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Protein

Regulator of G-protein signaling 6

Gene

Rgs6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 6
Short name:
RGS6
Gene namesi
Name:Rgs6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1354730. Rgs6.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmcytosol By similarity
  • Membrane By similarity; Peripheral membrane protein By similarity
  • Nucleus By similarity
  • Cell membrane 1 Publication

  • Note: Interaction with GNB5 mediates translocation to the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041931 – 472Regulator of G-protein signaling 6Add BLAST472

Proteomic databases

MaxQBiQ9Z2H2.
PaxDbiQ9Z2H2.
PRIDEiQ9Z2H2.

PTM databases

iPTMnetiQ9Z2H2.
PhosphoSitePlusiQ9Z2H2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021219.
CleanExiMM_RGS6.
ExpressionAtlasiQ9Z2H2. baseline and differential.
GenevisibleiQ9Z2H2. MM.

Interactioni

Subunit structurei

Interacts with GNB5 (By similarity). Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with GNB5 (PubMed:15632198, PubMed:15897264). Interacts with GNAI1 (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridi206111. 1 interactor.
IntActiQ9Z2H2. 1 interactor.
MINTiMINT-4132316.
STRINGi10090.ENSMUSP00000098793.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2H2.
SMRiQ9Z2H2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 115DEPPROSITE-ProRule annotationAdd BLAST76
Domaini261 – 330G protein gammaAdd BLAST70
Domaini336 – 451RGSPROSITE-ProRule annotationAdd BLAST116

Domaini

The RGS domain interacts avidly with Galpha and mediates the acceleration of Galpha-mediated GTP hydrolysis.By similarity

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 G protein gamma domain.Curated
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiQ9Z2H2.
KOiK16449.
PhylomeDBiQ9Z2H2.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGSGDQRA VGIADPEESS PNMIVYCKIE DIITKMQDDK TGGVPIRTVK
60 70 80 90 100
SFLSKIPSVV TGTDIVQWLM KNLSIEDPVE AIHLGSLIAA QGYIFPISDH
110 120 130 140 150
VLTMKDDGTF YRFQAPYFWP SNCWEPENTD YAIYLCKRTM QNKARLELAD
160 170 180 190 200
YEAENLARLQ RAFARKWEFI FMQAEAQVKI DRKKDKTERK ILDSQERAFW
210 220 230 240 250
DVHRPVPGCV NTTEMDIRKC RRLKNPQKVK KSVYGVTDET QSQSPVHIPS
260 270 280 290 300
QPIRKTTKDD IRKQITFLNA QIDRHCLKMS KVAESLIAYT EQYVEYDPFI
310 320 330 340 350
TPAEPSNPWI SDDITLWDIE MSKEPSQQRV KRWGFSFDEI LKDQVGRDQF
360 370 380 390 400
LRFLESEFSS ENLRFWLSVQ DLKKQPLQDV AKRVEEIWQE FLAPGAPSAI
410 420 430 440 450
NLDSHSYEIT SQNVKDGGRY TFEDAQEHIY KLMKSDSYAR FLRSNAYQDL
460 470
LLAKKKGKSL AGKRLTGLMQ SS
Length:472
Mass (Da):54,531
Last modified:August 31, 2004 - v2
Checksum:i94EB9AD49764196C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052527 mRNA. Translation: BAC35026.1.
AK053087 mRNA. Translation: BAC35262.1.
BC125029 mRNA. Translation: AAI25030.1.
BC125030 mRNA. Translation: AAI25031.1.
AF061933 mRNA. Translation: AAC70011.1.
CCDSiCCDS79132.1.
RefSeqiNP_001268990.1. NM_001282061.2.
NP_001297407.1. NM_001310478.2.
NP_056627.1. NM_015812.4.
UniGeneiMm.126176.
Mm.153013.

Genome annotation databases

EnsembliENSMUST00000186458; ENSMUSP00000139735; ENSMUSG00000021219.
ENSMUST00000200911; ENSMUSP00000143801; ENSMUSG00000021219.
ENSMUST00000202210; ENSMUSP00000143961; ENSMUSG00000021219.
GeneIDi50779.
KEGGimmu:50779.
UCSCiuc007oda.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052527 mRNA. Translation: BAC35026.1.
AK053087 mRNA. Translation: BAC35262.1.
BC125029 mRNA. Translation: AAI25030.1.
BC125030 mRNA. Translation: AAI25031.1.
AF061933 mRNA. Translation: AAC70011.1.
CCDSiCCDS79132.1.
RefSeqiNP_001268990.1. NM_001282061.2.
NP_001297407.1. NM_001310478.2.
NP_056627.1. NM_015812.4.
UniGeneiMm.126176.
Mm.153013.

3D structure databases

ProteinModelPortaliQ9Z2H2.
SMRiQ9Z2H2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206111. 1 interactor.
IntActiQ9Z2H2. 1 interactor.
MINTiMINT-4132316.
STRINGi10090.ENSMUSP00000098793.

PTM databases

iPTMnetiQ9Z2H2.
PhosphoSitePlusiQ9Z2H2.

Proteomic databases

MaxQBiQ9Z2H2.
PaxDbiQ9Z2H2.
PRIDEiQ9Z2H2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000186458; ENSMUSP00000139735; ENSMUSG00000021219.
ENSMUST00000200911; ENSMUSP00000143801; ENSMUSG00000021219.
ENSMUST00000202210; ENSMUSP00000143961; ENSMUSG00000021219.
GeneIDi50779.
KEGGimmu:50779.
UCSCiuc007oda.2. mouse.

Organism-specific databases

CTDi9628.
MGIiMGI:1354730. Rgs6.

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000119142.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiQ9Z2H2.
KOiK16449.
PhylomeDBiQ9Z2H2.

Miscellaneous databases

ChiTaRSiRgs6. mouse.
PROiQ9Z2H2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021219.
CleanExiMM_RGS6.
ExpressionAtlasiQ9Z2H2. baseline and differential.
GenevisibleiQ9Z2H2. MM.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGS6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2H2
Secondary accession number(s): Q08AT5, Q8BGI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: August 31, 2004
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.