Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uroplakin-1b

Gene

Upk1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-1b
Short name:
UP1b
Alternative name(s):
Uroplakin Ib
Short name:
UPIb
Gene namesi
Name:Upk1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:98912. Upk1b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 59ExtracellularSequence analysisAdd BLAST23
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 86CytoplasmicSequence analysis6
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 229ExtracellularSequence analysisAdd BLAST122
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 260CytoplasmicSequence analysis10

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192901 – 260Uroplakin-1bAdd BLAST260

Post-translational modificationi

N-glycosylated with high-mannose oligosaccharides.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9Z2C6.
PaxDbiQ9Z2C6.
PRIDEiQ9Z2C6.

PTM databases

PhosphoSitePlusiQ9Z2C6.

Expressioni

Tissue specificityi

Bladder epithelium.

Gene expression databases

BgeeiENSMUSG00000049436.
CleanExiMM_UPK1B.
GenevisibleiQ9Z2C6. MM.

Interactioni

Subunit structurei

Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).By similarity

Protein-protein interaction databases

IntActiQ9Z2C6. 2 interactors.
STRINGi10090.ENSMUSP00000052469.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00390000000126.
HOGENOMiHOG000230653.
HOVERGENiHBG054305.
InParanoidiQ9Z2C6.
KOiK17347.
OMAiDACKLGV.
OrthoDBiEOG091G0G8N.
PhylomeDBiQ9Z2C6.
TreeFamiTF335659.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiView protein in InterPro
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2_sf.
IPR034766. Uroplakin-1b.
PANTHERiPTHR19282:SF24. PTHR19282:SF24. 1 hit.
PfamiView protein in Pfam
PF00335. Tetraspannin. 1 hit.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z2C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDDSTVRC FQGLLIFGHV IVGMCGIALT AECIFFVSDQ HSLYPLLEAT
60 70 80 90 100
NNDDIFGAAW IGMFVGICLF CLSVLAIVGI MKSNRKILLA YFIMMFIVYG
110 120 130 140 150
FEVASCITAA TQRDFFTTNL FLKQMLMRYQ NNSPPTNDDE WKNNGVTKTW
160 170 180 190 200
DRLMLQDHCC GVNGPSDWQK YTSAFRVENN DADYPWPRQC CVMDKLKEPL
210 220 230 240 250
NLDACKLGVP GYYHSQGCYE LISGPMDRHA WGVAWFGFAI LCWTFWVLLG
260
TMFYWSRIEY
Length:260
Mass (Da):29,762
Last modified:January 23, 2007 - v3
Checksum:i91EB5816D59070A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136T → N in AAD02834 (PubMed:10343097).Curated1
Sequence conflicti140E → Q in AAD02834 (PubMed:10343097).Curated1
Sequence conflicti253F → L in BAC38760 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF274865 mRNA. Translation: AAM97593.1.
AK053004 mRNA. Translation: BAC35237.1.
AK083101 mRNA. Translation: BAC38760.1.
AK086926 mRNA. Translation: BAC39763.1.
BC046604 mRNA. Translation: AAH46604.1.
AF073956 Genomic DNA. Translation: AAD02834.1.
CCDSiCCDS28174.1.
RefSeqiNP_849255.2. NM_178924.4.
XP_017172432.1. XM_017316943.1.
UniGeneiMm.130793.

Genome annotation databases

EnsembliENSMUST00000057767; ENSMUSP00000052469; ENSMUSG00000049436.
GeneIDi22268.
KEGGimmu:22268.
UCSCiuc007zfm.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiUPK1B_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2C6
Secondary accession number(s): Q8C448, Q8K4M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families