Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase FKBP1B

Gene

Fkbp1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.By similarity

GO - Molecular functioni

  • calcium channel inhibitor activity Source: MGI
  • cyclic nucleotide binding Source: Ensembl
  • FK506 binding Source: MGI
  • ion channel binding Source: BHF-UCL
  • peptidyl-prolyl cis-trans isomerase activity Source: MGI
  • receptor binding Source: MGI

GO - Biological processi

  • insulin secretion Source: MGI
  • negative regulation of heart rate Source: BHF-UCL
  • negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  • negative regulation of protein phosphatase type 2B activity Source: MGI
  • negative regulation of release of sequestered calcium ion into cytosol Source: MGI
  • negative regulation of ryanodine-sensitive calcium-release channel activity Source: MGI
  • neuronal action potential propagation Source: MGI
  • positive regulation of axon regeneration Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: MGI
  • positive regulation of sequestering of calcium ion Source: MGI
  • protein folding Source: InterPro
  • protein peptidyl-prolyl isomerization Source: MGI
  • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
  • regulation of cytosolic calcium ion concentration Source: BHF-UCL
  • regulation of heart rate Source: MGI
  • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: MGI
  • regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
  • release of sequestered calcium ion into cytosol Source: MGI
  • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: MGI
  • response to glucose Source: MGI
  • response to hydrogen peroxide Source: Ensembl
  • response to redox state Source: MGI
  • response to vitamin E Source: Ensembl
  • smooth muscle contraction Source: MGI
  • T cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.
R-MMU-5578775. Ion homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP1B (EC:5.2.1.8)
Short name:
PPIase FKBP1B
Alternative name(s):
12.6 kDa FK506-binding protein
Short name:
12.6 kDa FKBP
Short name:
FKBP-12.6
FK506-binding protein 1B
Short name:
FKBP-1B
Immunophilin FKBP12.6
Rotamase
Gene namesi
Name:Fkbp1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1336205. Fkbp1b.

Subcellular locationi

GO - Cellular componenti

  • calcium channel complex Source: BHF-UCL
  • cytoplasm Source: MGI
  • cytosol Source: Ensembl
  • membrane Source: MGI
  • sarcoplasmic reticulum Source: MGI
  • sarcoplasmic reticulum membrane Source: MGI
  • Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 108107Peptidyl-prolyl cis-trans isomerase FKBP1BPRO_0000075296Add
BLAST

Proteomic databases

EPDiQ9Z2I2.
MaxQBiQ9Z2I2.
PaxDbiQ9Z2I2.
PRIDEiQ9Z2I2.

PTM databases

iPTMnetiQ9Z2I2.
PhosphoSiteiQ9Z2I2.

Expressioni

Gene expression databases

BgeeiQ9Z2I2.
CleanExiMM_FKBP1B.
ExpressionAtlasiQ9Z2I2. baseline and differential.
GenevisibleiQ9Z2I2. MM.

Interactioni

Subunit structurei

Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with RYR2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Ryr2E9Q4012EBI-6379859,EBI-643628

GO - Molecular functioni

  • ion channel binding Source: BHF-UCL
  • receptor binding Source: MGI

Protein-protein interaction databases

BioGridi199683. 3 interactions.
DIPiDIP-61117N.
IntActiQ9Z2I2. 1 interaction.
STRINGi10090.ENSMUSP00000020964.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2I2.
SMRiQ9Z2I2. Positions 2-108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 10889PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0544. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiQ9Z2I2.
KOiK09568.
OMAiERARLTC.
OrthoDBiEOG7ZGX5T.
PhylomeDBiQ9Z2I2.
TreeFamiTF105291.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z2I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVEIETISP GDGRTFPKKG QICVVHYTGM LQNGKKFDSS RDRNKPFKFR
60 70 80 90 100
IGKQEVIKGF EEGTAQMSLG QRAKLTCTPD VAYGATGHPG VIPPNATLIF

DVELLSLE
Length:108
Mass (Da):11,798
Last modified:January 23, 2007 - v3
Checksum:i36137EB599F62F1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060872 mRNA. Translation: AAC64923.1.
AK005201 mRNA. Translation: BAB23879.1.
BC061121 mRNA. Translation: AAH61121.1.
CCDSiCCDS25792.1.
RefSeqiNP_058559.3. NM_016863.3.
UniGeneiMm.20453.

Genome annotation databases

EnsembliENSMUST00000020964; ENSMUSP00000020964; ENSMUSG00000020635.
GeneIDi14226.
KEGGimmu:14226.
UCSCiuc007myj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060872 mRNA. Translation: AAC64923.1.
AK005201 mRNA. Translation: BAB23879.1.
BC061121 mRNA. Translation: AAH61121.1.
CCDSiCCDS25792.1.
RefSeqiNP_058559.3. NM_016863.3.
UniGeneiMm.20453.

3D structure databases

ProteinModelPortaliQ9Z2I2.
SMRiQ9Z2I2. Positions 2-108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199683. 3 interactions.
DIPiDIP-61117N.
IntActiQ9Z2I2. 1 interaction.
STRINGi10090.ENSMUSP00000020964.

PTM databases

iPTMnetiQ9Z2I2.
PhosphoSiteiQ9Z2I2.

Proteomic databases

EPDiQ9Z2I2.
MaxQBiQ9Z2I2.
PaxDbiQ9Z2I2.
PRIDEiQ9Z2I2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020964; ENSMUSP00000020964; ENSMUSG00000020635.
GeneIDi14226.
KEGGimmu:14226.
UCSCiuc007myj.1. mouse.

Organism-specific databases

CTDi2281.
MGIiMGI:1336205. Fkbp1b.

Phylogenomic databases

eggNOGiKOG0544. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiQ9Z2I2.
KOiK09568.
OMAiERARLTC.
OrthoDBiEOG7ZGX5T.
PhylomeDBiQ9Z2I2.
TreeFamiTF105291.

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.
R-MMU-5578775. Ion homeostasis.

Miscellaneous databases

PROiQ9Z2I2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z2I2.
CleanExiMM_FKBP1B.
ExpressionAtlasiQ9Z2I2. baseline and differential.
GenevisibleiQ9Z2I2. MM.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the murine FK506 binding protein (FKBP) 12.6 gene."
    Bennett J.A., Clancy Y.C., McNeish J.D.
    Mamm. Genome 9:1069-1071(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiFKB1B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.