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Protein

Myotubularin-related protein 7

Gene

Mtmr7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei338 – 3381Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei384 – 3841SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

  • inositol phosphate dephosphorylation Source: MGI
  • phosphatidylinositol dephosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1660517. Synthesis of PIPs at the late endosome membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 7 (EC:3.1.3.-)
Gene namesi
Name:Mtmr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1891693. Mtmr7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660Myotubularin-related protein 7PRO_0000094941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei578 – 5781PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z2C9.
PaxDbiQ9Z2C9.
PeptideAtlasiQ9Z2C9.
PRIDEiQ9Z2C9.

PTM databases

iPTMnetiQ9Z2C9.
PhosphoSiteiQ9Z2C9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039431.
CleanExiMM_MTMR7.
ExpressionAtlasiQ9Z2C9. baseline and differential.
GenevisibleiQ9Z2C9. MM.

Interactioni

Subunit structurei

Interacts with MTMR6, MTMR8 and MTMR9.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043851.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2C9.
SMRiQ9Z2C9. Positions 4-509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 504379Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni250 – 2534Substrate bindingBy similarity
Regioni275 – 2762Substrate bindingBy similarity
Regioni338 – 3447Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1089. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000210599.
HOVERGENiHBG000220.
InParanoidiQ9Z2C9.
KOiK18083.
OMAiCFSFNPM.
OrthoDBiEOG091G02LA.
PhylomeDBiQ9Z2C9.
TreeFamiTF315197.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR030572. MTMR7.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF35. PTHR10807:SF35. 1 hit.
PfamiPF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHIRTPKVE NVRLVDRVSC KKAALGTLYL TATHVIFVEN APDTRKETWI
60 70 80 90 100
LHSQISTIEK QATTATGCPL LIRCKNFQIV QLVIPQERDC HDVYISLIRL
110 120 130 140 150
ARPVKYEELY CFSFNPKLDK EEREQGWLLV DLSEEYKRMG LPDNYWQLSD
160 170 180 190 200
VNRDYRVCDS YPTELYVPRS ATAHIIVGSS KFRSRRRFPA LSYYCKDSHA
210 220 230 240 250
SICRSSQPLS GFSARCLEDE QMLQAIRKAN PGSDFIYVVD TRPKLNAMAN
260 270 280 290 300
RAAGKGYENE DNYSNIKFQF IGIENIHVMR NSLQKMLEVC ELKSPSMSDF
310 320 330 340 350
LWGLENSGWL RHIKAIMDAG IFIAKAVSEE GASVLVHCSD GWDRTAQVCS
360 370 380 390 400
VASLLLDPYY RTLKGFMVLI EKDWISFGHK FNHRYGNLDG DPKEISPVID
410 420 430 440 450
QFIECVWQLT EQFPCAFEFN ERFLTHIQHH VYSCQFGNFL CNSQKERREL
460 470 480 490 500
KIQERTYSLW SNLWKNRADY LNPLFRADHS QTQGSLHLPT APCNFTYKFW
510 520 530 540 550
NGMYNRFEKG LQPRQSVTDY LMAVKEESQQ LEEELESLEE RLEKIQKVHL
560 570 580 590 600
HGTKVKSKQS EPSKHSGFST SDHSTANTPQ DYSGNSKSFP SRSPSQGDED
610 620 630 640 650
SALILTQDNL KSSDPDLSVN SDQESGVEDL SCRSPSGGEH APSEDSGKDR
660
DSDEAVFLTA
Length:660
Mass (Da):75,608
Last modified:July 19, 2003 - v2
Checksum:i57CA1A447192A52B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti579 – 60224PQDYS…DEDSA → LRITVGTASPSHPGARPRVM KILL (PubMed:9736772).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081973 mRNA. Translation: BAC38383.1.
AF073882 mRNA. Translation: AAC80004.1.
CCDSiCCDS40324.1.
RefSeqiNP_001035789.1. NM_001040699.1.
UniGeneiMm.294871.

Genome annotation databases

EnsembliENSMUST00000048898; ENSMUSP00000043851; ENSMUSG00000039431.
GeneIDi54384.
KEGGimmu:54384.
UCSCiuc009lmz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK081973 mRNA. Translation: BAC38383.1.
AF073882 mRNA. Translation: AAC80004.1.
CCDSiCCDS40324.1.
RefSeqiNP_001035789.1. NM_001040699.1.
UniGeneiMm.294871.

3D structure databases

ProteinModelPortaliQ9Z2C9.
SMRiQ9Z2C9. Positions 4-509.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043851.

PTM databases

iPTMnetiQ9Z2C9.
PhosphoSiteiQ9Z2C9.

Proteomic databases

MaxQBiQ9Z2C9.
PaxDbiQ9Z2C9.
PeptideAtlasiQ9Z2C9.
PRIDEiQ9Z2C9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048898; ENSMUSP00000043851; ENSMUSG00000039431.
GeneIDi54384.
KEGGimmu:54384.
UCSCiuc009lmz.1. mouse.

Organism-specific databases

CTDi9108.
MGIiMGI:1891693. Mtmr7.

Phylogenomic databases

eggNOGiKOG1089. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000210599.
HOVERGENiHBG000220.
InParanoidiQ9Z2C9.
KOiK18083.
OMAiCFSFNPM.
OrthoDBiEOG091G02LA.
PhylomeDBiQ9Z2C9.
TreeFamiTF315197.

Enzyme and pathway databases

ReactomeiR-MMU-1660517. Synthesis of PIPs at the late endosome membrane.

Miscellaneous databases

ChiTaRSiMtmr7. mouse.
PROiQ9Z2C9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039431.
CleanExiMM_MTMR7.
ExpressionAtlasiQ9Z2C9. baseline and differential.
GenevisibleiQ9Z2C9. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR030572. MTMR7.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF35. PTHR10807:SF35. 1 hit.
PfamiPF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTMR7_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2C9
Secondary accession number(s): Q8C4J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 19, 2003
Last modified: September 7, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.