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Q9Z273

- TULP1_MOUSE

UniProt

Q9Z273 - TULP1_MOUSE

Protein

Tubby-related protein 1

Gene

Tulp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells. Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) By similarity. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.By similarity4 Publications

    GO - Molecular functioni

    1. actin filament binding Source: UniProtKB
    2. G-protein coupled photoreceptor activity Source: MGI
    3. phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. dendrite development Source: UniProtKB
    2. detection of visible light Source: GOC
    3. eye photoreceptor cell development Source: UniProtKB
    4. phagocytosis Source: UniProtKB-KW
    5. photoreceptor cell maintenance Source: UniProtKB
    6. phototransduction Source: MGI
    7. positive regulation of phagocytosis Source: UniProtKB
    8. retina development in camera-type eye Source: MGI
    9. visual perception Source: UniProtKB-KW

    Keywords - Biological processi

    Phagocytosis, Sensory transduction, Vision

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tubby-related protein 1
    Alternative name(s):
    Tubby-like protein 1
    Gene namesi
    Name:Tulp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:109571. Tulp1.

    Subcellular locationi

    Cytoplasm. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Secreted. Cell junctionsynapse
    Note: Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway.

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cell projection Source: UniProtKB
    3. cytoplasm Source: UniProtKB-SubCell
    4. extracellular region Source: UniProtKB-SubCell
    5. photoreceptor inner segment Source: UniProtKB
    6. photoreceptor outer segment Source: UniProtKB
    7. plasma membrane Source: UniProtKB
    8. synapse Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Membrane, Secreted, Synapse

    Pathology & Biotechi

    Disruption phenotypei

    Malformation of photoreceptor synapses, followed by photoreceptor degeneration.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 543543Tubby-related protein 1PRO_0000186467Add
    BLAST

    Proteomic databases

    PRIDEiQ9Z273.

    PTM databases

    PhosphoSiteiQ9Z273.

    Expressioni

    Tissue specificityi

    Retina specific. Detected in the outer plexiform layer in photoreceptor cells (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ9Z273.
    BgeeiQ9Z273.
    CleanExiMM_TULP1.
    GenevestigatoriQ9Z273.

    Interactioni

    Subunit structurei

    Homodimer Probable. May interact with ABCF1, PSIP1, ZEB1 and HMGB2 Potential. Interacts with F-actin By similarity. Interacts with DNM1. Interacts with TUB. Interacts with TYRO3.By similarity4 PublicationsCurated

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z273.
    SMRiQ9Z273. Positions 292-537.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi118 – 12710Poly-Asp
    Compositional biasi128 – 1325Poly-Glu
    Compositional biasi246 – 2549Poly-Glu

    Sequence similaritiesi

    Belongs to the TUB family.Curated

    Phylogenomic databases

    eggNOGiNOG286778.
    GeneTreeiENSGT00610000085970.
    HOGENOMiHOG000016044.
    HOVERGENiHBG018010.
    InParanoidiQ9Z273.
    OMAiEAPESPC.
    OrthoDBiEOG77HDDQ.
    PhylomeDBiQ9Z273.
    TreeFamiTF314076.

    Family and domain databases

    Gene3Di3.20.90.10. 1 hit.
    InterProiIPR000007. Tubby_C.
    IPR025659. Tubby_C-like.
    IPR018066. Tubby_C_CS.
    [Graphical view]
    PfamiPF01167. Tub. 1 hit.
    [Graphical view]
    PRINTSiPR01573. SUPERTUBBY.
    SUPFAMiSSF54518. SSF54518. 1 hit.
    PROSITEiPS01200. TUB_1. 1 hit.
    PS01201. TUB_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Z273-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLQEETLRE VWASDSGHEE DCLSPEPPLR PKQRPAQGQK LRKKKPETPD    50
    SLESKPRKAG AGRRKHEEPP ADSAEPRAAQ TVYAKFLRDP EAKKRDPREN 100
    FLVARAPDLG GEENSEEDSD DDDNDDDEEE EEKKEGKKEK SSLPPKKAPK 150
    EREKKAKALG PRGDVGSPDA PRKPLRTKKK EVGEGTKLRK AKKKGPGETD 200
    KDPAGSPAAL RKEFPAAMFL VGEGGAAEKG VKKKGPPKGS EEEKKEEEEE 250
    VEEEVASAVM KNSNQKGRAK GKGKKKVKEE RASSPPVEVG EPREFVLQPA 300
    PQGRAVRCRL TRDKKGMDRG MYPSYFLHLD TEKKVFLLAG RKRKRSKTAN 350
    YLISSDPTNL SRGGENFIGK LRSNLLGNRF TVFDNGQNPQ RGGGGDVGSL 400
    RQELAAVVYE TNVLGFRGPR RMTVIIPGMN SDNERVPIRP RNASDGLLVR 450
    WQNKTLESLI ELHNKPPIWN EDSGSYTLNF QGRVTQASVK NFQIVHADDP 500
    DYIVLQFGRV AEDAFTLDYR YPLCALQAFA IALSSFDGKL ACE 543
    Length:543
    Mass (Da):60,336
    Last modified:May 1, 1999 - v1
    Checksum:i0F0D9E4D2A2731E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085681 mRNA. Translation: AAD13757.1.
    AF105711 mRNA. Translation: AAD38451.1.
    CCDSiCCDS28578.1.
    RefSeqiNP_067453.1. NM_021478.1.
    UniGeneiMm.42102.

    Genome annotation databases

    EnsembliENSMUST00000041819; ENSMUSP00000049070; ENSMUSG00000037446.
    GeneIDi22157.
    KEGGimmu:22157.
    UCSCiuc008bqv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085681 mRNA. Translation: AAD13757.1 .
    AF105711 mRNA. Translation: AAD38451.1 .
    CCDSi CCDS28578.1.
    RefSeqi NP_067453.1. NM_021478.1.
    UniGenei Mm.42102.

    3D structure databases

    ProteinModelPortali Q9Z273.
    SMRi Q9Z273. Positions 292-537.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9Z273.

    Proteomic databases

    PRIDEi Q9Z273.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041819 ; ENSMUSP00000049070 ; ENSMUSG00000037446 .
    GeneIDi 22157.
    KEGGi mmu:22157.
    UCSCi uc008bqv.1. mouse.

    Organism-specific databases

    CTDi 7287.
    MGIi MGI:109571. Tulp1.

    Phylogenomic databases

    eggNOGi NOG286778.
    GeneTreei ENSGT00610000085970.
    HOGENOMi HOG000016044.
    HOVERGENi HBG018010.
    InParanoidi Q9Z273.
    OMAi EAPESPC.
    OrthoDBi EOG77HDDQ.
    PhylomeDBi Q9Z273.
    TreeFami TF314076.

    Miscellaneous databases

    ChiTaRSi TULP1. mouse.
    NextBioi 302082.
    PROi Q9Z273.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Z273.
    Bgeei Q9Z273.
    CleanExi MM_TULP1.
    Genevestigatori Q9Z273.

    Family and domain databases

    Gene3Di 3.20.90.10. 1 hit.
    InterProi IPR000007. Tubby_C.
    IPR025659. Tubby_C-like.
    IPR018066. Tubby_C_CS.
    [Graphical view ]
    Pfami PF01167. Tub. 1 hit.
    [Graphical view ]
    PRINTSi PR01573. SUPERTUBBY.
    SUPFAMi SSF54518. SSF54518. 1 hit.
    PROSITEi PS01200. TUB_1. 1 hit.
    PS01201. TUB_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular evolution of the tubby gene family."
      Naggert J.K., Nishina P.M., Fitch D., McGinnis N., Basson M., Yan G., Cardon L., Shiva N., Duyao M., Ikeda A., McGinnis A., North M.A.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "Apoptotic photoreceptor cell death in tubby mice and the localization of tubby gene family members in the retina."
      Ikeda S., Sorokina I., Naggert J.K., North M.A., Nishina P.M.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. "A role for the Tubby-like protein 1 in rhodopsin transport."
      Hagstrom S.A., Adamian M., Scimeca M., Pawlyk B.S., Yue G., Li T.
      Invest. Ophthalmol. Vis. Sci. 42:1955-1962(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION.
    4. "Interaction between the photoreceptor-specific tubby-like protein 1 and the neuronal-specific GTPase dynamin-1."
      Xi Q., Pauer G.J.T., Ball S.L., Rayborn M., Hollyfield J.G., Peachey N.S., Crabb J.W., Hagstrom S.A.
      Invest. Ophthalmol. Vis. Sci. 48:2837-2844(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DNM1, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, SUBUNIT, FUNCTION.
    5. "Unconventional secretion of tubby and tubby-like protein 1."
      Caberoy N.B., Li W.
      FEBS Lett. 583:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    6. Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
    7. "Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis."
      Caberoy N.B., Zhou Y., Li W.
      EMBO J. 29:3898-3910(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TYRO3.
    8. "Identification of tubby and tubby-like protein 1 as eat-me signals by phage display."
      Caberoy N.B., Maiguel D., Kim Y., Li W.
      Exp. Cell Res. 316:245-257(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TUB.
    9. "Efficient identification of tubby-binding proteins by an improved system of T7 phage display."
      Caberoy N.B., Zhou Y., Jiang X., Alvarado G., Li W.
      J. Mol. Recognit. 23:74-83(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HMGB2; ABCF1; PSIP1 AND ZEB1.

    Entry informationi

    Entry nameiTULP1_MOUSE
    AccessioniPrimary (citable) accession number: Q9Z273
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3