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Q9Z2C4 (MTMR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Myotubularin-related protein 1
EC=3.1.3.-
Gene names
Name:Mtmr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length669 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Lipid phosphatase that acts on phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bisphosphate By similarity.

Subunit structure

Interacts with MTMR12 By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Contains 1 GRAM domain.

Contains 1 myotubularin phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 669669Myotubularin-related protein 1
PRO_0000094933

Regions

Domain94 – 16572GRAM
Domain230 – 605376Myotubularin phosphatase
Region355 – 3584Substrate binding By similarity
Region380 – 3812Substrate binding By similarity
Region442 – 4487Substrate binding By similarity

Sites

Active site4421Phosphocysteine intermediate By similarity
Binding site4881Substrate By similarity

Amino acid modifications

Modified residue471Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9Z2C4 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 1856792245F2D800

FASTA66975,313
        10         20         30         40         50         60 
MDRPVAAAAA ASAASCEGAG GPGPGPGASW RPSRVAGGAS ASSRHPSIET LDSPTGSHVE 

        70         80         90        100        110        120 
WCKQLIAATI SSQISGSVTS ENVSRDYKAL RDGNKLAQME EAPLFPGESI KAIVKDVIYI 

       130        140        150        160        170        180 
CPFMGAVSGT LTVTDFKMYF KNVERDPHFV LDVPLGVISR VEKIGAQSHG DNSCGIEIVC 

       190        200        210        220        230        240 
KDMRNLRLAY KQEEQRKLGI FENLNKHAFP LSNGQVLFAF NYKEKFPVNG WKVYDPVSEY 

       250        260        270        280        290        300 
KRQGLPNESW KISKINSNYE FCDTYPAIIV VPTSVKDDDL SKVAAFRAKG RVPVLSWIHP 

       310        320        330        340        350        360 
ESQATITRCS QPLVGPNDKR CKEDEKYLQT IMDANAQSHK LTIFDARQNS VADTNKAKGG 

       370        380        390        400        410        420 
GYENESAYPN AELIFLEIHN IHVMRESLRK LKEIVYPSID ESHWLSNVDG THWLEYIRVL 

       430        440        450        460        470        480 
LAGAVRIADK IESGKTSVVI HCSDGWDRTS QLTSLAMLML DSYYRTIKGF EALIEKEWIS 

       490        500        510        520        530        540 
FGHRFALRVG HGDDNHADAD RSPIFLQFID CVWQMTRQFP SAFEFNELFL ITILDHLYSC 

       550        560        570        580        590        600 
LFGTFLCNCE QQRIKEDVYT NTISLWSYIN SQLDEFSNPF FVNYENHVLY PVASMSHLEL 

       610        620        630        640        650        660 
WVNYYVRWNP RMRPQMPIHQ NLKELLAIKA ELQKRVEDLQ REMATRTISS SSERGSSPTH 


SATPVHTSV

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human."
Laporte J., Blondeau F., Buj-Bello A., Tentler D., Kretz C., Dahl N., Mandel J.-L.
Hum. Mol. Genet. 7:1703-1712(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Comparative sequence analysis of the mouse Mtm locus and the corresponding region of human Xq28."
Wiehe T., Zhao W., Herman G.E., Rosenthal A., Platzer M.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[4]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47, MASS SPECTROMETRY.
Tissue: Melanoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF073997 mRNA. Translation: AAC77822.1.
AF125314 Genomic DNA. No translation available.
BC056376 mRNA. Translation: AAH56376.1.
BC057337 mRNA. Translation: AAH57337.1.
IPIIPI00131028.
RefSeqNP_058681.1. NM_016985.2.
UniGeneMm.219672.

3D structure databases

ProteinModelPortalQ9Z2C4.
SMRQ9Z2C4. Positions 99-610.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9Z2C4. 1 interaction.
STRING10090.ENSMUSP00000110249.

PTM databases

PhosphoSiteQ9Z2C4.

Proteomic databases

PaxDbQ9Z2C4.
PRIDEQ9Z2C4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000015358; ENSMUSP00000015358; ENSMUSG00000015214.
GeneID53332.
KEGGmmu:53332.
UCSCuc009tjt.1. mouse.

Organism-specific databases

CTD8776.
MGIMGI:1858271. Mtmr1.

Phylogenomic databases

eggNOGNOG322789.
GeneTreeENSGT00670000097670.
HOGENOMHOG000210598.
HOVERGENHBG000220.
KOK01112.

Enzyme and pathway databases

BRENDA3.1.3.64. 3474.

Gene expression databases

ArrayExpressQ9Z2C4.
BgeeQ9Z2C4.
CleanExMM_MTMR1.
GenevestigatorQ9Z2C4.
GermOnlineENSMUSG00000015214. Mus musculus.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR004182. GRAM.
IPR010569. Myotub-related.
IPR017906. Myotubularin_phosphatase_dom.
IPR011993. PH_like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTSM00568. GRAM. 1 hit.
[Graphical view]
PROSITEPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio310157.
SOURCESearch...

Entry information

Entry nameMTMR1_MOUSE
AccessionPrimary (citable) accession number: Q9Z2C4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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