Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Z282

- GP132_MOUSE

UniProt

Q9Z282 - GP132_MOUSE

Protein

Probable G-protein coupled receptor 132

Gene

Gpr132

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: MGI

    GO - Biological processi

    1. G1/S transition of mitotic cell cycle Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 132
    Alternative name(s):
    G2 accumulation protein
    Gene namesi
    Name:Gpr132
    Synonyms:G2a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1890220. Gpr132.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface.

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi137 – 1371R → A: Enhanced surface expression and a lower localization to endosomal vesicles. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Probable G-protein coupled receptor 132PRO_0000069462Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi112 ↔ 184PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9Z282.

    PTM databases

    PhosphoSiteiQ9Z282.

    Expressioni

    Tissue specificityi

    Highly expressed in hematopoietic tissues rich in lymphocytes like spleen and thymus. Weakly expressed in heart and lung. Highly expressed in infiltrating macrophages within atherosclerotic lesions.1 Publication

    Inductioni

    By DNA-damaging agents.

    Gene expression databases

    BgeeiQ9Z282.
    CleanExiMM_GPR132.
    GenevestigatoriQ9Z282.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z282.
    SMRiQ9Z282. Positions 38-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4242ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini66 – 7611CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini100 – 11314ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini136 – 15520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 19823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini222 – 24120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 28625ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini310 – 38273CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6523Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei77 – 9923Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 17520Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 22123Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei242 – 26120Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30923Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148904.
    GeneTreeiENSGT00600000084401.
    HOGENOMiHOG000013146.
    HOVERGENiHBG104029.
    InParanoidiQ0VBS4.
    KOiK08426.
    OMAiANCLTAW.
    OrthoDBiEOG76QFJ8.
    PhylomeDBiQ9Z282.
    TreeFamiTF331803.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR005388. G2A_lysphc_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01563. G2ARECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z282-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSEPTNAAG NTTLGVTSVL QSTSVPSSET CHVSYEESRV VLVVVYSAVC    50
    LLGLPANCLT AWLTLLQVLQ RNVLAVYLFC LSLCELLYIS TVPLWIIYIQ 100
    NQHKWNLGPQ ACKVTAYIFF CNIYISILLL CCISCDRYMA VVYALESRGH 150
    RHQRTAVTIS ACVILLVGLV NYPVFDMKVE KSFCFEPLRM NSKIAGYHYL 200
    RFTFGFAIPL GILAFTNHQI FRSIKLSDSL SAAQKNKVKR SAIAVVTIFL 250
    VCFAPYHVVL LVKAASFSFY QGDMDAVCAF ESRLYTVSMV FLCLSTVNSV 300
    ADPIIYVLGT DHSRQEVSRI HTGWKKWSTK TYVTCSKDSE ETHLPTELSN 350
    TYTFPNPAHP PGSQPAKLGL LCSPERLPEE LC 382
    Length:382
    Mass (Da):42,653
    Last modified:May 1, 1999 - v1
    Checksum:iD4F8CE0370CCD610
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083442 mRNA. Translation: AAC67542.1.
    AK089866 mRNA. Translation: BAC40980.1.
    AK153765 mRNA. Translation: BAE32176.1.
    BC120522 mRNA. Translation: AAI20523.1.
    BC120524 mRNA. Translation: AAI20525.1.
    CCDSiCCDS26199.1.
    RefSeqiNP_064309.1. NM_019925.4.
    XP_006516165.1. XM_006516102.1.
    XP_006516166.1. XM_006516103.1.
    UniGeneiMm.20455.

    Genome annotation databases

    EnsembliENSMUST00000021729; ENSMUSP00000021729; ENSMUSG00000021298.
    GeneIDi56696.
    KEGGimmu:56696.
    UCSCiuc007pfk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083442 mRNA. Translation: AAC67542.1 .
    AK089866 mRNA. Translation: BAC40980.1 .
    AK153765 mRNA. Translation: BAE32176.1 .
    BC120522 mRNA. Translation: AAI20523.1 .
    BC120524 mRNA. Translation: AAI20525.1 .
    CCDSi CCDS26199.1.
    RefSeqi NP_064309.1. NM_019925.4.
    XP_006516165.1. XM_006516102.1.
    XP_006516166.1. XM_006516103.1.
    UniGenei Mm.20455.

    3D structure databases

    ProteinModelPortali Q9Z282.
    SMRi Q9Z282. Positions 38-308.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9Z282.

    Proteomic databases

    PRIDEi Q9Z282.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021729 ; ENSMUSP00000021729 ; ENSMUSG00000021298 .
    GeneIDi 56696.
    KEGGi mmu:56696.
    UCSCi uc007pfk.1. mouse.

    Organism-specific databases

    CTDi 29933.
    MGIi MGI:1890220. Gpr132.

    Phylogenomic databases

    eggNOGi NOG148904.
    GeneTreei ENSGT00600000084401.
    HOGENOMi HOG000013146.
    HOVERGENi HBG104029.
    InParanoidi Q0VBS4.
    KOi K08426.
    OMAi ANCLTAW.
    OrthoDBi EOG76QFJ8.
    PhylomeDBi Q9Z282.
    TreeFami TF331803.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 313127.
    PROi Q9Z282.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Z282.
    CleanExi MM_GPR132.
    Genevestigatori Q9Z282.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR005388. G2A_lysphc_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01563. G2ARECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Spleen and Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques."
      Rikitake Y., Hirata K., Yamashita T., Iwai K., Kobayashi S., Itoh H., Ozaki M., Ejiri J., Shiomi M., Inoue N., Kawashima S., Yokoyama M.
      Arterioscler. Thromb. Vasc. Biol. 22:2049-2053(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A."
      Wang L., Radu C.G., Yang L.V., Bentolila L.A., Riedinger M., Witte O.N.
      Mol. Biol. Cell 16:2234-2247(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-137.

    Entry informationi

    Entry nameiGP132_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z282
    Secondary accession number(s): Q0VBS4, Q3U5A4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3