Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Z2C6

- UPK1B_MOUSE

UniProt

Q9Z2C6 - UPK1B_MOUSE

Protein

Uroplakin-1b

Gene

Upk1b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions By similarity.By similarity

    GO - Biological processi

    1. epithelial cell differentiation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroplakin-1b
    Short name:
    UP1b
    Alternative name(s):
    Uroplakin Ib
    Short name:
    UPIb
    Gene namesi
    Name:Upk1b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:98912. Upk1b.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 260259Uroplakin-1bPRO_0000219290Add
    BLAST

    Post-translational modificationi

    N-glycosylated with high-mannose oligosaccharides.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9Z2C6.

    Expressioni

    Tissue specificityi

    Bladder epithelium.

    Gene expression databases

    BgeeiQ9Z2C6.
    CleanExiMM_UPK1B.
    GenevestigatoriQ9Z2C6.

    Interactioni

    Subunit structurei

    Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2C6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 1514CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini37 – 5923ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini81 – 866CytoplasmicSequence Analysis
    Topological domaini108 – 229122ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini251 – 26010CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG247872.
    GeneTreeiENSGT00390000000126.
    HOGENOMiHOG000230653.
    HOVERGENiHBG054305.
    InParanoidiQ9Z2C6.
    KOiK17347.
    OMAiQGCYELI.
    OrthoDBiEOG7MD4QM.
    PhylomeDBiQ9Z2C6.
    TreeFamiTF335659.

    Family and domain databases

    InterProiIPR018499. Tetraspanin/Peripherin.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    SUPFAMiSSF48652. SSF48652. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z2C6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKDDSTVRC FQGLLIFGHV IVGMCGIALT AECIFFVSDQ HSLYPLLEAT    50
    NNDDIFGAAW IGMFVGICLF CLSVLAIVGI MKSNRKILLA YFIMMFIVYG 100
    FEVASCITAA TQRDFFTTNL FLKQMLMRYQ NNSPPTNDDE WKNNGVTKTW 150
    DRLMLQDHCC GVNGPSDWQK YTSAFRVENN DADYPWPRQC CVMDKLKEPL 200
    NLDACKLGVP GYYHSQGCYE LISGPMDRHA WGVAWFGFAI LCWTFWVLLG 250
    TMFYWSRIEY 260
    Length:260
    Mass (Da):29,762
    Last modified:January 23, 2007 - v3
    Checksum:i91EB5816D59070A4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti136 – 1361T → N in AAD02834. (PubMed:10343097)Curated
    Sequence conflicti140 – 1401E → Q in AAD02834. (PubMed:10343097)Curated
    Sequence conflicti253 – 2531F → L in BAC38760. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF274865 mRNA. Translation: AAM97593.1.
    AK053004 mRNA. Translation: BAC35237.1.
    AK083101 mRNA. Translation: BAC38760.1.
    AK086926 mRNA. Translation: BAC39763.1.
    BC046604 mRNA. Translation: AAH46604.1.
    AF073956 Genomic DNA. Translation: AAD02834.1.
    CCDSiCCDS28174.1.
    RefSeqiNP_849255.2. NM_178924.4.
    UniGeneiMm.130793.

    Genome annotation databases

    EnsembliENSMUST00000057767; ENSMUSP00000052469; ENSMUSG00000049436.
    GeneIDi22268.
    KEGGimmu:22268.
    UCSCiuc007zfm.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF274865 mRNA. Translation: AAM97593.1 .
    AK053004 mRNA. Translation: BAC35237.1 .
    AK083101 mRNA. Translation: BAC38760.1 .
    AK086926 mRNA. Translation: BAC39763.1 .
    BC046604 mRNA. Translation: AAH46604.1 .
    AF073956 Genomic DNA. Translation: AAD02834.1 .
    CCDSi CCDS28174.1.
    RefSeqi NP_849255.2. NM_178924.4.
    UniGenei Mm.130793.

    3D structure databases

    ProteinModelPortali Q9Z2C6.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9Z2C6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057767 ; ENSMUSP00000052469 ; ENSMUSG00000049436 .
    GeneIDi 22268.
    KEGGi mmu:22268.
    UCSCi uc007zfm.2. mouse.

    Organism-specific databases

    CTDi 7348.
    MGIi MGI:98912. Upk1b.

    Phylogenomic databases

    eggNOGi NOG247872.
    GeneTreei ENSGT00390000000126.
    HOGENOMi HOG000230653.
    HOVERGENi HBG054305.
    InParanoidi Q9Z2C6.
    KOi K17347.
    OMAi QGCYELI.
    OrthoDBi EOG7MD4QM.
    PhylomeDBi Q9Z2C6.
    TreeFami TF335659.

    Miscellaneous databases

    NextBioi 302367.
    PROi Q9Z2C6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z2C6.
    CleanExi MM_UPK1B.
    Genevestigatori Q9Z2C6.

    Family and domain databases

    InterProi IPR018499. Tetraspanin/Peripherin.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48652. SSF48652. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Mouse uroplakin Ib (UPIb) mRNA."
      Zhou G., Kong X.-P.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Urinary bladder.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head, Hippocampus and Lung.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.
    4. "Assignment of the Uroplakin 1b (Upk1b) gene to mouse chromosome 16 bands B5-C2 by in situ hybridization."
      Webb G.C., Finch J.L., Cowled P.A.
      Cytogenet. Cell Genet. 84:37-38(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 102-141.

    Entry informationi

    Entry nameiUPK1B_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z2C6
    Secondary accession number(s): Q8C448, Q8K4M0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 94 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3