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Q9Z282 (GP132_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 132
Alternative name(s):
G2 accumulation protein
Gene names
Name:Gpr132
Synonyms:G2a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication. Ref.5

Subcellular location

Cell membrane; Multi-pass membrane protein Probable. Note: Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface. Ref.5

Tissue specificity

Highly expressed in hematopoietic tissues rich in lymphocytes like spleen and thymus. Weakly expressed in heart and lung. Highly expressed in infiltrating macrophages within atherosclerotic lesions. Ref.4

Induction

By DNA-damaging agents.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382Probable G-protein coupled receptor 132
PRO_0000069462

Regions

Topological domain1 – 4242Extracellular Potential
Transmembrane43 – 6523Helical; Name=1; Potential
Topological domain66 – 7611Cytoplasmic Potential
Transmembrane77 – 9923Helical; Name=2; Potential
Topological domain100 – 11314Extracellular Potential
Transmembrane114 – 13522Helical; Name=3; Potential
Topological domain136 – 15520Cytoplasmic Potential
Transmembrane156 – 17520Helical; Name=4; Potential
Topological domain176 – 19823Extracellular Potential
Transmembrane199 – 22123Helical; Name=5; Potential
Topological domain222 – 24120Cytoplasmic Potential
Transmembrane242 – 26120Helical; Name=6; Potential
Topological domain262 – 28625Extracellular Potential
Transmembrane287 – 30923Helical; Name=7; Potential
Topological domain310 – 38273Cytoplasmic Potential

Amino acid modifications

Glycosylation111N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 184 By similarity

Experimental info

Mutagenesis1371R → A: Enhanced surface expression and a lower localization to endosomal vesicles. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9Z282 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: D4F8CE0370CCD610

FASTA38242,653
        10         20         30         40         50         60 
MRSEPTNAAG NTTLGVTSVL QSTSVPSSET CHVSYEESRV VLVVVYSAVC LLGLPANCLT 

        70         80         90        100        110        120 
AWLTLLQVLQ RNVLAVYLFC LSLCELLYIS TVPLWIIYIQ NQHKWNLGPQ ACKVTAYIFF 

       130        140        150        160        170        180 
CNIYISILLL CCISCDRYMA VVYALESRGH RHQRTAVTIS ACVILLVGLV NYPVFDMKVE 

       190        200        210        220        230        240 
KSFCFEPLRM NSKIAGYHYL RFTFGFAIPL GILAFTNHQI FRSIKLSDSL SAAQKNKVKR 

       250        260        270        280        290        300 
SAIAVVTIFL VCFAPYHVVL LVKAASFSFY QGDMDAVCAF ESRLYTVSMV FLCLSTVNSV 

       310        320        330        340        350        360 
ADPIIYVLGT DHSRQEVSRI HTGWKKWSTK TYVTCSKDSE ETHLPTELSN TYTFPNPAHP 

       370        380 
PGSQPAKLGL LCSPERLPEE LC 

« Hide

References

« Hide 'large scale' references
[1]"A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M."
Weng Z., Fluckiger A.-C., Nisitani S., Wahl M.I., Le L.Q., Hunter C.A., Fernal A.A., Le Beau M.M., Witte O.N.
Proc. Natl. Acad. Sci. U.S.A. 95:12334-12339(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Spleen and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques."
Rikitake Y., Hirata K., Yamashita T., Iwai K., Kobayashi S., Itoh H., Ozaki M., Ejiri J., Shiomi M., Inoue N., Kawashima S., Yokoyama M.
Arterioscler. Thromb. Vasc. Biol. 22:2049-2053(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A."
Wang L., Radu C.G., Yang L.V., Bentolila L.A., Riedinger M., Witte O.N.
Mol. Biol. Cell 16:2234-2247(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-137.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF083442 mRNA. Translation: AAC67542.1.
AK089866 mRNA. Translation: BAC40980.1.
AK153765 mRNA. Translation: BAE32176.1.
BC120522 mRNA. Translation: AAI20523.1.
BC120524 mRNA. Translation: AAI20525.1.
RefSeqNP_064309.1. NM_019925.4.
XP_006516165.1. XM_006516102.1.
XP_006516166.1. XM_006516103.1.
UniGeneMm.20455.

3D structure databases

ProteinModelPortalQ9Z282.
SMRQ9Z282. Positions 35-324.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9Z282.

Proteomic databases

PRIDEQ9Z282.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021729; ENSMUSP00000021729; ENSMUSG00000021298.
GeneID56696.
KEGGmmu:56696.
UCSCuc007pfk.1. mouse.

Organism-specific databases

CTD29933.
MGIMGI:1890220. Gpr132.

Phylogenomic databases

eggNOGNOG148904.
GeneTreeENSGT00600000084401.
HOGENOMHOG000013146.
HOVERGENHBG104029.
InParanoidQ0VBS4.
KOK08426.
OMAANCLTAW.
OrthoDBEOG76QFJ8.
PhylomeDBQ9Z282.
TreeFamTF331803.

Gene expression databases

BgeeQ9Z282.
CleanExMM_GPR132.
GenevestigatorQ9Z282.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR005388. G2A_lysphc_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01563. G2ARECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio313127.
PROQ9Z282.
SOURCESearch...

Entry information

Entry nameGP132_MOUSE
AccessionPrimary (citable) accession number: Q9Z282
Secondary accession number(s): Q0VBS4, Q3U5A4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries