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Q9Z2D6

- MECP2_MOUSE

UniProt

Q9Z2D6 - MECP2_MOUSE

Protein

Methyl-CpG-binding protein 2

Gene

Mecp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi185 – 19713A.T hook 1Add
    BLAST
    DNA bindingi265 – 27713A.T hook 2Add
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. double-stranded methylated DNA binding Source: MGI
    4. methyl-CpG binding Source: MGI
    5. mRNA binding Source: MGI
    6. protein binding Source: IntAct
    7. sequence-specific DNA binding transcription factor activity Source: MGI
    8. siRNA binding Source: MGI
    9. transcription factor binding Source: MGI

    GO - Biological processi

    1. adult locomotory behavior Source: MGI
    2. behavioral fear response Source: MGI
    3. brain development Source: MGI
    4. cardiolipin metabolic process Source: MGI
    5. catecholamine secretion Source: MGI
    6. cellular biogenic amine metabolic process Source: MGI
    7. cerebellum development Source: MGI
    8. chromatin silencing Source: MGI
    9. dendrite development Source: MGI
    10. glucocorticoid metabolic process Source: MGI
    11. glutamine metabolic process Source: MGI
    12. histone acetylation Source: MGI
    13. histone methylation Source: MGI
    14. inositol metabolic process Source: MGI
    15. learning Source: MGI
    16. long-term memory Source: MGI
    17. long-term synaptic potentiation Source: MGI
    18. memory Source: MGI
    19. mitochondrial electron transport, ubiquinol to cytochrome c Source: MGI
    20. multicellular organismal response to stress Source: MGI
    21. negative regulation of histone acetylation Source: MGI
    22. negative regulation of histone methylation Source: MGI
    23. negative regulation of neuron apoptotic process Source: MGI
    24. negative regulation of transcription, DNA-templated Source: MGI
    25. neurological system process involved in regulation of systemic arterial blood pressure Source: MGI
    26. neuromuscular process Source: MGI
    27. neuromuscular process controlling posture Source: MGI
    28. neuron differentiation Source: MGI
    29. neuron maturation Source: MGI
    30. neuron projection development Source: MGI
    31. pathogenesis Source: MGI
    32. phosphatidylcholine metabolic process Source: MGI
    33. positive regulation of cell proliferation Source: MGI
    34. positive regulation of synapse assembly Source: MGI
    35. positive regulation of transcription, DNA-templated Source: MGI
    36. post-embryonic development Source: MGI
    37. proprioception Source: MGI
    38. protein localization Source: MGI
    39. regulation of excitatory postsynaptic membrane potential Source: MGI
    40. regulation of gene expression Source: MGI
    41. regulation of gene expression, epigenetic Source: MGI
    42. regulation of gene expression by genetic imprinting Source: MGI
    43. regulation of respiratory gaseous exchange by neurological system process Source: MGI
    44. regulation of synaptic plasticity Source: MGI
    45. regulation of transcription, DNA-templated Source: MGI
    46. respiratory gaseous exchange Source: MGI
    47. response to hypoxia Source: MGI
    48. sensory perception of pain Source: MGI
    49. social behavior Source: MGI
    50. startle response Source: MGI
    51. synapse assembly Source: MGI
    52. synaptic transmission Source: MGI
    53. transcription, DNA-templated Source: UniProtKB-KW
    54. ventricular system development Source: MGI
    55. visual learning Source: MGI

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyl-CpG-binding protein 2
    Short name:
    MeCp-2 protein
    Short name:
    MeCp2
    Gene namesi
    Name:Mecp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:99918. Mecp2.

    Subcellular locationi

    Nucleus 2 Publications
    Note: Colocalized with methyl-CpG in the genome.

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. heterochromatin Source: MGI
    4. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Methyl-CpG-binding protein 2PRO_0000096347Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei80 – 801PhosphoserineBy similarity
    Modified residuei116 – 1161PhosphoserineBy similarity
    Modified residuei216 – 2161PhosphoserineBy similarity
    Modified residuei229 – 2291PhosphoserineBy similarity
    Modified residuei321 – 3211N6-acetyllysine1 Publication
    Modified residuei421 – 4211Phosphoserine; by CaMK21 Publication
    Modified residuei424 – 4241PhosphoserineBy similarity
    Modified residuei447 – 4471N6-acetyllysine1 Publication

    Post-translational modificationi

    Phosphorylated on Ser-421 by CaMK2 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation. Does not seem to be phosphorylated on Ser-421 in other tissues.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Z2D6.
    PaxDbiQ9Z2D6.
    PRIDEiQ9Z2D6.

    PTM databases

    PhosphoSiteiQ9Z2D6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Z2D6.
    BgeeiQ9Z2D6.
    CleanExiMM_MECP2.
    GenevestigatoriQ9Z2D6.

    Interactioni

    Subunit structurei

    Interacts with CDKL5 and FNBP3. Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AtrxQ616873EBI-1188816,EBI-2657527
    Smarca2O358462EBI-1188816,EBI-371564
    Smc1aQ9CU623EBI-1188816,EBI-2550016
    Smc3Q9CW033EBI-1188816,EBI-2550068

    Protein-protein interaction databases

    BioGridi201380. 10 interactions.
    IntActiQ9Z2D6. 7 interactions.
    MINTiMINT-225556.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2D6.
    SMRiQ9Z2D6. Positions 71-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini90 – 16273MBDPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi366 – 3727His-rich
    Compositional biasi379 – 40325Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 A.T hook DNA-binding domains.Curated
    Contains 1 MBD (methyl-CpG-binding) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG237320.
    GeneTreeiENSGT00530000063687.
    HOGENOMiHOG000015809.
    HOVERGENiHBG052445.
    InParanoidiB1AUZ3.
    KOiK11588.
    OMAiHETVLPI.
    OrthoDBiEOG71RXKS.
    PhylomeDBiQ9Z2D6.
    TreeFamiTF332974.

    Family and domain databases

    Gene3Di3.30.890.10. 1 hit.
    InterProiIPR017956. AT_hook_DNA-bd_motif.
    IPR016177. DNA-bd_dom.
    IPR017353. Me_CpG-bd_MeCP2.
    IPR001739. Methyl_CpG_DNA-bd.
    [Graphical view]
    PfamiPF01429. MBD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038006. Methyl_CpG_bd_MeCP2. 1 hit.
    SMARTiSM00384. AT_hook. 2 hits.
    SM00391. MBD. 1 hit.
    [Graphical view]
    SUPFAMiSSF54171. SSF54171. 1 hit.
    PROSITEiPS50982. MBD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q9Z2D6-1) [UniParc]FASTAAdd to Basket

    Also known as: Beta

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVAGMLGLRE EKSEDQDLQG LRDKPLKFKK AKKDKKEDKE GKHEPLQPSA    50
    HHSAEPAEAG KAETSESSGS APAVPEASAS PKQRRSIIRD RGPMYDDPTL 100
    PEGWTRKLKQ RKSGRSAGKY DVYLINPQGK AFRSKVELIA YFEKVGDTSL 150
    DPNDFDFTVT GRGSPSRREQ KPPKKPKSPK APGTGRGRGR PKGSGTGRPK 200
    AAASEGVQVK RVLEKSPGKL VVKMPFQASP GGKGEGGGAT TSAQVMVIKR 250
    PGRKRKAEAD PQAIPKKRGR KPGSVVAAAA AEAKKKAVKE SSIRSVHETV 300
    LPIKKRKTRE TVSIEVKEVV KPLLVSTLGE KSGKGLKTCK SPGRKSKESS 350
    PKGRSSSASS PPKKEHHHHH HHSESTKAPM PLLPSPPPPE PESSEDPISP 400
    PEPQDLSSSI CKEEKMPRGG SLESDGCPKE PAKTQPMVAT TTTVAEKYKH 450
    RGEGERKDIV SSSMPRPNRE EPVDSRTPVT ERVS 484
    Length:484
    Mass (Da):52,307
    Last modified:May 1, 1999 - v1
    Checksum:i62FD228F0118A49F
    GO
    Isoform B (identifier: Q9Z2D6-2) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: MVAGMLGLR → MAAAAATAAAAAAPSGGGGGGEEERL

    Note: Ten times higher expression levels than isoform A in brain (at protein level).

    Show »
    Length:501
    Mass (Da):53,576
    Checksum:iE88FC12C21F95F4C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti328 – 3281L → P in BAE34602. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 99MVAGMLGLR → MAAAAATAAAAAAPSGGGGG GEEERL in isoform B. 1 PublicationVSP_022949

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF072251 mRNA. Translation: AAC68880.1.
    AJ132922 mRNA. Translation: CAB46495.1.
    AF121351 Genomic DNA. No translation available.
    AF158181 mRNA. Translation: AAF33024.1.
    AK158664 mRNA. Translation: BAE34602.1.
    AL672002 Genomic DNA. Translation: CAM18741.1.
    AL672002 Genomic DNA. Translation: CAM18742.1.
    BC027153 mRNA. Translation: AAH27153.1.
    CCDSiCCDS41016.1. [Q9Z2D6-2]
    CCDS41017.1. [Q9Z2D6-1]
    RefSeqiNP_001075448.1. NM_001081979.1. [Q9Z2D6-2]
    NP_034918.1. NM_010788.3. [Q9Z2D6-1]
    XP_006527951.1. XM_006527888.1. [Q9Z2D6-1]
    UniGeneiMm.131408.
    Mm.414303.

    Genome annotation databases

    EnsembliENSMUST00000033770; ENSMUSP00000033770; ENSMUSG00000031393. [Q9Z2D6-2]
    ENSMUST00000100750; ENSMUSP00000098314; ENSMUSG00000031393. [Q9Z2D6-1]
    ENSMUST00000170481; ENSMUSP00000127115; ENSMUSG00000031393. [Q9Z2D6-1]
    GeneIDi17257.
    KEGGimmu:17257.
    UCSCiuc009tnt.2. mouse. [Q9Z2D6-1]
    uc009tnu.2. mouse. [Q9Z2D6-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF072251 mRNA. Translation: AAC68880.1 .
    AJ132922 mRNA. Translation: CAB46495.1 .
    AF121351 Genomic DNA. No translation available.
    AF158181 mRNA. Translation: AAF33024.1 .
    AK158664 mRNA. Translation: BAE34602.1 .
    AL672002 Genomic DNA. Translation: CAM18741.1 .
    AL672002 Genomic DNA. Translation: CAM18742.1 .
    BC027153 mRNA. Translation: AAH27153.1 .
    CCDSi CCDS41016.1. [Q9Z2D6-2 ]
    CCDS41017.1. [Q9Z2D6-1 ]
    RefSeqi NP_001075448.1. NM_001081979.1. [Q9Z2D6-2 ]
    NP_034918.1. NM_010788.3. [Q9Z2D6-1 ]
    XP_006527951.1. XM_006527888.1. [Q9Z2D6-1 ]
    UniGenei Mm.131408.
    Mm.414303.

    3D structure databases

    ProteinModelPortali Q9Z2D6.
    SMRi Q9Z2D6. Positions 71-195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201380. 10 interactions.
    IntActi Q9Z2D6. 7 interactions.
    MINTi MINT-225556.

    PTM databases

    PhosphoSitei Q9Z2D6.

    Proteomic databases

    MaxQBi Q9Z2D6.
    PaxDbi Q9Z2D6.
    PRIDEi Q9Z2D6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033770 ; ENSMUSP00000033770 ; ENSMUSG00000031393 . [Q9Z2D6-2 ]
    ENSMUST00000100750 ; ENSMUSP00000098314 ; ENSMUSG00000031393 . [Q9Z2D6-1 ]
    ENSMUST00000170481 ; ENSMUSP00000127115 ; ENSMUSG00000031393 . [Q9Z2D6-1 ]
    GeneIDi 17257.
    KEGGi mmu:17257.
    UCSCi uc009tnt.2. mouse. [Q9Z2D6-1 ]
    uc009tnu.2. mouse. [Q9Z2D6-2 ]

    Organism-specific databases

    CTDi 4204.
    MGIi MGI:99918. Mecp2.

    Phylogenomic databases

    eggNOGi NOG237320.
    GeneTreei ENSGT00530000063687.
    HOGENOMi HOG000015809.
    HOVERGENi HBG052445.
    InParanoidi B1AUZ3.
    KOi K11588.
    OMAi HETVLPI.
    OrthoDBi EOG71RXKS.
    PhylomeDBi Q9Z2D6.
    TreeFami TF332974.

    Miscellaneous databases

    NextBioi 291736.
    PROi Q9Z2D6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z2D6.
    Bgeei Q9Z2D6.
    CleanExi MM_MECP2.
    Genevestigatori Q9Z2D6.

    Family and domain databases

    Gene3Di 3.30.890.10. 1 hit.
    InterProi IPR017956. AT_hook_DNA-bd_motif.
    IPR016177. DNA-bd_dom.
    IPR017353. Me_CpG-bd_MeCP2.
    IPR001739. Methyl_CpG_DNA-bd.
    [Graphical view ]
    Pfami PF01429. MBD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038006. Methyl_CpG_bd_MeCP2. 1 hit.
    SMARTi SM00384. AT_hook. 2 hits.
    SM00391. MBD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54171. SSF54171. 1 hit.
    PROSITEi PS50982. MBD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a family of mammalian methyl-CpG binding proteins."
      Hendrich B., Bird A.
      Mol. Cell. Biol. 18:6538-6547(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM A).
      Strain: C57BL/6.
    2. "A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3'-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression."
      Coy J.F., Sedlacek Z., Baechner D., Delius H., Poustka A.
      Hum. Mol. Genet. 8:1253-1262(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM A).
    3. "Comparative analysis of the methyl CpG binding protein 2 locus in man and mouse reveals new untranslated sequences."
      Reichwald K., Thiessen J., Wiehe T., Kioschis P., Straetling W.H., Rosenthal A., Platzer M.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM A).
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
      Strain: C57BL/6J.
      Tissue: Visual cortex.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Strain: FVB/N.
      Tissue: Mammary gland.
    7. "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands."
      Bedford M.T., Chan D.C., Leder P.
      EMBO J. 16:2376-2383(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FNBP3.
    8. "The major form of MeCP2 has a novel N-terminus generated by alternative splicing."
      Kriaucionis S., Bird A.
      Nucleic Acids Res. 32:1818-1823(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION (ISOFORM B), SUBCELLULAR LOCATION.
    9. "Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation."
      Zhou Z., Hong E.J., Cohen S., Zhao W.-N., Ho H.H., Schmidt L., Chen W.G., Lin Y., Savner E., Griffith E.C., Hu L., Steen J.A.J., Weitz C.J., Greenberg M.E.
      Neuron 52:255-269(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-421.
    10. "Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation."
      Nan X., Hou J., Maclean A., Nasir J., Lafuente M.J., Shu X., Kriaucionis S., Bird A.
      Proc. Natl. Acad. Sci. U.S.A. 104:2709-2714(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATRX, SUBCELLULAR LOCATION.
    11. Cited for: FUNCTION, DNA-BINDING.
    12. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-321 AND LYS-447, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiMECP2_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z2D6
    Secondary accession number(s): B1AUZ2, B1AUZ3, Q3TYG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3