Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regulator of G-protein signaling 11

Gene

Rgs11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.By similarity

GO - Molecular functioni

  • G-protein beta-subunit binding Source: MGI
  • GTPase activator activity Source: MGI
  • signal transducer activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 11
Gene namesi
Name:Rgs11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1354739. Rgs11.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042111 – 443Regulator of G-protein signaling 11Add BLAST443

Proteomic databases

PaxDbiQ9Z2H1.
PRIDEiQ9Z2H1.

PTM databases

iPTMnetiQ9Z2H1.
PhosphoSitePlusiQ9Z2H1.

Expressioni

Gene expression databases

CleanExiMM_RGS11.

Interactioni

Subunit structurei

Heterodimer with Gbeta5 (By similarity). Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025020.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2H1.
SMRiQ9Z2H1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 86DEPPROSITE-ProRule annotationAdd BLAST76
Domaini198 – 259G protein gammaAdd BLAST62
Domaini280 – 395RGSPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
HOGENOMiHOG000220864.
HOVERGENiHBG007404.
InParanoidiQ9Z2H1.
PhylomeDBiQ9Z2H1.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.10.196.10. 2 hits.
InterProiView protein in InterPro
IPR000591. DEP_dom.
IPR015898. G-protein_gamma-like_dom.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00610. DEP. 1 hit.
PF00631. G-gamma. 1 hit.
PF00615. RGS. 1 hit.
PRINTSiPR01301. RGSPROTEIN.
SMARTiView protein in SMART
SM00049. DEP. 1 hit.
SM00224. GGL. 1 hit.
SM00315. RGS. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48097. SSF48097. 1 hit.
SSF48670. SSF48670. 1 hit.
PROSITEiView protein in PROSITE
PS50186. DEP. 1 hit.
PS50132. RGS. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z2H1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERVVVSMQD PDQGVKMRSQ RLLITVIPHA VAGRDLVEWL VQKFCILEDE
60 70 80 90 100
ALHLGTLLAQ HGYIYPLRES RDLTLRPDET PYRFQTPYFW TSTMWPAAEL
110 120 130 140 150
DYAIYLAKKN IQKQGALVDY EKEHYALLHK KINHAWDLVL MQAREQLRAA
160 170 180 190 200
KQRRKGDRMV ISCQEQTYWL VNKPPPGAPN ILEQGPERGS YNPSHMQMSS
210 220 230 240 250
DFYKCEIECF RKALGRNRVK SSACLEAYLK FSSQHGPHDP IMSGCLPSNP
260 270 280 290 300
WITDDVTYWA MNAPNVAAPT KLRVERWSFS FRELLDDPVG RAHFMDFLQK
310 320 330 340 350
EFSAENLSFW EACEELRFGG QAQVPTLVDS VYQQFLAPGA ARWINIDSRT
360 370 380 390 400
MERTLEGLRQ PHRYVLDAAQ LHIYMLMKKD SYPRFLKSDI YKGLLEEAVI
410 420 430 440
PLETKRWPFP FLRKPLHSSP SPALQSTPRE PAATSSPEGA DGE
Length:443
Mass (Da):51,075
Last modified:January 9, 2007 - v2
Checksum:i0781671E2C7272F3
GO
Isoform 2 (identifier: Q9Z2H1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-241: Missing.

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):23,077
Checksum:i80BD741A6C57D145
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83R → M in AAC70012 (Ref. 3) Curated1
Sequence conflicti299 – 300QK → HN in AAC70012 (Ref. 3) Curated2
Sequence conflicti441D → N in AAH19741 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0222391 – 241Missing in isoform 2. 1 PublicationAdd BLAST241

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126438 Genomic DNA. No translation available.
BC019741 mRNA. Translation: AAH19741.1.
AF061934 mRNA. Translation: AAC70012.1.
RefSeqiXP_017173057.1. XM_017317568.1. [Q9Z2H1-2]
XP_017173058.1. XM_017317569.1. [Q9Z2H1-2]
UniGeneiMm.109840.

Genome annotation databases

GeneIDi50782.
UCSCiuc008bds.1. mouse. [Q9Z2H1-1]
uc008bdt.1. mouse. [Q9Z2H1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRGS11_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2H1
Secondary accession number(s): Q8VCJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: January 9, 2007
Last modified: August 30, 2017
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot