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Q9Z2D3

- DFNA5_MOUSE

UniProt

Q9Z2D3 - DFNA5_MOUSE

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Protein

Non-syndromic hearing impairment protein 5 homolog

Gene

Dfna5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 (By similarity).By similarity

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. inner ear receptor cell differentiation Source: MGI
  3. negative regulation of cell proliferation Source: Ensembl
  4. positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
  5. sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Non-syndromic hearing impairment protein 5 homolog
Gene namesi
Name:Dfna5
Synonyms:Dfna5h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1889850. Dfna5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Non-syndromic hearing impairment protein 5 homologPRO_0000148179Add
BLAST

Proteomic databases

MaxQBiQ9Z2D3.
PaxDbiQ9Z2D3.
PRIDEiQ9Z2D3.

PTM databases

PhosphoSiteiQ9Z2D3.

Expressioni

Gene expression databases

BgeeiQ9Z2D3.
ExpressionAtlasiQ9Z2D3. baseline and differential.
GenevestigatoriQ9Z2D3.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gasdermin family.Curated

Phylogenomic databases

eggNOGiNOG40145.
GeneTreeiENSGT00530000063574.
HOGENOMiHOG000065726.
HOVERGENiHBG051340.
InParanoidiQ9Z2D3.
OMAiVVVESDF.
PhylomeDBiQ9Z2D3.
TreeFamiTF352821.

Family and domain databases

InterProiIPR007677. Gasdermin.
[Graphical view]
PfamiPF04598. Gasdermin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2D3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFAKATRNFL KEVDAGGDLI SVSHLNDSDK LQLLSLVTKK KRYWCWQRPK
60 70 80 90 100
YQILSATLED VLTEGHCLSP VVVESDFVKY ESKCENHKSG AIGTVVGKVK
110 120 130 140 150
LNVGGKGVVE SHSSFGTLRK QEVDVQQLIQ DAVKRTVNMD NLVLQQVLES
160 170 180 190 200
RNEVLCVLTQ KIMTTQKCVI SEHVQSEETC GGMVGIQTKT IQVSATEDGT
210 220 230 240 250
VTTDTNVVLE IPAATTIAYG IMELFVKQDG QFEFCLLQGK HGGFEHERKL
260 270 280 290 300
DSVYLDPLAY REFAFLDMLD GGQGISSQDG PLRVVKQATL HLERSFHPFA
310 320 330 340 350
VLPAQQQRAL FCVLQKILFD EELLRALEQV CDDVAGGLWS SQAVLAMEEL
360 370 380 390 400
TDSQQQDLTA FLQLVGYRIQ GEHPGPQDEV SNQKLFATAY FLVSALAEMP
410 420 430 440 450
DNATVFLGTC CKLHVISSLC CLLHALSDDS VCDFHNPTLA PLRDTERFGI
460 470 480 490 500
VQRLFASADI ALERMQFSAK ATILKDSCIF PLILHITLSG LSTLSKEHEE
510
ELCQSGHATG QD
Length:512
Mass (Da):56,631
Last modified:May 1, 1999 - v1
Checksum:i13AFB8627773C4A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF073309 mRNA. Translation: AAC69325.1.
AK016561 mRNA. Translation: BAB30305.1.
CCDSiCCDS20130.1.
RefSeqiNP_061239.1. NM_018769.3.
XP_006506464.1. XM_006506401.1.
UniGeneiMm.248361.

Genome annotation databases

EnsembliENSMUST00000031845; ENSMUSP00000031845; ENSMUSG00000029821.
ENSMUST00000170142; ENSMUSP00000126759; ENSMUSG00000029821.
GeneIDi54722.
KEGGimmu:54722.
UCSCiuc009bwx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF073309 mRNA. Translation: AAC69325.1 .
AK016561 mRNA. Translation: BAB30305.1 .
CCDSi CCDS20130.1.
RefSeqi NP_061239.1. NM_018769.3.
XP_006506464.1. XM_006506401.1.
UniGenei Mm.248361.

3D structure databases

ProteinModelPortali Q9Z2D3.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9Z2D3.

Proteomic databases

MaxQBi Q9Z2D3.
PaxDbi Q9Z2D3.
PRIDEi Q9Z2D3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031845 ; ENSMUSP00000031845 ; ENSMUSG00000029821 .
ENSMUST00000170142 ; ENSMUSP00000126759 ; ENSMUSG00000029821 .
GeneIDi 54722.
KEGGi mmu:54722.
UCSCi uc009bwx.1. mouse.

Organism-specific databases

CTDi 1687.
MGIi MGI:1889850. Dfna5.

Phylogenomic databases

eggNOGi NOG40145.
GeneTreei ENSGT00530000063574.
HOGENOMi HOG000065726.
HOVERGENi HBG051340.
InParanoidi Q9Z2D3.
OMAi VVVESDF.
PhylomeDBi Q9Z2D3.
TreeFami TF352821.

Miscellaneous databases

NextBioi 311574.
PROi Q9Z2D3.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z2D3.
ExpressionAtlasi Q9Z2D3. baseline and differential.
Genevestigatori Q9Z2D3.

Family and domain databases

InterProi IPR007677. Gasdermin.
[Graphical view ]
Pfami PF04598. Gasdermin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cochlea.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiDFNA5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3