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Q9Z2G7 (GRK7_SPETR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G protein-coupled receptor kinase 7

EC=2.7.11.14
EC=2.7.11.16
Alternative name(s):
G protein-coupled receptor kinase GRK7
Gene names
Name:GRK7
OrganismSpermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus) [Reference proteome]
Taxonomic identifier43179 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiSciuridaeXerinaeMarmotiniIctidomys

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO) By similarity.

Catalytic activity

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.

ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.

Enzyme regulation

Inhibited by phosphorylation of Ser-34 By similarity.

Subcellular location

Membrane; Lipid-anchor By similarity.

Tissue specificity

Retina. Cones and rod. Ref.1

Post-translational modification

Autophosphorylated. Phosphorylation at Ser-34 is regulated by light and activated by cAMP By similarity. Ref.1

Miscellaneous

Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 protein kinase domain.

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 545545G protein-coupled receptor kinase 7
PRO_0000024336
Propeptide546 – 5483Removed in mature form By similarity
PRO_0000024337

Regions

Domain54 – 171118RGS
Domain186 – 449264Protein kinase
Domain450 – 51566AGC-kinase C-terminal
Nucleotide binding192 – 2009ATP By similarity

Sites

Active site3111Proton acceptor By similarity
Binding site2151ATP By similarity

Amino acid modifications

Modified residue341Phosphoserine; by PKA By similarity
Modified residue5451Cysteine methyl ester Potential
Lipidation5451S-geranylgeranyl cysteine Potential

Sequences

Sequence LengthMass (Da)Tools
Q9Z2G7 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 092C5BFA5A42A200

FASTA54861,993
        10         20         30         40         50         60 
MDMGGLDNLI ANTAYLQARK TDSDSRELQR RRRSLALPGP QGCAELRQSL SPHFHSLCEQ 

        70         80         90        100        110        120 
QPIGRRLFRD FLATVPKYSQ AVAFLEDVQN WELAEEGPAK TSTLQQLAAT CARDPGPQSF 

       130        140        150        160        170        180 
LSQDLATKCR AASTDEERKT LVEQAKAETM SFLQEQPFQD FLASPFYDRF LQWKLFEMQP 

       190        200        210        220        230        240 
VSDKYFTEFR VLGKGGFGEV CAVQVRNTGK MYACKKLDKK RLKKKGGEKM ALLEKEILEK 

       250        260        270        280        290        300 
VNSPFIVSLA YAFESKTHLC LVMSLMNGGD LKFHIYNVGT RGLAMSRVIF YTAQMTCGVL 

       310        320        330        340        350        360 
HLHGLGIVYR DLKPENVLLD DLGNCRLSDL GLAVEVQDDK PITQRAGTNG YMAPEILMDK 

       370        380        390        400        410        420 
ASYSYPVDWF AMGCSIYEMV AGRTPFKDFK EKVSKEDLKE RTMKDEVAFH HENFTEETKD 

       430        440        450        460        470        480 
ICRLFLAKKP EQRLGSREKA DDPRKHPFFQ TVNFPRLEAG LVEPPFVPDP SVVYAKDVDE 

       490        500        510        520        530        540 
IDDFSEVRGV EFDDKDKQFF QRFSTGAVPV AWQEEIIETG LFEELNDPNR PSGDGKGDSS 


KSGVCLLL 

« Hide

References

[1]"The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas."
Weiss E.R., Raman D., Shirakawa S., Ducceschi M.S., Bertram P.T., Wong F., Kraft T.W., Osawa S.
Mol. Vis. 4:27-27(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AUTOPHOSPHORYLATION.
Tissue: Retina.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF063016 mRNA. Translation: AAC95001.1.
RefSeqNP_001269199.1. NM_001282270.1.

3D structure databases

ProteinModelPortalQ9Z2G7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101975039.

Organism-specific databases

CTD131890.

Phylogenomic databases

HOVERGENHBG004532.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR00717. GPCRKINASE.
SMARTSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGRK7_SPETR
AccessionPrimary (citable) accession number: Q9Z2G7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families