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Q9Z2D6

- MECP2_MOUSE

UniProt

Q9Z2D6 - MECP2_MOUSE

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Protein

Methyl-CpG-binding protein 2

Gene

Mecp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi185 – 19713A.T hook 1Add
BLAST
DNA bindingi265 – 27713A.T hook 2Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. double-stranded methylated DNA binding Source: MGI
  4. methyl-CpG binding Source: MGI
  5. mRNA binding Source: MGI
  6. sequence-specific DNA binding transcription factor activity Source: MGI
  7. siRNA binding Source: MGI
  8. transcription factor binding Source: MGI

GO - Biological processi

  1. adult locomotory behavior Source: MGI
  2. behavioral fear response Source: MGI
  3. brain development Source: MGI
  4. cardiolipin metabolic process Source: MGI
  5. catecholamine secretion Source: MGI
  6. cellular biogenic amine metabolic process Source: MGI
  7. cerebellum development Source: MGI
  8. chromatin silencing Source: MGI
  9. dendrite development Source: MGI
  10. glucocorticoid metabolic process Source: MGI
  11. glutamine metabolic process Source: MGI
  12. histone acetylation Source: MGI
  13. histone methylation Source: MGI
  14. inositol metabolic process Source: MGI
  15. learning Source: MGI
  16. long-term memory Source: MGI
  17. long-term synaptic potentiation Source: MGI
  18. memory Source: MGI
  19. mitochondrial electron transport, ubiquinol to cytochrome c Source: MGI
  20. multicellular organismal response to stress Source: MGI
  21. negative regulation of histone acetylation Source: MGI
  22. negative regulation of histone methylation Source: MGI
  23. negative regulation of neuron apoptotic process Source: MGI
  24. negative regulation of transcription, DNA-templated Source: MGI
  25. neurological system process involved in regulation of systemic arterial blood pressure Source: MGI
  26. neuromuscular process Source: MGI
  27. neuromuscular process controlling posture Source: MGI
  28. neuron differentiation Source: MGI
  29. neuron maturation Source: MGI
  30. neuron projection development Source: MGI
  31. pathogenesis Source: MGI
  32. phosphatidylcholine metabolic process Source: MGI
  33. positive regulation of cell proliferation Source: MGI
  34. positive regulation of synapse assembly Source: MGI
  35. positive regulation of transcription, DNA-templated Source: MGI
  36. post-embryonic development Source: MGI
  37. proprioception Source: MGI
  38. protein localization Source: MGI
  39. regulation of excitatory postsynaptic membrane potential Source: MGI
  40. regulation of gene expression Source: MGI
  41. regulation of gene expression, epigenetic Source: MGI
  42. regulation of gene expression by genetic imprinting Source: MGI
  43. regulation of respiratory gaseous exchange by neurological system process Source: MGI
  44. regulation of synaptic plasticity Source: MGI
  45. regulation of transcription, DNA-templated Source: MGI
  46. respiratory gaseous exchange Source: MGI
  47. response to hypoxia Source: MGI
  48. sensory perception of pain Source: MGI
  49. social behavior Source: MGI
  50. startle response Source: MGI
  51. synapse assembly Source: MGI
  52. synaptic transmission Source: MGI
  53. transcription, DNA-templated Source: UniProtKB-KW
  54. ventricular system development Source: MGI
  55. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-CpG-binding protein 2
Short name:
MeCp-2 protein
Short name:
MeCp2
Gene namesi
Name:Mecp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:99918. Mecp2.

Subcellular locationi

Nucleus 2 Publications
Note: Colocalized with methyl-CpG in the genome.

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. extracellular space Source: Ensembl
  4. heterochromatin Source: MGI
  5. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Methyl-CpG-binding protein 2PRO_0000096347Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801PhosphoserineBy similarity
Modified residuei116 – 1161PhosphoserineBy similarity
Modified residuei216 – 2161PhosphoserineBy similarity
Modified residuei229 – 2291PhosphoserineBy similarity
Modified residuei321 – 3211N6-acetyllysine1 Publication
Modified residuei421 – 4211Phosphoserine; by CaMK21 Publication
Modified residuei424 – 4241PhosphoserineBy similarity
Modified residuei447 – 4471N6-acetyllysine1 Publication

Post-translational modificationi

Phosphorylated on Ser-421 by CaMK2 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation. Does not seem to be phosphorylated on Ser-421 in other tissues.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Z2D6.
PaxDbiQ9Z2D6.
PRIDEiQ9Z2D6.

PTM databases

PhosphoSiteiQ9Z2D6.

Expressioni

Gene expression databases

BgeeiQ9Z2D6.
CleanExiMM_MECP2.
ExpressionAtlasiQ9Z2D6. baseline and differential.
GenevestigatoriQ9Z2D6.

Interactioni

Subunit structurei

Interacts with CDKL5 and FNBP3. Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AtrxQ616873EBI-1188816,EBI-2657527
Smarca2O358462EBI-1188816,EBI-371564
Smc1aQ9CU623EBI-1188816,EBI-2550016
Smc3Q9CW033EBI-1188816,EBI-2550068

Protein-protein interaction databases

BioGridi201380. 10 interactions.
IntActiQ9Z2D6. 7 interactions.
MINTiMINT-225556.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2D6.
SMRiQ9Z2D6. Positions 71-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 16273MBDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi366 – 3727His-rich
Compositional biasi379 – 40325Pro-richAdd
BLAST

Sequence similaritiesi

Contains 2 A.T hook DNA-binding domains.Curated
Contains 1 MBD (methyl-CpG-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG237320.
GeneTreeiENSGT00530000063687.
HOGENOMiHOG000015809.
HOVERGENiHBG052445.
InParanoidiQ9Z2D6.
KOiK11588.
OMAiHETVLPI.
OrthoDBiEOG71RXKS.
PhylomeDBiQ9Z2D6.
TreeFamiTF332974.

Family and domain databases

Gene3Di3.30.890.10. 1 hit.
InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR016177. DNA-bd_dom.
IPR017353. Me_CpG-bd_MeCP2.
IPR001739. Methyl_CpG_DNA-bd.
[Graphical view]
PfamiPF01429. MBD. 1 hit.
[Graphical view]
PIRSFiPIRSF038006. Methyl_CpG_bd_MeCP2. 1 hit.
SMARTiSM00384. AT_hook. 2 hits.
SM00391. MBD. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS50982. MBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q9Z2D6-1) [UniParc]FASTAAdd to Basket

Also known as: Beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAGMLGLRE EKSEDQDLQG LRDKPLKFKK AKKDKKEDKE GKHEPLQPSA
60 70 80 90 100
HHSAEPAEAG KAETSESSGS APAVPEASAS PKQRRSIIRD RGPMYDDPTL
110 120 130 140 150
PEGWTRKLKQ RKSGRSAGKY DVYLINPQGK AFRSKVELIA YFEKVGDTSL
160 170 180 190 200
DPNDFDFTVT GRGSPSRREQ KPPKKPKSPK APGTGRGRGR PKGSGTGRPK
210 220 230 240 250
AAASEGVQVK RVLEKSPGKL VVKMPFQASP GGKGEGGGAT TSAQVMVIKR
260 270 280 290 300
PGRKRKAEAD PQAIPKKRGR KPGSVVAAAA AEAKKKAVKE SSIRSVHETV
310 320 330 340 350
LPIKKRKTRE TVSIEVKEVV KPLLVSTLGE KSGKGLKTCK SPGRKSKESS
360 370 380 390 400
PKGRSSSASS PPKKEHHHHH HHSESTKAPM PLLPSPPPPE PESSEDPISP
410 420 430 440 450
PEPQDLSSSI CKEEKMPRGG SLESDGCPKE PAKTQPMVAT TTTVAEKYKH
460 470 480
RGEGERKDIV SSSMPRPNRE EPVDSRTPVT ERVS
Length:484
Mass (Da):52,307
Last modified:May 1, 1999 - v1
Checksum:i62FD228F0118A49F
GO
Isoform B (identifier: Q9Z2D6-2) [UniParc]FASTAAdd to Basket

Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MVAGMLGLR → MAAAAATAAAAAAPSGGGGGGEEERL

Note: Ten times higher expression levels than isoform A in brain (at protein level).

Show »
Length:501
Mass (Da):53,576
Checksum:iE88FC12C21F95F4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti328 – 3281L → P in BAE34602. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 99MVAGMLGLR → MAAAAATAAAAAAPSGGGGG GEEERL in isoform B. 1 PublicationVSP_022949

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072251 mRNA. Translation: AAC68880.1.
AJ132922 mRNA. Translation: CAB46495.1.
AF121351 Genomic DNA. No translation available.
AF158181 mRNA. Translation: AAF33024.1.
AK158664 mRNA. Translation: BAE34602.1.
AL672002 Genomic DNA. Translation: CAM18741.1.
AL672002 Genomic DNA. Translation: CAM18742.1.
BC027153 mRNA. Translation: AAH27153.1.
CCDSiCCDS41016.1. [Q9Z2D6-2]
CCDS41017.1. [Q9Z2D6-1]
RefSeqiNP_001075448.1. NM_001081979.2. [Q9Z2D6-2]
NP_034918.1. NM_010788.4. [Q9Z2D6-1]
XP_006527951.1. XM_006527888.1. [Q9Z2D6-1]
UniGeneiMm.131408.
Mm.414303.

Genome annotation databases

EnsembliENSMUST00000033770; ENSMUSP00000033770; ENSMUSG00000031393. [Q9Z2D6-2]
ENSMUST00000100750; ENSMUSP00000098314; ENSMUSG00000031393. [Q9Z2D6-1]
ENSMUST00000170481; ENSMUSP00000127115; ENSMUSG00000031393. [Q9Z2D6-1]
GeneIDi17257.
KEGGimmu:17257.
UCSCiuc009tnt.2. mouse. [Q9Z2D6-1]
uc009tnu.2. mouse. [Q9Z2D6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF072251 mRNA. Translation: AAC68880.1 .
AJ132922 mRNA. Translation: CAB46495.1 .
AF121351 Genomic DNA. No translation available.
AF158181 mRNA. Translation: AAF33024.1 .
AK158664 mRNA. Translation: BAE34602.1 .
AL672002 Genomic DNA. Translation: CAM18741.1 .
AL672002 Genomic DNA. Translation: CAM18742.1 .
BC027153 mRNA. Translation: AAH27153.1 .
CCDSi CCDS41016.1. [Q9Z2D6-2 ]
CCDS41017.1. [Q9Z2D6-1 ]
RefSeqi NP_001075448.1. NM_001081979.2. [Q9Z2D6-2 ]
NP_034918.1. NM_010788.4. [Q9Z2D6-1 ]
XP_006527951.1. XM_006527888.1. [Q9Z2D6-1 ]
UniGenei Mm.131408.
Mm.414303.

3D structure databases

ProteinModelPortali Q9Z2D6.
SMRi Q9Z2D6. Positions 71-195.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201380. 10 interactions.
IntActi Q9Z2D6. 7 interactions.
MINTi MINT-225556.

PTM databases

PhosphoSitei Q9Z2D6.

Proteomic databases

MaxQBi Q9Z2D6.
PaxDbi Q9Z2D6.
PRIDEi Q9Z2D6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033770 ; ENSMUSP00000033770 ; ENSMUSG00000031393 . [Q9Z2D6-2 ]
ENSMUST00000100750 ; ENSMUSP00000098314 ; ENSMUSG00000031393 . [Q9Z2D6-1 ]
ENSMUST00000170481 ; ENSMUSP00000127115 ; ENSMUSG00000031393 . [Q9Z2D6-1 ]
GeneIDi 17257.
KEGGi mmu:17257.
UCSCi uc009tnt.2. mouse. [Q9Z2D6-1 ]
uc009tnu.2. mouse. [Q9Z2D6-2 ]

Organism-specific databases

CTDi 4204.
MGIi MGI:99918. Mecp2.

Phylogenomic databases

eggNOGi NOG237320.
GeneTreei ENSGT00530000063687.
HOGENOMi HOG000015809.
HOVERGENi HBG052445.
InParanoidi Q9Z2D6.
KOi K11588.
OMAi HETVLPI.
OrthoDBi EOG71RXKS.
PhylomeDBi Q9Z2D6.
TreeFami TF332974.

Miscellaneous databases

NextBioi 291736.
PROi Q9Z2D6.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z2D6.
CleanExi MM_MECP2.
ExpressionAtlasi Q9Z2D6. baseline and differential.
Genevestigatori Q9Z2D6.

Family and domain databases

Gene3Di 3.30.890.10. 1 hit.
InterProi IPR017956. AT_hook_DNA-bd_motif.
IPR016177. DNA-bd_dom.
IPR017353. Me_CpG-bd_MeCP2.
IPR001739. Methyl_CpG_DNA-bd.
[Graphical view ]
Pfami PF01429. MBD. 1 hit.
[Graphical view ]
PIRSFi PIRSF038006. Methyl_CpG_bd_MeCP2. 1 hit.
SMARTi SM00384. AT_hook. 2 hits.
SM00391. MBD. 1 hit.
[Graphical view ]
SUPFAMi SSF54171. SSF54171. 1 hit.
PROSITEi PS50982. MBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a family of mammalian methyl-CpG binding proteins."
    Hendrich B., Bird A.
    Mol. Cell. Biol. 18:6538-6547(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM A).
    Strain: C57BL/6.
  2. "A complex pattern of evolutionary conservation and alternative polyadenylation within the long 3'-untranslated region of the methyl-CpG-binding protein 2 gene (MeCP2) suggests a regulatory role in gene expression."
    Coy J.F., Sedlacek Z., Baechner D., Delius H., Poustka A.
    Hum. Mol. Genet. 8:1253-1262(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM A).
  3. "Comparative analysis of the methyl CpG binding protein 2 locus in man and mouse reveals new untranslated sequences."
    Reichwald K., Thiessen J., Wiehe T., Kioschis P., Straetling W.H., Rosenthal A., Platzer M.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM A).
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    Strain: C57BL/6J.
    Tissue: Visual cortex.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: FVB/N.
    Tissue: Mammary gland.
  7. "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands."
    Bedford M.T., Chan D.C., Leder P.
    EMBO J. 16:2376-2383(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FNBP3.
  8. "The major form of MeCP2 has a novel N-terminus generated by alternative splicing."
    Kriaucionis S., Bird A.
    Nucleic Acids Res. 32:1818-1823(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION (ISOFORM B), SUBCELLULAR LOCATION.
  9. "Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation."
    Zhou Z., Hong E.J., Cohen S., Zhao W.-N., Ho H.H., Schmidt L., Chen W.G., Lin Y., Savner E., Griffith E.C., Hu L., Steen J.A.J., Weitz C.J., Greenberg M.E.
    Neuron 52:255-269(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-421.
  10. "Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation."
    Nan X., Hou J., Maclean A., Nasir J., Lafuente M.J., Shu X., Kriaucionis S., Bird A.
    Proc. Natl. Acad. Sci. U.S.A. 104:2709-2714(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATRX, SUBCELLULAR LOCATION.
  11. Cited for: FUNCTION, DNA-BINDING.
  12. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-321 AND LYS-447, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiMECP2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2D6
Secondary accession number(s): B1AUZ2, B1AUZ3, Q3TYG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3