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Reviewed, UniProtKB/Swiss-Prot Q9Z273 (TULP1_MOUSE)

Last modified June 16, 2009. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Tubby-related protein 1
Alternative name(s):
    Tubby-like protein 1
Gene names
Name: Tulp1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Not known; probably plays an essential role in the physiology of photoreceptors.

Tissue specificity

Retinal specific.

Sequence similarities

Belongs to the TUB family.

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Ontologies

Keywords
   Biological processSensory transduction
Vision
Gene Ontology (GO)
   Biological processphototransduction

Inferred from mutant phenotype. Source: MGI

   Molecular functionG-protein coupled photoreceptor activity

Inferred from mutant phenotype. Source: MGI

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 543543Tubby-related protein 1
PRO_0000186467

Regions

Compositional bias118 – 12710Poly-Asp
Compositional bias128 – 1325Poly-Glu
Compositional bias246 – 2549Poly-Glu

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Sequences

Sequence LengthMass (Da)Tools
Q9Z273-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 0F0D9E4D2A2731E7

FASTA54360,336
        10         20         30         40         50         60 
MPLQEETLRE VWASDSGHEE DCLSPEPPLR PKQRPAQGQK LRKKKPETPD SLESKPRKAG 

        70         80         90        100        110        120 
AGRRKHEEPP ADSAEPRAAQ TVYAKFLRDP EAKKRDPREN FLVARAPDLG GEENSEEDSD 

       130        140        150        160        170        180 
DDDNDDDEEE EEKKEGKKEK SSLPPKKAPK EREKKAKALG PRGDVGSPDA PRKPLRTKKK 

       190        200        210        220        230        240 
EVGEGTKLRK AKKKGPGETD KDPAGSPAAL RKEFPAAMFL VGEGGAAEKG VKKKGPPKGS 

       250        260        270        280        290        300 
EEEKKEEEEE VEEEVASAVM KNSNQKGRAK GKGKKKVKEE RASSPPVEVG EPREFVLQPA 

       310        320        330        340        350        360 
PQGRAVRCRL TRDKKGMDRG MYPSYFLHLD TEKKVFLLAG RKRKRSKTAN YLISSDPTNL 

       370        380        390        400        410        420 
SRGGENFIGK LRSNLLGNRF TVFDNGQNPQ RGGGGDVGSL RQELAAVVYE TNVLGFRGPR 

       430        440        450        460        470        480 
RMTVIIPGMN SDNERVPIRP RNASDGLLVR WQNKTLESLI ELHNKPPIWN EDSGSYTLNF 

       490        500        510        520        530        540 
QGRVTQASVK NFQIVHADDP DYIVLQFGRV AEDAFTLDYR YPLCALQAFA IALSSFDGKL 


ACE

« Hide

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References

[1]"Molecular evolution of the tubby gene family."
Naggert J.K., Nishina P.M., Fitch D., McGinnis N., Basson M., Yan G., Cardon L., Shiva N., Duyao M., Ikeda A., McGinnis A., North M.A.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"Apoptotic photoreceptor cell death in tubby mice and the localization of tubby gene family members in the retina."
Ikeda S., Sorokina I., Naggert J.K., North M.A., Nishina P.M.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF085681 mRNA. Translation: AAD13757.1.
AF105711 mRNA. Translation: AAD38451.1.
IPIIPI00130590.
RefSeqNP_067453.1.
UniGeneMm.42102

3D structure databases

HSSPHSSP built from PDB template 1I7E based on UniProtKB P50586.
SMRQ9Z273. Positions 292-537.
ModBaseSearch...

PTM databases

PhosphoSiteQ9Z273.

Proteomic databases

PRIDEQ9Z273.

Genome annotation databases

EnsemblENSMUSG00000037446. Mus musculus. [Contig view]
GeneID22157.
KEGGmmu:22157.

Organism-specific databases

MGIMGI:109571. Tulp1.

Phylogenomic databases

HOGENOMQ9Z273.
HOVERGENQ9Z273.
OMAQ9Z273. GQNPQRG.

Gene expression databases

ArrayExpressQ9Z273.
BgeeQ9Z273.
CleanExMM_TULP1.
GermOnlineENSMUSG00000037446. Mus musculus.

Family and domain databases

InterProIPR000007. Tubby_C.
IPR018066. Tubby_C_CS.
[Graphical view]
Gene3DG3DSA:3.20.90.10. Tubby_C. 1 hit.
PfamPF01167. Tub. 1 hit.
[Graphical view]
PRINTSPR01573. SUPERTUBBY.
PROSITEPS01200. TUB_1. 1 hit.
PS01201. TUB_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio302082.
SOURCESearch...

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Entry information

Entry nameTULP1_MOUSE
AccessionPrimary (citable) accession number: Q9Z273
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 1999
Last modified: June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents