Q9Z2B2 (UCP5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brain mitochondrial carrier protein 1
Short name=BMCP-1

Alternative name(s):
Mitochondrial uncoupling protein 5
Short name=UCP 5
Solute carrier family 25 member 14

Gene names

Name:	Slc25a14
Synonyms:	Bmcp1, Ucp5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Participates in the mitochondrial proton leak measured in brain mitochondria.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Mainly expressed in brain, particularly abundant in cortex, hippocampus thalamus, amygdala and hypothalamus. Expressed in other tissues to a lesser extent. Ref.2
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mitochondrial transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial envelope Inferred from direct assay Ref.1. Source: MGI mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Z2B2-1)

Also known as: UCP5L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Z2B2-2)

Also known as: UCP5S;

The sequence of this isoform differs from the canonical sequence as follows:
     23-25: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	Brain mitochondrial carrier protein 1		PRO_0000090678
Regions
	Transmembrane	38 – 54	17	Helical; Name=1; Potential
	Transmembrane	112 – 128	17	Helical; Name=2; Potential
	Transmembrane	145 – 165	21	Helical; Name=3; Potential
	Transmembrane	199 – 215	17	Helical; Name=4; Potential
	Transmembrane	240 – 256	17	Helical; Name=5; Potential
	Transmembrane	298 – 315	18	Helical; Name=6; Potential
	Repeat	42 – 131	90	Solcar 1
	Repeat	139 – 224	86	Solcar 2
	Repeat	233 – 323	91	Solcar 3
Natural variations
	Alternative sequence	23 – 25	3	Missing in isoform 2.		VSP_003274

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (UCP5L) [UniParc]. Last modified December 19, 2001. Version 2. Checksum: 19BF01EF12809D83	FASTA	325	36,286
	10 20 30 40 50 60 MGIFPGIILI FLRVKFATAA VIVSGHQKSS TLSHEMSGLN WKPFVYGGLA SIVAEFGTFP 70 80 90 100 110 120 VDLTKTRLQV QGQSIDVRFK EIKYRGMFHA LFRIYKEEGI LALYSGIAPA LLRQASYGTI 130 140 150 160 170 180 KIGIYQSLKR LFVERLEDET LLINMICGVV SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM 190 200 210 220 230 240 IGSFIDIYQQ EGTRGLWRGV VPTAQRAAIV VGVELPVYDI TKKHLIVSGM LGDTILTHFV 250 260 270 280 290 300 SSFTCGLAGA LASNPVDVVR TRMMNQRAIV GHVDLYKGTL DGILKMWKHE GFFALYKGFW 310 320 PNWLRLGPWN IIFFITYEQL KRLQI
	Isoform 2 (UCP5S) [UniParc]. Checksum: EE396FBCCD6BDB6B	FASTA	322	36,042
	10 20 30 40 50 60 MGIFPGIILI FLRVKFATAA VIHQKSSTLS HEMSGLNWKP FVYGGLASIV AEFGTFPVDL 70 80 90 100 110 120 TKTRLQVQGQ SIDVRFKEIK YRGMFHALFR IYKEEGILAL YSGIAPALLR QASYGTIKIG 130 140 150 160 170 180 IYQSLKRLFV ERLEDETLLI NMICGVVSGV ISSTIANPTD VLKIRMQAQG SLFQGSMIGS 190 200 210 220 230 240 FIDIYQQEGT RGLWRGVVPT AQRAAIVVGV ELPVYDITKK HLIVSGMLGD TILTHFVSSF 250 260 270 280 290 300 TCGLAGALAS NPVDVVRTRM MNQRAIVGHV DLYKGTLDGI LKMWKHEGFF ALYKGFWPNW 310 320 LRLGPWNIIF FITYEQLKRL QI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast." Sanchis D., Fleury C., Chomiki N., Goubern M., Huang Q., Neverova M., Gregoire F., Easlick J., Raimbault S., Levi-Meyrueis C., Miroux B., Collins S., Seldin M., Richard D., Warden C., Bouillaud F., Ricquier D. J. Biol. Chem. 273:34611-34615(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Strain: BALB/c. Tissue: Brain.
[2]	"Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation." Yu X.X., Mao W., Zhong A., Schow P., Brush J., Sherwood S.W., Adams S.H., Pan G. FASEB J. 14:1611-1618(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF076981 mRNA. Translation: AAD03674.1. AF155812 mRNA. Translation: AAG29585.1. AF155813 mRNA. Translation: AAG29586.1. BC048692 mRNA. Translation: AAH48692.1.
IPI	IPI00130996. IPI00226724.
RefSeq	NP_001159922.1. NM_001166450.1. NP_035528.1. NM_011398.2.
UniGene	Mm.34953.
3D structure databases
ProteinModelPortal	Q9Z2B2.
SMR	Q9Z2B2. Positions 44-322.
ModBase	Search...
PTM databases
PhosphoSite	Q9Z2B2.
Proteomic databases
PaxDb	Q9Z2B2.
PRIDE	Q9Z2B2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000033431; ENSMUSP00000033431; ENSMUSG00000031105. ENSMUST00000114936; ENSMUSP00000110586; ENSMUSG00000031105. ENSMUST00000177710; ENSMUSP00000136140; ENSMUSG00000031105.
GeneID	20523.
KEGG	mmu:20523.
Organism-specific databases
CTD	9016.
MGI	MGI:1330823. Slc25a14.
Phylogenomic databases
eggNOG	NOG240642.
GeneTree	ENSGT00550000074223.
HOGENOM	HOG000165140.
HOVERGEN	HBG009528.
KO	K15106.
Gene expression databases
ArrayExpress	Q9Z2B2.
Bgee	Q9Z2B2.
Genevestigator	Q9Z2B2.
GermOnline	ENSMUSG00000031105. Mus musculus.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR002030. Mit_uncoupling. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
PRINTS	PR00784. MTUNCOUPLING.
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	298755.
SOURCE	Search...

Entry information

Entry name

UCP5_MOUSE

Accession

Primary (citable) accession number: Q9Z2B2
Secondary accession number(s): Q9ESI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	December 19, 2001
Last modified:	May 1, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program