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Protein

Brain mitochondrial carrier protein 1

Gene

Slc25a14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the mitochondrial proton leak measured in brain mitochondria.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-167826 The fatty acid cycling model
R-MMU-167827 The proton buffering model

Names & Taxonomyi

Protein namesi
Recommended name:
Brain mitochondrial carrier protein 1
Short name:
BMCP-1
Alternative name(s):
Mitochondrial uncoupling protein 5
Short name:
UCP 5
Solute carrier family 25 member 14
Gene namesi
Name:Slc25a14
Synonyms:Bmcp1, Ucp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1330823 Slc25a14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 54Helical; Name=1Sequence analysisAdd BLAST17
Transmembranei112 – 128Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei145 – 165Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei199 – 215Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei240 – 256Helical; Name=5Sequence analysisAdd BLAST17
Transmembranei298 – 315Helical; Name=6Sequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906781 – 325Brain mitochondrial carrier protein 1Add BLAST325

Proteomic databases

PaxDbiQ9Z2B2
PRIDEiQ9Z2B2

PTM databases

PhosphoSitePlusiQ9Z2B2

Expressioni

Tissue specificityi

Mainly expressed in brain, particularly abundant in cortex, hippocampus thalamus, amygdala and hypothalamus. Expressed in other tissues to a lesser extent.1 Publication

Gene expression databases

BgeeiENSMUSG00000031105
ExpressionAtlasiQ9Z2B2 baseline and differential
GenevisibleiQ9Z2B2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110586

Structurei

3D structure databases

ProteinModelPortaliQ9Z2B2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati42 – 131Solcar 1Add BLAST90
Repeati139 – 224Solcar 2Add BLAST86
Repeati233 – 323Solcar 3Add BLAST91

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753 Eukaryota
ENOG410XRV1 LUCA
GeneTreeiENSGT00760000119170
HOGENOMiHOG000165140
HOVERGENiHBG009528
InParanoidiQ9Z2B2
KOiK15106
OMAiDQVANHF
OrthoDBiEOG091G0BQ7
PhylomeDBiQ9Z2B2
TreeFamiTF323211

Family and domain databases

Gene3Di1.50.40.101 hit
InterProiView protein in InterPro
IPR002030 Mit_uncoupling_UCP-like
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
IPR032933 SLC25A14
PANTHERiPTHR24089:SF299 PTHR24089:SF299, 1 hit
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00784 MTUNCOUPLING
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z2B2-1) [UniParc]FASTAAdd to basket
Also known as: UCP5L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGIFPGIILI FLRVKFATAA VIVSGHQKSS TLSHEMSGLN WKPFVYGGLA
60 70 80 90 100
SIVAEFGTFP VDLTKTRLQV QGQSIDVRFK EIKYRGMFHA LFRIYKEEGI
110 120 130 140 150
LALYSGIAPA LLRQASYGTI KIGIYQSLKR LFVERLEDET LLINMICGVV
160 170 180 190 200
SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM IGSFIDIYQQ EGTRGLWRGV
210 220 230 240 250
VPTAQRAAIV VGVELPVYDI TKKHLIVSGM LGDTILTHFV SSFTCGLAGA
260 270 280 290 300
LASNPVDVVR TRMMNQRAIV GHVDLYKGTL DGILKMWKHE GFFALYKGFW
310 320
PNWLRLGPWN IIFFITYEQL KRLQI
Length:325
Mass (Da):36,286
Last modified:December 19, 2001 - v2
Checksum:i19BF01EF12809D83
GO
Isoform 2 (identifier: Q9Z2B2-2) [UniParc]FASTAAdd to basket
Also known as: UCP5S

The sequence of this isoform differs from the canonical sequence as follows:
     23-25: Missing.

Show »
Length:322
Mass (Da):36,042
Checksum:iEE396FBCCD6BDB6B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00327423 – 25Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076981 mRNA Translation: AAD03674.1
AF155812 mRNA Translation: AAG29585.1
AF155813 mRNA Translation: AAG29586.1
BC048692 mRNA Translation: AAH48692.1
CCDSiCCDS30112.1 [Q9Z2B2-2]
CCDS53066.1 [Q9Z2B2-1]
RefSeqiNP_001159922.1, NM_001166450.2 [Q9Z2B2-1]
NP_001277634.1, NM_001290705.1
NP_035528.1, NM_011398.3 [Q9Z2B2-2]
XP_017173930.1, XM_017318441.1
UniGeneiMm.34953

Genome annotation databases

EnsembliENSMUST00000033431; ENSMUSP00000033431; ENSMUSG00000031105 [Q9Z2B2-2]
ENSMUST00000114936; ENSMUSP00000110586; ENSMUSG00000031105 [Q9Z2B2-1]
ENSMUST00000177710; ENSMUSP00000136140; ENSMUSG00000031105 [Q9Z2B2-1]
GeneIDi20523
KEGGimmu:20523
UCSCiuc009tco.3 mouse [Q9Z2B2-2]
uc009tcp.3 mouse [Q9Z2B2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUCP5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2B2
Secondary accession number(s): Q9ESI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 19, 2001
Last modified: April 25, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome