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Protein

Non-syndromic hearing impairment protein 5 homolog

Gene

Dfna5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Non-syndromic hearing impairment protein 5 homolog
Gene namesi
Name:Dfna5
Synonyms:Dfna5h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1889850. Dfna5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Non-syndromic hearing impairment protein 5 homologPRO_0000148179Add
BLAST

Proteomic databases

MaxQBiQ9Z2D3.
PaxDbiQ9Z2D3.
PRIDEiQ9Z2D3.

PTM databases

PhosphoSiteiQ9Z2D3.

Expressioni

Gene expression databases

BgeeiQ9Z2D3.
ExpressionAtlasiQ9Z2D3. baseline and differential.
GenevestigatoriQ9Z2D3.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gasdermin family.Curated

Phylogenomic databases

eggNOGiNOG40145.
GeneTreeiENSGT00530000063574.
HOGENOMiHOG000065726.
HOVERGENiHBG051340.
InParanoidiQ9Z2D3.
OMAiVVVESDF.
PhylomeDBiQ9Z2D3.
TreeFamiTF352821.

Family and domain databases

InterProiIPR007677. Gasdermin.
[Graphical view]
PfamiPF04598. Gasdermin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAKATRNFL KEVDAGGDLI SVSHLNDSDK LQLLSLVTKK KRYWCWQRPK
60 70 80 90 100
YQILSATLED VLTEGHCLSP VVVESDFVKY ESKCENHKSG AIGTVVGKVK
110 120 130 140 150
LNVGGKGVVE SHSSFGTLRK QEVDVQQLIQ DAVKRTVNMD NLVLQQVLES
160 170 180 190 200
RNEVLCVLTQ KIMTTQKCVI SEHVQSEETC GGMVGIQTKT IQVSATEDGT
210 220 230 240 250
VTTDTNVVLE IPAATTIAYG IMELFVKQDG QFEFCLLQGK HGGFEHERKL
260 270 280 290 300
DSVYLDPLAY REFAFLDMLD GGQGISSQDG PLRVVKQATL HLERSFHPFA
310 320 330 340 350
VLPAQQQRAL FCVLQKILFD EELLRALEQV CDDVAGGLWS SQAVLAMEEL
360 370 380 390 400
TDSQQQDLTA FLQLVGYRIQ GEHPGPQDEV SNQKLFATAY FLVSALAEMP
410 420 430 440 450
DNATVFLGTC CKLHVISSLC CLLHALSDDS VCDFHNPTLA PLRDTERFGI
460 470 480 490 500
VQRLFASADI ALERMQFSAK ATILKDSCIF PLILHITLSG LSTLSKEHEE
510
ELCQSGHATG QD
Length:512
Mass (Da):56,631
Last modified:May 1, 1999 - v1
Checksum:i13AFB8627773C4A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073309 mRNA. Translation: AAC69325.1.
AK016561 mRNA. Translation: BAB30305.1.
CCDSiCCDS20130.1.
RefSeqiNP_061239.1. NM_018769.3.
UniGeneiMm.248361.

Genome annotation databases

EnsembliENSMUST00000031845; ENSMUSP00000031845; ENSMUSG00000029821.
ENSMUST00000170142; ENSMUSP00000126759; ENSMUSG00000029821.
GeneIDi54722.
KEGGimmu:54722.
UCSCiuc009bwx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073309 mRNA. Translation: AAC69325.1.
AK016561 mRNA. Translation: BAB30305.1.
CCDSiCCDS20130.1.
RefSeqiNP_061239.1. NM_018769.3.
UniGeneiMm.248361.

3D structure databases

ProteinModelPortaliQ9Z2D3.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9Z2D3.

Proteomic databases

MaxQBiQ9Z2D3.
PaxDbiQ9Z2D3.
PRIDEiQ9Z2D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031845; ENSMUSP00000031845; ENSMUSG00000029821.
ENSMUST00000170142; ENSMUSP00000126759; ENSMUSG00000029821.
GeneIDi54722.
KEGGimmu:54722.
UCSCiuc009bwx.1. mouse.

Organism-specific databases

CTDi1687.
MGIiMGI:1889850. Dfna5.

Phylogenomic databases

eggNOGiNOG40145.
GeneTreeiENSGT00530000063574.
HOGENOMiHOG000065726.
HOVERGENiHBG051340.
InParanoidiQ9Z2D3.
OMAiVVVESDF.
PhylomeDBiQ9Z2D3.
TreeFamiTF352821.

Miscellaneous databases

NextBioi311574.
PROiQ9Z2D3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z2D3.
ExpressionAtlasiQ9Z2D3. baseline and differential.
GenevestigatoriQ9Z2D3.

Family and domain databases

InterProiIPR007677. Gasdermin.
[Graphical view]
PfamiPF04598. Gasdermin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cochlea.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiDFNA5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: April 1, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.