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Q9Z273 (TULP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tubby-related protein 1
Alternative name(s):
Tubby-like protein 1
Gene names
Name:Tulp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells. Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) By similarity. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. Ref.3 Ref.4 Ref.6 Ref.8

Subunit structure

Homodimer Probable. May interact with ABCF1, PSIP1, ZEB1 and HMGB2 Potential. Interacts with F-actin By similarity. Interacts with DNM1. Interacts with TUB. Interacts with TYRO3. Ref.4 Ref.7 Ref.8 Ref.9

Subcellular location

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Secreted. Cell junctionsynapse. Note: Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway. Ref.3 Ref.4 Ref.5

Tissue specificity

Retina specific. Detected in the outer plexiform layer in photoreceptor cells (at protein level). Ref.6

Disruption phenotype

Malformation of photoreceptor synapses, followed by photoreceptor degeneration. Ref.6

Sequence similarities

Belongs to the TUB family.

Ontologies

Keywords
   Biological processPhagocytosis
Sensory transduction
Vision
   Cellular componentCell junction
Cell membrane
Cytoplasm
Membrane
Secreted
Synapse
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdendrite development

Inferred from mutant phenotype Ref.6. Source: UniProtKB

detection of visible light

Inferred from mutant phenotype PubMed 10607826. Source: GOC

eye photoreceptor cell development

Inferred from mutant phenotype Ref.6. Source: UniProtKB

phagocytosis

Inferred from electronic annotation. Source: UniProtKB-KW

photoreceptor cell maintenance

Inferred from mutant phenotype Ref.6. Source: UniProtKB

phototransduction

Inferred from mutant phenotype PubMed 10607826. Source: MGI

positive regulation of phagocytosis

Inferred from sequence or structural similarity. Source: UniProtKB

retina development in camera-type eye

Inferred from mutant phenotype PubMed 21052544. Source: MGI

visual perception

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

cell projection

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

photoreceptor inner segment

Inferred from direct assay Ref.6. Source: UniProtKB

photoreceptor outer segment

Inferred from direct assay Ref.6. Source: UniProtKB

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

synapse

Inferred from direct assay Ref.6. Source: UniProtKB

   Molecular_functionG-protein coupled photoreceptor activity

Inferred from mutant phenotype PubMed 10607826. Source: MGI

actin filament binding

Inferred from sequence or structural similarity. Source: UniProtKB

phosphatidylinositol-4,5-bisphosphate binding

Inferred from sequence or structural similarity. Source: UniProtKB

protein binding

Inferred from physical interaction Ref.8. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 543543Tubby-related protein 1
PRO_0000186467

Regions

Compositional bias118 – 12710Poly-Asp
Compositional bias128 – 1325Poly-Glu
Compositional bias246 – 2549Poly-Glu

Sequences

Sequence LengthMass (Da)Tools
Q9Z273 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 0F0D9E4D2A2731E7

FASTA54360,336
        10         20         30         40         50         60 
MPLQEETLRE VWASDSGHEE DCLSPEPPLR PKQRPAQGQK LRKKKPETPD SLESKPRKAG 

        70         80         90        100        110        120 
AGRRKHEEPP ADSAEPRAAQ TVYAKFLRDP EAKKRDPREN FLVARAPDLG GEENSEEDSD 

       130        140        150        160        170        180 
DDDNDDDEEE EEKKEGKKEK SSLPPKKAPK EREKKAKALG PRGDVGSPDA PRKPLRTKKK 

       190        200        210        220        230        240 
EVGEGTKLRK AKKKGPGETD KDPAGSPAAL RKEFPAAMFL VGEGGAAEKG VKKKGPPKGS 

       250        260        270        280        290        300 
EEEKKEEEEE VEEEVASAVM KNSNQKGRAK GKGKKKVKEE RASSPPVEVG EPREFVLQPA 

       310        320        330        340        350        360 
PQGRAVRCRL TRDKKGMDRG MYPSYFLHLD TEKKVFLLAG RKRKRSKTAN YLISSDPTNL 

       370        380        390        400        410        420 
SRGGENFIGK LRSNLLGNRF TVFDNGQNPQ RGGGGDVGSL RQELAAVVYE TNVLGFRGPR 

       430        440        450        460        470        480 
RMTVIIPGMN SDNERVPIRP RNASDGLLVR WQNKTLESLI ELHNKPPIWN EDSGSYTLNF 

       490        500        510        520        530        540 
QGRVTQASVK NFQIVHADDP DYIVLQFGRV AEDAFTLDYR YPLCALQAFA IALSSFDGKL 


ACE 

« Hide

References

[1]"Molecular evolution of the tubby gene family."
Naggert J.K., Nishina P.M., Fitch D., McGinnis N., Basson M., Yan G., Cardon L., Shiva N., Duyao M., Ikeda A., McGinnis A., North M.A.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"Apoptotic photoreceptor cell death in tubby mice and the localization of tubby gene family members in the retina."
Ikeda S., Sorokina I., Naggert J.K., North M.A., Nishina P.M.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[3]"A role for the Tubby-like protein 1 in rhodopsin transport."
Hagstrom S.A., Adamian M., Scimeca M., Pawlyk B.S., Yue G., Li T.
Invest. Ophthalmol. Vis. Sci. 42:1955-1962(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, FUNCTION.
[4]"Interaction between the photoreceptor-specific tubby-like protein 1 and the neuronal-specific GTPase dynamin-1."
Xi Q., Pauer G.J.T., Ball S.L., Rayborn M., Hollyfield J.G., Peachey N.S., Crabb J.W., Hagstrom S.A.
Invest. Ophthalmol. Vis. Sci. 48:2837-2844(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DNM1, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, SUBUNIT, FUNCTION.
[5]"Unconventional secretion of tubby and tubby-like protein 1."
Caberoy N.B., Li W.
FEBS Lett. 583:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"Early synaptic defects in tulp1-/- mice."
Grossman G.H., Pauer G.J.T., Narendra U., Peachey N.S., Hagstrom S.A.
Invest. Ophthalmol. Vis. Sci. 50:3074-3083(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
[7]"Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis."
Caberoy N.B., Zhou Y., Li W.
EMBO J. 29:3898-3910(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TYRO3.
[8]"Identification of tubby and tubby-like protein 1 as eat-me signals by phage display."
Caberoy N.B., Maiguel D., Kim Y., Li W.
Exp. Cell Res. 316:245-257(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH TUB.
[9]"Efficient identification of tubby-binding proteins by an improved system of T7 phage display."
Caberoy N.B., Zhou Y., Jiang X., Alvarado G., Li W.
J. Mol. Recognit. 23:74-83(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HMGB2; ABCF1; PSIP1 AND ZEB1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF085681 mRNA. Translation: AAD13757.1.
AF105711 mRNA. Translation: AAD38451.1.
CCDSCCDS28578.1.
RefSeqNP_067453.1. NM_021478.1.
UniGeneMm.42102.

3D structure databases

ProteinModelPortalQ9Z273.
SMRQ9Z273. Positions 292-537.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9Z273.

Proteomic databases

PRIDEQ9Z273.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041819; ENSMUSP00000049070; ENSMUSG00000037446.
GeneID22157.
KEGGmmu:22157.
UCSCuc008bqv.1. mouse.

Organism-specific databases

CTD7287.
MGIMGI:109571. Tulp1.

Phylogenomic databases

eggNOGNOG286778.
GeneTreeENSGT00610000085970.
HOGENOMHOG000016044.
HOVERGENHBG018010.
InParanoidQ9Z273.
OMAEAPESPC.
OrthoDBEOG77HDDQ.
PhylomeDBQ9Z273.
TreeFamTF314076.

Gene expression databases

ArrayExpressQ9Z273.
BgeeQ9Z273.
CleanExMM_TULP1.
GenevestigatorQ9Z273.

Family and domain databases

Gene3D3.20.90.10. 1 hit.
InterProIPR000007. Tubby_C.
IPR025659. Tubby_C-like.
IPR018066. Tubby_C_CS.
[Graphical view]
PfamPF01167. Tub. 1 hit.
[Graphical view]
PRINTSPR01573. SUPERTUBBY.
SUPFAMSSF54518. SSF54518. 1 hit.
PROSITEPS01200. TUB_1. 1 hit.
PS01201. TUB_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTULP1. mouse.
NextBio302082.
PROQ9Z273.
SOURCESearch...

Entry information

Entry nameTULP1_MOUSE
AccessionPrimary (citable) accession number: Q9Z273
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot