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Protein

Myotubularin-related protein 9

Gene

Mtmr9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).Curated

GO - Molecular functioni

  • enzyme regulator activity Source: MGI
  • protein phosphatase binding Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1660499 Synthesis of PIPs at the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 9
Gene namesi
Name:Mtmr9
Synonyms:Mtmr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2442842 Mtmr9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949441 – 545Myotubularin-related protein 9Add BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Z2D0
MaxQBiQ9Z2D0
PaxDbiQ9Z2D0
PRIDEiQ9Z2D0

PTM databases

iPTMnetiQ9Z2D0
PhosphoSitePlusiQ9Z2D0

Expressioni

Gene expression databases

BgeeiENSMUSG00000035078
CleanExiMM_MTMR3
MM_MTMR9
GenevisibleiQ9Z2D0 MM

Interactioni

Subunit structurei

Interacts with MTMR6, MTMR7 and MTMR8.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229150, 1 interactor
STRINGi10090.ENSMUSP00000059894

Structurei

3D structure databases

ProteinModelPortaliQ9Z2D0
SMRiQ9Z2D0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 498Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST376

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1089 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00760000118832
HOGENOMiHOG000210599
HOVERGENiHBG105875
InParanoidiQ9Z2D0
KOiK18084
OMAiNSKQKWE
OrthoDBiEOG091G04A6
PhylomeDBiQ9Z2D0
TreeFamiTF315197

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
PANTHERiPTHR10807 PTHR10807, 1 hit
PfamiView protein in Pfam
PF06602 Myotub-related, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFAELIKTP RVDNVVLHRP FYTAVEGTLC LTGHHLILSS RQDNTEELWL
60 70 80 90 100
LHSNIDAIDK RFVGSLGTII IKCKDFRIIQ LDIPGMEECL NIASSIEALS
110 120 130 140 150
TLDSVTLMYP FFYRPMFEVI EDGWHSFLPE QEFEFYSSAT SEWRLSYINK
160 170 180 190 200
DFSICPSYPP TVIVPKSVDD EALRKVAAFR HGGRFPVLSY YHKKNGMVIM
210 220 230 240 250
RSGQPLTGTN GRRCKEDEKL INATLRAGKR GYLIDTRSLN VAQQARAKGG
260 270 280 290 300
GFEQEAHYPQ WRRIHKSIER YHVLQESLIK LVEACNEQTH NMDRWLGKLE
310 320 330 340 350
ASNWLTHIKE ILTTACLAAQ CIDREGASVL IHGTEGTDST LQVTSLAQII
360 370 380 390 400
LEPRSRTIRG FEALIEREWL QAGHPFQQRC AQSAYCSSKQ KWEAPVFLLF
410 420 430 440 450
LDCVWQILRQ FPCSFEFNEH FLIMLFEHAY ASQFGTFLGN NESERCKLKL
460 470 480 490 500
QQKTMSLWSW VNRPGELSKF TNPLFEANNL VIWPSVAPQS LQLWEGIFLR
510 520 530 540
WSRSSKYLDE AYEEMVNIIE YNKELQAKVN VLRRQLAELE TEDGL
Length:545
Mass (Da):62,908
Last modified:July 19, 2003 - v2
Checksum:i1A6F21023BA04AD5
GO

Sequence cautioni

The sequence AAC80003 differs from that shown. Reason: Frameshift at positions 497, 534 and 538.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046275 mRNA Translation: AAH46275.1
BC145946 mRNA Translation: AAI45947.1
BC145948 mRNA Translation: AAI45949.1
AF073881 mRNA Translation: AAC80003.1 Frameshift.
CCDSiCCDS27203.1
RefSeqiNP_808262.1, NM_177594.1
UniGeneiMm.441613
Mm.458343

Genome annotation databases

EnsembliENSMUST00000058679; ENSMUSP00000059894; ENSMUSG00000035078
GeneIDi210376
KEGGimmu:210376
UCSCiuc007uht.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMTMR9_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2D0
Secondary accession number(s): A6H6P1, Q80XL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 19, 2003
Last modified: April 25, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health