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Protein

Regulator of G-protein signaling 6

Gene

Rgs6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 6
Short name:
RGS6
Gene namesi
Name:Rgs6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1354730 Rgs6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041931 – 472Regulator of G-protein signaling 6Add BLAST472

Proteomic databases

MaxQBiQ9Z2H2
PaxDbiQ9Z2H2
PRIDEiQ9Z2H2

PTM databases

iPTMnetiQ9Z2H2
PhosphoSitePlusiQ9Z2H2

Expressioni

Gene expression databases

BgeeiENSMUSG00000021219
CleanExiMM_RGS6
ExpressionAtlasiQ9Z2H2 baseline and differential
GenevisibleiQ9Z2H2 MM

Interactioni

Subunit structurei

Interacts with GNB5 (By similarity). Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (PubMed:15632198, PubMed:15897264). Interacts with GNAI1 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi206111, 2 interactors
IntActiQ9Z2H2, 2 interactors
MINTiQ9Z2H2
STRINGi10090.ENSMUSP00000098793

Structurei

3D structure databases

ProteinModelPortaliQ9Z2H2
SMRiQ9Z2H2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 115DEPPROSITE-ProRule annotationAdd BLAST76
Domaini261 – 330G protein gammaAdd BLAST70
Domaini336 – 451RGSPROSITE-ProRule annotationAdd BLAST116

Domaini

The RGS domain interacts avidly with Galpha and mediates the acceleration of Galpha-mediated GTP hydrolysis.By similarity

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000220864
HOVERGENiHBG007404
InParanoidiQ9Z2H2
KOiK16449
PhylomeDBiQ9Z2H2

Family and domain databases

CDDicd00068 GGL, 1 hit
cd08737 RGS_RGS6, 1 hit
Gene3Di1.10.10.10, 1 hit
1.10.196.10, 2 hits
4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR016137 RGS
IPR037956 RGS6_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF00631 G-gamma, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00224 GGL, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48097 SSF48097, 1 hit
SSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGSGDQRA VGIADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK
60 70 80 90 100
SFLSKIPSVV TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH
110 120 130 140 150
VLTMKDDGTF YRFQAPYFWP SNCWEPENTD YAIYLCKRTM QNKARLELAD
160 170 180 190 200
YEAENLARLQ RAFARKWEFI FMQAEAQVKI DRKKDKTERK ILDSQERAFW
210 220 230 240 250
DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTDET QSQSPVHIPS
260 270 280 290 300
QPIRKTTKDD IRKQITFLNA QIDRHCLKMS KVAESLIAYT EQYVEYDPFI
310 320 330 340 350
TPAEPSNPWI SDDITLWDIE MSKEPSQQRV KRWGFSFDEI LKDQVGRDQF
360 370 380 390 400
LRFLESEFSS ENLRFWLSVQ DLKKQPLQDV AKRVEEIWQE FLAPGAPSAI
410 420 430 440 450
NLDSHSYEIT SQNVKDGGRY TFEDAQEHIY KLMKSDSYAR FLRSNAYQDL
460 470
LLAKKKGKSL AGKRLTGLMQ SS
Length:472
Mass (Da):54,531
Last modified:August 31, 2004 - v2
Checksum:i94EB9AD49764196C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052527 mRNA Translation: BAC35026.1
AK053087 mRNA Translation: BAC35262.1
BC125029 mRNA Translation: AAI25030.1
BC125030 mRNA Translation: AAI25031.1
AF061933 mRNA Translation: AAC70011.1
CCDSiCCDS79132.1
RefSeqiNP_001268990.1, NM_001282061.2
NP_001297407.1, NM_001310478.2
NP_056627.1, NM_015812.4
UniGeneiMm.126176
Mm.153013

Genome annotation databases

EnsembliENSMUST00000186458; ENSMUSP00000139735; ENSMUSG00000021219
ENSMUST00000200911; ENSMUSP00000143801; ENSMUSG00000021219
ENSMUST00000202210; ENSMUSP00000143961; ENSMUSG00000021219
GeneIDi50779
KEGGimmu:50779
UCSCiuc007oda.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRGS6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2H2
Secondary accession number(s): Q08AT5, Q8BGI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: August 31, 2004
Last modified: March 28, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health