SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Z282

- GP132_MOUSE

UniProt

Q9Z282 - GP132_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable G-protein coupled receptor 132

Gene
Gpr132, G2a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity By similarity.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: MGI

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 132
Alternative name(s):
G2 accumulation protein
Gene namesi
Name:Gpr132
Synonyms:G2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1890220. Gpr132.

Subcellular locationi

Cell membrane; Multi-pass membrane protein Inferred
Note: Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242Extracellular Reviewed predictionAdd
BLAST
Transmembranei43 – 6523Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini66 – 7611Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei77 – 9923Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini100 – 11314Extracellular Reviewed predictionAdd
BLAST
Transmembranei114 – 13522Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini136 – 15520Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei156 – 17520Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini176 – 19823Extracellular Reviewed predictionAdd
BLAST
Transmembranei199 – 22123Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini222 – 24120Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei242 – 26120Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini262 – 28625Extracellular Reviewed predictionAdd
BLAST
Transmembranei287 – 30923Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini310 – 38273Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi137 – 1371R → A: Enhanced surface expression and a lower localization to endosomal vesicles. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Probable G-protein coupled receptor 132PRO_0000069462Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi112 ↔ 184 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9Z282.

PTM databases

PhosphoSiteiQ9Z282.

Expressioni

Tissue specificityi

Highly expressed in hematopoietic tissues rich in lymphocytes like spleen and thymus. Weakly expressed in heart and lung. Highly expressed in infiltrating macrophages within atherosclerotic lesions.1 Publication

Inductioni

By DNA-damaging agents.

Gene expression databases

BgeeiQ9Z282.
CleanExiMM_GPR132.
GenevestigatoriQ9Z282.

Structurei

3D structure databases

ProteinModelPortaliQ9Z282.
SMRiQ9Z282. Positions 38-308.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148904.
GeneTreeiENSGT00600000084401.
HOGENOMiHOG000013146.
HOVERGENiHBG104029.
InParanoidiQ0VBS4.
KOiK08426.
OMAiANCLTAW.
OrthoDBiEOG76QFJ8.
PhylomeDBiQ9Z282.
TreeFamiTF331803.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR005388. G2A_lysphc_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01563. G2ARECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z282-1 [UniParc]FASTAAdd to Basket

« Hide

MRSEPTNAAG NTTLGVTSVL QSTSVPSSET CHVSYEESRV VLVVVYSAVC    50
LLGLPANCLT AWLTLLQVLQ RNVLAVYLFC LSLCELLYIS TVPLWIIYIQ 100
NQHKWNLGPQ ACKVTAYIFF CNIYISILLL CCISCDRYMA VVYALESRGH 150
RHQRTAVTIS ACVILLVGLV NYPVFDMKVE KSFCFEPLRM NSKIAGYHYL 200
RFTFGFAIPL GILAFTNHQI FRSIKLSDSL SAAQKNKVKR SAIAVVTIFL 250
VCFAPYHVVL LVKAASFSFY QGDMDAVCAF ESRLYTVSMV FLCLSTVNSV 300
ADPIIYVLGT DHSRQEVSRI HTGWKKWSTK TYVTCSKDSE ETHLPTELSN 350
TYTFPNPAHP PGSQPAKLGL LCSPERLPEE LC 382
Length:382
Mass (Da):42,653
Last modified:May 1, 1999 - v1
Checksum:iD4F8CE0370CCD610
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083442 mRNA. Translation: AAC67542.1.
AK089866 mRNA. Translation: BAC40980.1.
AK153765 mRNA. Translation: BAE32176.1.
BC120522 mRNA. Translation: AAI20523.1.
BC120524 mRNA. Translation: AAI20525.1.
CCDSiCCDS26199.1.
RefSeqiNP_064309.1. NM_019925.4.
XP_006516165.1. XM_006516102.1.
XP_006516166.1. XM_006516103.1.
UniGeneiMm.20455.

Genome annotation databases

EnsembliENSMUST00000021729; ENSMUSP00000021729; ENSMUSG00000021298.
GeneIDi56696.
KEGGimmu:56696.
UCSCiuc007pfk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF083442 mRNA. Translation: AAC67542.1 .
AK089866 mRNA. Translation: BAC40980.1 .
AK153765 mRNA. Translation: BAE32176.1 .
BC120522 mRNA. Translation: AAI20523.1 .
BC120524 mRNA. Translation: AAI20525.1 .
CCDSi CCDS26199.1.
RefSeqi NP_064309.1. NM_019925.4.
XP_006516165.1. XM_006516102.1.
XP_006516166.1. XM_006516103.1.
UniGenei Mm.20455.

3D structure databases

ProteinModelPortali Q9Z282.
SMRi Q9Z282. Positions 38-308.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9Z282.

Proteomic databases

PRIDEi Q9Z282.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021729 ; ENSMUSP00000021729 ; ENSMUSG00000021298 .
GeneIDi 56696.
KEGGi mmu:56696.
UCSCi uc007pfk.1. mouse.

Organism-specific databases

CTDi 29933.
MGIi MGI:1890220. Gpr132.

Phylogenomic databases

eggNOGi NOG148904.
GeneTreei ENSGT00600000084401.
HOGENOMi HOG000013146.
HOVERGENi HBG104029.
InParanoidi Q0VBS4.
KOi K08426.
OMAi ANCLTAW.
OrthoDBi EOG76QFJ8.
PhylomeDBi Q9Z282.
TreeFami TF331803.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 313127.
PROi Q9Z282.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z282.
CleanExi MM_GPR132.
Genevestigatori Q9Z282.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR005388. G2A_lysphc_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01563. G2ARECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Spleen and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques."
    Rikitake Y., Hirata K., Yamashita T., Iwai K., Kobayashi S., Itoh H., Ozaki M., Ejiri J., Shiomi M., Inoue N., Kawashima S., Yokoyama M.
    Arterioscler. Thromb. Vasc. Biol. 22:2049-2053(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A."
    Wang L., Radu C.G., Yang L.V., Bentolila L.A., Riedinger M., Witte O.N.
    Mol. Biol. Cell 16:2234-2247(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-137.

Entry informationi

Entry nameiGP132_MOUSE
AccessioniPrimary (citable) accession number: Q9Z282
Secondary accession number(s): Q0VBS4, Q3U5A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi