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Protein

Myotubularin-related protein 1

Gene

Mtmr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:12217958). Activity with phosphatidylinositol (3,5)-bisphosphate is controversial; it has been shown for the human ortholog (By similarity). In contrast, PubMed:12217958 find no activity with this substrate.By similarity1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.By similarity
1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei442Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei488SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.3.64. 3474.
ReactomeiR-MMU-1660499. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 1
Alternative name(s):
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95By similarity)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.641 Publication)
Gene namesi
Name:Mtmr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1858271. Mtmr1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949331 – 669Myotubularin-related protein 1Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei47PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Z2C4.
MaxQBiQ9Z2C4.
PaxDbiQ9Z2C4.
PeptideAtlasiQ9Z2C4.
PRIDEiQ9Z2C4.

PTM databases

iPTMnetiQ9Z2C4.
PhosphoSitePlusiQ9Z2C4.

Expressioni

Tissue specificityi

Widely expressed. Detected in skeletal muscle, heart, lung, liver and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000015214.
CleanExiMM_MTMR1.
ExpressionAtlasiQ9Z2C4. baseline and differential.
GenevisibleiQ9Z2C4. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207292. 2 interactors.
IntActiQ9Z2C4. 1 interactor.
STRINGi10090.ENSMUSP00000015358.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2C4.
SMRiQ9Z2C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 165GRAMAdd BLAST72
Domaini230 – 605Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST376

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni355 – 358Substrate bindingBy similarity4
Regioni380 – 381Substrate bindingBy similarity2
Regioni442 – 448Substrate bindingBy similarity7
Regioni612 – 669Required for dimerizationBy similarityAdd BLAST58

Domaini

The C-terminal region is required for dimerization.By similarity

Sequence similaritiesi

Contains 1 GRAM domain.Curated
Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1089. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000210598.
HOVERGENiHBG000220.
InParanoidiQ9Z2C4.
KOiK18081.
PhylomeDBiQ9Z2C4.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR004182. GRAM.
IPR030587. MTMR1.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF40. PTHR10807:SF40. 1 hit.
PfamiPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRPVAAAAA ASAASCEGAG GPGPGPGASW RPSRVAGGAS ASSRHPSIET
60 70 80 90 100
LDSPTGSHVE WCKQLIAATI SSQISGSVTS ENVSRDYKAL RDGNKLAQME
110 120 130 140 150
EAPLFPGESI KAIVKDVIYI CPFMGAVSGT LTVTDFKMYF KNVERDPHFV
160 170 180 190 200
LDVPLGVISR VEKIGAQSHG DNSCGIEIVC KDMRNLRLAY KQEEQRKLGI
210 220 230 240 250
FENLNKHAFP LSNGQVLFAF NYKEKFPVNG WKVYDPVSEY KRQGLPNESW
260 270 280 290 300
KISKINSNYE FCDTYPAIIV VPTSVKDDDL SKVAAFRAKG RVPVLSWIHP
310 320 330 340 350
ESQATITRCS QPLVGPNDKR CKEDEKYLQT IMDANAQSHK LTIFDARQNS
360 370 380 390 400
VADTNKAKGG GYENESAYPN AELIFLEIHN IHVMRESLRK LKEIVYPSID
410 420 430 440 450
ESHWLSNVDG THWLEYIRVL LAGAVRIADK IESGKTSVVI HCSDGWDRTS
460 470 480 490 500
QLTSLAMLML DSYYRTIKGF EALIEKEWIS FGHRFALRVG HGDDNHADAD
510 520 530 540 550
RSPIFLQFID CVWQMTRQFP SAFEFNELFL ITILDHLYSC LFGTFLCNCE
560 570 580 590 600
QQRIKEDVYT NTISLWSYIN SQLDEFSNPF FVNYENHVLY PVASMSHLEL
610 620 630 640 650
WVNYYVRWNP RMRPQMPIHQ NLKELLAIKA ELQKRVEDLQ REMATRTISS
660
SSERGSSPTH SATPVHTSV
Length:669
Mass (Da):75,313
Last modified:May 1, 1999 - v1
Checksum:i1856792245F2D800
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073997 mRNA. Translation: AAC77822.1.
AF125314 Genomic DNA. No translation available.
BC056376 mRNA. Translation: AAH56376.1.
BC057337 mRNA. Translation: AAH57337.1.
CCDSiCCDS30178.1.
RefSeqiNP_001300631.1. NM_001313702.1.
NP_001300632.1. NM_001313703.1.
NP_001300633.1. NM_001313704.1.
NP_001300635.1. NM_001313706.1.
NP_001300636.1. NM_001313707.1.
NP_058681.1. NM_016985.2.
UniGeneiMm.219672.

Genome annotation databases

EnsembliENSMUST00000015358; ENSMUSP00000015358; ENSMUSG00000015214.
GeneIDi53332.
KEGGimmu:53332.
UCSCiuc009tjt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073997 mRNA. Translation: AAC77822.1.
AF125314 Genomic DNA. No translation available.
BC056376 mRNA. Translation: AAH56376.1.
BC057337 mRNA. Translation: AAH57337.1.
CCDSiCCDS30178.1.
RefSeqiNP_001300631.1. NM_001313702.1.
NP_001300632.1. NM_001313703.1.
NP_001300633.1. NM_001313704.1.
NP_001300635.1. NM_001313706.1.
NP_001300636.1. NM_001313707.1.
NP_058681.1. NM_016985.2.
UniGeneiMm.219672.

3D structure databases

ProteinModelPortaliQ9Z2C4.
SMRiQ9Z2C4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207292. 2 interactors.
IntActiQ9Z2C4. 1 interactor.
STRINGi10090.ENSMUSP00000015358.

PTM databases

iPTMnetiQ9Z2C4.
PhosphoSitePlusiQ9Z2C4.

Proteomic databases

EPDiQ9Z2C4.
MaxQBiQ9Z2C4.
PaxDbiQ9Z2C4.
PeptideAtlasiQ9Z2C4.
PRIDEiQ9Z2C4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015358; ENSMUSP00000015358; ENSMUSG00000015214.
GeneIDi53332.
KEGGimmu:53332.
UCSCiuc009tjt.1. mouse.

Organism-specific databases

CTDi8776.
MGIiMGI:1858271. Mtmr1.

Phylogenomic databases

eggNOGiKOG1089. Eukaryota.
ENOG410XPTU. LUCA.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000210598.
HOVERGENiHBG000220.
InParanoidiQ9Z2C4.
KOiK18081.
PhylomeDBiQ9Z2C4.

Enzyme and pathway databases

BRENDAi3.1.3.64. 3474.
ReactomeiR-MMU-1660499. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

PROiQ9Z2C4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015214.
CleanExiMM_MTMR1.
ExpressionAtlasiQ9Z2C4. baseline and differential.
GenevisibleiQ9Z2C4. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR004182. GRAM.
IPR030587. MTMR1.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_dom-like.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF40. PTHR10807:SF40. 1 hit.
PfamiPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTMR1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.