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Protein

Tubby-related protein 1

Gene

Tulp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells. Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.By similarity4 Publications

GO - Molecular functioni

GO - Biological processi

  • dendrite development Source: UniProtKB
  • detection of light stimulus involved in visual perception Source: MGI
  • eye photoreceptor cell development Source: UniProtKB
  • phagocytosis, recognition Source: MGI
  • photoreceptor cell maintenance Source: UniProtKB
  • positive regulation of phagocytosis Source: UniProtKB
  • protein localization to photoreceptor outer segment Source: MGI
  • retina development in camera-type eye Source: MGI
  • retina homeostasis Source: MGI
  • vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Phagocytosis, Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Tubby-related protein 1
Alternative name(s):
Tubby-like protein 1
Gene namesi
Name:Tulp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:109571. Tulp1.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: MGI
  • cell junction Source: UniProtKB-KW
  • cell projection Source: UniProtKB
  • cytosol Source: MGI
  • extracellular region Source: MGI
  • photoreceptor inner segment Source: UniProtKB
  • photoreceptor outer segment Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Secreted, Synapse

Pathology & Biotechi

Disruption phenotypei

Malformation of photoreceptor synapses, followed by photoreceptor degeneration.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Tubby-related protein 1PRO_0000186467Add
BLAST

Proteomic databases

PRIDEiQ9Z273.

PTM databases

PhosphoSiteiQ9Z273.

Expressioni

Tissue specificityi

Retina specific. Detected in the outer plexiform layer in photoreceptor cells (at protein level).1 Publication

Gene expression databases

BgeeiQ9Z273.
CleanExiMM_TULP1.
ExpressionAtlasiQ9Z273. baseline and differential.
GenevestigatoriQ9Z273.

Interactioni

Subunit structurei

Homodimer (Probable). May interact with ABCF1, PSIP1, ZEB1 and HMGB2 (Potential). Interacts with F-actin (By similarity). Interacts with DNM1. Interacts with TUB. Interacts with TYRO3.By similarityCurated4 Publications

Structurei

3D structure databases

ProteinModelPortaliQ9Z273.
SMRiQ9Z273. Positions 292-537.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi118 – 12710Poly-Asp
Compositional biasi128 – 1325Poly-Glu
Compositional biasi246 – 2549Poly-Glu

Sequence similaritiesi

Belongs to the TUB family.Curated

Phylogenomic databases

eggNOGiNOG286778.
GeneTreeiENSGT00610000085970.
HOGENOMiHOG000016044.
HOVERGENiHBG018010.
InParanoidiQ9Z273.
OrthoDBiEOG77HDDQ.
PhylomeDBiQ9Z273.
TreeFamiTF314076.

Family and domain databases

Gene3Di3.20.90.10. 1 hit.
InterProiIPR000007. Tubby_C.
IPR025659. Tubby_C-like.
IPR018066. Tubby_C_CS.
[Graphical view]
PfamiPF01167. Tub. 1 hit.
[Graphical view]
PRINTSiPR01573. SUPERTUBBY.
SUPFAMiSSF54518. SSF54518. 1 hit.
PROSITEiPS01200. TUB_1. 1 hit.
PS01201. TUB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLQEETLRE VWASDSGHEE DCLSPEPPLR PKQRPAQGQK LRKKKPETPD
60 70 80 90 100
SLESKPRKAG AGRRKHEEPP ADSAEPRAAQ TVYAKFLRDP EAKKRDPREN
110 120 130 140 150
FLVARAPDLG GEENSEEDSD DDDNDDDEEE EEKKEGKKEK SSLPPKKAPK
160 170 180 190 200
EREKKAKALG PRGDVGSPDA PRKPLRTKKK EVGEGTKLRK AKKKGPGETD
210 220 230 240 250
KDPAGSPAAL RKEFPAAMFL VGEGGAAEKG VKKKGPPKGS EEEKKEEEEE
260 270 280 290 300
VEEEVASAVM KNSNQKGRAK GKGKKKVKEE RASSPPVEVG EPREFVLQPA
310 320 330 340 350
PQGRAVRCRL TRDKKGMDRG MYPSYFLHLD TEKKVFLLAG RKRKRSKTAN
360 370 380 390 400
YLISSDPTNL SRGGENFIGK LRSNLLGNRF TVFDNGQNPQ RGGGGDVGSL
410 420 430 440 450
RQELAAVVYE TNVLGFRGPR RMTVIIPGMN SDNERVPIRP RNASDGLLVR
460 470 480 490 500
WQNKTLESLI ELHNKPPIWN EDSGSYTLNF QGRVTQASVK NFQIVHADDP
510 520 530 540
DYIVLQFGRV AEDAFTLDYR YPLCALQAFA IALSSFDGKL ACE
Length:543
Mass (Da):60,336
Last modified:May 1, 1999 - v1
Checksum:i0F0D9E4D2A2731E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085681 mRNA. Translation: AAD13757.1.
AF105711 mRNA. Translation: AAD38451.1.
CCDSiCCDS28578.1.
RefSeqiNP_067453.1. NM_021478.1.
UniGeneiMm.42102.

Genome annotation databases

EnsembliENSMUST00000041819; ENSMUSP00000049070; ENSMUSG00000037446.
GeneIDi22157.
KEGGimmu:22157.
UCSCiuc008bqv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085681 mRNA. Translation: AAD13757.1.
AF105711 mRNA. Translation: AAD38451.1.
CCDSiCCDS28578.1.
RefSeqiNP_067453.1. NM_021478.1.
UniGeneiMm.42102.

3D structure databases

ProteinModelPortaliQ9Z273.
SMRiQ9Z273. Positions 292-537.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9Z273.

Proteomic databases

PRIDEiQ9Z273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041819; ENSMUSP00000049070; ENSMUSG00000037446.
GeneIDi22157.
KEGGimmu:22157.
UCSCiuc008bqv.1. mouse.

Organism-specific databases

CTDi7287.
MGIiMGI:109571. Tulp1.

Phylogenomic databases

eggNOGiNOG286778.
GeneTreeiENSGT00610000085970.
HOGENOMiHOG000016044.
HOVERGENiHBG018010.
InParanoidiQ9Z273.
OrthoDBiEOG77HDDQ.
PhylomeDBiQ9Z273.
TreeFamiTF314076.

Miscellaneous databases

ChiTaRSiTulp1. mouse.
NextBioi302082.
PROiQ9Z273.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z273.
CleanExiMM_TULP1.
ExpressionAtlasiQ9Z273. baseline and differential.
GenevestigatoriQ9Z273.

Family and domain databases

Gene3Di3.20.90.10. 1 hit.
InterProiIPR000007. Tubby_C.
IPR025659. Tubby_C-like.
IPR018066. Tubby_C_CS.
[Graphical view]
PfamiPF01167. Tub. 1 hit.
[Graphical view]
PRINTSiPR01573. SUPERTUBBY.
SUPFAMiSSF54518. SSF54518. 1 hit.
PROSITEiPS01200. TUB_1. 1 hit.
PS01201. TUB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular evolution of the tubby gene family."
    Naggert J.K., Nishina P.M., Fitch D., McGinnis N., Basson M., Yan G., Cardon L., Shiva N., Duyao M., Ikeda A., McGinnis A., North M.A.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Apoptotic photoreceptor cell death in tubby mice and the localization of tubby gene family members in the retina."
    Ikeda S., Sorokina I., Naggert J.K., North M.A., Nishina P.M.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "A role for the Tubby-like protein 1 in rhodopsin transport."
    Hagstrom S.A., Adamian M., Scimeca M., Pawlyk B.S., Yue G., Li T.
    Invest. Ophthalmol. Vis. Sci. 42:1955-1962(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.
  4. "Interaction between the photoreceptor-specific tubby-like protein 1 and the neuronal-specific GTPase dynamin-1."
    Xi Q., Pauer G.J.T., Ball S.L., Rayborn M., Hollyfield J.G., Peachey N.S., Crabb J.W., Hagstrom S.A.
    Invest. Ophthalmol. Vis. Sci. 48:2837-2844(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DNM1, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, SUBUNIT, FUNCTION.
  5. "Unconventional secretion of tubby and tubby-like protein 1."
    Caberoy N.B., Li W.
    FEBS Lett. 583:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
  7. "Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis."
    Caberoy N.B., Zhou Y., Li W.
    EMBO J. 29:3898-3910(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TYRO3.
  8. "Identification of tubby and tubby-like protein 1 as eat-me signals by phage display."
    Caberoy N.B., Maiguel D., Kim Y., Li W.
    Exp. Cell Res. 316:245-257(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TUB.
  9. "Efficient identification of tubby-binding proteins by an improved system of T7 phage display."
    Caberoy N.B., Zhou Y., Jiang X., Alvarado G., Li W.
    J. Mol. Recognit. 23:74-83(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HMGB2; ABCF1; PSIP1 AND ZEB1.

Entry informationi

Entry nameiTULP1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 1999
Last modified: April 29, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.