##gff-version 3 Q9Z272 UniProtKB Chain 1 770 . . . ID=PRO_0000074202;Note=ARF GTPase-activating protein GIT1 Q9Z272 UniProtKB Domain 1 124 . . . Note=Arf-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00288 Q9Z272 UniProtKB Repeat 132 161 . . . Note=ANK 1 Q9Z272 UniProtKB Repeat 166 195 . . . Note=ANK 2 Q9Z272 UniProtKB Repeat 199 228 . . . Note=ANK 3 Q9Z272 UniProtKB Zinc finger 11 34 . . . Note=C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00288 Q9Z272 UniProtKB Region 1 124 . . . Note=Interaction with gamma-tubulin and localization to the centrosome;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2X7 Q9Z272 UniProtKB Region 245 374 . . . Note=Interaction with PCLO;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12473661;Dbxref=PMID:12473661 Q9Z272 UniProtKB Region 253 424 . . . Note=Interaction with PTK2/FAK1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10938112;Dbxref=PMID:10938112 Q9Z272 UniProtKB Region 254 376 . . . Note=Interaction with ARHGEF7;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10938112;Dbxref=PMID:10938112 Q9Z272 UniProtKB Region 363 425 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Z272 UniProtKB Region 375 596 . . . Note=Interaction with NCK2 and GRIN3A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17310244,ECO:0000269|PubMed:24297929;Dbxref=PMID:17310244,PMID:24297929 Q9Z272 UniProtKB Region 375 596 . . . Note=Required for localization at synapses;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2X7 Q9Z272 UniProtKB Region 420 475 . . . Note=Interaction with MAPK1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FF6 Q9Z272 UniProtKB Region 429 629 . . . Note=Interaction with IKBKG;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2X7 Q9Z272 UniProtKB Region 574 615 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Z272 UniProtKB Region 646 770 . . . Note=Interaction with PXN and TGFB1I1;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10938112,ECO:0000269|PubMed:12153727;Dbxref=PMID:10938112,PMID:12153727 Q9Z272 UniProtKB Coiled coil 449 483 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255,ECO:0000269|PubMed:19136011;Dbxref=PMID:19136011 Q9Z272 UniProtKB Compositional bias 363 380 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Z272 UniProtKB Compositional bias 407 425 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Z272 UniProtKB Compositional bias 574 591 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Z272 UniProtKB Modified residue 224 224 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FF6 Q9Z272 UniProtKB Modified residue 368 368 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FF6 Q9Z272 UniProtKB Modified residue 371 371 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 Q9Z272 UniProtKB Modified residue 373 373 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2X7 Q9Z272 UniProtKB Modified residue 379 379 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2X7 Q9Z272 UniProtKB Modified residue 384 384 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 Q9Z272 UniProtKB Modified residue 392 392 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2X7 Q9Z272 UniProtKB Modified residue 394 394 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2X7 Q9Z272 UniProtKB Modified residue 397 397 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 Q9Z272 UniProtKB Modified residue 401 401 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 Q9Z272 UniProtKB Modified residue 419 419 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 Q9Z272 UniProtKB Modified residue 422 422 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FF6 Q9Z272 UniProtKB Modified residue 426 426 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FF6 Q9Z272 UniProtKB Modified residue 507 507 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2X7 Q9Z272 UniProtKB Modified residue 545 545 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FF6 Q9Z272 UniProtKB Modified residue 546 546 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q68FF6 Q9Z272 UniProtKB Modified residue 554 554 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2X7 Q9Z272 UniProtKB Modified residue 563 563 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2X7 Q9Z272 UniProtKB Modified residue 570 570 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 Q9Z272 UniProtKB Modified residue 580 580 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 Q9Z272 UniProtKB Modified residue 601 601 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 Q9Z272 UniProtKB Modified residue 605 605 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2X7 Q9Z272 UniProtKB Modified residue 610 610 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y2X7 Q9Z272 UniProtKB Modified residue 639 639 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 Q9Z272 UniProtKB Mutagenesis 285 285 . . . Note=Loss of interaction with FAK1%2C decreased interaction with PCLO%2C no effect on interaction with ARHGEF7. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12473661;Dbxref=PMID:12473661 Q9Z272 UniProtKB Mutagenesis 288 288 . . . Note=Loss of interaction with PCLO and FAK1%2C no effect on interaction with ARHGEF7. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12473661;Dbxref=PMID:12473661 Q9Z272 UniProtKB Mutagenesis 298 298 . . . Note=Loss of interaction with FAK1%2C decreased interaction with PCLO%2C no effect on interaction with ARHGEF7. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12473661;Dbxref=PMID:12473661 Q9Z272 UniProtKB Mutagenesis 299 299 . . . Note=Loss of interaction with FAK1%2C decreased interaction with PCLO%2C no effect on interaction with ARHGEF7. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12473661;Dbxref=PMID:12473661 Q9Z272 UniProtKB Mutagenesis 392 392 . . . Note=Loss of interaction with NCK2. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17310244;Dbxref=PMID:17310244 Q9Z272 UniProtKB Mutagenesis 432 483 . . . Note=Decreased homooligomerization and loss of formation of a ternary complex between GIT1%2C ARHGEF7 and PCLO. Does not affect ARHGEF7- and PCLO-binding to GIT1 monomer. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12473661;Dbxref=PMID:12473661 Q9Z272 UniProtKB Helix 432 481 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W6A Q9Z272 UniProtKB Beta strand 645 647 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2JX0 Q9Z272 UniProtKB Helix 651 673 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6IUH Q9Z272 UniProtKB Helix 677 679 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6IUH Q9Z272 UniProtKB Helix 680 695 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6IUH Q9Z272 UniProtKB Beta strand 700 702 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2JX0 Q9Z272 UniProtKB Helix 705 725 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6IUH Q9Z272 UniProtKB Helix 726 728 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6IUH Q9Z272 UniProtKB Helix 739 766 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6IUH