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Protein

Protein atonal homolog 7

Gene

Atoh7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor involved in the differentiation of most retinal ganglion cells, including those constituting the retino-hypothalamic tract.4 Publications

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • circadian rhythm Source: MGI
  • entrainment of circadian clock Source: MGI
  • neural retina development Source: MGI
  • optic nerve development Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein atonal homolog 7
Alternative name(s):
Helix-loop-helix protein mATH-5
Short name:
mATH5
Gene namesi
Name:Atoh7
Synonyms:Ath5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1355553. Atoh7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile. However, due to a lack of most retinal ganglion cells, they are blind and unable to entrain normally to light/dark cycles.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Protein atonal homolog 7PRO_0000292407Add
BLAST

Proteomic databases

PaxDbiQ9Z2E5.
PRIDEiQ9Z2E5.

PTM databases

PhosphoSiteiQ9Z2E5.

Expressioni

Developmental stagei

Expression initiates at E11 in the central optic cup and is detected in retinal progenitor cells until birth. Not expressed in the adult retina. In addition to the eye, only expressed in the developing tenth cranial ganglion between E13.5 and E15.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000036816.
CleanExiMM_ATOH7.
GenevisibleiQ9Z2E5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039801.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2E5.
SMRiQ9Z2E5. Positions 42-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 9353bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4395. Eukaryota.
ENOG411269K. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000034180.
HOVERGENiHBG094840.
InParanoidiQ9Z2E5.
KOiK09083.
OMAiHYLPFAG.
OrthoDBiEOG091G0R1N.
PhylomeDBiQ9Z2E5.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR032663. Atoh7.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR19290:SF99. PTHR19290:SF99. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSACKPHGP PAGARGAPPC AGAAERAVSC AGPGRLESAA RRRLAANARE
60 70 80 90 100
RRRMQGLNTA FDRLRRVVPQ WGQDKKLSKY ETLQMALSYI IALTRILAEA
110 120 130 140
ERDWVGLRCE QRGRDHPYLP FPGARLQVDP EPYGQRLFGF QPEPFPMAS
Length:149
Mass (Da):16,569
Last modified:May 1, 1999 - v1
Checksum:iDF78A25190B5FD3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071223 mRNA. Translation: AAC68868.1.
AF418923 Genomic DNA. Translation: AAL11912.1.
BC092234 mRNA. Translation: AAH92234.1.
CCDSiCCDS23896.1.
RefSeqiNP_058560.1. NM_016864.1.
UniGeneiMm.228661.

Genome annotation databases

EnsembliENSMUST00000044059; ENSMUSP00000039801; ENSMUSG00000036816.
GeneIDi53404.
KEGGimmu:53404.
UCSCiuc007fjv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071223 mRNA. Translation: AAC68868.1.
AF418923 Genomic DNA. Translation: AAL11912.1.
BC092234 mRNA. Translation: AAH92234.1.
CCDSiCCDS23896.1.
RefSeqiNP_058560.1. NM_016864.1.
UniGeneiMm.228661.

3D structure databases

ProteinModelPortaliQ9Z2E5.
SMRiQ9Z2E5. Positions 42-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039801.

PTM databases

PhosphoSiteiQ9Z2E5.

Proteomic databases

PaxDbiQ9Z2E5.
PRIDEiQ9Z2E5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044059; ENSMUSP00000039801; ENSMUSG00000036816.
GeneIDi53404.
KEGGimmu:53404.
UCSCiuc007fjv.1. mouse.

Organism-specific databases

CTDi220202.
MGIiMGI:1355553. Atoh7.

Phylogenomic databases

eggNOGiKOG4395. Eukaryota.
ENOG411269K. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000034180.
HOVERGENiHBG094840.
InParanoidiQ9Z2E5.
KOiK09083.
OMAiHYLPFAG.
OrthoDBiEOG091G0R1N.
PhylomeDBiQ9Z2E5.
TreeFamiTF315153.

Miscellaneous databases

PROiQ9Z2E5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036816.
CleanExiMM_ATOH7.
GenevisibleiQ9Z2E5. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR032663. Atoh7.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR19290:SF99. PTHR19290:SF99. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATOH7_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.