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Protein

Band 4.1-like protein 1

Gene

Epb41l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Band 4.1-like protein 1
Alternative name(s):
Neuronal protein 4.1
Short name:
4.1N
Gene namesi
Name:Epb41l1
Synonyms:Epb4, Epb4.1l1, Kiaa0338
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103010 Epb41l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193961 – 879Band 4.1-like protein 1Add BLAST879

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphothreonineCombined sources1
Modified residuei75PhosphoserineBy similarity1
Modified residuei79PhosphothreonineBy similarity1
Modified residuei343PhosphotyrosineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1
Modified residuei437PhosphoserineBy similarity1
Modified residuei461PhosphoserineBy similarity1
Modified residuei466PhosphoserineBy similarity1
Modified residuei475PhosphothreonineBy similarity1
Modified residuei510PhosphoserineBy similarity1
Modified residuei540PhosphoserineBy similarity1
Modified residuei541PhosphoserineBy similarity1
Modified residuei544PhosphoserineCombined sources1
Modified residuei546PhosphoserineCombined sources1
Modified residuei550PhosphothreonineCombined sources1
Modified residuei564PhosphoserineBy similarity1
Modified residuei578PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Modified residuei650PhosphoserineCombined sources1
Modified residuei665PhosphoserineCombined sources1
Modified residuei666PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Modified residuei677PhosphoserineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei685PhosphothreonineCombined sources1
Modified residuei721PhosphoserineCombined sources1
Modified residuei782PhosphoserineBy similarity1
Modified residuei868PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z2H5
PeptideAtlasiQ9Z2H5
PRIDEiQ9Z2H5

PTM databases

iPTMnetiQ9Z2H5
PhosphoSitePlusiQ9Z2H5
SwissPalmiQ9Z2H5

Expressioni

Tissue specificityi

Highest expression in brain, also present in kidney, olfactory epithelium, retina, sensory ganglia, gastrointestinal tract (only enteric neurons) and lung.

Gene expression databases

CleanExiMM_EPB4.1L1

Interactioni

Subunit structurei

Interacts with AGAP2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199459, 7 interactors
IntActiQ9Z2H5, 9 interactors
MINTiQ9Z2H5
STRINGi10090.ENSMUSP00000029155

Structurei

3D structure databases

ProteinModelPortaliQ9Z2H5
SMRiQ9Z2H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 378FERMPROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni381 – 482HydrophilicAdd BLAST102
Regioni483 – 541Spectrin--actin-bindingAdd BLAST59
Regioni743 – 879C-terminal (CTD)Add BLAST137

Phylogenomic databases

eggNOGiKOG3527 Eukaryota
ENOG410Y7NQ LUCA
HOGENOMiHOG000228841
HOVERGENiHBG007777
InParanoidiQ9Z2H5
KOiK06107
PhylomeDBiQ9Z2H5

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR008379 Band_4.1_C
IPR019749 Band_41_domain
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR007477 SAB_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF05902 4_1_CTD, 1 hit
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF04382 SAB, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z2H5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTETGPDSE VKKAQEETPQ QPEAAAAVTT PVTPAGHSHP ETNSNEKHLT
60 70 80 90 100
QQDTRPAEQS LDMDDKDYSE ADGLSERTTP SKAQKSPQKI AKKFKSAICR
110 120 130 140 150
VTLLDASEYE CEVEKHGRGQ VLFDLVCEHL NLLEKDYFGL TFCDADSQKN
160 170 180 190 200
WLDPSKEIKK QIRSSPWNFA FTVKFYPPDP AQLTEDITRY YLCLQLRADI
210 220 230 240 250
ITGRLPCSFV THALLGSYAV QAELGDYDAE EHVGNYVSEL RFAPNQTREL
260 270 280 290 300
EERIMELHKT YRGMTPGEAE IHFLENAKKL SMYGVDLHHA KDSEGIDIML
310 320 330 340 350
GVCANGLLIY RDRLRINRFA WPKILKISYK RSNFYIKIRP GEYEQFESTI
360 370 380 390 400
GFKLPNHRSA KRLWKVCIEH HTFFRLVSPE PPPKGFLVMG SKFRYSGRTQ
410 420 430 440 450
AQTRQASALI DRPAPFFERS SSKRYTMSRS LDGAEFSRPA SVSENHDAGP
460 470 480 490 500
EGDKREDDAE SGGRRSEAEE GEVRTPTKIK ELKPEQETTP RHKQEFLDKP
510 520 530 540 550
EDVLLKHQAS INELKRTLKE PNSKLIHRDR DWDRERRLPS SPASPSPKGT
560 570 580 590 600
PEKASERAGL REGSEEKVKP PRPRAPESDM GDEDQDQERD AVFLKDNHLA
610 620 630 640 650
IERKCSSITV SSTSSLEAEV DFTVIGDYHG GAFEDFSRSL PELDRDKSDS
660 670 680 690 700
ETEGLVFAQD LKGPSSQEDE SGGLEDSPDR GACSTPEMPQ FESVKAETMT
710 720 730 740 750
VSSLAIRKKI EPEAMLQSRV SAADSTQVDG GTPMVKDFMT TPPCITTETI
760 770 780 790 800
STTMENSLKS GKGAAAMIPG PQTVATEIRS LSPIIGKDVL TSTYGATAET
810 820 830 840 850
LSTSTTTHVT KTVKGGFSET RIEKRIIITG DEDVDQDQAL ALAIKEAKLQ
860 870
HPDMLVTKAV VYRETDPSPE ERDKKPQES
Length:879
Mass (Da):98,315
Last modified:March 20, 2007 - v2
Checksum:iE5C91175FA33D067
GO
Isoform 2 (identifier: Q9Z2H5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     484-495: Missing.

Show »
Length:867
Mass (Da):96,853
Checksum:iEB0CFD9EADDB9590
GO
Isoform 3 (identifier: Q9Z2H5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     484-495: Missing.
     556-691: Missing.

Show »
Length:731
Mass (Da):81,960
Checksum:i09EA8EF42AEA6ACD
GO

Sequence cautioni

The sequence BAC65533 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26A → T in BAC65533 (PubMed:12693553).Curated1
Sequence conflicti142F → Y in AAC68583 (PubMed:10414974).Curated1
Sequence conflicti142F → Y in BAE27810 (PubMed:16141072).Curated1
Sequence conflicti142F → Y in BAE32774 (PubMed:16141072).Curated1
Sequence conflicti434Missing in BAE27810 (PubMed:16141072).Curated1
Sequence conflicti451E → D in AAC68583 (PubMed:10414974).Curated1
Sequence conflicti451E → D in BAE27810 (PubMed:16141072).Curated1
Sequence conflicti451E → D in BAE32774 (PubMed:16141072).Curated1
Sequence conflicti580M → T in AAC68583 (PubMed:10414974).Curated1
Sequence conflicti659Q → R in AAC68583 (PubMed:10414974).Curated1
Sequence conflicti708K → R in BAE27810 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023964484 – 495Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_023965556 – 691Missing in isoform 3. 1 PublicationAdd BLAST136

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061283 mRNA Translation: AAC68583.1
AK122251 mRNA Translation: BAC65533.1 Different initiation.
AK147272 mRNA Translation: BAE27810.1
AK154704 mRNA Translation: BAE32774.1
BC034751 mRNA Translation: AAH34751.1
CCDSiCCDS16966.1 [Q9Z2H5-1]
CCDS71169.1 [Q9Z2H5-2]
RefSeqiNP_001006665.1, NM_001006664.3
NP_001278049.1, NM_001291120.1
NP_001278051.1, NM_001291122.1
NP_001278052.1, NM_001291123.1
NP_038538.1, NM_013510.4
UniGeneiMm.20852

Genome annotation databases

GeneIDi13821
KEGGimmu:13821

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiE41L1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2H5
Secondary accession number(s): Q3U3L1
, Q3UHP7, Q80U34, Q8K204
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: March 20, 2007
Last modified: May 23, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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