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Q9Z2H1 (RGS11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 11
Gene names
Name:Rgs11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form By similarity.

Subunit structure

Heterodimer with Gbeta5 By similarity. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Ref.4 Ref.5

Sequence similarities

Contains 1 DEP domain.

Contains 1 G protein gamma domain.

Contains 1 RGS domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Z2H1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Z2H1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-241: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Regulator of G-protein signaling 11
PRO_0000204211

Regions

Domain11 – 8676DEP
Domain198 – 25962G protein gamma
Domain280 – 395116RGS

Natural variations

Alternative sequence1 – 241241Missing in isoform 2.
VSP_022239

Experimental info

Sequence conflict831R → M in AAC70012. Ref.3
Sequence conflict299 – 3002QK → HN in AAC70012. Ref.3
Sequence conflict4411D → N in AAH19741. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 9, 2007. Version 2.
Checksum: 0781671E2C7272F3

FASTA44351,075
        10         20         30         40         50         60 
MERVVVSMQD PDQGVKMRSQ RLLITVIPHA VAGRDLVEWL VQKFCILEDE ALHLGTLLAQ 

        70         80         90        100        110        120 
HGYIYPLRES RDLTLRPDET PYRFQTPYFW TSTMWPAAEL DYAIYLAKKN IQKQGALVDY 

       130        140        150        160        170        180 
EKEHYALLHK KINHAWDLVL MQAREQLRAA KQRRKGDRMV ISCQEQTYWL VNKPPPGAPN 

       190        200        210        220        230        240 
ILEQGPERGS YNPSHMQMSS DFYKCEIECF RKALGRNRVK SSACLEAYLK FSSQHGPHDP 

       250        260        270        280        290        300 
IMSGCLPSNP WITDDVTYWA MNAPNVAAPT KLRVERWSFS FRELLDDPVG RAHFMDFLQK 

       310        320        330        340        350        360 
EFSAENLSFW EACEELRFGG QAQVPTLVDS VYQQFLAPGA ARWINIDSRT MERTLEGLRQ 

       370        380        390        400        410        420 
PHRYVLDAAQ LHIYMLMKKD SYPRFLKSDI YKGLLEEAVI PLETKRWPFP FLRKPLHSSP 

       430        440 
SPALQSTPRE PAATSSPEGA DGE

« Hide

Isoform 2 [UniParc].

Checksum: 80BD741A6C57D145
Show »

FASTA20223,077

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: FVB/N.
Tissue: Mammary gland.
[3]He W., Wensel T.G.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-443 (ISOFORM 1).
[4]"R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family."
Martemyanov K.A., Yoo P.J., Skiba N.P., Arshavsky V.Y.
J. Biol. Chem. 280:5133-5136(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RGS7BP.
[5]"Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family."
Drenan R.M., Doupnik C.A., Boyle M.P., Muglia L.J., Huettner J.E., Linder M.E., Blumer K.J.
J. Cell Biol. 169:623-633(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RGS7BP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC126438 Genomic DNA. No translation available.
BC019741 mRNA. Translation: AAH19741.1.
AF061934 mRNA. Translation: AAC70012.1.
IPIIPI00131162.
IPI00660036.
UniGeneMm.109840.

3D structure databases

ProteinModelPortalQ9Z2H1.
SMRQ9Z2H1. Positions 1-401.
ModBaseSearch...

PTM databases

PhosphoSiteQ9Z2H1.

Proteomic databases

PRIDEQ9Z2H1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc008bdr.1. mouse.
uc008bdt.1. mouse.

Organism-specific databases

MGIMGI:1354739. Rgs11.

Phylogenomic databases

eggNOGNOG327614.
HOGENOMHOG000220864.
HOVERGENHBG007404.
InParanoidQ9Z2H1.
OrthoDBEOG44XJGT.

Gene expression databases

ArrayExpressQ9Z2H1.
BgeeQ9Z2H1.
CleanExMM_RGS11.
GenevestigatorQ9Z2H1.
GermOnlineENSMUSG00000024186. Mus musculus.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR000342. Regulat_G_prot_signal.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48670. G-protein_gamma-like. 1 hit.
SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITEPS50186. DEP. 1 hit.
PS50058. G_PROTEIN_GAMMA. False negative.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRGS11. mouse.
SOURCESearch...

Entry information

Entry nameRGS11_MOUSE
AccessionPrimary (citable) accession number: Q9Z2H1
Secondary accession number(s): Q8VCJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: January 9, 2007
Last modified: May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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