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Protein

Myotubularin-related protein 1

Gene

Mtmr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol (3,5)-bisphosphate.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei442 – 4421Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei488 – 4881SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.3.64. 3474.
ReactomeiREACT_272541. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 1
Alternative name(s):
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.641 Publication)
Gene namesi
Name:Mtmr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1858271. Mtmr1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Myotubularin-related protein 1PRO_0000094933Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Z2C4.
PaxDbiQ9Z2C4.
PRIDEiQ9Z2C4.

PTM databases

PhosphoSiteiQ9Z2C4.

Expressioni

Tissue specificityi

Widely expressed. Detected in skeletal muscle, heart, lung, liver and brain.1 Publication

Gene expression databases

BgeeiQ9Z2C4.
CleanExiMM_MTMR1.
ExpressionAtlasiQ9Z2C4. baseline and differential.
GenevestigatoriQ9Z2C4.

Interactioni

Protein-protein interaction databases

BioGridi207292. 2 interactions.
IntActiQ9Z2C4. 1 interaction.
STRINGi10090.ENSMUSP00000110249.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2C4.
SMRiQ9Z2C4. Positions 99-610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 16572GRAMAdd
BLAST
Domaini230 – 605376Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni355 – 3584Substrate bindingBy similarity
Regioni380 – 3812Substrate bindingBy similarity
Regioni442 – 4487Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 GRAM domain.Curated
Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG322789.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000210598.
HOVERGENiHBG000220.
InParanoidiQ9Z2C4.
KOiK18081.
PhylomeDBiQ9Z2C4.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004182. GRAM.
IPR030587. MTMR1/MTMR2.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF40. PTHR10807:SF40. 1 hit.
PfamiPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRPVAAAAA ASAASCEGAG GPGPGPGASW RPSRVAGGAS ASSRHPSIET
60 70 80 90 100
LDSPTGSHVE WCKQLIAATI SSQISGSVTS ENVSRDYKAL RDGNKLAQME
110 120 130 140 150
EAPLFPGESI KAIVKDVIYI CPFMGAVSGT LTVTDFKMYF KNVERDPHFV
160 170 180 190 200
LDVPLGVISR VEKIGAQSHG DNSCGIEIVC KDMRNLRLAY KQEEQRKLGI
210 220 230 240 250
FENLNKHAFP LSNGQVLFAF NYKEKFPVNG WKVYDPVSEY KRQGLPNESW
260 270 280 290 300
KISKINSNYE FCDTYPAIIV VPTSVKDDDL SKVAAFRAKG RVPVLSWIHP
310 320 330 340 350
ESQATITRCS QPLVGPNDKR CKEDEKYLQT IMDANAQSHK LTIFDARQNS
360 370 380 390 400
VADTNKAKGG GYENESAYPN AELIFLEIHN IHVMRESLRK LKEIVYPSID
410 420 430 440 450
ESHWLSNVDG THWLEYIRVL LAGAVRIADK IESGKTSVVI HCSDGWDRTS
460 470 480 490 500
QLTSLAMLML DSYYRTIKGF EALIEKEWIS FGHRFALRVG HGDDNHADAD
510 520 530 540 550
RSPIFLQFID CVWQMTRQFP SAFEFNELFL ITILDHLYSC LFGTFLCNCE
560 570 580 590 600
QQRIKEDVYT NTISLWSYIN SQLDEFSNPF FVNYENHVLY PVASMSHLEL
610 620 630 640 650
WVNYYVRWNP RMRPQMPIHQ NLKELLAIKA ELQKRVEDLQ REMATRTISS
660
SSERGSSPTH SATPVHTSV
Length:669
Mass (Da):75,313
Last modified:May 1, 1999 - v1
Checksum:i1856792245F2D800
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073997 mRNA. Translation: AAC77822.1.
AF125314 Genomic DNA. No translation available.
BC056376 mRNA. Translation: AAH56376.1.
BC057337 mRNA. Translation: AAH57337.1.
CCDSiCCDS30178.1.
RefSeqiNP_058681.1. NM_016985.2.
UniGeneiMm.219672.

Genome annotation databases

EnsembliENSMUST00000015358; ENSMUSP00000015358; ENSMUSG00000015214.
GeneIDi53332.
KEGGimmu:53332.
UCSCiuc009tjt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073997 mRNA. Translation: AAC77822.1.
AF125314 Genomic DNA. No translation available.
BC056376 mRNA. Translation: AAH56376.1.
BC057337 mRNA. Translation: AAH57337.1.
CCDSiCCDS30178.1.
RefSeqiNP_058681.1. NM_016985.2.
UniGeneiMm.219672.

3D structure databases

ProteinModelPortaliQ9Z2C4.
SMRiQ9Z2C4. Positions 99-610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207292. 2 interactions.
IntActiQ9Z2C4. 1 interaction.
STRINGi10090.ENSMUSP00000110249.

PTM databases

PhosphoSiteiQ9Z2C4.

Proteomic databases

MaxQBiQ9Z2C4.
PaxDbiQ9Z2C4.
PRIDEiQ9Z2C4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015358; ENSMUSP00000015358; ENSMUSG00000015214.
GeneIDi53332.
KEGGimmu:53332.
UCSCiuc009tjt.1. mouse.

Organism-specific databases

CTDi8776.
MGIiMGI:1858271. Mtmr1.

Phylogenomic databases

eggNOGiNOG322789.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000210598.
HOVERGENiHBG000220.
InParanoidiQ9Z2C4.
KOiK18081.
PhylomeDBiQ9Z2C4.

Enzyme and pathway databases

BRENDAi3.1.3.64. 3474.
ReactomeiREACT_272541. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

NextBioi310157.
PROiQ9Z2C4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z2C4.
CleanExiMM_MTMR1.
ExpressionAtlasiQ9Z2C4. baseline and differential.
GenevestigatoriQ9Z2C4.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004182. GRAM.
IPR030587. MTMR1/MTMR2.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PTHR10807:SF40. PTHR10807:SF40. 1 hit.
PfamiPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human."
    Laporte J., Blondeau F., Buj-Bello A., Tentler D., Kretz C., Dahl N., Mandel J.-L.
    Hum. Mol. Genet. 7:1703-1712(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Comparative sequence analysis of the mouse Mtm locus and the corresponding region of human Xq28."
    Wiehe T., Zhao W., Herman G.E., Rosenthal A., Platzer M.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Muscle-specific alternative splicing of myotubularin-related 1 gene is impaired in DM1 muscle cells."
    Buj-Bello A., Furling D., Tronchere H., Laporte J., Lerouge T., Butler-Browne G.S., Mandel J.L.
    Hum. Mol. Genet. 11:2297-2307(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiMTMR1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 27, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.