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Q9Z2F6 (BCL3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
B-cell lymphoma 3 protein homolog

Short name=BCL-3
Gene names
Name:Bcl3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit By similarity. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation. Ref.3

Subunit structure

Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR By similarity. Interacts with CYLD. Ref.3 Ref.4

Subcellular location

Nucleus. Cytoplasm. Cytoplasmperinuclear region. Note: Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Ref.3

Post-translational modification

Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation.

Activated by phosphorylation By similarity.

Sequence similarities

Contains 7 ANK repeats.

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.

Sequence caution

The sequence AAC79694.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   DomainANK repeat
Repeat
   Molecular functionActivator
   PTMPhosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA damage response, signal transduction by p53 class mediator

Inferred from electronic annotation. Source: Ensembl

I-kappaB kinase/NF-kappaB signaling

Inferred from electronic annotation. Source: Ensembl

T-helper 1 type immune response

Inferred from mutant phenotype PubMed 9009202. Source: MGI

T-helper 2 cell differentiation

Inferred from mutant phenotype PubMed 16081776. Source: MGI

antimicrobial humoral response

Inferred from mutant phenotype PubMed 9009202. Source: MGI

defense response to bacterium

Inferred from mutant phenotype PubMed 9009202. Source: MGI

defense response to protozoan

Inferred from mutant phenotype PubMed 9009202. Source: MGI

extracellular matrix organization

Inferred from mutant phenotype PubMed 10586052. Source: MGI

follicular dendritic cell differentiation

Inferred from mutant phenotype PubMed 10586052. Source: MGI

germinal center formation

Inferred from mutant phenotype PubMed 10586052PubMed 9009202PubMed 9133427. Source: MGI

humoral immune response mediated by circulating immunoglobulin

Inferred from mutant phenotype PubMed 9009202. Source: MGI

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Inferred from electronic annotation. Source: Ensembl

marginal zone B cell differentiation

Inferred from mutant phenotype PubMed 9009202. Source: MGI

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 16832056. Source: MGI

negative regulation of interleukin-8 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

negative regulation of tumor necrosis factor biosynthetic process

Inferred from mutant phenotype PubMed 15465827. Source: MGI

positive regulation of interferon-gamma production

Inferred from mutant phenotype PubMed 16790793. Source: MGI

positive regulation of interleukin-10 biosynthetic process

Inferred from mutant phenotype PubMed 15465827. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16081776. Source: MGI

positive regulation of translation

Inferred from electronic annotation. Source: Ensembl

protein import into nucleus, translocation

Inferred from electronic annotation. Source: Ensembl

regulation of DNA binding

Inferred from electronic annotation. Source: Ensembl

regulation of NF-kappaB import into nucleus

Inferred from electronic annotation. Source: Ensembl

response to UV-C

Inferred from electronic annotation. Source: Ensembl

response to virus

Inferred from electronic annotation. Source: Ensembl

spleen development

Inferred from mutant phenotype PubMed 10586052. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentBcl3-Bcl10 complex

Inferred from electronic annotation. Source: Ensembl

Bcl3/NF-kappaB2 complex

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from direct assay PubMed 16081776. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 16081776. Source: MGI

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CyldQ80TQ25EBI-943884,EBI-943859

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448B-cell lymphoma 3 protein homolog
PRO_0000066977

Regions

Repeat129 – 16133ANK 1
Repeat166 – 19530ANK 2
Repeat199 – 22830ANK 3
Repeat236 – 26530ANK 4
Repeat270 – 29930ANK 5
Repeat303 – 33230ANK 6
Repeat333 – 36230ANK 7
Compositional bias358 – 44588Pro/Ser-rich

Amino acid modifications

Modified residue3961Phosphoserine; by GSK3 By similarity
Modified residue4001Phosphoserine; by GSK3 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z2F6 [UniParc].

Last modified April 20, 2010. Version 2.
Checksum: 7665D28BBC3EE194

FASTA44847,216
        10         20         30         40         50         60 
MPRCPAGAMD EGPVDLRTRP KGTPGAALPL RKRPLRPASP EPATTRSPAG PLDALRSGCD 

        70         80         90        100        110        120 
VPVVPGPPHC VARPEALYYQ GPLMPIYSTP TMAPHFPLLN LPTHPYSMIC PMEHPLSADI 

       130        140        150        160        170        180 
AMATRVDEDG DTPLHIAVVQ NNIAAVYRIL SLFKLGSREV DVHNNLRQTP LHLAVITTLP 

       190        200        210        220        230        240 
DMVRLLVTAG ASPMALDRHG QTAIHLACEH RSPSCLQALL DSATSGSVDL EVRNYEGLTA 

       250        260        270        280        290        300 
LHVAVNTGCQ EAVLLLLERG ADIDAVDIKS GRSPLIHAVE NNSLNMVQLL LLHGANVNAQ 

       310        320        330        340        350        360 
MYSGSSALHS ASGRGLLPLV RTLVRSGADS GLKNCHNDTP LMVARSRRVI DILRGKASRA 

       370        380        390        400        410        420 
ASGSQPEPSP DQSATNSPES SSRLSSNGLQ SSPSSSPSLS PPKDAPGFPA TPQNFFLPTT 

       430        440 
STPAFLPFPG VLRGPGRPVP PSPAPGSS 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"Interleukin-9 regulates NF-kappaB activity through BCL3 gene induction."
Richard M., Louahed J., Demoulin J.-B., Renauld J.-C.
Blood 93:4318-4327(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[3]"Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling."
Massoumi R., Chmielarska K., Hennecke K., Pfeifer A., Fassler R.
Cell 125:665-677(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CYLD, SUBCELLULAR LOCATION.
[4]"CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin."
Wickstrom S.A., Masoumi K.C., Khochbin S., Fassler R., Massoumi R.
EMBO J. 29:131-144(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CYLD.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC149085 Genomic DNA. No translation available.
AC149282 Genomic DNA. No translation available.
AF067774 mRNA. Translation: AAC79694.1. Different initiation.
RefSeqNP_291079.2. NM_033601.3.
UniGeneMm.439658.

3D structure databases

ProteinModelPortalQ9Z2F6.
SMRQ9Z2F6. Positions 128-426.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198326. 3 interactions.
IntActQ9Z2F6. 1 interaction.

PTM databases

PhosphoSiteQ9Z2F6.

Proteomic databases

PRIDEQ9Z2F6.

Protocols and materials databases

DNASU12051.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000120537; ENSMUSP00000113851; ENSMUSG00000053175.
GeneID12051.
KEGGmmu:12051.
UCSCuc009fnk.2. mouse.

Organism-specific databases

CTD602.
MGIMGI:88140. Bcl3.

Phylogenomic databases

eggNOGCOG0666.
GeneTreeENSGT00550000074527.
HOGENOMHOG000095189.
HOVERGENHBG108320.
InParanoidQ9Z2F6.
KOK09258.
OMAPLYPMMC.
OrthoDBEOG7W154S.
PhylomeDBQ9Z2F6.
TreeFamTF320166.

Gene expression databases

ArrayExpressQ9Z2F6.
BgeeQ9Z2F6.
CleanExMM_BCL3.
GenevestigatorQ9Z2F6.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio280347.
PROQ9Z2F6.
SOURCESearch...

Entry information

Entry nameBCL3_MOUSE
AccessionPrimary (citable) accession number: Q9Z2F6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: April 20, 2010
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot