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Q9Z269 (VAPB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Vesicle-associated membrane protein-associated protein B
Short name=VAMP-B
Short name=VAMP-associated protein B
Short name=VAP-B
Gene names
Name:Vapb
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in vesicle trafficking.

Subunit structure

Homodimer, and heterodimer with VAPA. Interacts with VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27 By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type IV membrane protein By similarity.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. [View classification]

Contains 1 MSP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 243242Vesicle-associated membrane protein-associated protein B
PRO_0000213475

Regions

Topological domain2 – 218217Cytoplasmic Potential
Transmembrane219 – 23921Helical; Anchor for type IV membrane protein; Potential
Domain7 – 124118MSP
Coiled coil161 – 19636 Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue31N6-acetyllysine By similarity
Modified residue1591Phosphoserine By similarity
Modified residue2061Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z269 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 870B177B0798B4EA

FASTA24326,916
        10         20         30         40         50         60 
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGV 

        70         80         90        100        110        120 
IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS DMEAVWKEAK PEDLMDSKLR 

       130        140        150        160        170        180 
CVFELPAENA KPHDVEINKI MPTSASKTEA PVAAKPLTSP LDDAEVKKVM EECRRLQGEV 

       190        200        210        220        230        240 
QRLREESRQL KEEDGLRARK ALPSNSPMAA LAASGKEEGL SARLLALVVL FFIVGVIIGK 


IAL

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins."
Nishimura Y., Hayashi M., Inada H., Tanaka T.
Biochem. Biophys. Res. Commun. 254:21-26(1999) [PubMed: 9920726] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Lubec G., Kang S.U.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 176-182, MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF086631 mRNA. Translation: AAD13580.1.
BC065576 mRNA. Translation: AAH65576.1.
IPIIPI00209283.
RefSeqNP_068619.1. NM_021847.3.
UniGeneRn.52500.

3D structure databases

ProteinModelPortalQ9Z269.
SMRQ9Z269. Positions 1-134.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4566897.
STRINGQ9Z269.

Proteomic databases

PRIDEQ9Z269.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000007554; ENSRNOP00000007554; ENSRNOG00000005331.
GeneID60431.
KEGGrno:60431.
UCSCNM_021847. rat.

Organism-specific databases

CTD9217.
RGD68326. Vapb.

Phylogenomic databases

eggNOGroNOG07345.
GeneTreeENSGT00390000006947.
HOVERGENHBG028551.
InParanoidQ9Z269.
OMAVMSKSIS.
OrthoDBEOG4DNF5D.
PhylomeDBQ9Z269.

Gene expression databases

ArrayExpressQ9Z269.
GenevestigatorQ9Z269.
GermOnlineENSRNOG00000005331. Rattus norvegicus.

Family and domain databases

InterProIPR000535. Major_sperm.
IPR008962. PapD-like.
IPR016763. Vesicle-associated_membrane.
[Graphical view]
Gene3DG3DSA:2.60.40.360. MSP. 1 hit.
KOK10707.
PfamPF00635. Motile_Sperm. 1 hit.
[Graphical view]
PIRSFPIRSF019693. VAMP-associated. 1 hit.
SUPFAMSSF49354. PapD-like. 1 hit.
PROSITEPS50202. MSP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio612154.

Entry information

Entry nameVAPB_RAT
AccessionPrimary (citable) accession number: Q9Z269
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 23, 2007
Last modified: November 16, 2011
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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