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Q9Z2H1

- RGS11_MOUSE

UniProt

Q9Z2H1 - RGS11_MOUSE

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Protein
Regulator of G-protein signaling 11
Gene
Rgs11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form By similarity.

GO - Molecular functioni

  1. GTPase activator activity Source: RefGenome
  2. signal transducer activity Source: InterPro

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: MGI
  2. intracellular signal transduction Source: InterPro
  3. positive regulation of GTPase activity Source: GOC
  4. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 11
Gene namesi
Name:Rgs11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1354739. Rgs11.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. dendrite terminus Source: MGI
  3. heterotrimeric G-protein complex Source: InterPro
  4. plasma membrane Source: RefGenome
  5. protein complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Regulator of G-protein signaling 11
PRO_0000204211Add
BLAST

Proteomic databases

PRIDEiQ9Z2H1.

PTM databases

PhosphoSiteiQ9Z2H1.

Expressioni

Gene expression databases

ArrayExpressiQ9Z2H1.
BgeeiQ9Z2H1.
CleanExiMM_RGS11.
GenevestigatoriQ9Z2H1.

Interactioni

Subunit structurei

Heterodimer with Gbeta5 By similarity. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5.2 Publications

Structurei

3D structure databases

ProteinModelPortaliQ9Z2H1.
SMRiQ9Z2H1. Positions 1-401.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 8676DEP
Add
BLAST
Domaini198 – 25962G protein gamma
Add
BLAST
Domaini280 – 395116RGS
Add
BLAST

Sequence similaritiesi

Contains 1 DEP domain.
Contains 1 RGS domain.

Phylogenomic databases

eggNOGiNOG327614.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiQ9Z2H1.
PhylomeDBiQ9Z2H1.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Z2H1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MERVVVSMQD PDQGVKMRSQ RLLITVIPHA VAGRDLVEWL VQKFCILEDE    50
ALHLGTLLAQ HGYIYPLRES RDLTLRPDET PYRFQTPYFW TSTMWPAAEL 100
DYAIYLAKKN IQKQGALVDY EKEHYALLHK KINHAWDLVL MQAREQLRAA 150
KQRRKGDRMV ISCQEQTYWL VNKPPPGAPN ILEQGPERGS YNPSHMQMSS 200
DFYKCEIECF RKALGRNRVK SSACLEAYLK FSSQHGPHDP IMSGCLPSNP 250
WITDDVTYWA MNAPNVAAPT KLRVERWSFS FRELLDDPVG RAHFMDFLQK 300
EFSAENLSFW EACEELRFGG QAQVPTLVDS VYQQFLAPGA ARWINIDSRT 350
MERTLEGLRQ PHRYVLDAAQ LHIYMLMKKD SYPRFLKSDI YKGLLEEAVI 400
PLETKRWPFP FLRKPLHSSP SPALQSTPRE PAATSSPEGA DGE 443
Length:443
Mass (Da):51,075
Last modified:January 9, 2007 - v2
Checksum:i0781671E2C7272F3
GO
Isoform 2 (identifier: Q9Z2H1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-241: Missing.

Note: No experimental confirmation available.

Show »
Length:202
Mass (Da):23,077
Checksum:i80BD741A6C57D145
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 241241Missing in isoform 2.
VSP_022239Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831R → M in AAC70012. 1 Publication
Sequence conflicti299 – 3002QK → HN in AAC70012. 1 Publication
Sequence conflicti441 – 4411D → N in AAH19741. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126438 Genomic DNA. No translation available.
BC019741 mRNA. Translation: AAH19741.1.
AF061934 mRNA. Translation: AAC70012.1.
UniGeneiMm.109840.

Genome annotation databases

UCSCiuc008bds.1. mouse. [Q9Z2H1-1]
uc008bdt.1. mouse. [Q9Z2H1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126438 Genomic DNA. No translation available.
BC019741 mRNA. Translation: AAH19741.1 .
AF061934 mRNA. Translation: AAC70012.1 .
UniGenei Mm.109840.

3D structure databases

ProteinModelPortali Q9Z2H1.
SMRi Q9Z2H1. Positions 1-401.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9Z2H1.

Proteomic databases

PRIDEi Q9Z2H1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc008bds.1. mouse. [Q9Z2H1-1 ]
uc008bdt.1. mouse. [Q9Z2H1-2 ]

Organism-specific databases

MGIi MGI:1354739. Rgs11.

Phylogenomic databases

eggNOGi NOG327614.
HOGENOMi HOG000220864.
HOVERGENi HBG007404.
InParanoidi Q9Z2H1.
PhylomeDBi Q9Z2H1.

Miscellaneous databases

ChiTaRSi RGS11. mouse.
PROi Q9Z2H1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Z2H1.
Bgeei Q9Z2H1.
CleanExi MM_RGS11.
Genevestigatori Q9Z2H1.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. He W., Wensel T.G.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-443 (ISOFORM 1).
  4. "R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family."
    Martemyanov K.A., Yoo P.J., Skiba N.P., Arshavsky V.Y.
    J. Biol. Chem. 280:5133-5136(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RGS7BP.
  5. "Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family."
    Drenan R.M., Doupnik C.A., Boyle M.P., Muglia L.J., Huettner J.E., Linder M.E., Blumer K.J.
    J. Cell Biol. 169:623-633(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RGS7BP.

Entry informationi

Entry nameiRGS11_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2H1
Secondary accession number(s): Q8VCJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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