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Protein

Band 4.1-like protein 1

Gene

Epb41l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Band 4.1-like protein 1
Alternative name(s):
Neuronal protein 4.1
Short name:
4.1N
Gene namesi
Name:Epb41l1
Synonyms:Epb4, Epb4.1l1, Kiaa0338
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103010. Epb41l1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193961 – 879Band 4.1-like protein 1Add BLAST879

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphothreonineCombined sources1
Modified residuei75PhosphoserineBy similarity1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei343PhosphotyrosineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1
Modified residuei437PhosphoserineBy similarity1
Modified residuei461PhosphoserineBy similarity1
Modified residuei466PhosphoserineBy similarity1
Modified residuei475PhosphothreonineBy similarity1
Modified residuei510PhosphoserineBy similarity1
Modified residuei540PhosphoserineBy similarity1
Modified residuei541PhosphoserineBy similarity1
Modified residuei544PhosphoserineCombined sources1
Modified residuei546PhosphoserineCombined sources1
Modified residuei550PhosphothreonineCombined sources1
Modified residuei564PhosphoserineBy similarity1
Modified residuei578PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Modified residuei650PhosphoserineCombined sources1
Modified residuei665PhosphoserineCombined sources1
Modified residuei666PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Modified residuei677PhosphoserineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei685PhosphothreonineCombined sources1
Modified residuei721PhosphoserineCombined sources1
Modified residuei782PhosphoserineBy similarity1
Modified residuei868PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z2H5.
PeptideAtlasiQ9Z2H5.
PRIDEiQ9Z2H5.

PTM databases

iPTMnetiQ9Z2H5.
PhosphoSitePlusiQ9Z2H5.
SwissPalmiQ9Z2H5.

Expressioni

Tissue specificityi

Highest expression in brain, also present in kidney, olfactory epithelium, retina, sensory ganglia, gastrointestinal tract (only enteric neurons) and lung.

Gene expression databases

CleanExiMM_EPB4.1L1.

Interactioni

Subunit structurei

Interacts with AGAP2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199459. 1 interactor.
IntActiQ9Z2H5. 4 interactors.
MINTiMINT-4093814.
STRINGi10090.ENSMUSP00000029155.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2H5.
SMRiQ9Z2H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 378FERMPROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni381 – 482HydrophilicAdd BLAST102
Regioni483 – 541Spectrin--actin-bindingAdd BLAST59
Regioni743 – 879C-terminal (CTD)Add BLAST137

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3527. Eukaryota.
ENOG410Y7NQ. LUCA.
HOGENOMiHOG000228841.
HOVERGENiHBG007777.
InParanoidiQ9Z2H5.
KOiK06107.
PhylomeDBiQ9Z2H5.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR008379. Band_4.1_C.
IPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR007477. SAB_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF05902. 4_1_CTD. 1 hit.
PF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF04382. SAB. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z2H5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTETGPDSE VKKAQEETPQ QPEAAAAVTT PVTPAGHSHP ETNSNEKHLT
60 70 80 90 100
QQDTRPAEQS LDMDDKDYSE ADGLSERTTP SKAQKSPQKI AKKFKSAICR
110 120 130 140 150
VTLLDASEYE CEVEKHGRGQ VLFDLVCEHL NLLEKDYFGL TFCDADSQKN
160 170 180 190 200
WLDPSKEIKK QIRSSPWNFA FTVKFYPPDP AQLTEDITRY YLCLQLRADI
210 220 230 240 250
ITGRLPCSFV THALLGSYAV QAELGDYDAE EHVGNYVSEL RFAPNQTREL
260 270 280 290 300
EERIMELHKT YRGMTPGEAE IHFLENAKKL SMYGVDLHHA KDSEGIDIML
310 320 330 340 350
GVCANGLLIY RDRLRINRFA WPKILKISYK RSNFYIKIRP GEYEQFESTI
360 370 380 390 400
GFKLPNHRSA KRLWKVCIEH HTFFRLVSPE PPPKGFLVMG SKFRYSGRTQ
410 420 430 440 450
AQTRQASALI DRPAPFFERS SSKRYTMSRS LDGAEFSRPA SVSENHDAGP
460 470 480 490 500
EGDKREDDAE SGGRRSEAEE GEVRTPTKIK ELKPEQETTP RHKQEFLDKP
510 520 530 540 550
EDVLLKHQAS INELKRTLKE PNSKLIHRDR DWDRERRLPS SPASPSPKGT
560 570 580 590 600
PEKASERAGL REGSEEKVKP PRPRAPESDM GDEDQDQERD AVFLKDNHLA
610 620 630 640 650
IERKCSSITV SSTSSLEAEV DFTVIGDYHG GAFEDFSRSL PELDRDKSDS
660 670 680 690 700
ETEGLVFAQD LKGPSSQEDE SGGLEDSPDR GACSTPEMPQ FESVKAETMT
710 720 730 740 750
VSSLAIRKKI EPEAMLQSRV SAADSTQVDG GTPMVKDFMT TPPCITTETI
760 770 780 790 800
STTMENSLKS GKGAAAMIPG PQTVATEIRS LSPIIGKDVL TSTYGATAET
810 820 830 840 850
LSTSTTTHVT KTVKGGFSET RIEKRIIITG DEDVDQDQAL ALAIKEAKLQ
860 870
HPDMLVTKAV VYRETDPSPE ERDKKPQES
Length:879
Mass (Da):98,315
Last modified:March 20, 2007 - v2
Checksum:iE5C91175FA33D067
GO
Isoform 2 (identifier: Q9Z2H5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     484-495: Missing.

Show »
Length:867
Mass (Da):96,853
Checksum:iEB0CFD9EADDB9590
GO
Isoform 3 (identifier: Q9Z2H5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     484-495: Missing.
     556-691: Missing.

Show »
Length:731
Mass (Da):81,960
Checksum:i09EA8EF42AEA6ACD
GO

Sequence cautioni

The sequence BAC65533 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26A → T in BAC65533 (PubMed:12693553).Curated1
Sequence conflicti142F → Y in AAC68583 (PubMed:10414974).Curated1
Sequence conflicti142F → Y in BAE27810 (PubMed:16141072).Curated1
Sequence conflicti142F → Y in BAE32774 (PubMed:16141072).Curated1
Sequence conflicti434Missing in BAE27810 (PubMed:16141072).Curated1
Sequence conflicti451E → D in AAC68583 (PubMed:10414974).Curated1
Sequence conflicti451E → D in BAE27810 (PubMed:16141072).Curated1
Sequence conflicti451E → D in BAE32774 (PubMed:16141072).Curated1
Sequence conflicti580M → T in AAC68583 (PubMed:10414974).Curated1
Sequence conflicti659Q → R in AAC68583 (PubMed:10414974).Curated1
Sequence conflicti708K → R in BAE27810 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023964484 – 495Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_023965556 – 691Missing in isoform 3. 1 PublicationAdd BLAST136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061283 mRNA. Translation: AAC68583.1.
AK122251 mRNA. Translation: BAC65533.1. Different initiation.
AK147272 mRNA. Translation: BAE27810.1.
AK154704 mRNA. Translation: BAE32774.1.
BC034751 mRNA. Translation: AAH34751.1.
CCDSiCCDS16966.1. [Q9Z2H5-1]
CCDS71169.1. [Q9Z2H5-2]
RefSeqiNP_001006665.1. NM_001006664.3.
NP_001278049.1. NM_001291120.1.
NP_001278051.1. NM_001291122.1.
NP_001278052.1. NM_001291123.1.
NP_038538.1. NM_013510.4.
UniGeneiMm.20852.

Genome annotation databases

GeneIDi13821.
KEGGimmu:13821.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061283 mRNA. Translation: AAC68583.1.
AK122251 mRNA. Translation: BAC65533.1. Different initiation.
AK147272 mRNA. Translation: BAE27810.1.
AK154704 mRNA. Translation: BAE32774.1.
BC034751 mRNA. Translation: AAH34751.1.
CCDSiCCDS16966.1. [Q9Z2H5-1]
CCDS71169.1. [Q9Z2H5-2]
RefSeqiNP_001006665.1. NM_001006664.3.
NP_001278049.1. NM_001291120.1.
NP_001278051.1. NM_001291122.1.
NP_001278052.1. NM_001291123.1.
NP_038538.1. NM_013510.4.
UniGeneiMm.20852.

3D structure databases

ProteinModelPortaliQ9Z2H5.
SMRiQ9Z2H5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199459. 1 interactor.
IntActiQ9Z2H5. 4 interactors.
MINTiMINT-4093814.
STRINGi10090.ENSMUSP00000029155.

PTM databases

iPTMnetiQ9Z2H5.
PhosphoSitePlusiQ9Z2H5.
SwissPalmiQ9Z2H5.

Proteomic databases

PaxDbiQ9Z2H5.
PeptideAtlasiQ9Z2H5.
PRIDEiQ9Z2H5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13821.
KEGGimmu:13821.

Organism-specific databases

CTDi2036.
MGIiMGI:103010. Epb41l1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3527. Eukaryota.
ENOG410Y7NQ. LUCA.
HOGENOMiHOG000228841.
HOVERGENiHBG007777.
InParanoidiQ9Z2H5.
KOiK06107.
PhylomeDBiQ9Z2H5.

Miscellaneous databases

PROiQ9Z2H5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_EPB4.1L1.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR008379. Band_4.1_C.
IPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR007477. SAB_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF05902. 4_1_CTD. 1 hit.
PF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF04382. SAB. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE41L1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2H5
Secondary accession number(s): Q3U3L1
, Q3UHP7, Q80U34, Q8K204
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: March 20, 2007
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.