Reviewed,
UniProtKB/Swiss-Prot Q9Z2G7 (GRK7_SPETR)
Last modified
October 13, 2009.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: G protein-coupled receptor kinase 7 EC=2.7.11.16 Alternative name(s): G protein-coupled receptor kinase GRK7 | ||
| Gene names |
| ||
| Organism | Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) | ||
| Taxonomic identifier | 43179 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Sciuridae › Xerinae › Marmotini › Spermophilus |
Protein attributes
| Sequence length | 548 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Phosphorylates cone opsins thereby initiating their deactivation. |
| Catalytic activity | ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate. |
| Subcellular location | |
| Tissue specificity | Retina. Cones and rod. |
| Sequence similarities | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 RGS domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Sensory transduction Vision |
| Cellular component | Membrane |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| PTM | Lipoprotein Methylation Prenylation |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro response to stimulusInferred from electronic annotation. Source: UniProtKB-KW signal transductionInferred from electronic annotation. Source: InterPro visual perceptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW G-protein coupled receptor kinase activityInferred from electronic annotation. Source: EC signal transducer activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 545 | 545 | G protein-coupled receptor kinase 7 | PRO_0000024336 | |||||
| Propeptide | 546 – 548 | 3 | Removed in mature form By similarity | PRO_0000024337 | |||||
Regions | |||||||||
| Domain | 54 – 171 | 118 | RGS | ||||||
| Domain | 186 – 449 | 264 | Protein kinase | ||||||
| Domain | 450 – 515 | 66 | AGC-kinase C-terminal | ||||||
| Nucleotide binding | 192 – 200 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 311 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 215 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 545 | 1 | Cysteine methyl ester Potential | ||||||
| Lipidation | 545 | 1 | S-geranylgeranyl cysteine Potential | ||||||
Sequences
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References
| [1] | "The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas." Weiss E.R., Raman D., Shirakawa S., Ducceschi M.S., Bertram P.T., Wong F., Kraft T.W., Osawa S. Mol. Vis. 4:27-27(1998) [PubMed: 9852166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina. |
Cross-references
Sequence databases | |
|---|---|
| AF063016 mRNA. Translation: AAC95001.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GZK based on UniProtKB P31751. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9Z2G7. |
Phylogenomic databases | |
| HOVERGEN | Q9Z2G7. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.16. 277892. |
Family and domain databases | |
| InterPro | IPR000961. AGC-kinase_C. IPR000239. GPCR_kinase. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR000342. Regulat_G_prot_signal. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. PF00615. RGS. 1 hit. [Graphical view] |
| PRINTS | PR00717. GPCRKINASE. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00315. RGS. 1 hit. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS50132. RGS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GRK7_SPETR | ||||||||
| Accession | Primary (citable) accession number: Q9Z2G7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


