Reviewed,
UniProtKB/Swiss-Prot Q9Z2F6 (BCL3_MOUSE)
Last modified
November 24, 2009.
Version 69.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: B-cell lymphoma 3-encoded protein homolog Short name=Protein Bcl-3 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 440 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Could be a transcriptional activating factor. Functions as a form of I-kappa-B specific for NF-kappa-B p50 subunit inhibiting its translocation to the nucleus By similarity. |
| Subunit structure | Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2 and COPS5 By similarity. |
| Subcellular location | Nucleus By similarity. |
| Post-translational modification | Activated by phosphorylation By similarity. |
| Sequence similarities | Contains 7 ANK repeats. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 440 | 440 | B-cell lymphoma 3-encoded protein homolog | PRO_0000066977 | |||||
Regions | |||||||||
| Repeat | 121 – 153 | 33 | ANK 1 | ||||||
| Repeat | 158 – 187 | 30 | ANK 2 | ||||||
| Repeat | 191 – 220 | 30 | ANK 3 | ||||||
| Repeat | 228 – 257 | 30 | ANK 4 | ||||||
| Repeat | 262 – 291 | 30 | ANK 5 | ||||||
| Repeat | 295 – 324 | 30 | ANK 6 | ||||||
| Repeat | 325 – 354 | 30 | ANK 7 | ||||||
| Compositional bias | 350 – 437 | 88 | Pro/Ser-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 388 | 1 | Phosphoserine; by GSK3 By similarity | ||||||
| Modified residue | 392 | 1 | Phosphoserine; by GSK3 By similarity | ||||||
Sequences
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References
| [1] | "Interleukin-9 regulates NF-kappaB activity through BCL3 gene induction." Richard M., Louahed J., Demoulin J.-B., Renauld J.-C. Blood 93:4318-4327(1999) [PubMed: 10361130] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF067774 mRNA. Translation: AAC79694.1. | |
| IPI | IPI00131124. |
| RefSeq | NP_291079.2. |
| UniGene | Mm.439658 |
3D structure databases | |
| SMR | Q9Z2F6. Positions 120-347. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9Z2F6. 1 interaction. |
| STRING | Q9Z2F6. |
PTM databases | |
| PhosphoSite | Q9Z2F6. |
Proteomic databases | |
| PRIDE | Q9Z2F6. |
Genome annotation databases | |
| Ensembl | ENSMUST00000065454; ENSMUSP00000070884; ENSMUSG00000053175; Mus musculus. [Genome view] ENSMUST00000120537; ENSMUSP00000113851; ENSMUSG00000053175; Mus musculus. [Genome view] |
| GeneID | 12051. |
| KEGG | mmu:12051. |
| UCSC | uc009fnk.1. mouse. |
Organism-specific databases | |
| CTD | 12051. |
| MGI | MGI:88140. Bcl3. |
Phylogenomic databases | |
| HOGENOM | Q9Z2F6. |
| HOVERGEN | Q9Z2F6. |
| OMA | QHGGREL |
Gene expression databases | |
| ArrayExpress | Q9Z2F6. |
| Bgee | Q9Z2F6. |
| CleanEx | MM_BCL3. |
| Genevestigator | Q9Z2F6. |
| GermOnline | ENSMUSG00000053175. Mus musculus. |
Family and domain databases | |
| InterPro | IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view] |
| Gene3D | G3DSA:1.25.40.20. ANK. 1 hit. |
| Pfam | PF00023. Ank. 7 hits. [Graphical view] |
| SMART | SM00248. ANK. 6 hits. [Graphical view] |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 280347. |
| SOURCE | Search... |
Entry information
| Entry name | BCL3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9Z2F6 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


