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Protein

Myotubularin-related protein 1

Gene

Mtmr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:12217958). Activity with phosphatidylinositol (3,5)-bisphosphate is controversial; it has been shown for the human ortholog (By similarity). In contrast, PubMed:12217958 find no activity with this substrate.By similarity1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.By similarity
1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei442Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei488SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism

Enzyme and pathway databases

BRENDAi3.1.3.64 3474
ReactomeiR-MMU-1660499 Synthesis of PIPs at the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 1
Alternative name(s):
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95By similarity)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.641 Publication)
Gene namesi
Name:Mtmr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1858271 Mtmr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949331 – 669Myotubularin-related protein 1Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei47PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Z2C4
MaxQBiQ9Z2C4
PaxDbiQ9Z2C4
PeptideAtlasiQ9Z2C4
PRIDEiQ9Z2C4

PTM databases

iPTMnetiQ9Z2C4
PhosphoSitePlusiQ9Z2C4

Expressioni

Tissue specificityi

Widely expressed. Detected in skeletal muscle, heart, lung, liver and brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000015214
CleanExiMM_MTMR1
ExpressionAtlasiQ9Z2C4 baseline and differential
GenevisibleiQ9Z2C4 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207292, 3 interactors
IntActiQ9Z2C4, 1 interactor
STRINGi10090.ENSMUSP00000015358

Structurei

3D structure databases

ProteinModelPortaliQ9Z2C4
SMRiQ9Z2C4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 165GRAMAdd BLAST72
Domaini230 – 605Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST376

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni355 – 358Substrate bindingBy similarity4
Regioni380 – 381Substrate bindingBy similarity2
Regioni442 – 448Substrate bindingBy similarity7
Regioni612 – 669Required for dimerizationBy similarityAdd BLAST58

Domaini

The C-terminal region is required for dimerization.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1089 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00760000118832
HOGENOMiHOG000210598
HOVERGENiHBG000220
InParanoidiQ9Z2C4
KOiK18081
PhylomeDBiQ9Z2C4

Family and domain databases

CDDicd13358 PH-GRAM_MTMR1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR004182 GRAM
IPR030587 MTMR1
IPR037857 MTMR1_PH-GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PANTHERiPTHR10807 PTHR10807, 1 hit
PTHR10807:SF40 PTHR10807:SF40, 1 hit
PfamiView protein in Pfam
PF02893 GRAM, 1 hit
PF06602 Myotub-related, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRPVAAAAA ASAASCEGAG GPGPGPGASW RPSRVAGGAS ASSRHPSIET
60 70 80 90 100
LDSPTGSHVE WCKQLIAATI SSQISGSVTS ENVSRDYKAL RDGNKLAQME
110 120 130 140 150
EAPLFPGESI KAIVKDVIYI CPFMGAVSGT LTVTDFKMYF KNVERDPHFV
160 170 180 190 200
LDVPLGVISR VEKIGAQSHG DNSCGIEIVC KDMRNLRLAY KQEEQRKLGI
210 220 230 240 250
FENLNKHAFP LSNGQVLFAF NYKEKFPVNG WKVYDPVSEY KRQGLPNESW
260 270 280 290 300
KISKINSNYE FCDTYPAIIV VPTSVKDDDL SKVAAFRAKG RVPVLSWIHP
310 320 330 340 350
ESQATITRCS QPLVGPNDKR CKEDEKYLQT IMDANAQSHK LTIFDARQNS
360 370 380 390 400
VADTNKAKGG GYENESAYPN AELIFLEIHN IHVMRESLRK LKEIVYPSID
410 420 430 440 450
ESHWLSNVDG THWLEYIRVL LAGAVRIADK IESGKTSVVI HCSDGWDRTS
460 470 480 490 500
QLTSLAMLML DSYYRTIKGF EALIEKEWIS FGHRFALRVG HGDDNHADAD
510 520 530 540 550
RSPIFLQFID CVWQMTRQFP SAFEFNELFL ITILDHLYSC LFGTFLCNCE
560 570 580 590 600
QQRIKEDVYT NTISLWSYIN SQLDEFSNPF FVNYENHVLY PVASMSHLEL
610 620 630 640 650
WVNYYVRWNP RMRPQMPIHQ NLKELLAIKA ELQKRVEDLQ REMATRTISS
660
SSERGSSPTH SATPVHTSV
Length:669
Mass (Da):75,313
Last modified:May 1, 1999 - v1
Checksum:i1856792245F2D800
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073997 mRNA Translation: AAC77822.1
AF125314 Genomic DNA No translation available.
BC056376 mRNA Translation: AAH56376.1
BC057337 mRNA Translation: AAH57337.1
CCDSiCCDS30178.1
RefSeqiNP_001300631.1, NM_001313702.1
NP_001300632.1, NM_001313703.1
NP_001300633.1, NM_001313704.1
NP_001300635.1, NM_001313706.1
NP_001300636.1, NM_001313707.1
NP_058681.1, NM_016985.2
UniGeneiMm.219672

Genome annotation databases

EnsembliENSMUST00000015358; ENSMUSP00000015358; ENSMUSG00000015214
GeneIDi53332
KEGGimmu:53332
UCSCiuc009tjt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMTMR1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health