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Reviewed, UniProtKB/Swiss-Prot Q9Z2F6 (BCL3_MOUSE)

Last modified November 24, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    B-cell lymphoma 3-encoded protein homolog
      Short name=Protein Bcl-3
Gene names
Name: Bcl3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Could be a transcriptional activating factor. Functions as a form of I-kappa-B specific for NF-kappa-B p50 subunit inhibiting its translocation to the nucleus By similarity.

Subunit structure

Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2 and COPS5 By similarity.

Subcellular location

Nucleus By similarity.

Post-translational modification

Activated by phosphorylation By similarity.

Sequence similarities

Contains 7 ANK repeats.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainANK repeat
Repeat
   Molecular functionActivator
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological processT-helper 1 type immune response

Inferred from mutant phenotype. Source: MGI

T-helper 2 cell differentiation

Inferred from mutant phenotype. Source: MGI

antimicrobial humoral response

Inferred from mutant phenotype. Source: MGI

defense response to bacterium

Inferred from mutant phenotype. Source: MGI

defense response to protozoan

Inferred from mutant phenotype. Source: MGI

extracellular matrix organization

Inferred from mutant phenotype. Source: MGI

follicular dendritic cell differentiation

Inferred from mutant phenotype. Source: MGI

germinal center formation

Inferred from mutant phenotype. Source: MGI

humoral immune response mediated by circulating immunoglobulin

Inferred from mutant phenotype. Source: MGI

marginal zone B cell differentiation

Inferred from mutant phenotype. Source: MGI

negative regulation of apoptosis

Inferred from genetic interaction. Source: MGI

negative regulation of tumor necrosis factor biosynthetic process

Inferred from mutant phenotype. Source: MGI

positive regulation of interferon-gamma production

Inferred from mutant phenotype. Source: MGI

positive regulation of interleukin-10 biosynthetic process

Inferred from mutant phenotype. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay. Source: MGI

spleen development

Inferred from mutant phenotype. Source: MGI

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiontranscription factor activity

Inferred from direct assay. Source: MGI

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

CyldQ80TQ21EBI-943884,EBI-943859

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 440440B-cell lymphoma 3-encoded protein homolog
PRO_0000066977

Regions

Repeat121 – 15333ANK 1
Repeat158 – 18730ANK 2
Repeat191 – 22030ANK 3
Repeat228 – 25730ANK 4
Repeat262 – 29130ANK 5
Repeat295 – 32430ANK 6
Repeat325 – 35430ANK 7
Compositional bias350 – 43788Pro/Ser-rich

Amino acid modifications

Modified residue3881Phosphoserine; by GSK3 By similarity
Modified residue3921Phosphoserine; by GSK3 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9Z2F6-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 59F9B078CDAD8196

FASTA44046,432
        10         20         30         40         50         60 
MDEGPVDLRT RPKGTPGAAL PLRKRPLRPA SPEPATTRSP AGPLDALRSG CDVPVVPGPP 

        70         80         90        100        110        120 
HCVARPEALY YQGPLMPIYS TPTMAPHFPL LNLPTHPYSM ICPMEHPLSA DIAMATRVDE 

       130        140        150        160        170        180 
DGDTPLHIAV VQNNIAAVYR ILSLFKLGSR EVDVHNNLRQ TPLHLAVITT LPDMVRLLVT 

       190        200        210        220        230        240 
AGASPMALDR HGQTAIHLAC EHRSPSCLQA LLDSATSGSV DLEVRNYEGL TALHVAVNTG 

       250        260        270        280        290        300 
CQEAVLLLLE RGADIDAVDI KSGRSPLIHA VENNSLNMVQ LLLLHGANVN AQMYSGSSAL 

       310        320        330        340        350        360 
HSASGRGLLP LVRTLVRSGA DSGLKNCHND TPLMVARSRR VIDILRGKAS RAASGSQPEP 

       370        380        390        400        410        420 
SPDQSATNSP ESSSRLSSNG LQSSPSSSPS LSPPKDAPGF PATPQNFFLP TTSTPAFLPF 

       430        440 
PGVLRGPGRP VPPSPAPGSS

« Hide

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References

[1]"Interleukin-9 regulates NF-kappaB activity through BCL3 gene induction."
Richard M., Louahed J., Demoulin J.-B., Renauld J.-C.
Blood 93:4318-4327(1999) [PubMed: 10361130] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF067774 mRNA. Translation: AAC79694.1.
IPIIPI00131124.
RefSeqNP_291079.2.
UniGeneMm.439658

3D structure databases

SMRQ9Z2F6. Positions 120-347.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9Z2F6. 1 interaction.
STRINGQ9Z2F6.

PTM databases

PhosphoSiteQ9Z2F6.

Proteomic databases

PRIDEQ9Z2F6.

Genome annotation databases

EnsemblENSMUST00000065454; ENSMUSP00000070884; ENSMUSG00000053175; Mus musculus. [Genome view]
ENSMUST00000120537; ENSMUSP00000113851; ENSMUSG00000053175; Mus musculus. [Genome view]
GeneID12051.
KEGGmmu:12051.
UCSCuc009fnk.1. mouse.

Organism-specific databases

CTD12051.
MGIMGI:88140. Bcl3.

Phylogenomic databases

HOGENOMQ9Z2F6.
HOVERGENQ9Z2F6.
OMAQHGGREL

Gene expression databases

ArrayExpressQ9Z2F6.
BgeeQ9Z2F6.
CleanExMM_BCL3.
GenevestigatorQ9Z2F6.
GermOnlineENSMUSG00000053175. Mus musculus.

Family and domain databases

InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 1 hit.
PfamPF00023. Ank. 7 hits.
[Graphical view]
SMARTSM00248. ANK. 6 hits.
[Graphical view]
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio280347.
SOURCESearch...

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Entry information

Entry nameBCL3_MOUSE
AccessionPrimary (citable) accession number: Q9Z2F6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 1999
Last modified: November 24, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents