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Q9Z2C4

- MTMR1_MOUSE

UniProt

Q9Z2C4 - MTMR1_MOUSE

Protein

Myotubularin-related protein 1

Gene

Mtmr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Lipid phosphatase that acts on phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bisphosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei442 – 4421Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei488 – 4881SubstrateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol-3-phosphatase activity Source: MGI
    2. protein tyrosine phosphatase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BRENDAi3.1.3.64. 3474.
    ReactomeiREACT_198973. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotubularin-related protein 1 (EC:3.1.3.-)
    Gene namesi
    Name:Mtmr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1858271. Mtmr1.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 669669Myotubularin-related protein 1PRO_0000094933Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9Z2C4.
    PaxDbiQ9Z2C4.
    PRIDEiQ9Z2C4.

    PTM databases

    PhosphoSiteiQ9Z2C4.

    Expressioni

    Gene expression databases

    BgeeiQ9Z2C4.
    CleanExiMM_MTMR1.
    GenevestigatoriQ9Z2C4.

    Interactioni

    Subunit structurei

    Interacts with MTMR12.By similarity

    Protein-protein interaction databases

    BioGridi207292. 2 interactions.
    IntActiQ9Z2C4. 1 interaction.
    STRINGi10090.ENSMUSP00000110249.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2C4.
    SMRiQ9Z2C4. Positions 99-610.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini94 – 16572GRAMAdd
    BLAST
    Domaini230 – 605376Myotubularin phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni355 – 3584Substrate bindingBy similarity
    Regioni380 – 3812Substrate bindingBy similarity
    Regioni442 – 4487Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 GRAM domain.Curated
    Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG322789.
    GeneTreeiENSGT00670000097670.
    HOGENOMiHOG000210598.
    HOVERGENiHBG000220.
    KOiK18081.
    PhylomeDBiQ9Z2C4.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR004182. GRAM.
    IPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PfamiPF02893. GRAM. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view]
    SMARTiSM00568. GRAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z2C4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRPVAAAAA ASAASCEGAG GPGPGPGASW RPSRVAGGAS ASSRHPSIET    50
    LDSPTGSHVE WCKQLIAATI SSQISGSVTS ENVSRDYKAL RDGNKLAQME 100
    EAPLFPGESI KAIVKDVIYI CPFMGAVSGT LTVTDFKMYF KNVERDPHFV 150
    LDVPLGVISR VEKIGAQSHG DNSCGIEIVC KDMRNLRLAY KQEEQRKLGI 200
    FENLNKHAFP LSNGQVLFAF NYKEKFPVNG WKVYDPVSEY KRQGLPNESW 250
    KISKINSNYE FCDTYPAIIV VPTSVKDDDL SKVAAFRAKG RVPVLSWIHP 300
    ESQATITRCS QPLVGPNDKR CKEDEKYLQT IMDANAQSHK LTIFDARQNS 350
    VADTNKAKGG GYENESAYPN AELIFLEIHN IHVMRESLRK LKEIVYPSID 400
    ESHWLSNVDG THWLEYIRVL LAGAVRIADK IESGKTSVVI HCSDGWDRTS 450
    QLTSLAMLML DSYYRTIKGF EALIEKEWIS FGHRFALRVG HGDDNHADAD 500
    RSPIFLQFID CVWQMTRQFP SAFEFNELFL ITILDHLYSC LFGTFLCNCE 550
    QQRIKEDVYT NTISLWSYIN SQLDEFSNPF FVNYENHVLY PVASMSHLEL 600
    WVNYYVRWNP RMRPQMPIHQ NLKELLAIKA ELQKRVEDLQ REMATRTISS 650
    SSERGSSPTH SATPVHTSV 669
    Length:669
    Mass (Da):75,313
    Last modified:May 1, 1999 - v1
    Checksum:i1856792245F2D800
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF073997 mRNA. Translation: AAC77822.1.
    AF125314 Genomic DNA. No translation available.
    BC056376 mRNA. Translation: AAH56376.1.
    BC057337 mRNA. Translation: AAH57337.1.
    CCDSiCCDS30178.1.
    RefSeqiNP_058681.1. NM_016985.2.
    UniGeneiMm.219672.

    Genome annotation databases

    EnsembliENSMUST00000015358; ENSMUSP00000015358; ENSMUSG00000015214.
    GeneIDi53332.
    KEGGimmu:53332.
    UCSCiuc009tjt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF073997 mRNA. Translation: AAC77822.1 .
    AF125314 Genomic DNA. No translation available.
    BC056376 mRNA. Translation: AAH56376.1 .
    BC057337 mRNA. Translation: AAH57337.1 .
    CCDSi CCDS30178.1.
    RefSeqi NP_058681.1. NM_016985.2.
    UniGenei Mm.219672.

    3D structure databases

    ProteinModelPortali Q9Z2C4.
    SMRi Q9Z2C4. Positions 99-610.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207292. 2 interactions.
    IntActi Q9Z2C4. 1 interaction.
    STRINGi 10090.ENSMUSP00000110249.

    PTM databases

    PhosphoSitei Q9Z2C4.

    Proteomic databases

    MaxQBi Q9Z2C4.
    PaxDbi Q9Z2C4.
    PRIDEi Q9Z2C4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000015358 ; ENSMUSP00000015358 ; ENSMUSG00000015214 .
    GeneIDi 53332.
    KEGGi mmu:53332.
    UCSCi uc009tjt.1. mouse.

    Organism-specific databases

    CTDi 8776.
    MGIi MGI:1858271. Mtmr1.

    Phylogenomic databases

    eggNOGi NOG322789.
    GeneTreei ENSGT00670000097670.
    HOGENOMi HOG000210598.
    HOVERGENi HBG000220.
    KOi K18081.
    PhylomeDBi Q9Z2C4.

    Enzyme and pathway databases

    BRENDAi 3.1.3.64. 3474.
    Reactomei REACT_198973. Synthesis of PIPs at the plasma membrane.

    Miscellaneous databases

    NextBioi 310157.
    PROi Q9Z2C4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z2C4.
    CleanExi MM_MTMR1.
    Genevestigatori Q9Z2C4.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR004182. GRAM.
    IPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    Pfami PF02893. GRAM. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view ]
    SMARTi SM00568. GRAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human."
      Laporte J., Blondeau F., Buj-Bello A., Tentler D., Kretz C., Dahl N., Mandel J.-L.
      Hum. Mol. Genet. 7:1703-1712(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Comparative sequence analysis of the mouse Mtm locus and the corresponding region of human Xq28."
      Wiehe T., Zhao W., Herman G.E., Rosenthal A., Platzer M.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiMTMR1_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z2C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3