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Protein

Brain mitochondrial carrier protein 1

Gene

Slc25a14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the mitochondrial proton leak measured in brain mitochondria.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-167826. The fatty acid cycling model.
R-MMU-167827. The proton buffering model.

Names & Taxonomyi

Protein namesi
Recommended name:
Brain mitochondrial carrier protein 1
Short name:
BMCP-1
Alternative name(s):
Mitochondrial uncoupling protein 5
Short name:
UCP 5
Solute carrier family 25 member 14
Gene namesi
Name:Slc25a14
Synonyms:Bmcp1, Ucp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1330823. Slc25a14.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 54Helical; Name=1Sequence analysisAdd BLAST17
Transmembranei112 – 128Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei145 – 165Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei199 – 215Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei240 – 256Helical; Name=5Sequence analysisAdd BLAST17
Transmembranei298 – 315Helical; Name=6Sequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial envelope Source: MGI
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906781 – 325Brain mitochondrial carrier protein 1Add BLAST325

Proteomic databases

PaxDbiQ9Z2B2.
PRIDEiQ9Z2B2.

PTM databases

PhosphoSitePlusiQ9Z2B2.

Expressioni

Tissue specificityi

Mainly expressed in brain, particularly abundant in cortex, hippocampus thalamus, amygdala and hypothalamus. Expressed in other tissues to a lesser extent.1 Publication

Gene expression databases

BgeeiENSMUSG00000031105.
ExpressionAtlasiQ9Z2B2. baseline and differential.
GenevisibleiQ9Z2B2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110586.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2B2.
SMRiQ9Z2B2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati42 – 131Solcar 1Add BLAST90
Repeati139 – 224Solcar 2Add BLAST86
Repeati233 – 323Solcar 3Add BLAST91

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiQ9Z2B2.
KOiK15106.
OMAiKIGTYNT.
OrthoDBiEOG091G0BQ7.
PhylomeDBiQ9Z2B2.
TreeFamiTF323211.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR032933. SLC25A14.
[Graphical view]
PANTHERiPTHR24089:SF299. PTHR24089:SF299. 1 hit.
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z2B2-1) [UniParc]FASTAAdd to basket
Also known as: UCP5L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGIFPGIILI FLRVKFATAA VIVSGHQKSS TLSHEMSGLN WKPFVYGGLA
60 70 80 90 100
SIVAEFGTFP VDLTKTRLQV QGQSIDVRFK EIKYRGMFHA LFRIYKEEGI
110 120 130 140 150
LALYSGIAPA LLRQASYGTI KIGIYQSLKR LFVERLEDET LLINMICGVV
160 170 180 190 200
SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM IGSFIDIYQQ EGTRGLWRGV
210 220 230 240 250
VPTAQRAAIV VGVELPVYDI TKKHLIVSGM LGDTILTHFV SSFTCGLAGA
260 270 280 290 300
LASNPVDVVR TRMMNQRAIV GHVDLYKGTL DGILKMWKHE GFFALYKGFW
310 320
PNWLRLGPWN IIFFITYEQL KRLQI
Length:325
Mass (Da):36,286
Last modified:December 19, 2001 - v2
Checksum:i19BF01EF12809D83
GO
Isoform 2 (identifier: Q9Z2B2-2) [UniParc]FASTAAdd to basket
Also known as: UCP5S

The sequence of this isoform differs from the canonical sequence as follows:
     23-25: Missing.

Show »
Length:322
Mass (Da):36,042
Checksum:iEE396FBCCD6BDB6B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00327423 – 25Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076981 mRNA. Translation: AAD03674.1.
AF155812 mRNA. Translation: AAG29585.1.
AF155813 mRNA. Translation: AAG29586.1.
BC048692 mRNA. Translation: AAH48692.1.
CCDSiCCDS30112.1. [Q9Z2B2-2]
CCDS53066.1. [Q9Z2B2-1]
RefSeqiNP_001159922.1. NM_001166450.2. [Q9Z2B2-1]
NP_001277634.1. NM_001290705.1.
NP_035528.1. NM_011398.3. [Q9Z2B2-2]
XP_017173930.1. XM_017318441.1. [Q9Z2B2-2]
UniGeneiMm.34953.

Genome annotation databases

EnsembliENSMUST00000033431; ENSMUSP00000033431; ENSMUSG00000031105. [Q9Z2B2-2]
ENSMUST00000114936; ENSMUSP00000110586; ENSMUSG00000031105. [Q9Z2B2-1]
ENSMUST00000177710; ENSMUSP00000136140; ENSMUSG00000031105. [Q9Z2B2-1]
GeneIDi20523.
KEGGimmu:20523.
UCSCiuc009tco.3. mouse. [Q9Z2B2-2]
uc009tcp.3. mouse. [Q9Z2B2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076981 mRNA. Translation: AAD03674.1.
AF155812 mRNA. Translation: AAG29585.1.
AF155813 mRNA. Translation: AAG29586.1.
BC048692 mRNA. Translation: AAH48692.1.
CCDSiCCDS30112.1. [Q9Z2B2-2]
CCDS53066.1. [Q9Z2B2-1]
RefSeqiNP_001159922.1. NM_001166450.2. [Q9Z2B2-1]
NP_001277634.1. NM_001290705.1.
NP_035528.1. NM_011398.3. [Q9Z2B2-2]
XP_017173930.1. XM_017318441.1. [Q9Z2B2-2]
UniGeneiMm.34953.

3D structure databases

ProteinModelPortaliQ9Z2B2.
SMRiQ9Z2B2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110586.

PTM databases

PhosphoSitePlusiQ9Z2B2.

Proteomic databases

PaxDbiQ9Z2B2.
PRIDEiQ9Z2B2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033431; ENSMUSP00000033431; ENSMUSG00000031105. [Q9Z2B2-2]
ENSMUST00000114936; ENSMUSP00000110586; ENSMUSG00000031105. [Q9Z2B2-1]
ENSMUST00000177710; ENSMUSP00000136140; ENSMUSG00000031105. [Q9Z2B2-1]
GeneIDi20523.
KEGGimmu:20523.
UCSCiuc009tco.3. mouse. [Q9Z2B2-2]
uc009tcp.3. mouse. [Q9Z2B2-1]

Organism-specific databases

CTDi9016.
MGIiMGI:1330823. Slc25a14.

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiQ9Z2B2.
KOiK15106.
OMAiKIGTYNT.
OrthoDBiEOG091G0BQ7.
PhylomeDBiQ9Z2B2.
TreeFamiTF323211.

Enzyme and pathway databases

ReactomeiR-MMU-167826. The fatty acid cycling model.
R-MMU-167827. The proton buffering model.

Miscellaneous databases

PROiQ9Z2B2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031105.
ExpressionAtlasiQ9Z2B2. baseline and differential.
GenevisibleiQ9Z2B2. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR032933. SLC25A14.
[Graphical view]
PANTHERiPTHR24089:SF299. PTHR24089:SF299. 1 hit.
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUCP5_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2B2
Secondary accession number(s): Q9ESI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 19, 2001
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.