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Q9Z269

- VAPB_RAT

UniProt

Q9Z269 - VAPB_RAT

Protein

Vesicle-associated membrane protein-associated protein B

Gene

Vapb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.By similarity

    GO - Molecular functioni

    1. beta-tubulin binding Source: UniProtKB
    2. enzyme binding Source: UniProtKB
    3. protein homodimerization activity Source: UniProtKB
    4. structural molecule activity Source: InterPro

    GO - Biological processi

    1. activation of signaling protein activity involved in unfolded protein response Source: UniProtKB
    2. cellular calcium ion homeostasis Source: UniProtKB
    3. endoplasmic reticulum unfolded protein response Source: UniProtKB
    4. modulation by virus of host morphology or physiology Source: UniProtKB
    5. positive regulation of viral genome replication Source: UniProtKB

    Keywords - Biological processi

    Unfolded protein response

    Enzyme and pathway databases

    ReactomeiREACT_196736. Sphingolipid de novo biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vesicle-associated membrane protein-associated protein B
    Short name:
    VAMP-B
    Short name:
    VAMP-associated protein B
    Short name:
    VAP-B
    Gene namesi
    Name:Vapb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi68326. Vapb.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB
    3. Golgi apparatus Source: UniProtKB
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 243242Vesicle-associated membrane protein-associated protein BPRO_0000213475Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9Z269.
    PRIDEiQ9Z269.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    GenevestigatoriQ9Z269.

    Interactioni

    Subunit structurei

    Homodimer, and heterodimer with VAPA. Interacts with RMDN3, VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9Z269. 2 interactions.
    MINTiMINT-4566897.
    STRINGi10116.ENSRNOP00000007554.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Z269.
    SMRiQ9Z269. Positions 1-134.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 218217CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei219 – 23921Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 124118MSPPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili161 – 19636Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MSP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5066.
    GeneTreeiENSGT00390000006947.
    HOGENOMiHOG000293182.
    HOVERGENiHBG028551.
    InParanoidiQ9Z269.
    KOiK10707.
    OMAiPHDIEIN.
    OrthoDBiEOG7CK389.
    PhylomeDBiQ9Z269.
    TreeFamiTF317024.

    Family and domain databases

    Gene3Di2.60.40.360. 1 hit.
    InterProiIPR000535. MSP_dom.
    IPR008962. PapD-like.
    IPR016763. Vesicle-associated_membrane.
    [Graphical view]
    PfamiPF00635. Motile_Sperm. 1 hit.
    [Graphical view]
    PIRSFiPIRSF019693. VAMP-associated. 1 hit.
    SUPFAMiSSF49354. SSF49354. 1 hit.
    PROSITEiPS50202. MSP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Z269-1 [UniParc]FASTAAdd to Basket

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    MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR    50
    RYCVRPNSGV IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS 100
    DMEAVWKEAK PEDLMDSKLR CVFELPAENA KPHDVEINKI MPTSASKTEA 150
    PVAAKPLTSP LDDAEVKKVM EECRRLQGEV QRLREESRQL KEEDGLRARK 200
    ALPSNSPMAA LAASGKEEGL SARLLALVVL FFIVGVIIGK IAL 243
    Length:243
    Mass (Da):26,916
    Last modified:January 23, 2007 - v3
    Checksum:i870B177B0798B4EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF086631 mRNA. Translation: AAD13580.1.
    BC065576 mRNA. Translation: AAH65576.1.
    RefSeqiNP_068619.1. NM_021847.3.
    UniGeneiRn.52500.

    Genome annotation databases

    EnsembliENSRNOT00000007554; ENSRNOP00000007554; ENSRNOG00000005331.
    GeneIDi60431.
    KEGGirno:60431.
    UCSCiRGD:68326. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF086631 mRNA. Translation: AAD13580.1 .
    BC065576 mRNA. Translation: AAH65576.1 .
    RefSeqi NP_068619.1. NM_021847.3.
    UniGenei Rn.52500.

    3D structure databases

    ProteinModelPortali Q9Z269.
    SMRi Q9Z269. Positions 1-134.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9Z269. 2 interactions.
    MINTi MINT-4566897.
    STRINGi 10116.ENSRNOP00000007554.

    Proteomic databases

    PaxDbi Q9Z269.
    PRIDEi Q9Z269.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000007554 ; ENSRNOP00000007554 ; ENSRNOG00000005331 .
    GeneIDi 60431.
    KEGGi rno:60431.
    UCSCi RGD:68326. rat.

    Organism-specific databases

    CTDi 9217.
    RGDi 68326. Vapb.

    Phylogenomic databases

    eggNOGi COG5066.
    GeneTreei ENSGT00390000006947.
    HOGENOMi HOG000293182.
    HOVERGENi HBG028551.
    InParanoidi Q9Z269.
    KOi K10707.
    OMAi PHDIEIN.
    OrthoDBi EOG7CK389.
    PhylomeDBi Q9Z269.
    TreeFami TF317024.

    Enzyme and pathway databases

    Reactomei REACT_196736. Sphingolipid de novo biosynthesis.

    Miscellaneous databases

    NextBioi 612154.
    PROi Q9Z269.

    Gene expression databases

    Genevestigatori Q9Z269.

    Family and domain databases

    Gene3Di 2.60.40.360. 1 hit.
    InterProi IPR000535. MSP_dom.
    IPR008962. PapD-like.
    IPR016763. Vesicle-associated_membrane.
    [Graphical view ]
    Pfami PF00635. Motile_Sperm. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF019693. VAMP-associated. 1 hit.
    SUPFAMi SSF49354. SSF49354. 1 hit.
    PROSITEi PS50202. MSP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins."
      Nishimura Y., Hayashi M., Inada H., Tanaka T.
      Biochem. Biophys. Res. Commun. 254:21-26(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Lubec G., Kang S.U.
      Submitted (JUL-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 176-182, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiVAPB_RAT
    AccessioniPrimary (citable) accession number: Q9Z269
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3