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Q9Z2F6

- BCL3_MOUSE

UniProt

Q9Z2F6 - BCL3_MOUSE

Protein

B-cell lymphoma 3 protein homolog

Gene

Bcl3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit By similarity. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation.By similarity1 Publication

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. antimicrobial humoral response Source: MGI
    2. defense response to bacterium Source: MGI
    3. defense response to protozoan Source: MGI
    4. DNA damage response, signal transduction by p53 class mediator Source: Ensembl
    5. extracellular matrix organization Source: MGI
    6. follicular dendritic cell differentiation Source: MGI
    7. germinal center formation Source: MGI
    8. humoral immune response mediated by circulating immunoglobulin Source: MGI
    9. I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    10. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
    11. marginal zone B cell differentiation Source: MGI
    12. negative regulation of apoptotic process Source: MGI
    13. negative regulation of interleukin-8 biosynthetic process Source: Ensembl
    14. negative regulation of transcription, DNA-templated Source: Ensembl
    15. negative regulation of tumor necrosis factor biosynthetic process Source: MGI
    16. positive regulation of interferon-gamma production Source: MGI
    17. positive regulation of interleukin-10 biosynthetic process Source: MGI
    18. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    19. positive regulation of translation Source: Ensembl
    20. protein import into nucleus, translocation Source: Ensembl
    21. regulation of DNA binding Source: Ensembl
    22. regulation of NF-kappaB import into nucleus Source: Ensembl
    23. response to UV-C Source: Ensembl
    24. response to virus Source: Ensembl
    25. spleen development Source: MGI
    26. T-helper 1 type immune response Source: MGI
    27. T-helper 2 cell differentiation Source: MGI
    28. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B-cell lymphoma 3 protein homolog
    Short name:
    BCL-3
    Gene namesi
    Name:Bcl3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:88140. Bcl3.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication. Cytoplasmperinuclear region 1 Publication
    Note: Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation.

    GO - Cellular componenti

    1. Bcl3/NF-kappaB2 complex Source: Ensembl
    2. Bcl3-Bcl10 complex Source: Ensembl
    3. nucleus Source: UniProtKB-SubCell
    4. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448B-cell lymphoma 3 protein homologPRO_0000066977Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei396 – 3961Phosphoserine; by GSK3By similarity
    Modified residuei400 – 4001Phosphoserine; by GSK3By similarity

    Post-translational modificationi

    Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation.
    Activated by phosphorylation.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ9Z2F6.

    PTM databases

    PhosphoSiteiQ9Z2F6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Z2F6.
    BgeeiQ9Z2F6.
    CleanExiMM_BCL3.
    GenevestigatoriQ9Z2F6.

    Interactioni

    Subunit structurei

    Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR By similarity. Interacts with CYLD.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CyldQ80TQ25EBI-943884,EBI-943859

    Protein-protein interaction databases

    BioGridi198326. 3 interactions.
    IntActiQ9Z2F6. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2F6.
    SMRiQ9Z2F6. Positions 128-426.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati129 – 16133ANK 1Add
    BLAST
    Repeati166 – 19530ANK 2Add
    BLAST
    Repeati199 – 22830ANK 3Add
    BLAST
    Repeati236 – 26530ANK 4Add
    BLAST
    Repeati270 – 29930ANK 5Add
    BLAST
    Repeati303 – 33230ANK 6Add
    BLAST
    Repeati333 – 36230ANK 7Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi358 – 44588Pro/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 7 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    GeneTreeiENSGT00550000074527.
    HOGENOMiHOG000095189.
    HOVERGENiHBG108320.
    InParanoidiQ9Z2F6.
    KOiK09258.
    OMAiPLYPMMC.
    OrthoDBiEOG7W154S.
    PhylomeDBiQ9Z2F6.
    TreeFamiTF320166.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 6 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z2F6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRCPAGAMD EGPVDLRTRP KGTPGAALPL RKRPLRPASP EPATTRSPAG    50
    PLDALRSGCD VPVVPGPPHC VARPEALYYQ GPLMPIYSTP TMAPHFPLLN 100
    LPTHPYSMIC PMEHPLSADI AMATRVDEDG DTPLHIAVVQ NNIAAVYRIL 150
    SLFKLGSREV DVHNNLRQTP LHLAVITTLP DMVRLLVTAG ASPMALDRHG 200
    QTAIHLACEH RSPSCLQALL DSATSGSVDL EVRNYEGLTA LHVAVNTGCQ 250
    EAVLLLLERG ADIDAVDIKS GRSPLIHAVE NNSLNMVQLL LLHGANVNAQ 300
    MYSGSSALHS ASGRGLLPLV RTLVRSGADS GLKNCHNDTP LMVARSRRVI 350
    DILRGKASRA ASGSQPEPSP DQSATNSPES SSRLSSNGLQ SSPSSSPSLS 400
    PPKDAPGFPA TPQNFFLPTT STPAFLPFPG VLRGPGRPVP PSPAPGSS 448
    Length:448
    Mass (Da):47,216
    Last modified:April 20, 2010 - v2
    Checksum:i7665D28BBC3EE194
    GO

    Sequence cautioni

    The sequence AAC79694.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC149085 Genomic DNA. No translation available.
    AC149282 Genomic DNA. No translation available.
    AF067774 mRNA. Translation: AAC79694.1. Different initiation.
    CCDSiCCDS20914.2.
    RefSeqiNP_291079.2. NM_033601.3.
    UniGeneiMm.439658.

    Genome annotation databases

    EnsembliENSMUST00000120537; ENSMUSP00000113851; ENSMUSG00000053175.
    GeneIDi12051.
    KEGGimmu:12051.
    UCSCiuc009fnk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC149085 Genomic DNA. No translation available.
    AC149282 Genomic DNA. No translation available.
    AF067774 mRNA. Translation: AAC79694.1 . Different initiation.
    CCDSi CCDS20914.2.
    RefSeqi NP_291079.2. NM_033601.3.
    UniGenei Mm.439658.

    3D structure databases

    ProteinModelPortali Q9Z2F6.
    SMRi Q9Z2F6. Positions 128-426.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198326. 3 interactions.
    IntActi Q9Z2F6. 1 interaction.

    PTM databases

    PhosphoSitei Q9Z2F6.

    Proteomic databases

    PRIDEi Q9Z2F6.

    Protocols and materials databases

    DNASUi 12051.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000120537 ; ENSMUSP00000113851 ; ENSMUSG00000053175 .
    GeneIDi 12051.
    KEGGi mmu:12051.
    UCSCi uc009fnk.2. mouse.

    Organism-specific databases

    CTDi 602.
    MGIi MGI:88140. Bcl3.

    Phylogenomic databases

    eggNOGi COG0666.
    GeneTreei ENSGT00550000074527.
    HOGENOMi HOG000095189.
    HOVERGENi HBG108320.
    InParanoidi Q9Z2F6.
    KOi K09258.
    OMAi PLYPMMC.
    OrthoDBi EOG7W154S.
    PhylomeDBi Q9Z2F6.
    TreeFami TF320166.

    Miscellaneous databases

    NextBioi 280347.
    PROi Q9Z2F6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z2F6.
    Bgeei Q9Z2F6.
    CleanExi MM_BCL3.
    Genevestigatori Q9Z2F6.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 6 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Interleukin-9 regulates NF-kappaB activity through BCL3 gene induction."
      Richard M., Louahed J., Demoulin J.-B., Renauld J.-C.
      Blood 93:4318-4327(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    3. "Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling."
      Massoumi R., Chmielarska K., Hennecke K., Pfeifer A., Fassler R.
      Cell 125:665-677(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CYLD, SUBCELLULAR LOCATION.
    4. "CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin."
      Wickstrom S.A., Masoumi K.C., Khochbin S., Fassler R., Massoumi R.
      EMBO J. 29:131-144(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CYLD.

    Entry informationi

    Entry nameiBCL3_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z2F6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-9 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3