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Q9Z2B2

- UCP5_MOUSE

UniProt

Q9Z2B2 - UCP5_MOUSE

Protein

Brain mitochondrial carrier protein 1

Gene

Slc25a14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (19 Dec 2001)
      Previous versions | rss
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    Functioni

    Participates in the mitochondrial proton leak measured in brain mitochondria.

    GO - Biological processi

    1. mitochondrial transport Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain mitochondrial carrier protein 1
    Short name:
    BMCP-1
    Alternative name(s):
    Mitochondrial uncoupling protein 5
    Short name:
    UCP 5
    Solute carrier family 25 member 14
    Gene namesi
    Name:Slc25a14
    Synonyms:Bmcp1, Ucp5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1330823. Slc25a14.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial envelope Source: MGI
    3. mitochondrial inner membrane Source: UniProtKB-SubCell
    4. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Brain mitochondrial carrier protein 1PRO_0000090678Add
    BLAST

    Proteomic databases

    PaxDbiQ9Z2B2.
    PRIDEiQ9Z2B2.

    PTM databases

    PhosphoSiteiQ9Z2B2.

    Expressioni

    Tissue specificityi

    Mainly expressed in brain, particularly abundant in cortex, hippocampus thalamus, amygdala and hypothalamus. Expressed in other tissues to a lesser extent.1 Publication

    Gene expression databases

    BgeeiQ9Z2B2.
    GenevestigatoriQ9Z2B2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z2B2.
    SMRiQ9Z2B2. Positions 44-322.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5417Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 12817Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21517Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 25617Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei298 – 31518Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati42 – 13190Solcar 1Add
    BLAST
    Repeati139 – 22486Solcar 2Add
    BLAST
    Repeati233 – 32391Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG240642.
    GeneTreeiENSGT00750000117602.
    HOGENOMiHOG000165140.
    HOVERGENiHBG009528.
    KOiK15106.
    OMAiWRCLCSK.
    OrthoDBiEOG793B7Z.
    PhylomeDBiQ9Z2B2.
    TreeFamiTF323211.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00784. MTUNCOUPLING.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Z2B2-1) [UniParc]FASTAAdd to Basket

    Also known as: UCP5L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGIFPGIILI FLRVKFATAA VIVSGHQKSS TLSHEMSGLN WKPFVYGGLA    50
    SIVAEFGTFP VDLTKTRLQV QGQSIDVRFK EIKYRGMFHA LFRIYKEEGI 100
    LALYSGIAPA LLRQASYGTI KIGIYQSLKR LFVERLEDET LLINMICGVV 150
    SGVISSTIAN PTDVLKIRMQ AQGSLFQGSM IGSFIDIYQQ EGTRGLWRGV 200
    VPTAQRAAIV VGVELPVYDI TKKHLIVSGM LGDTILTHFV SSFTCGLAGA 250
    LASNPVDVVR TRMMNQRAIV GHVDLYKGTL DGILKMWKHE GFFALYKGFW 300
    PNWLRLGPWN IIFFITYEQL KRLQI 325
    Length:325
    Mass (Da):36,286
    Last modified:December 19, 2001 - v2
    Checksum:i19BF01EF12809D83
    GO
    Isoform 2 (identifier: Q9Z2B2-2) [UniParc]FASTAAdd to Basket

    Also known as: UCP5S

    The sequence of this isoform differs from the canonical sequence as follows:
         23-25: Missing.

    Show »
    Length:322
    Mass (Da):36,042
    Checksum:iEE396FBCCD6BDB6B
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei23 – 253Missing in isoform 2. 1 PublicationVSP_003274

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF076981 mRNA. Translation: AAD03674.1.
    AF155812 mRNA. Translation: AAG29585.1.
    AF155813 mRNA. Translation: AAG29586.1.
    BC048692 mRNA. Translation: AAH48692.1.
    CCDSiCCDS30112.1. [Q9Z2B2-2]
    CCDS53066.1. [Q9Z2B2-1]
    RefSeqiNP_001159922.1. NM_001166450.2. [Q9Z2B2-1]
    NP_001277634.1. NM_001290705.1.
    NP_035528.1. NM_011398.3. [Q9Z2B2-2]
    XP_006541511.1. XM_006541448.1. [Q9Z2B2-1]
    UniGeneiMm.34953.

    Genome annotation databases

    EnsembliENSMUST00000033431; ENSMUSP00000033431; ENSMUSG00000031105. [Q9Z2B2-2]
    ENSMUST00000114936; ENSMUSP00000110586; ENSMUSG00000031105. [Q9Z2B2-1]
    ENSMUST00000177710; ENSMUSP00000136140; ENSMUSG00000031105. [Q9Z2B2-1]
    GeneIDi20523.
    KEGGimmu:20523.
    UCSCiuc009tcp.2. mouse. [Q9Z2B2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF076981 mRNA. Translation: AAD03674.1 .
    AF155812 mRNA. Translation: AAG29585.1 .
    AF155813 mRNA. Translation: AAG29586.1 .
    BC048692 mRNA. Translation: AAH48692.1 .
    CCDSi CCDS30112.1. [Q9Z2B2-2 ]
    CCDS53066.1. [Q9Z2B2-1 ]
    RefSeqi NP_001159922.1. NM_001166450.2. [Q9Z2B2-1 ]
    NP_001277634.1. NM_001290705.1.
    NP_035528.1. NM_011398.3. [Q9Z2B2-2 ]
    XP_006541511.1. XM_006541448.1. [Q9Z2B2-1 ]
    UniGenei Mm.34953.

    3D structure databases

    ProteinModelPortali Q9Z2B2.
    SMRi Q9Z2B2. Positions 44-322.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9Z2B2.

    Proteomic databases

    PaxDbi Q9Z2B2.
    PRIDEi Q9Z2B2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033431 ; ENSMUSP00000033431 ; ENSMUSG00000031105 . [Q9Z2B2-2 ]
    ENSMUST00000114936 ; ENSMUSP00000110586 ; ENSMUSG00000031105 . [Q9Z2B2-1 ]
    ENSMUST00000177710 ; ENSMUSP00000136140 ; ENSMUSG00000031105 . [Q9Z2B2-1 ]
    GeneIDi 20523.
    KEGGi mmu:20523.
    UCSCi uc009tcp.2. mouse. [Q9Z2B2-1 ]

    Organism-specific databases

    CTDi 9016.
    MGIi MGI:1330823. Slc25a14.

    Phylogenomic databases

    eggNOGi NOG240642.
    GeneTreei ENSGT00750000117602.
    HOGENOMi HOG000165140.
    HOVERGENi HBG009528.
    KOi K15106.
    OMAi WRCLCSK.
    OrthoDBi EOG793B7Z.
    PhylomeDBi Q9Z2B2.
    TreeFami TF323211.

    Miscellaneous databases

    NextBioi 298755.
    PROi Q9Z2B2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z2B2.
    Genevestigatori Q9Z2B2.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002030. Mit_uncoupling.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00784. MTUNCOUPLING.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast."
      Sanchis D., Fleury C., Chomiki N., Goubern M., Huang Q., Neverova M., Gregoire F., Easlick J., Raimbault S., Levi-Meyrueis C., Miroux B., Collins S., Seldin M., Richard D., Warden C., Bouillaud F., Ricquier D.
      J. Biol. Chem. 273:34611-34615(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: BALB/c.
      Tissue: Brain.
    2. "Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation."
      Yu X.X., Mao W., Zhong A., Schow P., Brush J., Sherwood S.W., Adams S.H., Pan G.
      FASEB J. 14:1611-1618(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryo.

    Entry informationi

    Entry nameiUCP5_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z2B2
    Secondary accession number(s): Q9ESI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: December 19, 2001
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3