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Q9Z2D6 (MECP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methyl-CpG-binding protein 2

Short name=MeCp-2 protein
Short name=MeCp2
Gene names
Name:Mecp2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). Ref.11

Subunit structure

Interacts with CDKL5 and FNBP3. Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells. Ref.7 Ref.10

Subcellular location

Nucleus. Note: Colocalized with methyl-CpG in the genome. Ref.8 Ref.10

Post-translational modification

Phosphorylated on Ser-421 by CaMK2 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation. Does not seem to be phosphorylated on Ser-421 in other tissues. Ref.9

Sequence similarities

Contains 2 A.T hook DNA-binding domains.

Contains 1 MBD (methyl-CpG-binding) domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
   LigandDNA-binding
   Molecular functionRepressor
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadult locomotory behavior

Inferred from mutant phenotype PubMed 11242117PubMed 16467389. Source: MGI

behavioral fear response

Inferred from mutant phenotype PubMed 16199017PubMed 16467389. Source: MGI

brain development

Inferred from mutant phenotype PubMed 18571096. Source: MGI

cardiolipin metabolic process

Inferred from mutant phenotype PubMed 17237885. Source: MGI

catecholamine secretion

Inferred from mutant phenotype PubMed 17050729. Source: MGI

cellular biogenic amine metabolic process

Inferred from mutant phenotype PubMed 15975715. Source: MGI

cerebellum development

Inferred from mutant phenotype PubMed 18571096. Source: MGI

chromatin silencing

Inferred from mutant phenotype PubMed 15608638. Source: MGI

dendrite development

Inferred from mutant phenotype PubMed 15519245PubMed 17532643. Source: MGI

glucocorticoid metabolic process

Inferred from mutant phenotype PubMed 17108082. Source: MGI

glutamine metabolic process

Inferred from mutant phenotype PubMed 17237885. Source: MGI

histone acetylation

Inferred from mutant phenotype PubMed 15608638. Source: MGI

histone methylation

Inferred from mutant phenotype PubMed 15608638. Source: MGI

inositol metabolic process

Inferred from mutant phenotype PubMed 17237885. Source: MGI

learning

Inferred from mutant phenotype PubMed 16467389PubMed 18321864. Source: MGI

long-term memory

Inferred from mutant phenotype PubMed 16399702. Source: MGI

long-term synaptic potentiation

Inferred from mutant phenotype PubMed 16087343. Source: MGI

memory

Inferred from mutant phenotype PubMed 16399702. Source: MGI

mitochondrial electron transport, ubiquinol to cytochrome c

Inferred from mutant phenotype PubMed 16782889. Source: MGI

multicellular organismal response to stress

Inferred from mutant phenotype PubMed 17108082. Source: MGI

negative regulation of histone acetylation

Inferred from mutant phenotype PubMed 15757975. Source: MGI

negative regulation of histone methylation

Inferred from mutant phenotype PubMed 15757975. Source: MGI

negative regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 17997046. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 10888872PubMed 18511691. Source: MGI

neurological system process involved in regulation of systemic arterial blood pressure

Inferred from mutant phenotype PubMed 17544925. Source: MGI

neuromuscular process

Inferred from mutant phenotype PubMed 16199017PubMed 16467389. Source: MGI

neuromuscular process controlling posture

Inferred from mutant phenotype PubMed 11242117. Source: MGI

neuron differentiation

Inferred from mutant phenotype PubMed 15345242. Source: MGI

neuron maturation

Inferred from mutant phenotype PubMed 15519245PubMed 17532643PubMed 18295506. Source: MGI

neuron projection development

Inferred from mutant phenotype PubMed 15345242. Source: MGI

pathogenesis

Inferred from mutant phenotype PubMed 17997046. Source: MGI

phosphatidylcholine metabolic process

Inferred from mutant phenotype PubMed 17237885. Source: MGI

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 15939091. Source: MGI

positive regulation of synapse assembly

Inferred from mutant phenotype PubMed 17920015. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 16782889PubMed 18511691. Source: MGI

post-embryonic development

Inferred from mutant phenotype PubMed 16467389. Source: MGI

proprioception

Inferred from mutant phenotype PubMed 16467389PubMed 18321864. Source: MGI

protein localization

Inferred from mutant phenotype Ref.10. Source: MGI

regulation of excitatory postsynaptic membrane potential

Inferred from mutant phenotype PubMed 17920015. Source: MGI

regulation of gene expression

Inferred from direct assay PubMed 18203756. Source: MGI

regulation of gene expression by genetic imprinting

Inferred from mutant phenotype PubMed 15608638. Source: MGI

regulation of gene expression, epigenetic

Inferred from mutant phenotype PubMed 15757975PubMed 17532643. Source: MGI

regulation of respiratory gaseous exchange by neurological system process

Inferred from mutant phenotype PubMed 16354910PubMed 18321864. Source: MGI

regulation of synaptic plasticity

Inferred from mutant phenotype PubMed 16399702. Source: MGI

regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 16087343. Source: MGI

respiratory gaseous exchange

Inferred from mutant phenotype PubMed 11242117. Source: MGI

response to hypoxia

Inferred from mutant phenotype PubMed 17997046. Source: MGI

sensory perception of pain

Inferred from mutant phenotype PubMed 18321864. Source: MGI

social behavior

Inferred from mutant phenotype PubMed 16199017PubMed 18321864. Source: MGI

startle response

Inferred from mutant phenotype PubMed 18321864. Source: MGI

synapse assembly

Inferred from mutant phenotype PubMed 18295506. Source: MGI

synaptic transmission

Inferred from mutant phenotype PubMed 16399702. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

ventricular system development

Inferred from mutant phenotype PubMed 18571096. Source: MGI

visual learning

Inferred from mutant phenotype PubMed 16399702. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 17546630. Source: MGI

cytosol

Inferred from direct assay PubMed 15939091. Source: MGI

heterochromatin

Inferred from direct assay PubMed 14519686Ref.10. Source: MGI

nucleus

Inferred from direct assay PubMed 11809720PubMed 14593184Ref.8PubMed 15939091PubMed 16199017PubMed 17546630PubMed 17997046PubMed 18334558PubMed 18511691. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15608638PubMed 16782889PubMed 18511691. Source: MGI

chromatin binding

Inferred from direct assay PubMed 18334558. Source: MGI

double-stranded methylated DNA binding

Inferred from direct assay PubMed 14593184PubMed 15757975. Source: MGI

mRNA binding

Inferred from direct assay PubMed 15342650. Source: MGI

methyl-CpG binding

Inferred from direct assay PubMed 15342650PubMed 17108082. Source: MGI

protein binding

Inferred from physical interaction PubMed 15696166. Source: IntAct

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 16782889PubMed 18511691. Source: MGI

siRNA binding

Inferred from direct assay PubMed 15342650. Source: MGI

transcription factor binding

Inferred from physical interaction PubMed 14593184. Source: MGI

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Smarca2O358462EBI-1188816,EBI-371564

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q9Z2D6-1)

Also known as: Beta;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q9Z2D6-2)

Also known as: Alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MVAGMLGLR → MAAAAATAAAAAAPSGGGGGGEEERL
Note: Ten times higher expression levels than isoform A in brain (at protein level).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 484484Methyl-CpG-binding protein 2
PRO_0000096347

Regions

Domain90 – 16273MBD
DNA binding185 – 19713A.T hook 1 Ref.11
DNA binding265 – 27713A.T hook 2 Ref.11
Compositional bias366 – 3727His-rich
Compositional bias379 – 40325Pro-rich

Amino acid modifications

Modified residue801Phosphoserine By similarity
Modified residue1161Phosphoserine By similarity
Modified residue2161Phosphoserine By similarity
Modified residue2291Phosphoserine By similarity
Modified residue3211N6-acetyllysine Ref.12
Modified residue4211Phosphoserine; by CaMK2 Ref.9
Modified residue4241Phosphoserine By similarity
Modified residue4471N6-acetyllysine Ref.12

Natural variations

Alternative sequence1 – 99MVAGMLGLR → MAAAAATAAAAAAPSGGGGG GEEERL in isoform B.
VSP_022949

Experimental info

Sequence conflict3281L → P in BAE34602. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform A (Beta) [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 62FD228F0118A49F

FASTA48452,307
        10         20         30         40         50         60 
MVAGMLGLRE EKSEDQDLQG LRDKPLKFKK AKKDKKEDKE GKHEPLQPSA HHSAEPAEAG 

        70         80         90        100        110        120 
KAETSESSGS APAVPEASAS PKQRRSIIRD RGPMYDDPTL PEGWTRKLKQ RKSGRSAGKY 

       130        140        150        160        170        180 
DVYLINPQGK AFRSKVELIA YFEKVGDTSL DPNDFDFTVT GRGSPSRREQ KPPKKPKSPK 

       190        200        210        220        230        240 
APGTGRGRGR PKGSGTGRPK AAASEGVQVK RVLEKSPGKL VVKMPFQASP GGKGEGGGAT 

       250        260        270        280        290        300 
TSAQVMVIKR PGRKRKAEAD PQAIPKKRGR KPGSVVAAAA AEAKKKAVKE SSIRSVHETV 

       310        320        330        340        350        360 
LPIKKRKTRE TVSIEVKEVV KPLLVSTLGE KSGKGLKTCK SPGRKSKESS PKGRSSSASS 

       370        380        390        400        410        420 
PPKKEHHHHH HHSESTKAPM PLLPSPPPPE PESSEDPISP PEPQDLSSSI CKEEKMPRGG 

       430        440        450        460        470        480 
SLESDGCPKE PAKTQPMVAT TTTVAEKYKH RGEGERKDIV SSSMPRPNRE EPVDSRTPVT 


ERVS 

« Hide

Isoform B (Alpha) [UniParc].

Checksum: E88FC12C21F95F4C
Show »

FASTA50153,576

References

« Hide 'large scale' references
[1]"Identification and characterization of a family of mammalian methyl-CpG binding proteins."
Hendrich B., Bird A.
Mol. Cell. Biol. 18:6538-6547(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM A).
Strain: C57BL/6.
[2]"A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3'-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression."
Coy J.F., Sedlacek Z., Baechner D., Delius H., Poustka A.
Hum. Mol. Genet. 8:1253-1262(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM A).
[3]"Comparative analysis of the methyl CpG binding protein 2 locus in man and mouse reveals new untranslated sequences."
Reichwald K., Thiessen J., Wiehe T., Kioschis P., Straetling W.H., Rosenthal A., Platzer M.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM A).
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
Strain: C57BL/6J.
Tissue: Visual cortex.
[5]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Strain: FVB/N.
Tissue: Mammary gland.
[7]"FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands."
Bedford M.T., Chan D.C., Leder P.
EMBO J. 16:2376-2383(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FNBP3.
[8]"The major form of MeCP2 has a novel N-terminus generated by alternative splicing."
Kriaucionis S., Bird A.
Nucleic Acids Res. 32:1818-1823(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION (ISOFORM B), SUBCELLULAR LOCATION.
[9]"Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation."
Zhou Z., Hong E.J., Cohen S., Zhao W.-N., Ho H.H., Schmidt L., Chen W.G., Lin Y., Savner E., Griffith E.C., Hu L., Steen J.A.J., Weitz C.J., Greenberg M.E.
Neuron 52:255-269(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-421.
[10]"Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation."
Nan X., Hou J., Maclean A., Nasir J., Lafuente M.J., Shu X., Kriaucionis S., Bird A.
Proc. Natl. Acad. Sci. U.S.A. 104:2709-2714(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ATRX, SUBCELLULAR LOCATION.
[11]"Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives."
Spruijt C.G., Gnerlich F., Smits A.H., Pfaffeneder T., Jansen P.W., Bauer C., Munzel M., Wagner M., Muller M., Khan F., Eberl H.C., Mensinga A., Brinkman A.B., Lephikov K., Muller U., Walter J., Boelens R., van Ingen H. expand/collapse author list , Leonhardt H., Carell T., Vermeulen M.
Cell 152:1146-1159(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DNA-BINDING.
[12]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-321 AND LYS-447, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF072251 mRNA. Translation: AAC68880.1.
AJ132922 mRNA. Translation: CAB46495.1.
AF121351 Genomic DNA. No translation available.
AF158181 mRNA. Translation: AAF33024.1.
AK158664 mRNA. Translation: BAE34602.1.
AL672002 Genomic DNA. Translation: CAM18741.1.
AL672002 Genomic DNA. Translation: CAM18742.1.
BC027153 mRNA. Translation: AAH27153.1.
CCDSCCDS41016.1. [Q9Z2D6-2]
CCDS41017.1. [Q9Z2D6-1]
RefSeqNP_001075448.1. NM_001081979.1. [Q9Z2D6-2]
NP_034918.1. NM_010788.3. [Q9Z2D6-1]
XP_006527951.1. XM_006527888.1. [Q9Z2D6-1]
UniGeneMm.131408.
Mm.414303.

3D structure databases

ProteinModelPortalQ9Z2D6.
SMRQ9Z2D6. Positions 71-195.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201380. 10 interactions.
IntActQ9Z2D6. 4 interactions.
MINTMINT-225556.

PTM databases

PhosphoSiteQ9Z2D6.

Proteomic databases

MaxQBQ9Z2D6.
PaxDbQ9Z2D6.
PRIDEQ9Z2D6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033770; ENSMUSP00000033770; ENSMUSG00000031393. [Q9Z2D6-2]
ENSMUST00000100750; ENSMUSP00000098314; ENSMUSG00000031393. [Q9Z2D6-1]
ENSMUST00000170481; ENSMUSP00000127115; ENSMUSG00000031393. [Q9Z2D6-1]
GeneID17257.
KEGGmmu:17257.
UCSCuc009tnt.2. mouse. [Q9Z2D6-1]
uc009tnu.2. mouse. [Q9Z2D6-2]

Organism-specific databases

CTD4204.
MGIMGI:99918. Mecp2.

Phylogenomic databases

eggNOGNOG237320.
GeneTreeENSGT00530000063687.
HOGENOMHOG000015809.
HOVERGENHBG052445.
InParanoidB1AUZ3.
KOK11588.
OMAHETVLPI.
OrthoDBEOG71RXKS.
PhylomeDBQ9Z2D6.
TreeFamTF332974.

Gene expression databases

ArrayExpressQ9Z2D6.
BgeeQ9Z2D6.
CleanExMM_MECP2.
GenevestigatorQ9Z2D6.

Family and domain databases

Gene3D3.30.890.10. 1 hit.
InterProIPR017956. AT_hook_DNA-bd_motif.
IPR016177. DNA-bd_dom.
IPR017353. Me_CpG-bd_MeCP2.
IPR001739. Methyl_CpG_DNA-bd.
[Graphical view]
PfamPF01429. MBD. 1 hit.
[Graphical view]
PIRSFPIRSF038006. Methyl_CpG_bd_MeCP2. 1 hit.
SMARTSM00384. AT_hook. 2 hits.
SM00391. MBD. 1 hit.
[Graphical view]
SUPFAMSSF54171. SSF54171. 1 hit.
PROSITEPS50982. MBD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291736.
PROQ9Z2D6.
SOURCESearch...

Entry information

Entry nameMECP2_MOUSE
AccessionPrimary (citable) accession number: Q9Z2D6
Secondary accession number(s): B1AUZ2, B1AUZ3, Q3TYG1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot