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Q9Z269

- VAPB_RAT

UniProt

Q9Z269 - VAPB_RAT

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Protein
Vesicle-associated membrane protein-associated protein B
Gene
Vapb
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity By similarity. Involved in cellular calcium homeostasis regulation By similarity.

GO - Molecular functioni

  1. beta-tubulin binding Source: UniProtKB
  2. enzyme binding Source: UniProtKB
  3. protein homodimerization activity Source: UniProtKB
  4. structural molecule activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. activation of signaling protein activity involved in unfolded protein response Source: UniProtKB
  2. cellular calcium ion homeostasis Source: UniProtKB
  3. endoplasmic reticulum unfolded protein response Source: UniProtKB
  4. modulation by virus of host morphology or physiology Source: UniProtKB
  5. positive regulation of viral genome replication Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Unfolded protein response

Enzyme and pathway databases

ReactomeiREACT_196736. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein-associated protein B
Short name:
VAMP-B
Short name:
VAMP-associated protein B
Short name:
VAP-B
Gene namesi
Name:Vapb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi68326. Vapb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 218217Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei219 – 23921Helical; Anchor for type IV membrane protein; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. endoplasmic reticulum Source: UniProtKB
  3. endoplasmic reticulum membrane Source: UniProtKB
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 243242Vesicle-associated membrane protein-associated protein B
PRO_0000213475Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9Z269.
PRIDEiQ9Z269.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

GenevestigatoriQ9Z269.

Interactioni

Subunit structurei

Homodimer, and heterodimer with VAPA. Interacts with RMDN3, VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27 By similarity.

Protein-protein interaction databases

IntActiQ9Z269. 2 interactions.
MINTiMINT-4566897.
STRINGi10116.ENSRNOP00000007554.

Structurei

3D structure databases

ProteinModelPortaliQ9Z269.
SMRiQ9Z269. Positions 1-134.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 124118MSP
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili161 – 19636 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 MSP domain.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5066.
GeneTreeiENSGT00390000006947.
HOGENOMiHOG000293182.
HOVERGENiHBG028551.
InParanoidiQ9Z269.
KOiK10707.
OMAiPHDIEIN.
OrthoDBiEOG7CK389.
PhylomeDBiQ9Z269.
TreeFamiTF317024.

Family and domain databases

Gene3Di2.60.40.360. 1 hit.
InterProiIPR000535. MSP_dom.
IPR008962. PapD-like.
IPR016763. Vesicle-associated_membrane.
[Graphical view]
PfamiPF00635. Motile_Sperm. 1 hit.
[Graphical view]
PIRSFiPIRSF019693. VAMP-associated. 1 hit.
SUPFAMiSSF49354. SSF49354. 1 hit.
PROSITEiPS50202. MSP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Z269-1 [UniParc]FASTAAdd to Basket

« Hide

MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR    50
RYCVRPNSGV IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS 100
DMEAVWKEAK PEDLMDSKLR CVFELPAENA KPHDVEINKI MPTSASKTEA 150
PVAAKPLTSP LDDAEVKKVM EECRRLQGEV QRLREESRQL KEEDGLRARK 200
ALPSNSPMAA LAASGKEEGL SARLLALVVL FFIVGVIIGK IAL 243
Length:243
Mass (Da):26,916
Last modified:January 23, 2007 - v3
Checksum:i870B177B0798B4EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF086631 mRNA. Translation: AAD13580.1.
BC065576 mRNA. Translation: AAH65576.1.
RefSeqiNP_068619.1. NM_021847.3.
UniGeneiRn.52500.

Genome annotation databases

EnsembliENSRNOT00000007554; ENSRNOP00000007554; ENSRNOG00000005331.
GeneIDi60431.
KEGGirno:60431.
UCSCiRGD:68326. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF086631 mRNA. Translation: AAD13580.1 .
BC065576 mRNA. Translation: AAH65576.1 .
RefSeqi NP_068619.1. NM_021847.3.
UniGenei Rn.52500.

3D structure databases

ProteinModelPortali Q9Z269.
SMRi Q9Z269. Positions 1-134.
ModBasei Search...

Protein-protein interaction databases

IntActi Q9Z269. 2 interactions.
MINTi MINT-4566897.
STRINGi 10116.ENSRNOP00000007554.

Proteomic databases

PaxDbi Q9Z269.
PRIDEi Q9Z269.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000007554 ; ENSRNOP00000007554 ; ENSRNOG00000005331 .
GeneIDi 60431.
KEGGi rno:60431.
UCSCi RGD:68326. rat.

Organism-specific databases

CTDi 9217.
RGDi 68326. Vapb.

Phylogenomic databases

eggNOGi COG5066.
GeneTreei ENSGT00390000006947.
HOGENOMi HOG000293182.
HOVERGENi HBG028551.
InParanoidi Q9Z269.
KOi K10707.
OMAi PHDIEIN.
OrthoDBi EOG7CK389.
PhylomeDBi Q9Z269.
TreeFami TF317024.

Enzyme and pathway databases

Reactomei REACT_196736. Sphingolipid de novo biosynthesis.

Miscellaneous databases

NextBioi 612154.
PROi Q9Z269.

Gene expression databases

Genevestigatori Q9Z269.

Family and domain databases

Gene3Di 2.60.40.360. 1 hit.
InterProi IPR000535. MSP_dom.
IPR008962. PapD-like.
IPR016763. Vesicle-associated_membrane.
[Graphical view ]
Pfami PF00635. Motile_Sperm. 1 hit.
[Graphical view ]
PIRSFi PIRSF019693. VAMP-associated. 1 hit.
SUPFAMi SSF49354. SSF49354. 1 hit.
PROSITEi PS50202. MSP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins."
    Nishimura Y., Hayashi M., Inada H., Tanaka T.
    Biochem. Biophys. Res. Commun. 254:21-26(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 176-182, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiVAPB_RAT
AccessioniPrimary (citable) accession number: Q9Z269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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