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Protein

Interleukin-18 receptor accessory protein

Gene

Il18rap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18 receptor accessory protein
Short name:
IL-18 receptor accessory protein
Short name:
IL-18RAcP
Alternative name(s):
Accessory protein-like
Short name:
AcPL
CD218 antigen-like family member B
IL-1R accessory protein-like
Short name:
IL-1RAcPL
Interleukin-18 receptor accessory protein-like
Interleukin-18 receptor beta
Short name:
IL-18R-beta
Short name:
IL-18Rbeta
CD_antigen: CD218b
Gene namesi
Name:Il18rap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1338888. Il18rap.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 356337ExtracellularSequence analysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence analysisAdd
BLAST
Topological domaini378 – 614237CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Impaired IL-18 signaling.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 614595Interleukin-18 receptor accessory proteinPRO_0000042186Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis
Disulfide bondi179 ↔ 220PROSITE-ProRule annotation
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence analysis
Disulfide bondi272 ↔ 336PROSITE-ProRule annotation
Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9Z2B1.
PaxDbiQ9Z2B1.
PRIDEiQ9Z2B1.

PTM databases

iPTMnetiQ9Z2B1.
PhosphoSiteiQ9Z2B1.

Expressioni

Gene expression databases

BgeeiQ9Z2B1.
CleanExiMM_IL18RAP.
ExpressionAtlasiQ9Z2B1. baseline and differential.
GenevisibleiQ9Z2B1. MM.

Interactioni

Subunit structurei

Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027237.

Structurei

3D structure databases

ProteinModelPortaliQ9Z2B1.
SMRiQ9Z2B1. Positions 30-354, 405-559.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini148 – 23487Ig-like C2-type 1Add
BLAST
Domaini250 – 352103Ig-like C2-type 2Add
BLAST
Domaini405 – 561157TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGUG. Eukaryota.
ENOG410Y9SN. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000060101.
HOVERGENiHBG081778.
InParanoidiQ9Z2B1.
KOiK05174.
OMAiYVCDYTQ.
OrthoDBiEOG7CVPXJ.
PhylomeDBiQ9Z2B1.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 2 hits.
PfamiPF00047. ig. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z2B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCLGWVFLW FVAGEKTTGF NHSACATKKL LWTYSARGAE NFVLFCDLQE
60 70 80 90 100
LQEQKFSHAS QLSPTQSPAH KPCSGSQKDL SDVQWYMQPR SGSPLEEISR
110 120 130 140 150
NSPHMQSEGM LHILAPQTNS IWSYICRPRI RSPQDMACCI KTVLEVKPQR
160 170 180 190 200
NVSCGNTAQD EQVLLLGSTG SIHCPSLSCQ SDVQSPEMTW YKDGRLLPEH
210 220 230 240 250
KKNPIEMADI YVFNQGLYVC DYTQSDNVSS WTVRAVVKVR TIGKDINVKP
260 270 280 290 300
EILDPITDTL DVELGKPLTL PCRVQFGFQR LSKPVIKWYV KESTQEWEMS
310 320 330 340 350
VFEEKRIQST FKNEVIERTI FLREVTQRDL SRKFVCFAQN SIGNTTRTIR
360 370 380 390 400
LRKKEEVVFV YILLGTALML VGVLVAAAFL YWYWIEVVLL CRTYKNKDET
410 420 430 440 450
LGDKKEFDAF VSYSNWSSPE TDAVGSLSEE HLALNLFPEV LEDTYGYRLC
460 470 480 490 500
LLDRDVTPGG VYADDIVSII KKSRRGIFIL SPSYLNGPRV FELQAAVNLA
510 520 530 540 550
LVDQTLKLIL IKFCSFQEPE SLPYLVKKAL RVLPTVTWKG LKSVHASSRF
560 570 580 590 600
WTQIRYHMPV KNSNRFMFNG LRIFLKGFSP EKDLVTQKPL EGMPKSGNDH
610
GAQNLLLYSD QKRC
Length:614
Mass (Da):70,094
Last modified:May 1, 1999 - v1
Checksum:iB71D005E4FA99BA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077347 mRNA. Translation: AAC72197.1.
CCDSiCCDS14912.1.
RefSeqiNP_034683.1. NM_010553.4.
XP_006495772.1. XM_006495709.2.
UniGeneiMm.20466.
Mm.392521.

Genome annotation databases

EnsembliENSMUST00000027237; ENSMUSP00000027237; ENSMUSG00000026068.
GeneIDi16174.
KEGGimmu:16174.
UCSCiuc007auk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077347 mRNA. Translation: AAC72197.1.
CCDSiCCDS14912.1.
RefSeqiNP_034683.1. NM_010553.4.
XP_006495772.1. XM_006495709.2.
UniGeneiMm.20466.
Mm.392521.

3D structure databases

ProteinModelPortaliQ9Z2B1.
SMRiQ9Z2B1. Positions 30-354, 405-559.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027237.

PTM databases

iPTMnetiQ9Z2B1.
PhosphoSiteiQ9Z2B1.

Proteomic databases

EPDiQ9Z2B1.
PaxDbiQ9Z2B1.
PRIDEiQ9Z2B1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027237; ENSMUSP00000027237; ENSMUSG00000026068.
GeneIDi16174.
KEGGimmu:16174.
UCSCiuc007auk.2. mouse.

Organism-specific databases

CTDi8807.
MGIiMGI:1338888. Il18rap.

Phylogenomic databases

eggNOGiENOG410IGUG. Eukaryota.
ENOG410Y9SN. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000060101.
HOVERGENiHBG081778.
InParanoidiQ9Z2B1.
KOiK05174.
OMAiYVCDYTQ.
OrthoDBiEOG7CVPXJ.
PhylomeDBiQ9Z2B1.
TreeFamiTF325519.

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

PROiQ9Z2B1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z2B1.
CleanExiMM_IL18RAP.
ExpressionAtlasiQ9Z2B1. baseline and differential.
GenevisibleiQ9Z2B1. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR013151. Immunoglobulin.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 2 hits.
PfamiPF00047. ig. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling."
    Born T.L., Thomassen E., Bird T.A., Sims J.E.
    J. Biol. Chem. 273:29445-29450(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18."
    Debets R., Timans J.C., Churakowa T., Zurawski S., de Waal Malefyt R., Moore K.W., Abrams J.S., O'Garra A., Bazan J.F., Kastelein R.A.
    J. Immunol. 165:4950-4956(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Accessory protein-like is essential for IL-18-mediated signaling."
    Cheung H., Chen N.-J., Cao Z., Ono N., Ohashi P.S., Yeh W.-C.
    J. Immunol. 174:5351-5357(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiI18RA_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.