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Q9Z273

- TULP1_MOUSE

UniProt

Q9Z273 - TULP1_MOUSE

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Protein

Tubby-related protein 1

Gene

Tulp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells. Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.By similarity4 Publications

GO - Molecular functioni

  1. actin filament binding Source: UniProtKB
  2. G-protein coupled photoreceptor activity Source: MGI
  3. phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB

GO - Biological processi

  1. dendrite development Source: UniProtKB
  2. detection of light stimulus involved in visual perception Source: Ensembl
  3. eye photoreceptor cell development Source: UniProtKB
  4. phagocytosis Source: UniProtKB-KW
  5. photoreceptor cell maintenance Source: UniProtKB
  6. phototransduction Source: MGI
  7. positive regulation of phagocytosis Source: UniProtKB
  8. retina development in camera-type eye Source: MGI
Complete GO annotation...

Keywords - Biological processi

Phagocytosis, Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Tubby-related protein 1
Alternative name(s):
Tubby-like protein 1
Gene namesi
Name:Tulp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:109571. Tulp1.

Subcellular locationi

Cytoplasm. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Secreted. Cell junctionsynapse
Note: Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell projection Source: UniProtKB
  3. cytoplasm Source: UniProtKB-KW
  4. extracellular region Source: UniProtKB-KW
  5. photoreceptor inner segment Source: UniProtKB
  6. photoreceptor outer segment Source: UniProtKB
  7. plasma membrane Source: UniProtKB
  8. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Secreted, Synapse

Pathology & Biotechi

Disruption phenotypei

Malformation of photoreceptor synapses, followed by photoreceptor degeneration.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Tubby-related protein 1PRO_0000186467Add
BLAST

Proteomic databases

PRIDEiQ9Z273.

PTM databases

PhosphoSiteiQ9Z273.

Expressioni

Tissue specificityi

Retina specific. Detected in the outer plexiform layer in photoreceptor cells (at protein level).1 Publication

Gene expression databases

BgeeiQ9Z273.
CleanExiMM_TULP1.
ExpressionAtlasiQ9Z273. baseline and differential.
GenevestigatoriQ9Z273.

Interactioni

Subunit structurei

Homodimer (Probable). May interact with ABCF1, PSIP1, ZEB1 and HMGB2 (Potential). Interacts with F-actin (By similarity). Interacts with DNM1. Interacts with TUB. Interacts with TYRO3.By similarity4 PublicationsCurated

Structurei

3D structure databases

ProteinModelPortaliQ9Z273.
SMRiQ9Z273. Positions 292-537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi118 – 12710Poly-Asp
Compositional biasi128 – 1325Poly-Glu
Compositional biasi246 – 2549Poly-Glu

Sequence similaritiesi

Belongs to the TUB family.Curated

Phylogenomic databases

eggNOGiNOG286778.
GeneTreeiENSGT00610000085970.
HOGENOMiHOG000016044.
HOVERGENiHBG018010.
InParanoidiQ9Z273.
OMAiEAPESPC.
OrthoDBiEOG77HDDQ.
PhylomeDBiQ9Z273.
TreeFamiTF314076.

Family and domain databases

Gene3Di3.20.90.10. 1 hit.
InterProiIPR000007. Tubby_C.
IPR025659. Tubby_C-like.
IPR018066. Tubby_C_CS.
[Graphical view]
PfamiPF01167. Tub. 1 hit.
[Graphical view]
PRINTSiPR01573. SUPERTUBBY.
SUPFAMiSSF54518. SSF54518. 1 hit.
PROSITEiPS01200. TUB_1. 1 hit.
PS01201. TUB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z273-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLQEETLRE VWASDSGHEE DCLSPEPPLR PKQRPAQGQK LRKKKPETPD
60 70 80 90 100
SLESKPRKAG AGRRKHEEPP ADSAEPRAAQ TVYAKFLRDP EAKKRDPREN
110 120 130 140 150
FLVARAPDLG GEENSEEDSD DDDNDDDEEE EEKKEGKKEK SSLPPKKAPK
160 170 180 190 200
EREKKAKALG PRGDVGSPDA PRKPLRTKKK EVGEGTKLRK AKKKGPGETD
210 220 230 240 250
KDPAGSPAAL RKEFPAAMFL VGEGGAAEKG VKKKGPPKGS EEEKKEEEEE
260 270 280 290 300
VEEEVASAVM KNSNQKGRAK GKGKKKVKEE RASSPPVEVG EPREFVLQPA
310 320 330 340 350
PQGRAVRCRL TRDKKGMDRG MYPSYFLHLD TEKKVFLLAG RKRKRSKTAN
360 370 380 390 400
YLISSDPTNL SRGGENFIGK LRSNLLGNRF TVFDNGQNPQ RGGGGDVGSL
410 420 430 440 450
RQELAAVVYE TNVLGFRGPR RMTVIIPGMN SDNERVPIRP RNASDGLLVR
460 470 480 490 500
WQNKTLESLI ELHNKPPIWN EDSGSYTLNF QGRVTQASVK NFQIVHADDP
510 520 530 540
DYIVLQFGRV AEDAFTLDYR YPLCALQAFA IALSSFDGKL ACE
Length:543
Mass (Da):60,336
Last modified:May 1, 1999 - v1
Checksum:i0F0D9E4D2A2731E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085681 mRNA. Translation: AAD13757.1.
AF105711 mRNA. Translation: AAD38451.1.
CCDSiCCDS28578.1.
RefSeqiNP_067453.1. NM_021478.1.
UniGeneiMm.42102.

Genome annotation databases

EnsembliENSMUST00000041819; ENSMUSP00000049070; ENSMUSG00000037446.
GeneIDi22157.
KEGGimmu:22157.
UCSCiuc008bqv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085681 mRNA. Translation: AAD13757.1 .
AF105711 mRNA. Translation: AAD38451.1 .
CCDSi CCDS28578.1.
RefSeqi NP_067453.1. NM_021478.1.
UniGenei Mm.42102.

3D structure databases

ProteinModelPortali Q9Z273.
SMRi Q9Z273. Positions 292-537.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9Z273.

Proteomic databases

PRIDEi Q9Z273.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041819 ; ENSMUSP00000049070 ; ENSMUSG00000037446 .
GeneIDi 22157.
KEGGi mmu:22157.
UCSCi uc008bqv.1. mouse.

Organism-specific databases

CTDi 7287.
MGIi MGI:109571. Tulp1.

Phylogenomic databases

eggNOGi NOG286778.
GeneTreei ENSGT00610000085970.
HOGENOMi HOG000016044.
HOVERGENi HBG018010.
InParanoidi Q9Z273.
OMAi EAPESPC.
OrthoDBi EOG77HDDQ.
PhylomeDBi Q9Z273.
TreeFami TF314076.

Miscellaneous databases

ChiTaRSi TULP1. mouse.
NextBioi 302082.
PROi Q9Z273.
SOURCEi Search...

Gene expression databases

Bgeei Q9Z273.
CleanExi MM_TULP1.
ExpressionAtlasi Q9Z273. baseline and differential.
Genevestigatori Q9Z273.

Family and domain databases

Gene3Di 3.20.90.10. 1 hit.
InterProi IPR000007. Tubby_C.
IPR025659. Tubby_C-like.
IPR018066. Tubby_C_CS.
[Graphical view ]
Pfami PF01167. Tub. 1 hit.
[Graphical view ]
PRINTSi PR01573. SUPERTUBBY.
SUPFAMi SSF54518. SSF54518. 1 hit.
PROSITEi PS01200. TUB_1. 1 hit.
PS01201. TUB_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular evolution of the tubby gene family."
    Naggert J.K., Nishina P.M., Fitch D., McGinnis N., Basson M., Yan G., Cardon L., Shiva N., Duyao M., Ikeda A., McGinnis A., North M.A.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Apoptotic photoreceptor cell death in tubby mice and the localization of tubby gene family members in the retina."
    Ikeda S., Sorokina I., Naggert J.K., North M.A., Nishina P.M.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "A role for the Tubby-like protein 1 in rhodopsin transport."
    Hagstrom S.A., Adamian M., Scimeca M., Pawlyk B.S., Yue G., Li T.
    Invest. Ophthalmol. Vis. Sci. 42:1955-1962(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.
  4. "Interaction between the photoreceptor-specific tubby-like protein 1 and the neuronal-specific GTPase dynamin-1."
    Xi Q., Pauer G.J.T., Ball S.L., Rayborn M., Hollyfield J.G., Peachey N.S., Crabb J.W., Hagstrom S.A.
    Invest. Ophthalmol. Vis. Sci. 48:2837-2844(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DNM1, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, SUBUNIT, FUNCTION.
  5. "Unconventional secretion of tubby and tubby-like protein 1."
    Caberoy N.B., Li W.
    FEBS Lett. 583:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
  7. "Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis."
    Caberoy N.B., Zhou Y., Li W.
    EMBO J. 29:3898-3910(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TYRO3.
  8. "Identification of tubby and tubby-like protein 1 as eat-me signals by phage display."
    Caberoy N.B., Maiguel D., Kim Y., Li W.
    Exp. Cell Res. 316:245-257(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TUB.
  9. "Efficient identification of tubby-binding proteins by an improved system of T7 phage display."
    Caberoy N.B., Zhou Y., Jiang X., Alvarado G., Li W.
    J. Mol. Recognit. 23:74-83(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HMGB2; ABCF1; PSIP1 AND ZEB1.

Entry informationi

Entry nameiTULP1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3