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Protein

Uroplakin-1b

Gene

Upk1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).By similarity

GO - Biological processi

  1. epithelial cell differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-1b
Short name:
UP1b
Alternative name(s):
Uroplakin Ib
Short name:
UPIb
Gene namesi
Name:Upk1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:98912. Upk1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 1514CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Topological domaini37 – 5923ExtracellularSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Topological domaini81 – 866CytoplasmicSequence Analysis
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Topological domaini108 – 229122ExtracellularSequence AnalysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence AnalysisAdd
BLAST
Topological domaini251 – 26010CytoplasmicSequence Analysis

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 260259Uroplakin-1bPRO_0000219290Add
BLAST

Post-translational modificationi

N-glycosylated with high-mannose oligosaccharides.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9Z2C6.

Expressioni

Tissue specificityi

Bladder epithelium.

Gene expression databases

BgeeiQ9Z2C6.
CleanExiMM_UPK1B.
GenevestigatoriQ9Z2C6.

Interactioni

Subunit structurei

Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG247872.
GeneTreeiENSGT00390000000126.
HOGENOMiHOG000230653.
HOVERGENiHBG054305.
InParanoidiQ9Z2C6.
KOiK17347.
OMAiQGCYELI.
OrthoDBiEOG7MD4QM.
PhylomeDBiQ9Z2C6.
TreeFamiTF335659.

Family and domain databases

InterProiIPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z2C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDDSTVRC FQGLLIFGHV IVGMCGIALT AECIFFVSDQ HSLYPLLEAT
60 70 80 90 100
NNDDIFGAAW IGMFVGICLF CLSVLAIVGI MKSNRKILLA YFIMMFIVYG
110 120 130 140 150
FEVASCITAA TQRDFFTTNL FLKQMLMRYQ NNSPPTNDDE WKNNGVTKTW
160 170 180 190 200
DRLMLQDHCC GVNGPSDWQK YTSAFRVENN DADYPWPRQC CVMDKLKEPL
210 220 230 240 250
NLDACKLGVP GYYHSQGCYE LISGPMDRHA WGVAWFGFAI LCWTFWVLLG
260
TMFYWSRIEY
Length:260
Mass (Da):29,762
Last modified:January 23, 2007 - v3
Checksum:i91EB5816D59070A4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361T → N in AAD02834 (PubMed:10343097).Curated
Sequence conflicti140 – 1401E → Q in AAD02834 (PubMed:10343097).Curated
Sequence conflicti253 – 2531F → L in BAC38760 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274865 mRNA. Translation: AAM97593.1.
AK053004 mRNA. Translation: BAC35237.1.
AK083101 mRNA. Translation: BAC38760.1.
AK086926 mRNA. Translation: BAC39763.1.
BC046604 mRNA. Translation: AAH46604.1.
AF073956 Genomic DNA. Translation: AAD02834.1.
CCDSiCCDS28174.1.
RefSeqiNP_849255.2. NM_178924.4.
UniGeneiMm.130793.

Genome annotation databases

EnsembliENSMUST00000057767; ENSMUSP00000052469; ENSMUSG00000049436.
GeneIDi22268.
KEGGimmu:22268.
UCSCiuc007zfm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274865 mRNA. Translation: AAM97593.1.
AK053004 mRNA. Translation: BAC35237.1.
AK083101 mRNA. Translation: BAC38760.1.
AK086926 mRNA. Translation: BAC39763.1.
BC046604 mRNA. Translation: AAH46604.1.
AF073956 Genomic DNA. Translation: AAD02834.1.
CCDSiCCDS28174.1.
RefSeqiNP_849255.2. NM_178924.4.
UniGeneiMm.130793.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9Z2C6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057767; ENSMUSP00000052469; ENSMUSG00000049436.
GeneIDi22268.
KEGGimmu:22268.
UCSCiuc007zfm.2. mouse.

Organism-specific databases

CTDi7348.
MGIiMGI:98912. Upk1b.

Phylogenomic databases

eggNOGiNOG247872.
GeneTreeiENSGT00390000000126.
HOGENOMiHOG000230653.
HOVERGENiHBG054305.
InParanoidiQ9Z2C6.
KOiK17347.
OMAiQGCYELI.
OrthoDBiEOG7MD4QM.
PhylomeDBiQ9Z2C6.
TreeFamiTF335659.

Miscellaneous databases

NextBioi302367.
PROiQ9Z2C6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z2C6.
CleanExiMM_UPK1B.
GenevestigatoriQ9Z2C6.

Family and domain databases

InterProiIPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
SUPFAMiSSF48652. SSF48652. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse uroplakin Ib (UPIb) mRNA."
    Zhou G., Kong X.-P.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Urinary bladder.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head, Hippocampus and Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  4. "Assignment of the Uroplakin 1b (Upk1b) gene to mouse chromosome 16 bands B5-C2 by in situ hybridization."
    Webb G.C., Finch J.L., Cowled P.A.
    Cytogenet. Cell Genet. 84:37-38(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 102-141.

Entry informationi

Entry nameiUPK1B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2C6
Secondary accession number(s): Q8C448, Q8K4M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.