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi478 – 480Combined sources3
Beta strandi488 – 494Combined sources7
Beta strandi496 – 499Combined sources4
Beta strandi501 – 504Combined sources4
Beta strandi506 – 509Combined sources4
Beta strandi511 – 514Combined sources4
Beta strandi516 – 519Combined sources4
Beta strandi521 – 524Combined sources4
Beta strandi526 – 529Combined sources4
Beta strandi531 – 534Combined sources4
Beta strandi536 – 539Combined sources4
Beta strandi541 – 545Combined sources5
Helixi549 – 551Combined sources3
Beta strandi552 – 554Combined sources3
Beta strandi556 – 562Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JMCX-ray2.64B/D/F/H455-577[»]
ProteinModelPortaliQ9Z2I6.
SMRiQ9Z2I6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 57Interaction with SYT11 PublicationAdd BLAST57
Regioni529 – 566BOTA-bindingAdd BLAST38

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRID. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ9Z2I6.
KOiK06258.
OMAiDFEPYKF.
OrthoDBiEOG091G02NC.
PhylomeDBiQ9Z2I6.
TreeFamiTF324824.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSYKDRTS LMKGAKDIAK EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ
60 70 80 90 100
DEDDDDDYYP PGETYSGEAN DDEGSSEATE GHDEEDEIYE GEYQGIPSTN
110 120 130 140 150
QGKDSIVSVG QPKGDEYKDR RELESERRAD EEELAQQYEL IIQECGHGRF
160 170 180 190 200
QWALFFVLGM ALMADGVEVF VVGFVLPSAE TDLCIPNSGS GWLGSIVYLG
210 220 230 240 250
MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG YGFFLLCRLL
260 270 280 290 300
SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI
310 320 330 340 350
IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV
360 370 380 390 400
GKHDEAWMIL KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG
410 420 430 440 450
TWYRRCFVRI RTELYGIWLT FMRCFNYPVR ENTIKLTIVW FTLSFGYYGL
460 470 480 490 500
SVWFPDVIKH LQSDEYALLT RNVQKDKYAN FSINFTMENQ VHTGMEYDNG
510 520 530 540 550
RFLGVKFKSV TFKDSVFKSC TFDDVTSVNT YFKNCTFIDT LFENTDFEPY
560 570 580 590 600
KFIDSEFQNC SFLHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS
610 620 630 640 650
ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA
660 670 680 690 700
WNSLDVVTVE LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKAIP
710 720
ILLASTVLVC GGLVGLRLPD TRTQVLM
Length:727
Mass (Da):82,249
Last modified:May 1, 1999 - v1
Checksum:i4C154C69341D8DB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060174 mRNA. Translation: AAC78628.1.
RefSeqiNP_113781.1. NM_031593.1.
XP_017446285.1. XM_017590796.1.
UniGeneiRn.161757.

Genome annotation databases

EnsembliENSRNOT00000024459; ENSRNOP00000024459; ENSRNOG00000018094.
GeneIDi29643.
KEGGirno:29643.
UCSCiRGD:619718. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060174 mRNA. Translation: AAC78628.1.
RefSeqiNP_113781.1. NM_031593.1.
XP_017446285.1. XM_017590796.1.
UniGeneiRn.161757.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JMCX-ray2.64B/D/F/H455-577[»]
ProteinModelPortaliQ9Z2I6.
SMRiQ9Z2I6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2I6. 1 interactor.
MINTiMINT-1795475.
STRINGi10116.ENSRNOP00000024459.

PTM databases

iPTMnetiQ9Z2I6.
PhosphoSitePlusiQ9Z2I6.

Proteomic databases

PaxDbiQ9Z2I6.
PRIDEiQ9Z2I6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024459; ENSRNOP00000024459; ENSRNOG00000018094.
GeneIDi29643.
KEGGirno:29643.
UCSCiRGD:619718. rat.

Organism-specific databases

CTDi22987.
RGDi619718. Sv2c.

Phylogenomic databases

eggNOGiENOG410IRID. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ9Z2I6.
KOiK06258.
OMAiDFEPYKF.
OrthoDBiEOG091G02NC.
PhylomeDBiQ9Z2I6.
TreeFamiTF324824.

Miscellaneous databases

PROiQ9Z2I6.

Gene expression databases

BgeeiENSRNOG00000018094.
GenevisibleiQ9Z2I6. RN.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSV2C_RAT
AccessioniPrimary (citable) accession number: Q9Z2I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.