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Q9Z2H1

- RGS11_MOUSE

UniProt

Q9Z2H1 - RGS11_MOUSE

Protein

Regulator of G-protein signaling 11

Gene

Rgs11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome
    2. signal transducer activity Source: InterPro

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: MGI
    2. intracellular signal transduction Source: InterPro
    3. positive regulation of GTPase activity Source: GOC
    4. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 11
    Gene namesi
    Name:Rgs11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1354739. Rgs11.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. dendrite terminus Source: MGI
    3. heterotrimeric G-protein complex Source: InterPro
    4. plasma membrane Source: RefGenome
    5. protein complex Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Regulator of G-protein signaling 11PRO_0000204211Add
    BLAST

    Proteomic databases

    PRIDEiQ9Z2H1.

    PTM databases

    PhosphoSiteiQ9Z2H1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Z2H1.
    BgeeiQ9Z2H1.
    CleanExiMM_RGS11.
    GenevestigatoriQ9Z2H1.

    Interactioni

    Subunit structurei

    Heterodimer with Gbeta5 By similarity. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5.By similarity2 Publications

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2H1.
    SMRiQ9Z2H1. Positions 1-401.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 8676DEPPROSITE-ProRule annotationAdd
    BLAST
    Domaini198 – 25962G protein gammaAdd
    BLAST
    Domaini280 – 395116RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 G protein gamma domain.Curated
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327614.
    HOGENOMiHOG000220864.
    HOVERGENiHBG007404.
    InParanoidiQ9Z2H1.
    PhylomeDBiQ9Z2H1.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Z2H1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERVVVSMQD PDQGVKMRSQ RLLITVIPHA VAGRDLVEWL VQKFCILEDE    50
    ALHLGTLLAQ HGYIYPLRES RDLTLRPDET PYRFQTPYFW TSTMWPAAEL 100
    DYAIYLAKKN IQKQGALVDY EKEHYALLHK KINHAWDLVL MQAREQLRAA 150
    KQRRKGDRMV ISCQEQTYWL VNKPPPGAPN ILEQGPERGS YNPSHMQMSS 200
    DFYKCEIECF RKALGRNRVK SSACLEAYLK FSSQHGPHDP IMSGCLPSNP 250
    WITDDVTYWA MNAPNVAAPT KLRVERWSFS FRELLDDPVG RAHFMDFLQK 300
    EFSAENLSFW EACEELRFGG QAQVPTLVDS VYQQFLAPGA ARWINIDSRT 350
    MERTLEGLRQ PHRYVLDAAQ LHIYMLMKKD SYPRFLKSDI YKGLLEEAVI 400
    PLETKRWPFP FLRKPLHSSP SPALQSTPRE PAATSSPEGA DGE 443
    Length:443
    Mass (Da):51,075
    Last modified:January 9, 2007 - v2
    Checksum:i0781671E2C7272F3
    GO
    Isoform 2 (identifier: Q9Z2H1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-241: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:202
    Mass (Da):23,077
    Checksum:i80BD741A6C57D145
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti83 – 831R → M in AAC70012. 1 PublicationCurated
    Sequence conflicti299 – 3002QK → HN in AAC70012. 1 PublicationCurated
    Sequence conflicti441 – 4411D → N in AAH19741. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 241241Missing in isoform 2. 1 PublicationVSP_022239Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126438 Genomic DNA. No translation available.
    BC019741 mRNA. Translation: AAH19741.1.
    AF061934 mRNA. Translation: AAC70012.1.
    UniGeneiMm.109840.

    Genome annotation databases

    UCSCiuc008bds.1. mouse. [Q9Z2H1-1]
    uc008bdt.1. mouse. [Q9Z2H1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126438 Genomic DNA. No translation available.
    BC019741 mRNA. Translation: AAH19741.1 .
    AF061934 mRNA. Translation: AAC70012.1 .
    UniGenei Mm.109840.

    3D structure databases

    ProteinModelPortali Q9Z2H1.
    SMRi Q9Z2H1. Positions 1-401.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9Z2H1.

    Proteomic databases

    PRIDEi Q9Z2H1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc008bds.1. mouse. [Q9Z2H1-1 ]
    uc008bdt.1. mouse. [Q9Z2H1-2 ]

    Organism-specific databases

    MGIi MGI:1354739. Rgs11.

    Phylogenomic databases

    eggNOGi NOG327614.
    HOGENOMi HOG000220864.
    HOVERGENi HBG007404.
    InParanoidi Q9Z2H1.
    PhylomeDBi Q9Z2H1.

    Miscellaneous databases

    ChiTaRSi RGS11. mouse.
    PROi Q9Z2H1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z2H1.
    Bgeei Q9Z2H1.
    CleanExi MM_RGS11.
    Genevestigatori Q9Z2H1.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.196.10. 1 hit.
    4.10.260.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR015898. G-protein_gamma-like_dom.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00610. DEP. 1 hit.
    PF00631. G-gamma. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00049. DEP. 1 hit.
    SM00224. GGL. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF48670. SSF48670. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Mammary gland.
    3. He W., Wensel T.G.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-443 (ISOFORM 1).
    4. "R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family."
      Martemyanov K.A., Yoo P.J., Skiba N.P., Arshavsky V.Y.
      J. Biol. Chem. 280:5133-5136(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RGS7BP.
    5. "Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family."
      Drenan R.M., Doupnik C.A., Boyle M.P., Muglia L.J., Huettner J.E., Linder M.E., Blumer K.J.
      J. Cell Biol. 169:623-633(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RGS7BP.

    Entry informationi

    Entry nameiRGS11_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z2H1
    Secondary accession number(s): Q8VCJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3