ID   Q9Z2A1_RAT              Unreviewed;       608 AA.
AC   Q9Z2A1;
DT   01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1999, sequence version 1.
DT   13-SEP-2023, entry version 89.
DE   SubName: Full=Patched {ECO:0000313|EMBL:AAC99398.1};
DE   Flags: Fragment;
GN   Name=ptc {ECO:0000313|EMBL:AAC99398.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AAC99398.1};
RN   [1] {ECO:0000313|EMBL:AAC99398.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sprague Dawley {ECO:0000313|EMBL:AAC99398.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:AAC99398.1};
RA   Zhao P., Roy N.K., Xu G., Burns F.J.;
RT   "Partial cDNA sequence of rat ptc gene.";
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
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DR   EMBL; AF079162; AAC99398.1; -; mRNA.
DR   AlphaFoldDB; Q9Z2A1; -.
DR   UCSC; RGD:621425; rat.
DR   PhylomeDB; Q9Z2A1; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR   InterPro; IPR000731; SSD.
DR   InterPro; IPR004766; TM_rcpt_patched.
DR   NCBIfam; TIGR00918; 2A060602; 1.
DR   PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR   PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR   Pfam; PF12349; Sterol-sensing; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR   PROSITE; PS50156; SSD; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        425..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        456..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        487..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        530..553
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        559..582
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          424..584
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         608
FT                   /evidence="ECO:0000313|EMBL:AAC99398.1"
SQ   SEQUENCE   608 AA;  67328 MW;  73F505A1512EE9C5 CRC64;
     MASAGNAAGA LGRQAGGGRR RRTGGPHRAA PDRDYLHRPS YCDAAFAMEQ ISKGKATGRK
     APLWLRAKFQ RLLFKLGCYI QKDCGKFLVV GLLIFGAFAV GLKAANLETN VEELWVEVGG
     RVSRELNYTR QKIGEEAMFN PQLMIQTPKE EGANVLTTEA LLQHLDSALQ ASRVHVYMYN
     RQWKLEHLCY KSGELITETG YMDQIIEYLY PCLIITPLDC FWEGAKLQSG TAYLLGKPPL
     RWTNFDPLEF LEELKKINYQ VDSWEEMLNK AEVGHGYMDR PCLNPADPDC PATAPNKNST
     KPLDVALVLN GGCQGLSRKY MHWQEELIVG GTVKNATGKL VSAHALQTMF QLMTPKQMYE
     HFRGYDYVSH INWNEDRAAA ILEAWQRTYV EVVHQSVAPN STQKVLSFTT RTLDDILKSF
     SDVSVIRVAS GYLLMLAYAC LTMLRWDCSK SQGAVGLAGV LLVALSVAAG LGLCSLIGIS
     FNAATTQVLP FLALGVGVDD VFLLAHAFSE TGQNKRIPIE DRTGECLKRT GASVALTSIS
     NVTAFFMAAL IPIPALRAFS LQAAVVVVFN FAMVLLIFPA ILSMDLYRRE DRRLDIFCCF
     TSPCVSLV
//