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Protein

Myotubularin-related protein 7

Gene

Mtmr7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei338Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei384SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • inositol phosphate dephosphorylation Source: MGI
  • phosphatidylinositol dephosphorylation Source: MGI

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1660517 Synthesis of PIPs at the late endosome membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 7 (EC:3.1.3.-)
Gene namesi
Name:Mtmr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1891693 Mtmr7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949411 – 660Myotubularin-related protein 7Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei578PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z2C9
PaxDbiQ9Z2C9
PeptideAtlasiQ9Z2C9
PRIDEiQ9Z2C9

PTM databases

iPTMnetiQ9Z2C9
PhosphoSitePlusiQ9Z2C9

Expressioni

Gene expression databases

BgeeiENSMUSG00000039431
CleanExiMM_MTMR7
ExpressionAtlasiQ9Z2C9 baseline and differential
GenevisibleiQ9Z2C9 MM

Interactioni

Subunit structurei

Interacts with MTMR6, MTMR8 and MTMR9.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043851

Structurei

3D structure databases

ProteinModelPortaliQ9Z2C9
SMRiQ9Z2C9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 504Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST379

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni250 – 253Substrate bindingBy similarity4
Regioni275 – 276Substrate bindingBy similarity2
Regioni338 – 344Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1089 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00760000118832
HOGENOMiHOG000210599
HOVERGENiHBG000220
InParanoidiQ9Z2C9
KOiK18083
OMAiRCKNFQI
OrthoDBiEOG091G02LA
PhylomeDBiQ9Z2C9
TreeFamiTF315197

Family and domain databases

CDDicd13344 PH-GRAM_MTMR7, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030572 MTMR7
IPR036003 MTMR7_PH-GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF35 PTHR10807:SF35, 1 hit
PfamiView protein in Pfam
PF06602 Myotub-related, 1 hit
SMARTiView protein in SMART
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHIRTPKVE NVRLVDRVSC KKAALGTLYL TATHVIFVEN APDTRKETWI
60 70 80 90 100
LHSQISTIEK QATTATGCPL LIRCKNFQIV QLVIPQERDC HDVYISLIRL
110 120 130 140 150
ARPVKYEELY CFSFNPKLDK EEREQGWLLV DLSEEYKRMG LPDNYWQLSD
160 170 180 190 200
VNRDYRVCDS YPTELYVPRS ATAHIIVGSS KFRSRRRFPA LSYYCKDSHA
210 220 230 240 250
SICRSSQPLS GFSARCLEDE QMLQAIRKAN PGSDFIYVVD TRPKLNAMAN
260 270 280 290 300
RAAGKGYENE DNYSNIKFQF IGIENIHVMR NSLQKMLEVC ELKSPSMSDF
310 320 330 340 350
LWGLENSGWL RHIKAIMDAG IFIAKAVSEE GASVLVHCSD GWDRTAQVCS
360 370 380 390 400
VASLLLDPYY RTLKGFMVLI EKDWISFGHK FNHRYGNLDG DPKEISPVID
410 420 430 440 450
QFIECVWQLT EQFPCAFEFN ERFLTHIQHH VYSCQFGNFL CNSQKERREL
460 470 480 490 500
KIQERTYSLW SNLWKNRADY LNPLFRADHS QTQGSLHLPT APCNFTYKFW
510 520 530 540 550
NGMYNRFEKG LQPRQSVTDY LMAVKEESQQ LEEELESLEE RLEKIQKVHL
560 570 580 590 600
HGTKVKSKQS EPSKHSGFST SDHSTANTPQ DYSGNSKSFP SRSPSQGDED
610 620 630 640 650
SALILTQDNL KSSDPDLSVN SDQESGVEDL SCRSPSGGEH APSEDSGKDR
660
DSDEAVFLTA
Length:660
Mass (Da):75,608
Last modified:July 19, 2003 - v2
Checksum:i57CA1A447192A52B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti579 – 602PQDYS…DEDSA → LRITVGTASPSHPGARPRVM KILL (PubMed:9736772).CuratedAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081973 mRNA Translation: BAC38383.1
AF073882 mRNA Translation: AAC80004.1
CCDSiCCDS40324.1
RefSeqiNP_001035789.1, NM_001040699.1
UniGeneiMm.294871

Genome annotation databases

EnsembliENSMUST00000048898; ENSMUSP00000043851; ENSMUSG00000039431
GeneIDi54384
KEGGimmu:54384
UCSCiuc009lmz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMTMR7_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2C9
Secondary accession number(s): Q8C4J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 19, 2003
Last modified: March 28, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health