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Protein

Arginyl-tRNA--protein transferase 1

Gene

Ate1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues.1 Publication

Catalytic activityi

L-arginyl-tRNA(Arg) + [protein] = tRNA(Arg) + L-arginyl-[protein].

GO - Molecular functioni

  • arginyltransferase activity Source: MGI

GO - Biological processi

  • protein arginylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BRENDAi2.3.2.8. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginyl-tRNA--protein transferase 1 (EC:2.3.2.8)
Short name:
Arginyltransferase 1
Short name:
R-transferase 1
Alternative name(s):
Arginine-tRNA--protein transferase 1
Gene namesi
Name:Ate1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1333870. Ate1.

Subcellular locationi

Isoform ATE1-1 :
  • Nucleus 1 Publication
  • Cytoplasm 1 Publication
Isoform ATE1-2 :
  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Arginyl-tRNA--protein transferase 1PRO_0000195089Add
BLAST

Proteomic databases

EPDiQ9Z2A5.
MaxQBiQ9Z2A5.
PaxDbiQ9Z2A5.
PRIDEiQ9Z2A5.

PTM databases

iPTMnetiQ9Z2A5.
PhosphoSiteiQ9Z2A5.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000030850.
CleanExiMM_ATE1.
ExpressionAtlasiQ9Z2A5. baseline and differential.
GenevisibleiQ9Z2A5. MM.

Interactioni

Subunit structurei

Monomer. Interacts with LIAT1.Curated1 Publication

Protein-protein interaction databases

IntActiQ9Z2A5. 1 interaction.
MINTiMINT-4088706.
STRINGi10090.ENSMUSP00000033139.

Family & Domainsi

Sequence similaritiesi

Belongs to the R-transferase family.Curated

Phylogenomic databases

eggNOGiKOG1193. Eukaryota.
COG2935. LUCA.
GeneTreeiENSGT00500000044926.
HOGENOMiHOG000007968.
HOVERGENiHBG004299.
InParanoidiQ9Z2A5.
KOiK00685.
OMAiDPSECSE.
TreeFamiTF105976.

Family and domain databases

InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR017137. Arg-tRNA-P_Trfase_1_euk.
IPR007472. Arg-tRNA-P_Trfase_C.
IPR030700. Arg-tRNA_Trfase.
IPR007471. Arg_tRNA_PTrfase_N.
[Graphical view]
PANTHERiPTHR21367. PTHR21367. 1 hit.
PfamiPF04377. ATE_C. 1 hit.
PF04376. ATE_N. 1 hit.
[Graphical view]
PIRSFiPIRSF037207. ATE1_euk. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform ATE1-1 (identifier: Q9Z2A5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASWSAPSPS LVEYFEGQTS FQCGYCKNKL GSRSYGMWAH SMTVQDYQDL
60 70 80 90 100
IDRGWRRSGK YVYKPVMDQT CCPQYTIRCH PLQFQPSKSH KKVLKKMLKF
110 120 130 140 150
LAKGEISKGN CEDEPMDSTV EDAVDGDFAL INKLDIKCDL KTLSDLKGSI
160 170 180 190 200
ESEEKEKEKS IKKEGSKEFI HPQSIEEKLG SGEPSHPIKV HIGPKPGKGA
210 220 230 240 250
DLSKPPCRKA REMRKERQRL KRMQQASAAA SEAQGQPVCL LPKAKSNQPK
260 270 280 290 300
SLEDLIFQSL PENASHKLEV RVVRSSPPSP QFRATFQESY QVYKRYQMVV
310 320 330 340 350
HKDPPDKPTV SQFTRFLCSS PLEAEHPADG PECGYGSFHQ QYWLDGKIIA
360 370 380 390 400
VGVLDILPYC VSSVYLYYDP DYSFLSLGVY SALREIAFTR QLHEKTSQLS
410 420 430 440 450
YYYMGFYIHS CPKMRYKGQY RPSDLLCPET YVWVPIEQCL PSLDNSKYCR
460 470 480 490 500
FNQDPEAEDE GRSKELDRLR VFHRRSAMPY GVYKNHQEDP SEEAGVLEYA
510
NLVGQKCSER MLLFRH
Note: Shows significantly higher activity than isoform ATE1-2.
Length:516
Mass (Da):59,146
Last modified:July 27, 2011 - v2
Checksum:i40CCC7756C75858A
GO
Isoform ATE1-2 (identifier: Q9Z2A5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-312: VVRSSPPSPQ...DPPDKPTVSQ → LVPASFEDPE...EAPEICEKSE

Show »
Length:516
Mass (Da):59,048
Checksum:iF7C19A086881067B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti362 – 3621S → F in AAD12364 (PubMed:9858543).Curated
Sequence conflicti362 – 3621S → F in AAD12365 (PubMed:9858543).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei272 – 31241VVRSS…PTVSQ → LVPASFEDPEFNSSFNQSFS LYTKYQVAIHQEAPEICEKS E in isoform ATE1-2. 1 PublicationVSP_000337Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079096 mRNA. Translation: AAD12364.1.
AF079097 mRNA. Translation: AAD12365.1.
AK148442 mRNA. Translation: BAE28555.1.
AK167591 mRNA. Translation: BAE39649.1.
BC042601 mRNA. Translation: AAH42601.1.
CCDSiCCDS21902.1. [Q9Z2A5-1]
CCDS52414.1. [Q9Z2A5-2]
RefSeqiNP_038827.2. NM_013799.3. [Q9Z2A5-1]
UniGeneiMm.216321.

Genome annotation databases

EnsembliENSMUST00000033139; ENSMUSP00000033139; ENSMUSG00000030850. [Q9Z2A5-1]
ENSMUST00000035458; ENSMUSP00000043365; ENSMUSG00000030850. [Q9Z2A5-2]
GeneIDi11907.
KEGGimmu:11907.
UCSCiuc009kaa.2. mouse. [Q9Z2A5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079096 mRNA. Translation: AAD12364.1.
AF079097 mRNA. Translation: AAD12365.1.
AK148442 mRNA. Translation: BAE28555.1.
AK167591 mRNA. Translation: BAE39649.1.
BC042601 mRNA. Translation: AAH42601.1.
CCDSiCCDS21902.1. [Q9Z2A5-1]
CCDS52414.1. [Q9Z2A5-2]
RefSeqiNP_038827.2. NM_013799.3. [Q9Z2A5-1]
UniGeneiMm.216321.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z2A5. 1 interaction.
MINTiMINT-4088706.
STRINGi10090.ENSMUSP00000033139.

PTM databases

iPTMnetiQ9Z2A5.
PhosphoSiteiQ9Z2A5.

Proteomic databases

EPDiQ9Z2A5.
MaxQBiQ9Z2A5.
PaxDbiQ9Z2A5.
PRIDEiQ9Z2A5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033139; ENSMUSP00000033139; ENSMUSG00000030850. [Q9Z2A5-1]
ENSMUST00000035458; ENSMUSP00000043365; ENSMUSG00000030850. [Q9Z2A5-2]
GeneIDi11907.
KEGGimmu:11907.
UCSCiuc009kaa.2. mouse. [Q9Z2A5-1]

Organism-specific databases

CTDi11101.
MGIiMGI:1333870. Ate1.

Phylogenomic databases

eggNOGiKOG1193. Eukaryota.
COG2935. LUCA.
GeneTreeiENSGT00500000044926.
HOGENOMiHOG000007968.
HOVERGENiHBG004299.
InParanoidiQ9Z2A5.
KOiK00685.
OMAiDPSECSE.
TreeFamiTF105976.

Enzyme and pathway databases

BRENDAi2.3.2.8. 3474.

Miscellaneous databases

ChiTaRSiAte1. mouse.
PROiQ9Z2A5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030850.
CleanExiMM_ATE1.
ExpressionAtlasiQ9Z2A5. baseline and differential.
GenevisibleiQ9Z2A5. MM.

Family and domain databases

InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR017137. Arg-tRNA-P_Trfase_1_euk.
IPR007472. Arg-tRNA-P_Trfase_C.
IPR030700. Arg-tRNA_Trfase.
IPR007471. Arg_tRNA_PTrfase_N.
[Graphical view]
PANTHERiPTHR21367. PTHR21367. 1 hit.
PfamiPF04377. ATE_C. 1 hit.
PF04376. ATE_N. 1 hit.
[Graphical view]
PIRSFiPIRSF037207. ATE1_euk. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiATE1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2A5
Secondary accession number(s): Q8CFP7, Q9Z2A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.