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Protein

RPE-retinal G protein-coupled receptor

Gene

Rgr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: MGI
  • photoreceptor activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Chromophore

Names & Taxonomyi

Protein namesi
Recommended name:
RPE-retinal G protein-coupled receptor
Gene namesi
Name:Rgr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1929473. Rgr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515ExtracellularSequence analysisAdd
BLAST
Transmembranei16 – 3621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini37 – 5216CytoplasmicSequence analysisAdd
BLAST
Transmembranei53 – 7321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini74 – 9118ExtracellularSequence analysisAdd
BLAST
Transmembranei92 – 11221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini113 – 13018CytoplasmicSequence analysisAdd
BLAST
Transmembranei131 – 15121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini152 – 17524ExtracellularSequence analysisAdd
BLAST
Transmembranei176 – 19621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini197 – 21923CytoplasmicSequence analysisAdd
BLAST
Transmembranei220 – 24021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini241 – 2477ExtracellularSequence analysis
Transmembranei248 – 26821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini269 – 29123CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291RPE-retinal G protein-coupled receptorPRO_0000197823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi88 ↔ 162PROSITE-ProRule annotation
Modified residuei255 – 2551N6-(retinylidene)lysineBy similarity

Post-translational modificationi

Covalently binds all-trans- and 11-cis-retinal.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Z2B3.
PRIDEiQ9Z2B3.

PTM databases

PhosphoSiteiQ9Z2B3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021804.
CleanExiMM_RGR.
ExpressionAtlasiQ9Z2B3. baseline and differential.
GenevisibleiQ9Z2B3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022338.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2B3.
SMRiQ9Z2B3. Positions 13-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119394.
HOGENOMiHOG000293329.
HOVERGENiHBG017721.
InParanoidiQ9Z2B3.
KOiK04254.
OMAiSHRRWPY.
OrthoDBiEOG091G0CL2.
PhylomeDBiQ9Z2B3.
TreeFamiTF324998.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001793. RPE_GPCR.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00667. RPERETINALR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z2B3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATRALPAG LGELEVLAVG TVLLMEALSG ISLNGLTIFS FCKTPDLRTP
60 70 80 90 100
SNLLVLSLAL ADTGISLNAL VAAVSSLLRR WPHGSEGCQV HGFQGFATAL
110 120 130 140 150
ASICGSAAVA WGRYHHYCTR RQLAWDTAIP LVLFVWMSSA FWASLPLMGW
160 170 180 190 200
GHYDYEPVGT CCTLDYSRGD RNFISFLFTM AFFNFLVPLF ITHTSYRFME
210 220 230 240 250
QKFSRSGHLP VNTTLPGRML LLGWGPYALL YLYAAIADVS FISPKLQMVP
260 270 280 290
ALIAKTMPTI NAINYALHRE MVCRGTWQCL SPQKSKKDRT Q
Length:291
Mass (Da):32,127
Last modified:May 1, 1999 - v1
Checksum:iED31E1F937810A7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076930 mRNA. Translation: AAC69836.1.
CCDSiCCDS26949.1.
RefSeqiNP_067315.1. NM_021340.4.
UniGeneiMm.20460.

Genome annotation databases

EnsembliENSMUST00000022338; ENSMUSP00000022338; ENSMUSG00000021804.
GeneIDi57811.
KEGGimmu:57811.
UCSCiuc007tbp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076930 mRNA. Translation: AAC69836.1.
CCDSiCCDS26949.1.
RefSeqiNP_067315.1. NM_021340.4.
UniGeneiMm.20460.

3D structure databases

ProteinModelPortaliQ9Z2B3.
SMRiQ9Z2B3. Positions 13-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022338.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9Z2B3.

Proteomic databases

PaxDbiQ9Z2B3.
PRIDEiQ9Z2B3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022338; ENSMUSP00000022338; ENSMUSG00000021804.
GeneIDi57811.
KEGGimmu:57811.
UCSCiuc007tbp.2. mouse.

Organism-specific databases

CTDi5995.
MGIiMGI:1929473. Rgr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119394.
HOGENOMiHOG000293329.
HOVERGENiHBG017721.
InParanoidiQ9Z2B3.
KOiK04254.
OMAiSHRRWPY.
OrthoDBiEOG091G0CL2.
PhylomeDBiQ9Z2B3.
TreeFamiTF324998.

Miscellaneous databases

ChiTaRSiRgr. mouse.
PROiQ9Z2B3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021804.
CleanExiMM_RGR.
ExpressionAtlasiQ9Z2B3. baseline and differential.
GenevisibleiQ9Z2B3. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001793. RPE_GPCR.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00667. RPERETINALR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGR_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.