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Protein

Myotubularin-related protein 9

Gene

Mtmr9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).Curated

GO - Molecular functioni

  • enzyme regulator activity Source: MGI

GO - Biological processi

  • regulation of catalytic activity Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 9
Gene namesi
Name:Mtmr9
Synonyms:Mtmr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2442842. Mtmr9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545Myotubularin-related protein 9PRO_0000094944Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Z2D0.
MaxQBiQ9Z2D0.
PaxDbiQ9Z2D0.
PRIDEiQ9Z2D0.

PTM databases

iPTMnetiQ9Z2D0.
PhosphoSiteiQ9Z2D0.

Expressioni

Gene expression databases

BgeeiQ9Z2D0.
CleanExiMM_MTMR3.
MM_MTMR9.
GenevisibleiQ9Z2D0. MM.

Interactioni

Subunit structurei

Interacts with MTMR6, MTMR7 and MTMR8.By similarity

Protein-protein interaction databases

BioGridi229150. 1 interaction.
STRINGi10090.ENSMUSP00000059894.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2D0.
SMRiQ9Z2D0. Positions 20-502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 498376Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1089. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000210599.
HOVERGENiHBG105875.
InParanoidiQ9Z2D0.
KOiK18084.
OMAiQELWLLH.
OrthoDBiEOG79PJNX.
PhylomeDBiQ9Z2D0.
TreeFamiTF315197.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PfamiPF06602. Myotub-related. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFAELIKTP RVDNVVLHRP FYTAVEGTLC LTGHHLILSS RQDNTEELWL
60 70 80 90 100
LHSNIDAIDK RFVGSLGTII IKCKDFRIIQ LDIPGMEECL NIASSIEALS
110 120 130 140 150
TLDSVTLMYP FFYRPMFEVI EDGWHSFLPE QEFEFYSSAT SEWRLSYINK
160 170 180 190 200
DFSICPSYPP TVIVPKSVDD EALRKVAAFR HGGRFPVLSY YHKKNGMVIM
210 220 230 240 250
RSGQPLTGTN GRRCKEDEKL INATLRAGKR GYLIDTRSLN VAQQARAKGG
260 270 280 290 300
GFEQEAHYPQ WRRIHKSIER YHVLQESLIK LVEACNEQTH NMDRWLGKLE
310 320 330 340 350
ASNWLTHIKE ILTTACLAAQ CIDREGASVL IHGTEGTDST LQVTSLAQII
360 370 380 390 400
LEPRSRTIRG FEALIEREWL QAGHPFQQRC AQSAYCSSKQ KWEAPVFLLF
410 420 430 440 450
LDCVWQILRQ FPCSFEFNEH FLIMLFEHAY ASQFGTFLGN NESERCKLKL
460 470 480 490 500
QQKTMSLWSW VNRPGELSKF TNPLFEANNL VIWPSVAPQS LQLWEGIFLR
510 520 530 540
WSRSSKYLDE AYEEMVNIIE YNKELQAKVN VLRRQLAELE TEDGL
Length:545
Mass (Da):62,908
Last modified:July 19, 2003 - v2
Checksum:i1A6F21023BA04AD5
GO

Sequence cautioni

The sequence AAC80003.1 differs from that shown. Reason: Frameshift at positions 497, 534 and 538. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046275 mRNA. Translation: AAH46275.1.
BC145946 mRNA. Translation: AAI45947.1.
BC145948 mRNA. Translation: AAI45949.1.
AF073881 mRNA. Translation: AAC80003.1. Frameshift.
CCDSiCCDS27203.1.
RefSeqiNP_808262.1. NM_177594.1.
UniGeneiMm.441613.
Mm.458343.

Genome annotation databases

EnsembliENSMUST00000058679; ENSMUSP00000059894; ENSMUSG00000035078.
GeneIDi210376.
KEGGimmu:210376.
UCSCiuc007uht.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046275 mRNA. Translation: AAH46275.1.
BC145946 mRNA. Translation: AAI45947.1.
BC145948 mRNA. Translation: AAI45949.1.
AF073881 mRNA. Translation: AAC80003.1. Frameshift.
CCDSiCCDS27203.1.
RefSeqiNP_808262.1. NM_177594.1.
UniGeneiMm.441613.
Mm.458343.

3D structure databases

ProteinModelPortaliQ9Z2D0.
SMRiQ9Z2D0. Positions 20-502.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229150. 1 interaction.
STRINGi10090.ENSMUSP00000059894.

PTM databases

iPTMnetiQ9Z2D0.
PhosphoSiteiQ9Z2D0.

Proteomic databases

EPDiQ9Z2D0.
MaxQBiQ9Z2D0.
PaxDbiQ9Z2D0.
PRIDEiQ9Z2D0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058679; ENSMUSP00000059894; ENSMUSG00000035078.
GeneIDi210376.
KEGGimmu:210376.
UCSCiuc007uht.1. mouse.

Organism-specific databases

CTDi66036.
MGIiMGI:2442842. Mtmr9.

Phylogenomic databases

eggNOGiKOG1089. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000210599.
HOVERGENiHBG105875.
InParanoidiQ9Z2D0.
KOiK18084.
OMAiQELWLLH.
OrthoDBiEOG79PJNX.
PhylomeDBiQ9Z2D0.
TreeFamiTF315197.

Miscellaneous databases

NextBioi372941.
PROiQ9Z2D0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z2D0.
CleanExiMM_MTMR3.
MM_MTMR9.
GenevisibleiQ9Z2D0. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PfamiPF06602. Myotub-related. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Olfactory epithelium.
  2. "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human."
    Laporte J., Blondeau F., Buj-Bello A., Tentler D., Kretz C., Dahl N., Mandel J.-L.
    Hum. Mol. Genet. 7:1703-1712(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 392-545.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Lung and Testis.

Entry informationi

Entry nameiMTMR9_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2D0
Secondary accession number(s): A6H6P1, Q80XL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 19, 2003
Last modified: March 16, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.