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Q9Z2B1 (I18RA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-18 receptor accessory protein

Short name=IL-18 receptor accessory protein
Short name=IL-18RAcP
Alternative name(s):
Accessory protein-like
Short name=AcPL
CD218 antigen-like family member B
IL-1R accessory protein-like
Short name=IL-1RAcPL
Interleukin-18 receptor accessory protein-like
Interleukin-18 receptor beta
Short name=IL-18R-beta
Short name=IL-18Rbeta
CD_antigen=CD218b
Gene names
Name:Il18rap
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length614 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Ref.1 Ref.2 Ref.3

Subunit structure

Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Disruption phenotype

Impaired IL-18 signaling. Ref.3

Sequence similarities

Belongs to the interleukin-1 receptor family.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 TIR domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioninterleukin-1 receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 614595Interleukin-18 receptor accessory protein
PRO_0000042186

Regions

Topological domain20 – 356337Extracellular Potential
Transmembrane357 – 37721Helical; Potential
Topological domain378 – 614237Cytoplasmic Potential
Domain148 – 23487Ig-like C2-type 1
Domain250 – 352103Ig-like C2-type 2
Domain405 – 561157TIR

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential
Glycosylation1511N-linked (GlcNAc...) Potential
Glycosylation2271N-linked (GlcNAc...) Potential
Glycosylation3441N-linked (GlcNAc...) Potential
Disulfide bond179 ↔ 220 By similarity
Disulfide bond272 ↔ 336 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z2B1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: B71D005E4FA99BA1

FASTA61470,094
        10         20         30         40         50         60 
MLCLGWVFLW FVAGEKTTGF NHSACATKKL LWTYSARGAE NFVLFCDLQE LQEQKFSHAS 

        70         80         90        100        110        120 
QLSPTQSPAH KPCSGSQKDL SDVQWYMQPR SGSPLEEISR NSPHMQSEGM LHILAPQTNS 

       130        140        150        160        170        180 
IWSYICRPRI RSPQDMACCI KTVLEVKPQR NVSCGNTAQD EQVLLLGSTG SIHCPSLSCQ 

       190        200        210        220        230        240 
SDVQSPEMTW YKDGRLLPEH KKNPIEMADI YVFNQGLYVC DYTQSDNVSS WTVRAVVKVR 

       250        260        270        280        290        300 
TIGKDINVKP EILDPITDTL DVELGKPLTL PCRVQFGFQR LSKPVIKWYV KESTQEWEMS 

       310        320        330        340        350        360 
VFEEKRIQST FKNEVIERTI FLREVTQRDL SRKFVCFAQN SIGNTTRTIR LRKKEEVVFV 

       370        380        390        400        410        420 
YILLGTALML VGVLVAAAFL YWYWIEVVLL CRTYKNKDET LGDKKEFDAF VSYSNWSSPE 

       430        440        450        460        470        480 
TDAVGSLSEE HLALNLFPEV LEDTYGYRLC LLDRDVTPGG VYADDIVSII KKSRRGIFIL 

       490        500        510        520        530        540 
SPSYLNGPRV FELQAAVNLA LVDQTLKLIL IKFCSFQEPE SLPYLVKKAL RVLPTVTWKG 

       550        560        570        580        590        600 
LKSVHASSRF WTQIRYHMPV KNSNRFMFNG LRIFLKGFSP EKDLVTQKPL EGMPKSGNDH 

       610 
GAQNLLLYSD QKRC 

« Hide

References

[1]"Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling."
Born T.L., Thomassen E., Bird T.A., Sims J.E.
J. Biol. Chem. 273:29445-29450(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]"IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18."
Debets R., Timans J.C., Churakowa T., Zurawski S., de Waal Malefyt R., Moore K.W., Abrams J.S., O'Garra A., Bazan J.F., Kastelein R.A.
J. Immunol. 165:4950-4956(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[3]"Accessory protein-like is essential for IL-18-mediated signaling."
Cheung H., Chen N.-J., Cao Z., Ono N., Ohashi P.S., Yeh W.-C.
J. Immunol. 174:5351-5357(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF077347 mRNA. Translation: AAC72197.1.
RefSeqNP_034683.1. NM_010553.4.
XP_006495771.1. XM_006495708.1.
XP_006495772.1. XM_006495709.1.
UniGeneMm.20466.
Mm.392521.

3D structure databases

ProteinModelPortalQ9Z2B1.
SMRQ9Z2B1. Positions 57-355, 405-559.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000027237.

PTM databases

PhosphoSiteQ9Z2B1.

Proteomic databases

PRIDEQ9Z2B1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027237; ENSMUSP00000027237; ENSMUSG00000026068.
GeneID16174.
KEGGmmu:16174.
UCSCuc007auk.1. mouse.

Organism-specific databases

CTD8807.
MGIMGI:1338888. Il18rap.

Phylogenomic databases

eggNOGNOG40454.
GeneTreeENSGT00680000099724.
HOGENOMHOG000060101.
HOVERGENHBG081778.
InParanoidQ9Z2B1.
KOK05174.
OMAYVCDYTQ.
OrthoDBEOG7CVPXJ.
PhylomeDBQ9Z2B1.
TreeFamTF325519.

Gene expression databases

ArrayExpressQ9Z2B1.
BgeeQ9Z2B1.
CleanExMM_IL18RAP.
GenevestigatorQ9Z2B1.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERPTHR11890. PTHR11890. 1 hit.
PfamPF01582. TIR. 1 hit.
[Graphical view]
PRINTSPR01536. INTRLKN1R12F.
SMARTSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMSSF52200. SSF52200. 1 hit.
PROSITEPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289029.
PROQ9Z2B1.
SOURCESearch...

Entry information

Entry nameI18RA_MOUSE
AccessionPrimary (citable) accession number: Q9Z2B1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot