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Protein

Oxidoreductase HTATIP2

Gene

Htatip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei131SubstrateBy similarity1
Active sitei143Proton acceptorBy similarity1
Active sitei147By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 52NADPBy similarityAdd BLAST34

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Oxidoreductase

Keywords - Biological processi

Angiogenesis, Apoptosis, Differentiation

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Oxidoreductase HTATIP2 (EC:1.1.1.-)
Gene namesi
Name:Htatip2Imported
Synonyms:Cc31 Publication, Tip301 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1859271. Htatip2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • membrane Source: MGI
  • nuclear envelope Source: UniProtKB
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are haploinsufficient for tumor suppression. 50% develop tumors within their second year. 30% of the tumors are hepatocellular carcinomas.1 Publication

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000725452 – 242Oxidoreductase HTATIP2Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Z2G9.
PaxDbiQ9Z2G9.
PeptideAtlasiQ9Z2G9.
PRIDEiQ9Z2G9.

PTM databases

iPTMnetiQ9Z2G9.
PhosphoSitePlusiQ9Z2G9.
SwissPalmiQ9Z2G9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039745.
CleanExiMM_HTATIP2.
ExpressionAtlasiQ9Z2G9. baseline and differential.
GenevisibleiQ9Z2G9. MM.

Interactioni

Subunit structurei

Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082374.

Structurei

Secondary structure

1242
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 16Combined sources10
Beta strandi20 – 24Combined sources5
Helixi29 – 41Combined sources13
Beta strandi45 – 53Combined sources9
Beta strandi66 – 69Combined sources4
Helixi72 – 82Combined sources11
Beta strandi86 – 90Combined sources5
Helixi101 – 108Combined sources8
Helixi110 – 121Combined sources12
Beta strandi126 – 130Combined sources5
Helixi142 – 156Combined sources15
Beta strandi160 – 166Combined sources7
Beta strandi168 – 171Combined sources4
Helixi195 – 199Combined sources5
Beta strandi200 – 202Combined sources3
Helixi203 – 215Combined sources13
Beta strandi219 – 226Combined sources8
Helixi227 – 233Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FMUX-ray2.30A7-242[»]
ProteinModelPortaliQ9Z2G9.
SMRiQ9Z2G9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z2G9.

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4039. Eukaryota.
COG0702. LUCA.
GeneTreeiENSGT00390000008184.
HOVERGENiHBG052833.
InParanoidiQ9Z2G9.
KOiK17290.
OrthoDBiEOG091G0S5T.
TreeFamiTF312849.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF13460. NAD_binding_10. 1 hit.
[Graphical view]
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9Z2G9-1) [UniParc]FASTAAdd to basket
Also known as: TIP301 Publication, CC31 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADKEALPKL REDFKMQNKS VFILGASGET GKVLLKEILG QNLFSKVTLI
60 70 80 90 100
GRRKLTFEEE AYKNVNQEVV DFEKLDVYAS AFQGHDVGFC CLGTTRSKAG
110 120 130 140 150
AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSRGADKSSS FLYLQVKGEV
160 170 180 190 200
EAKVEELKFD RLSVFRPGVL LCDRQESRPG EWLARKFFGS LPDSWASGYA
210 220 230 240
VPVVTVVRAM LNNLVSPSSG QMELLENKAI LHLGKDRDVP KL
Length:242
Mass (Da):26,870
Last modified:October 3, 2012 - v3
Checksum:i034F02137D3BF22A
GO
Isoform 2Curated (identifier: Q9Z2G9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-105: EGFV → VSKK
     106-242: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:105
Mass (Da):11,661
Checksum:i8DF855A01EEF6BEB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8P → R in AAC69617 (PubMed:14695192).Curated1
Sequence conflicti10L → P in BAB29825 (PubMed:16141072).Curated1
Sequence conflicti27S → T in BAB29825 (PubMed:16141072).Curated1
Sequence conflicti39L → V in AAC69617 (PubMed:14695192).Curated1
Sequence conflicti77V → G in AAN84531 (Ref. 2) Curated1
Sequence conflicti213N → S in AAC69617 (PubMed:14695192).Curated1
Sequence conflicti235K → I in BAB25792 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051866102 – 105EGFV → VSKK in isoform 2. 1 Publication4
Alternative sequenceiVSP_051867106 – 242Missing in isoform 2. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061972 mRNA. Translation: AAC69617.1.
AY151050 Genomic DNA. Translation: AAN84531.1.
AK008630 mRNA. Translation: BAB25792.1.
AK015389 mRNA. Translation: BAB29825.1.
AK144837 mRNA. Translation: BAE26091.1.
AC124775 Genomic DNA. No translation available.
CH466603 Genomic DNA. Translation: EDL22975.1.
CH466603 Genomic DNA. Translation: EDL22976.1.
CH466603 Genomic DNA. Translation: EDL22977.1.
BC004083 mRNA. Translation: AAH04083.1.
BC017372 mRNA. Translation: AAH17372.1.
CCDSiCCDS52260.1. [Q9Z2G9-1]
RefSeqiNP_001139521.1. NM_001146049.1. [Q9Z2G9-1]
NP_001139522.1. NM_001146050.1. [Q9Z2G9-1]
NP_001139524.1. NM_001146052.1. [Q9Z2G9-1]
NP_001139525.1. NM_001146053.1. [Q9Z2G9-1]
UniGeneiMm.20801.

Genome annotation databases

EnsembliENSMUST00000085272; ENSMUSP00000082374; ENSMUSG00000039745. [Q9Z2G9-1]
GeneIDi53415.
KEGGimmu:53415.
UCSCiuc009hbo.2. mouse. [Q9Z2G9-2]
uc009hbq.2. mouse. [Q9Z2G9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061972 mRNA. Translation: AAC69617.1.
AY151050 Genomic DNA. Translation: AAN84531.1.
AK008630 mRNA. Translation: BAB25792.1.
AK015389 mRNA. Translation: BAB29825.1.
AK144837 mRNA. Translation: BAE26091.1.
AC124775 Genomic DNA. No translation available.
CH466603 Genomic DNA. Translation: EDL22975.1.
CH466603 Genomic DNA. Translation: EDL22976.1.
CH466603 Genomic DNA. Translation: EDL22977.1.
BC004083 mRNA. Translation: AAH04083.1.
BC017372 mRNA. Translation: AAH17372.1.
CCDSiCCDS52260.1. [Q9Z2G9-1]
RefSeqiNP_001139521.1. NM_001146049.1. [Q9Z2G9-1]
NP_001139522.1. NM_001146050.1. [Q9Z2G9-1]
NP_001139524.1. NM_001146052.1. [Q9Z2G9-1]
NP_001139525.1. NM_001146053.1. [Q9Z2G9-1]
UniGeneiMm.20801.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FMUX-ray2.30A7-242[»]
ProteinModelPortaliQ9Z2G9.
SMRiQ9Z2G9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082374.

PTM databases

iPTMnetiQ9Z2G9.
PhosphoSitePlusiQ9Z2G9.
SwissPalmiQ9Z2G9.

Proteomic databases

EPDiQ9Z2G9.
PaxDbiQ9Z2G9.
PeptideAtlasiQ9Z2G9.
PRIDEiQ9Z2G9.

Protocols and materials databases

DNASUi53415.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085272; ENSMUSP00000082374; ENSMUSG00000039745. [Q9Z2G9-1]
GeneIDi53415.
KEGGimmu:53415.
UCSCiuc009hbo.2. mouse. [Q9Z2G9-2]
uc009hbq.2. mouse. [Q9Z2G9-1]

Organism-specific databases

CTDi10553.
MGIiMGI:1859271. Htatip2.

Phylogenomic databases

eggNOGiKOG4039. Eukaryota.
COG0702. LUCA.
GeneTreeiENSGT00390000008184.
HOVERGENiHBG052833.
InParanoidiQ9Z2G9.
KOiK17290.
OrthoDBiEOG091G0S5T.
TreeFamiTF312849.

Miscellaneous databases

EvolutionaryTraceiQ9Z2G9.
PROiQ9Z2G9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039745.
CleanExiMM_HTATIP2.
ExpressionAtlasiQ9Z2G9. baseline and differential.
GenevisibleiQ9Z2G9. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF13460. NAD_binding_10. 1 hit.
[Graphical view]
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHTAI2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2G9
Secondary accession number(s): Q810Y5
, Q99KN6, Q9D5F8, Q9D804
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.