Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Z2D3

- DFNA5_MOUSE

UniProt

Q9Z2D3 - DFNA5_MOUSE

Protein

Non-syndromic hearing impairment protein 5 homolog

Gene

Dfna5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 By similarity.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. inner ear receptor cell differentiation Source: MGI
    3. negative regulation of cell proliferation Source: Ensembl
    4. positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
    5. sensory perception of sound Source: MGI

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-syndromic hearing impairment protein 5 homolog
    Gene namesi
    Name:Dfna5
    Synonyms:Dfna5h
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1889850. Dfna5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Non-syndromic hearing impairment protein 5 homologPRO_0000148179Add
    BLAST

    Proteomic databases

    MaxQBiQ9Z2D3.
    PaxDbiQ9Z2D3.
    PRIDEiQ9Z2D3.

    PTM databases

    PhosphoSiteiQ9Z2D3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Z2D3.
    BgeeiQ9Z2D3.
    GenevestigatoriQ9Z2D3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2D3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gasdermin family.Curated

    Phylogenomic databases

    eggNOGiNOG40145.
    GeneTreeiENSGT00530000063574.
    HOGENOMiHOG000065726.
    HOVERGENiHBG051340.
    InParanoidiQ9Z2D3.
    OMAiVVVESDF.
    PhylomeDBiQ9Z2D3.
    TreeFamiTF352821.

    Family and domain databases

    InterProiIPR007677. Gasdermin.
    [Graphical view]
    PfamiPF04598. Gasdermin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z2D3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFAKATRNFL KEVDAGGDLI SVSHLNDSDK LQLLSLVTKK KRYWCWQRPK    50
    YQILSATLED VLTEGHCLSP VVVESDFVKY ESKCENHKSG AIGTVVGKVK 100
    LNVGGKGVVE SHSSFGTLRK QEVDVQQLIQ DAVKRTVNMD NLVLQQVLES 150
    RNEVLCVLTQ KIMTTQKCVI SEHVQSEETC GGMVGIQTKT IQVSATEDGT 200
    VTTDTNVVLE IPAATTIAYG IMELFVKQDG QFEFCLLQGK HGGFEHERKL 250
    DSVYLDPLAY REFAFLDMLD GGQGISSQDG PLRVVKQATL HLERSFHPFA 300
    VLPAQQQRAL FCVLQKILFD EELLRALEQV CDDVAGGLWS SQAVLAMEEL 350
    TDSQQQDLTA FLQLVGYRIQ GEHPGPQDEV SNQKLFATAY FLVSALAEMP 400
    DNATVFLGTC CKLHVISSLC CLLHALSDDS VCDFHNPTLA PLRDTERFGI 450
    VQRLFASADI ALERMQFSAK ATILKDSCIF PLILHITLSG LSTLSKEHEE 500
    ELCQSGHATG QD 512
    Length:512
    Mass (Da):56,631
    Last modified:May 1, 1999 - v1
    Checksum:i13AFB8627773C4A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF073309 mRNA. Translation: AAC69325.1.
    AK016561 mRNA. Translation: BAB30305.1.
    CCDSiCCDS20130.1.
    RefSeqiNP_061239.1. NM_018769.3.
    XP_006506464.1. XM_006506401.1.
    UniGeneiMm.248361.

    Genome annotation databases

    EnsembliENSMUST00000031845; ENSMUSP00000031845; ENSMUSG00000029821.
    ENSMUST00000170142; ENSMUSP00000126759; ENSMUSG00000029821.
    GeneIDi54722.
    KEGGimmu:54722.
    UCSCiuc009bwx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF073309 mRNA. Translation: AAC69325.1 .
    AK016561 mRNA. Translation: BAB30305.1 .
    CCDSi CCDS20130.1.
    RefSeqi NP_061239.1. NM_018769.3.
    XP_006506464.1. XM_006506401.1.
    UniGenei Mm.248361.

    3D structure databases

    ProteinModelPortali Q9Z2D3.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9Z2D3.

    Proteomic databases

    MaxQBi Q9Z2D3.
    PaxDbi Q9Z2D3.
    PRIDEi Q9Z2D3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031845 ; ENSMUSP00000031845 ; ENSMUSG00000029821 .
    ENSMUST00000170142 ; ENSMUSP00000126759 ; ENSMUSG00000029821 .
    GeneIDi 54722.
    KEGGi mmu:54722.
    UCSCi uc009bwx.1. mouse.

    Organism-specific databases

    CTDi 1687.
    MGIi MGI:1889850. Dfna5.

    Phylogenomic databases

    eggNOGi NOG40145.
    GeneTreei ENSGT00530000063574.
    HOGENOMi HOG000065726.
    HOVERGENi HBG051340.
    InParanoidi Q9Z2D3.
    OMAi VVVESDF.
    PhylomeDBi Q9Z2D3.
    TreeFami TF352821.

    Miscellaneous databases

    NextBioi 311574.
    PROi Q9Z2D3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z2D3.
    Bgeei Q9Z2D3.
    Genevestigatori Q9Z2D3.

    Family and domain databases

    InterProi IPR007677. Gasdermin.
    [Graphical view ]
    Pfami PF04598. Gasdermin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cochlea.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.

    Entry informationi

    Entry nameiDFNA5_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z2D3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3