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Protein

Regulator of G-protein signaling 11

Gene

Rgs11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

GO - Molecular functioni

  1. G-protein beta-subunit binding Source: MGI
  2. GTPase activator activity Source: GO_Central
  3. signal transducer activity Source: InterPro

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: MGI
  2. intracellular signal transduction Source: InterPro
  3. positive regulation of GTPase activity Source: GOC
  4. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 11
Gene namesi
Name:Rgs11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1354739. Rgs11.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. dendrite terminus Source: MGI
  3. heterotrimeric G-protein complex Source: InterPro
  4. plasma membrane Source: GO_Central
  5. protein complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Regulator of G-protein signaling 11PRO_0000204211Add
BLAST

Proteomic databases

PRIDEiQ9Z2H1.

PTM databases

PhosphoSiteiQ9Z2H1.

Expressioni

Gene expression databases

BgeeiQ9Z2H1.
CleanExiMM_RGS11.
ExpressionAtlasiQ9Z2H1. baseline and differential.
GenevestigatoriQ9Z2H1.

Interactioni

Subunit structurei

Heterodimer with Gbeta5 (By similarity). Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5.By similarity2 Publications

Structurei

3D structure databases

ProteinModelPortaliQ9Z2H1.
SMRiQ9Z2H1. Positions 1-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 8676DEPPROSITE-ProRule annotationAdd
BLAST
Domaini198 – 25962G protein gammaAdd
BLAST
Domaini280 – 395116RGSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 G protein gamma domain.Curated
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG327614.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiQ9Z2H1.
PhylomeDBiQ9Z2H1.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Z2H1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERVVVSMQD PDQGVKMRSQ RLLITVIPHA VAGRDLVEWL VQKFCILEDE
60 70 80 90 100
ALHLGTLLAQ HGYIYPLRES RDLTLRPDET PYRFQTPYFW TSTMWPAAEL
110 120 130 140 150
DYAIYLAKKN IQKQGALVDY EKEHYALLHK KINHAWDLVL MQAREQLRAA
160 170 180 190 200
KQRRKGDRMV ISCQEQTYWL VNKPPPGAPN ILEQGPERGS YNPSHMQMSS
210 220 230 240 250
DFYKCEIECF RKALGRNRVK SSACLEAYLK FSSQHGPHDP IMSGCLPSNP
260 270 280 290 300
WITDDVTYWA MNAPNVAAPT KLRVERWSFS FRELLDDPVG RAHFMDFLQK
310 320 330 340 350
EFSAENLSFW EACEELRFGG QAQVPTLVDS VYQQFLAPGA ARWINIDSRT
360 370 380 390 400
MERTLEGLRQ PHRYVLDAAQ LHIYMLMKKD SYPRFLKSDI YKGLLEEAVI
410 420 430 440
PLETKRWPFP FLRKPLHSSP SPALQSTPRE PAATSSPEGA DGE
Length:443
Mass (Da):51,075
Last modified:January 9, 2007 - v2
Checksum:i0781671E2C7272F3
GO
Isoform 2 (identifier: Q9Z2H1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-241: Missing.

Note: No experimental confirmation available.

Show »
Length:202
Mass (Da):23,077
Checksum:i80BD741A6C57D145
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831R → M in AAC70012. 1 PublicationCurated
Sequence conflicti299 – 3002QK → HN in AAC70012. 1 PublicationCurated
Sequence conflicti441 – 4411D → N in AAH19741. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 241241Missing in isoform 2. 1 PublicationVSP_022239Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126438 Genomic DNA. No translation available.
BC019741 mRNA. Translation: AAH19741.1.
AF061934 mRNA. Translation: AAC70012.1.
UniGeneiMm.109840.

Genome annotation databases

UCSCiuc008bds.1. mouse. [Q9Z2H1-1]
uc008bdt.1. mouse. [Q9Z2H1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126438 Genomic DNA. No translation available.
BC019741 mRNA. Translation: AAH19741.1.
AF061934 mRNA. Translation: AAC70012.1.
UniGeneiMm.109840.

3D structure databases

ProteinModelPortaliQ9Z2H1.
SMRiQ9Z2H1. Positions 1-401.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9Z2H1.

Proteomic databases

PRIDEiQ9Z2H1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc008bds.1. mouse. [Q9Z2H1-1]
uc008bdt.1. mouse. [Q9Z2H1-2]

Organism-specific databases

MGIiMGI:1354739. Rgs11.

Phylogenomic databases

eggNOGiNOG327614.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiQ9Z2H1.
PhylomeDBiQ9Z2H1.

Miscellaneous databases

ChiTaRSiRgs11. mouse.
PROiQ9Z2H1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z2H1.
CleanExiMM_RGS11.
ExpressionAtlasiQ9Z2H1. baseline and differential.
GenevestigatoriQ9Z2H1.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 1 hit.
4.10.260.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. He W., Wensel T.G.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-443 (ISOFORM 1).
  4. "R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family."
    Martemyanov K.A., Yoo P.J., Skiba N.P., Arshavsky V.Y.
    J. Biol. Chem. 280:5133-5136(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RGS7BP.
  5. "Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family."
    Drenan R.M., Doupnik C.A., Boyle M.P., Muglia L.J., Huettner J.E., Linder M.E., Blumer K.J.
    J. Cell Biol. 169:623-633(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RGS7BP.

Entry informationi

Entry nameiRGS11_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2H1
Secondary accession number(s): Q8VCJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: January 9, 2007
Last modified: February 4, 2015
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.