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Protein

LETM1 and EF-hand domain-containing protein 1, mitochondrial

Gene

Letm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi675 – 68713Sequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
LETM1 and EF-hand domain-containing protein 1, mitochondrial
Alternative name(s):
Leucine zipper-EF-hand-containing transmembrane protein 1
Gene namesi
Name:Letm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1932557. Letm1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini115 – 20793Mitochondrial intermembraneSequence analysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence analysisAdd
BLAST
Topological domaini229 – 738510Mitochondrial matrixSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 114114MitochondrionSequence analysisAdd
BLAST
Chaini115 – 738624LETM1 and EF-hand domain-containing protein 1, mitochondrialPRO_0000017695Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei596 – 5961N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Z2I0.
MaxQBiQ9Z2I0.
PaxDbiQ9Z2I0.
PRIDEiQ9Z2I0.

PTM databases

iPTMnetiQ9Z2I0.
PhosphoSiteiQ9Z2I0.
SwissPalmiQ9Z2I0.

Expressioni

Gene expression databases

BgeeiQ9Z2I0.
ExpressionAtlasiQ9Z2I0. baseline and differential.
GenevisibleiQ9Z2I0. MM.

Interactioni

Subunit structurei

Interacts with BCS1L.By similarity

Protein-protein interaction databases

IntActiQ9Z2I0. 4 interactions.
MINTiMINT-1843443.
STRINGi10090.ENSMUSP00000005431.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2I0.
SMRiQ9Z2I0. Positions 251-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini251 – 536286Letm1 RBDPROSITE-ProRule annotationAdd
BLAST
Domaini662 – 69736EF-handAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili115 – 13521Sequence analysisAdd
BLAST
Coiled coili247 – 28337Sequence analysisAdd
BLAST
Coiled coili445 – 49248Sequence analysisAdd
BLAST
Coiled coili537 – 62690Sequence analysisAdd
BLAST
Coiled coili707 – 73832Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 EF-hand domain.Curated
Contains 1 Letm1 RBD (ribosome-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1043. Eukaryota.
ENOG410XRSP. LUCA.
GeneTreeiENSGT00390000011225.
HOGENOMiHOG000290246.
HOVERGENiHBG052322.
InParanoidiQ9Z2I0.
KOiK17800.
OMAiSEEIMKF.
OrthoDBiEOG79PJNQ.
PhylomeDBiQ9Z2I0.
TreeFamiTF316321.

Family and domain databases

InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS51758. LETM1_RBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z2I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASILLRSCR GRGPARLAPP RAASPRGSLR DRACLSCTRT LGLTSRESVL
60 70 80 90 100
SRCCTPAHPV YLCFKGEPLS CWTQRPECQG TAARTTWTPA SARLVVTGPQ
110 120 130 140 150
YLPVRGWHSS SPLGEDSVIE KSLKSLKDKN KKLEEGGPVY SPPAQVVVRK
160 170 180 190 200
SLGQKVLDEL RHYYHGFRLL WIDTKIAARM LWRILNGHTL TRRERRQFLR
210 220 230 240 250
ICADLFRLVP FLVFVVVPFM EFLLPVVVKL FPNMLPSTFE TQSIKEERLK
260 270 280 290 300
KELRVKLELA KFLQDTIEEM ALKNKAAKGN ATKDFSAFFQ KIRETGERPS
310 320 330 340 350
NEEIMRFSKL FEDELTLDNL TRPQLVALCK LLELQSIGTN NFLRFQLTMR
360 370 380 390 400
LRSIKADDKL ISEEGVDSLT VKELQAACRA RGMRALGVTE DRLKGQLKQW
410 420 430 440 450
LDLHLHHEIP TSLLILSRAM YLPDTLSPAD QLKSTLQTLP EIVAKEAQVK
460 470 480 490 500
VAEVEGEKVD NKAKLEATLQ EEAAIQQEHL EELKRASEAV KDIQPEVAEA
510 520 530 540 550
TLPGRPGPEP QPPVDDVILP SEVLTDTAPV LEGLKGEEIT KEEIDILSDA
560 570 580 590 600
CSKLQEQKKS LTKEKEELEL LKEDVQDYSE DLQEIKKELS KTGEEKYIEE
610 620 630 640 650
SAASKRLSKR VQQMIGQIDG LITQLETTQQ DGKLGPSQST PTGESVISIT
660 670 680 690 700
ELISAMKQIK HIPEHKLISL TSALDDNKDG NINIDDLVKV IDLVNKEDVQ
710 720 730
ISTTQVAEIV ATLEKEEKIE EKEKAKEKAE KEAAEVKN
Length:738
Mass (Da):82,989
Last modified:May 1, 1999 - v1
Checksum:i5074CE6309940729
GO

Sequence cautioni

The sequence AAH23862.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH46326.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH55865.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti271 – 2711A → P in AAH23862 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061026 mRNA. Translation: AAD13139.1.
BC023862 mRNA. Translation: AAH23862.1. Sequence problems.
BC046326 mRNA. Translation: AAH46326.1. Sequence problems.
BC055865 mRNA. Translation: AAH55865.1. Sequence problems.
BC061115 mRNA. Translation: AAH61115.1.
AB041582 mRNA. Translation: BAB93544.1.
CCDSiCCDS19207.1.
RefSeqiNP_062668.1. NM_019694.1.
UniGeneiMm.260538.

Genome annotation databases

EnsembliENSMUST00000005431; ENSMUSP00000005431; ENSMUSG00000005299.
GeneIDi56384.
KEGGimmu:56384.
UCSCiuc008xbi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061026 mRNA. Translation: AAD13139.1.
BC023862 mRNA. Translation: AAH23862.1. Sequence problems.
BC046326 mRNA. Translation: AAH46326.1. Sequence problems.
BC055865 mRNA. Translation: AAH55865.1. Sequence problems.
BC061115 mRNA. Translation: AAH61115.1.
AB041582 mRNA. Translation: BAB93544.1.
CCDSiCCDS19207.1.
RefSeqiNP_062668.1. NM_019694.1.
UniGeneiMm.260538.

3D structure databases

ProteinModelPortaliQ9Z2I0.
SMRiQ9Z2I0. Positions 251-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2I0. 4 interactions.
MINTiMINT-1843443.
STRINGi10090.ENSMUSP00000005431.

PTM databases

iPTMnetiQ9Z2I0.
PhosphoSiteiQ9Z2I0.
SwissPalmiQ9Z2I0.

Proteomic databases

EPDiQ9Z2I0.
MaxQBiQ9Z2I0.
PaxDbiQ9Z2I0.
PRIDEiQ9Z2I0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005431; ENSMUSP00000005431; ENSMUSG00000005299.
GeneIDi56384.
KEGGimmu:56384.
UCSCiuc008xbi.1. mouse.

Organism-specific databases

CTDi3954.
MGIiMGI:1932557. Letm1.

Phylogenomic databases

eggNOGiKOG1043. Eukaryota.
ENOG410XRSP. LUCA.
GeneTreeiENSGT00390000011225.
HOGENOMiHOG000290246.
HOVERGENiHBG052322.
InParanoidiQ9Z2I0.
KOiK17800.
OMAiSEEIMKF.
OrthoDBiEOG79PJNQ.
PhylomeDBiQ9Z2I0.
TreeFamiTF316321.

Miscellaneous databases

NextBioi312472.
PROiQ9Z2I0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z2I0.
ExpressionAtlasiQ9Z2I0. baseline and differential.
GenevisibleiQ9Z2I0. MM.

Family and domain databases

InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF07766. LETM1. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS51758. LETM1_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients."
    Endele S., Fuhry M., Pak S.-J., Zabel B.U., Winterpacht A.
    Genomics 60:218-225(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Colon and Mammary gland.
  3. Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-737.
    Strain: C57BL/6J.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiLETM1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2I0
Secondary accession number(s): Q5PQC5
, Q7TMK8, Q80ZX6, Q8CGJ3, Q8K5E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.