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Q9Z2B2 (UCP5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brain mitochondrial carrier protein 1

Short name=BMCP-1
Alternative name(s):
Mitochondrial uncoupling protein 5
Short name=UCP 5
Solute carrier family 25 member 14
Gene names
Name:Slc25a14
Synonyms:Bmcp1, Ucp5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Participates in the mitochondrial proton leak measured in brain mitochondria.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Mainly expressed in brain, particularly abundant in cortex, hippocampus thalamus, amygdala and hypothalamus. Expressed in other tissues to a lesser extent. Ref.2

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Z2B2-1)

Also known as: UCP5L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Z2B2-2)

Also known as: UCP5S;

The sequence of this isoform differs from the canonical sequence as follows:
     23-25: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Brain mitochondrial carrier protein 1
PRO_0000090678

Regions

Transmembrane38 – 5417Helical; Name=1; Potential
Transmembrane112 – 12817Helical; Name=2; Potential
Transmembrane145 – 16521Helical; Name=3; Potential
Transmembrane199 – 21517Helical; Name=4; Potential
Transmembrane240 – 25617Helical; Name=5; Potential
Transmembrane298 – 31518Helical; Name=6; Potential
Repeat42 – 13190Solcar 1
Repeat139 – 22486Solcar 2
Repeat233 – 32391Solcar 3

Natural variations

Alternative sequence23 – 253Missing in isoform 2.
VSP_003274

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (UCP5L) [UniParc].

Last modified December 19, 2001. Version 2.
Checksum: 19BF01EF12809D83

FASTA32536,286
        10         20         30         40         50         60 
MGIFPGIILI FLRVKFATAA VIVSGHQKSS TLSHEMSGLN WKPFVYGGLA SIVAEFGTFP 

        70         80         90        100        110        120 
VDLTKTRLQV QGQSIDVRFK EIKYRGMFHA LFRIYKEEGI LALYSGIAPA LLRQASYGTI 

       130        140        150        160        170        180 
KIGIYQSLKR LFVERLEDET LLINMICGVV SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM 

       190        200        210        220        230        240 
IGSFIDIYQQ EGTRGLWRGV VPTAQRAAIV VGVELPVYDI TKKHLIVSGM LGDTILTHFV 

       250        260        270        280        290        300 
SSFTCGLAGA LASNPVDVVR TRMMNQRAIV GHVDLYKGTL DGILKMWKHE GFFALYKGFW 

       310        320 
PNWLRLGPWN IIFFITYEQL KRLQI 

« Hide

Isoform 2 (UCP5S) [UniParc].

Checksum: EE396FBCCD6BDB6B
Show »

FASTA32236,042

References

« Hide 'large scale' references
[1]"BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast."
Sanchis D., Fleury C., Chomiki N., Goubern M., Huang Q., Neverova M., Gregoire F., Easlick J., Raimbault S., Levi-Meyrueis C., Miroux B., Collins S., Seldin M., Richard D., Warden C., Bouillaud F., Ricquier D.
J. Biol. Chem. 273:34611-34615(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Strain: BALB/c.
Tissue: Brain.
[2]"Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation."
Yu X.X., Mao W., Zhong A., Schow P., Brush J., Sherwood S.W., Adams S.H., Pan G.
FASEB J. 14:1611-1618(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF076981 mRNA. Translation: AAD03674.1.
AF155812 mRNA. Translation: AAG29585.1.
AF155813 mRNA. Translation: AAG29586.1.
BC048692 mRNA. Translation: AAH48692.1.
CCDSCCDS30112.1. [Q9Z2B2-2]
CCDS53066.1. [Q9Z2B2-1]
RefSeqNP_001159922.1. NM_001166450.2. [Q9Z2B2-1]
NP_001277634.1. NM_001290705.1.
NP_035528.1. NM_011398.3. [Q9Z2B2-2]
XP_006541511.1. XM_006541448.1. [Q9Z2B2-1]
UniGeneMm.34953.

3D structure databases

ProteinModelPortalQ9Z2B2.
SMRQ9Z2B2. Positions 44-322.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9Z2B2.

Proteomic databases

PaxDbQ9Z2B2.
PRIDEQ9Z2B2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033431; ENSMUSP00000033431; ENSMUSG00000031105. [Q9Z2B2-2]
ENSMUST00000114936; ENSMUSP00000110586; ENSMUSG00000031105. [Q9Z2B2-1]
ENSMUST00000177710; ENSMUSP00000136140; ENSMUSG00000031105. [Q9Z2B2-1]
GeneID20523.
KEGGmmu:20523.
UCSCuc009tcp.2. mouse. [Q9Z2B2-1]

Organism-specific databases

CTD9016.
MGIMGI:1330823. Slc25a14.

Phylogenomic databases

eggNOGNOG240642.
GeneTreeENSGT00750000117602.
HOGENOMHOG000165140.
HOVERGENHBG009528.
KOK15106.
OMAWRCLCSK.
OrthoDBEOG793B7Z.
PhylomeDBQ9Z2B2.
TreeFamTF323211.

Gene expression databases

BgeeQ9Z2B2.
GenevestigatorQ9Z2B2.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00784. MTUNCOUPLING.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio298755.
PROQ9Z2B2.
SOURCESearch...

Entry information

Entry nameUCP5_MOUSE
AccessionPrimary (citable) accession number: Q9Z2B2
Secondary accession number(s): Q9ESI8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 19, 2001
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot