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Protein

Probable G-protein coupled receptor 132

Gene

Gpr132

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity (By similarity).By similarity1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: MGI

GO - Biological processi

  • G1/S transition of mitotic cell cycle Source: MGI
  • negative regulation of G2/M transition of mitotic cell cycle Source: CACAO

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 132
Alternative name(s):
G2 accumulation protein
Gene namesi
Name:Gpr132
Synonyms:G2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1890220. Gpr132.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
Transmembranei43 – 65Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini66 – 76CytoplasmicSequence analysisAdd BLAST11
Transmembranei77 – 99Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini100 – 113ExtracellularSequence analysisAdd BLAST14
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 155CytoplasmicSequence analysisAdd BLAST20
Transmembranei156 – 175Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini176 – 198ExtracellularSequence analysisAdd BLAST23
Transmembranei199 – 221Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini222 – 241CytoplasmicSequence analysisAdd BLAST20
Transmembranei242 – 261Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini262 – 286ExtracellularSequence analysisAdd BLAST25
Transmembranei287 – 309Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini310 – 382CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi137R → A: Enhanced surface expression and a lower localization to endosomal vesicles. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694621 – 382Probable G-protein coupled receptor 132Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi112 ↔ 184PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9Z282.
MaxQBiQ9Z282.
PaxDbiQ9Z282.
PRIDEiQ9Z282.

PTM databases

PhosphoSitePlusiQ9Z282.

Expressioni

Tissue specificityi

Highly expressed in hematopoietic tissues rich in lymphocytes like spleen and thymus. Weakly expressed in heart and lung. Highly expressed in infiltrating macrophages within atherosclerotic lesions.1 Publication

Inductioni

By DNA-damaging agents.

Gene expression databases

BgeeiENSMUSG00000021298.
CleanExiMM_GPR132.
GenevisibleiQ9Z282. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021729.

Structurei

3D structure databases

ProteinModelPortaliQ9Z282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKDS. Eukaryota.
ENOG4111F3F. LUCA.
GeneTreeiENSGT00900000140916.
HOGENOMiHOG000013146.
HOVERGENiHBG104029.
InParanoidiQ9Z282.
KOiK08426.
OMAiNSVADPI.
OrthoDBiEOG091G0BBZ.
PhylomeDBiQ9Z282.
TreeFamiTF331803.

Family and domain databases

InterProiView protein in InterPro
IPR005388. G2A_lysphc_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR01563. G2ARECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Z282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSEPTNAAG NTTLGVTSVL QSTSVPSSET CHVSYEESRV VLVVVYSAVC
60 70 80 90 100
LLGLPANCLT AWLTLLQVLQ RNVLAVYLFC LSLCELLYIS TVPLWIIYIQ
110 120 130 140 150
NQHKWNLGPQ ACKVTAYIFF CNIYISILLL CCISCDRYMA VVYALESRGH
160 170 180 190 200
RHQRTAVTIS ACVILLVGLV NYPVFDMKVE KSFCFEPLRM NSKIAGYHYL
210 220 230 240 250
RFTFGFAIPL GILAFTNHQI FRSIKLSDSL SAAQKNKVKR SAIAVVTIFL
260 270 280 290 300
VCFAPYHVVL LVKAASFSFY QGDMDAVCAF ESRLYTVSMV FLCLSTVNSV
310 320 330 340 350
ADPIIYVLGT DHSRQEVSRI HTGWKKWSTK TYVTCSKDSE ETHLPTELSN
360 370 380
TYTFPNPAHP PGSQPAKLGL LCSPERLPEE LC
Length:382
Mass (Da):42,653
Last modified:May 1, 1999 - v1
Checksum:iD4F8CE0370CCD610
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083442 mRNA. Translation: AAC67542.1.
AK089866 mRNA. Translation: BAC40980.1.
AK153765 mRNA. Translation: BAE32176.1.
BC120522 mRNA. Translation: AAI20523.1.
BC120524 mRNA. Translation: AAI20525.1.
CCDSiCCDS26199.1.
RefSeqiNP_064309.1. NM_019925.4.
XP_006516165.1. XM_006516102.2.
XP_006516166.1. XM_006516103.2.
UniGeneiMm.20455.

Genome annotation databases

EnsembliENSMUST00000021729; ENSMUSP00000021729; ENSMUSG00000021298.
GeneIDi56696.
KEGGimmu:56696.
UCSCiuc007pfk.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiGP132_MOUSE
AccessioniPrimary (citable) accession number: Q9Z282
Secondary accession number(s): Q0VBS4, Q3U5A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families