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Q9Z2B2

- UCP5_MOUSE

UniProt

Q9Z2B2 - UCP5_MOUSE

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Protein

Brain mitochondrial carrier protein 1

Gene

Slc25a14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Participates in the mitochondrial proton leak measured in brain mitochondria.

GO - Biological processi

  1. mitochondrial transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Brain mitochondrial carrier protein 1
Short name:
BMCP-1
Alternative name(s):
Mitochondrial uncoupling protein 5
Short name:
UCP 5
Solute carrier family 25 member 14
Gene namesi
Name:Slc25a14
Synonyms:Bmcp1, Ucp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1330823. Slc25a14.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial envelope Source: MGI
  3. mitochondrial inner membrane Source: UniProtKB-KW
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Brain mitochondrial carrier protein 1PRO_0000090678Add
BLAST

Proteomic databases

MaxQBiQ9Z2B2.
PaxDbiQ9Z2B2.
PRIDEiQ9Z2B2.

PTM databases

PhosphoSiteiQ9Z2B2.

Expressioni

Tissue specificityi

Mainly expressed in brain, particularly abundant in cortex, hippocampus thalamus, amygdala and hypothalamus. Expressed in other tissues to a lesser extent.1 Publication

Gene expression databases

BgeeiQ9Z2B2.
ExpressionAtlasiQ9Z2B2. baseline and differential.
GenevestigatoriQ9Z2B2.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2B2.
SMRiQ9Z2B2. Positions 44-322.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5417Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei112 – 12817Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei199 – 21517Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei240 – 25617Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei298 – 31518Helical; Name=6Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 13190Solcar 1Add
BLAST
Repeati139 – 22486Solcar 2Add
BLAST
Repeati233 – 32391Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG240642.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiQ9Z2B2.
KOiK15106.
OMAiWRCLCSK.
OrthoDBiEOG793B7Z.
PhylomeDBiQ9Z2B2.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Z2B2-1) [UniParc]FASTAAdd to Basket

Also known as: UCP5L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGIFPGIILI FLRVKFATAA VIVSGHQKSS TLSHEMSGLN WKPFVYGGLA
60 70 80 90 100
SIVAEFGTFP VDLTKTRLQV QGQSIDVRFK EIKYRGMFHA LFRIYKEEGI
110 120 130 140 150
LALYSGIAPA LLRQASYGTI KIGIYQSLKR LFVERLEDET LLINMICGVV
160 170 180 190 200
SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM IGSFIDIYQQ EGTRGLWRGV
210 220 230 240 250
VPTAQRAAIV VGVELPVYDI TKKHLIVSGM LGDTILTHFV SSFTCGLAGA
260 270 280 290 300
LASNPVDVVR TRMMNQRAIV GHVDLYKGTL DGILKMWKHE GFFALYKGFW
310 320
PNWLRLGPWN IIFFITYEQL KRLQI
Length:325
Mass (Da):36,286
Last modified:December 19, 2001 - v2
Checksum:i19BF01EF12809D83
GO
Isoform 2 (identifier: Q9Z2B2-2) [UniParc]FASTAAdd to Basket

Also known as: UCP5S

The sequence of this isoform differs from the canonical sequence as follows:
     23-25: Missing.

Show »
Length:322
Mass (Da):36,042
Checksum:iEE396FBCCD6BDB6B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei23 – 253Missing in isoform 2. 1 PublicationVSP_003274

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF076981 mRNA. Translation: AAD03674.1.
AF155812 mRNA. Translation: AAG29585.1.
AF155813 mRNA. Translation: AAG29586.1.
BC048692 mRNA. Translation: AAH48692.1.
CCDSiCCDS30112.1. [Q9Z2B2-2]
CCDS53066.1. [Q9Z2B2-1]
RefSeqiNP_001159922.1. NM_001166450.2. [Q9Z2B2-1]
NP_001277634.1. NM_001290705.1.
NP_035528.1. NM_011398.3. [Q9Z2B2-2]
XP_006541511.1. XM_006541448.1. [Q9Z2B2-1]
UniGeneiMm.34953.

Genome annotation databases

EnsembliENSMUST00000033431; ENSMUSP00000033431; ENSMUSG00000031105. [Q9Z2B2-2]
ENSMUST00000114936; ENSMUSP00000110586; ENSMUSG00000031105. [Q9Z2B2-1]
ENSMUST00000177710; ENSMUSP00000136140; ENSMUSG00000031105. [Q9Z2B2-1]
GeneIDi20523.
KEGGimmu:20523.
UCSCiuc009tcp.2. mouse. [Q9Z2B2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF076981 mRNA. Translation: AAD03674.1 .
AF155812 mRNA. Translation: AAG29585.1 .
AF155813 mRNA. Translation: AAG29586.1 .
BC048692 mRNA. Translation: AAH48692.1 .
CCDSi CCDS30112.1. [Q9Z2B2-2 ]
CCDS53066.1. [Q9Z2B2-1 ]
RefSeqi NP_001159922.1. NM_001166450.2. [Q9Z2B2-1 ]
NP_001277634.1. NM_001290705.1.
NP_035528.1. NM_011398.3. [Q9Z2B2-2 ]
XP_006541511.1. XM_006541448.1. [Q9Z2B2-1 ]
UniGenei Mm.34953.

3D structure databases

ProteinModelPortali Q9Z2B2.
SMRi Q9Z2B2. Positions 44-322.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9Z2B2.

Proteomic databases

MaxQBi Q9Z2B2.
PaxDbi Q9Z2B2.
PRIDEi Q9Z2B2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033431 ; ENSMUSP00000033431 ; ENSMUSG00000031105 . [Q9Z2B2-2 ]
ENSMUST00000114936 ; ENSMUSP00000110586 ; ENSMUSG00000031105 . [Q9Z2B2-1 ]
ENSMUST00000177710 ; ENSMUSP00000136140 ; ENSMUSG00000031105 . [Q9Z2B2-1 ]
GeneIDi 20523.
KEGGi mmu:20523.
UCSCi uc009tcp.2. mouse. [Q9Z2B2-1 ]

Organism-specific databases

CTDi 9016.
MGIi MGI:1330823. Slc25a14.

Phylogenomic databases

eggNOGi NOG240642.
GeneTreei ENSGT00760000119170.
HOGENOMi HOG000165140.
HOVERGENi HBG009528.
InParanoidi Q9Z2B2.
KOi K15106.
OMAi WRCLCSK.
OrthoDBi EOG793B7Z.
PhylomeDBi Q9Z2B2.
TreeFami TF323211.

Miscellaneous databases

NextBioi 298755.
PROi Q9Z2B2.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z2B2.
ExpressionAtlasi Q9Z2B2. baseline and differential.
Genevestigatori Q9Z2B2.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00784. MTUNCOUPLING.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast."
    Sanchis D., Fleury C., Chomiki N., Goubern M., Huang Q., Neverova M., Gregoire F., Easlick J., Raimbault S., Levi-Meyrueis C., Miroux B., Collins S., Seldin M., Richard D., Warden C., Bouillaud F., Ricquier D.
    J. Biol. Chem. 273:34611-34615(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: BALB/c.
    Tissue: Brain.
  2. "Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation."
    Yu X.X., Mao W., Zhong A., Schow P., Brush J., Sherwood S.W., Adams S.H., Pan G.
    FASEB J. 14:1611-1618(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo.

Entry informationi

Entry nameiUCP5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2B2
Secondary accession number(s): Q9ESI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 19, 2001
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3