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Protein

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

Gene

Bnip3l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May function as a tumor suppressor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-MMU-6803204. TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.

Names & Taxonomyi

Protein namesi
Recommended name:
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
Alternative name(s):
NIP3-like protein X
Short name:
NIP3L
Gene namesi
Name:Bnip3l
Synonyms:Nix
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1332659. Bnip3l.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-likePRO_0000064958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611PhosphoserineCombined sources
Modified residuei116 – 1161PhosphoserineCombined sources
Modified residuei117 – 1171PhosphoserineCombined sources
Modified residuei119 – 1191PhosphoserineCombined sources
Modified residuei165 – 1651PhosphoserineBy similarity

Post-translational modificationi

Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Z2F7.
MaxQBiQ9Z2F7.
PaxDbiQ9Z2F7.
PRIDEiQ9Z2F7.

PTM databases

iPTMnetiQ9Z2F7.
PhosphoSiteiQ9Z2F7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022051.
CleanExiMM_BNIP3L.
ExpressionAtlasiQ9Z2F7. baseline and differential.
GenevisibleiQ9Z2F7. MM.

Interactioni

Subunit structurei

Self-associates. Interacts with BNIP3 and STEAP3. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains) (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951662EBI-1774669,EBI-712001From a different organism.
GABARAPL1Q9H0R84EBI-1774669,EBI-3464833From a different organism.
GABARAPL2P605202EBI-1774669,EBI-720116From a different organism.
MAP1LC3AQ9H4927EBI-1774669,EBI-720768From a different organism.
MAP1LC3BQ9GZQ85EBI-1774669,EBI-373144From a different organism.
Sh3rf1Q69ZI14EBI-1774669,EBI-957380

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9Z2F7. 7 interactions.
STRINGi10090.ENSMUSP00000022634.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2F7.
SMRiQ9Z2F7. Positions 177-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi125 – 14723BH3Add
BLAST

Sequence similaritiesi

Belongs to the NIP3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK24. Eukaryota.
ENOG4111HIM. LUCA.
GeneTreeiENSGT00390000013415.
HOGENOMiHOG000232139.
HOVERGENiHBG050707.
InParanoidiQ9Z2F7.
KOiK15465.
OMAiMVGGLEH.
OrthoDBiEOG091G0REJ.
PhylomeDBiQ9Z2F7.
TreeFamiTF315424.

Family and domain databases

InterProiIPR010548. BNIP3.
[Graphical view]
PfamiPF06553. BNIP3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLVEPPPP LHNNNNNCEE GEQPLPPPAG LNSSWVELPM NSSNGNENGN
60 70 80 90 100
GKNGGLEHVP SSSSIHNGDM EKILLDAQHE SGQSSSRGSS HCDSPSPQED
110 120 130 140 150
GQIMFDVEMH TSRDHSSQSE EEVVEGEKEV EALKKSADWV SDWSSRPENI
160 170 180 190 200
PPKEFHFRHP KRAASLSMRK SGAMKKGGIF SAEFLKVFIP SLFLSHVLAL
210
GLGIYIGKRL STPSASTY
Length:218
Mass (Da):23,766
Last modified:May 1, 1999 - v1
Checksum:iEAA839DEFDDE50D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067395 mRNA. Translation: AAD03588.1.
AK004667 mRNA. Translation: BAB23456.1.
AK007920 mRNA. Translation: BAB25351.1.
AK013467 mRNA. Translation: BAB28869.1.
AK018668 mRNA. Translation: BAB31334.1.
AK139950 mRNA. Translation: BAE24194.1.
AK155040 mRNA. Translation: BAE33007.1.
BC085237 mRNA. Translation: AAH85237.1.
CCDSiCCDS27227.1.
RefSeqiNP_033891.1. NM_009761.3.
UniGeneiMm.29820.
Mm.347081.

Genome annotation databases

EnsembliENSMUST00000022634; ENSMUSP00000022634; ENSMUSG00000022051.
GeneIDi12177.
KEGGimmu:12177.
UCSCiuc007uks.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067395 mRNA. Translation: AAD03588.1.
AK004667 mRNA. Translation: BAB23456.1.
AK007920 mRNA. Translation: BAB25351.1.
AK013467 mRNA. Translation: BAB28869.1.
AK018668 mRNA. Translation: BAB31334.1.
AK139950 mRNA. Translation: BAE24194.1.
AK155040 mRNA. Translation: BAE33007.1.
BC085237 mRNA. Translation: AAH85237.1.
CCDSiCCDS27227.1.
RefSeqiNP_033891.1. NM_009761.3.
UniGeneiMm.29820.
Mm.347081.

3D structure databases

ProteinModelPortaliQ9Z2F7.
SMRiQ9Z2F7. Positions 177-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2F7. 7 interactions.
STRINGi10090.ENSMUSP00000022634.

PTM databases

iPTMnetiQ9Z2F7.
PhosphoSiteiQ9Z2F7.

Proteomic databases

EPDiQ9Z2F7.
MaxQBiQ9Z2F7.
PaxDbiQ9Z2F7.
PRIDEiQ9Z2F7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022634; ENSMUSP00000022634; ENSMUSG00000022051.
GeneIDi12177.
KEGGimmu:12177.
UCSCiuc007uks.2. mouse.

Organism-specific databases

CTDi665.
MGIiMGI:1332659. Bnip3l.

Phylogenomic databases

eggNOGiENOG410IK24. Eukaryota.
ENOG4111HIM. LUCA.
GeneTreeiENSGT00390000013415.
HOGENOMiHOG000232139.
HOVERGENiHBG050707.
InParanoidiQ9Z2F7.
KOiK15465.
OMAiMVGGLEH.
OrthoDBiEOG091G0REJ.
PhylomeDBiQ9Z2F7.
TreeFamiTF315424.

Enzyme and pathway databases

ReactomeiR-MMU-6803204. TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.

Miscellaneous databases

PROiQ9Z2F7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022051.
CleanExiMM_BNIP3L.
ExpressionAtlasiQ9Z2F7. baseline and differential.
GenevisibleiQ9Z2F7. MM.

Family and domain databases

InterProiIPR010548. BNIP3.
[Graphical view]
PfamiPF06553. BNIP3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBNI3L_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2F7
Secondary accession number(s): Q545J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.