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Q9Z269 (VAPB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vesicle-associated membrane protein-associated protein B

Short name=VAMP-B
Short name=VAMP-associated protein B
Short name=VAP-B
Gene names
Name:Vapb
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity By similarity. Involved in cellular calcium homeostasis regulation By similarity.

Subunit structure

Homodimer, and heterodimer with VAPA. Interacts with RMDN3, VAMP1 and VAMP2. Interacts (via MSP domain) with ZFYVE27 By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type IV membrane protein By similarity.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. [View classification]

Contains 1 MSP domain.

Ontologies

Keywords
   Biological processUnfolded protein response
   Cellular componentEndoplasmic reticulum
Membrane
   DomainCoiled coil
Transmembrane
Transmembrane helix
   PTMAcetylation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of signaling protein activity involved in unfolded protein response

Inferred from sequence or structural similarity. Source: UniProtKB

cellular calcium ion homeostasis

Inferred from sequence or structural similarity. Source: UniProtKB

endoplasmic reticulum unfolded protein response

Inferred from sequence or structural similarity. Source: UniProtKB

modulation by virus of host morphology or physiology

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of viral genome replication

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentGolgi apparatus

Inferred from sequence or structural similarity. Source: UniProtKB

endoplasmic reticulum

Inferred from sequence or structural similarity. Source: UniProtKB

endoplasmic reticulum membrane

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-tubulin binding

Inferred from sequence or structural similarity. Source: UniProtKB

enzyme binding

Inferred from sequence or structural similarity. Source: UniProtKB

protein homodimerization activity

Inferred from sequence or structural similarity. Source: UniProtKB

structural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 243242Vesicle-associated membrane protein-associated protein B
PRO_0000213475

Regions

Topological domain2 – 218217Cytoplasmic Potential
Transmembrane219 – 23921Helical; Anchor for type IV membrane protein; Potential
Domain7 – 124118MSP
Coiled coil161 – 19636 Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9Z269 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 870B177B0798B4EA

FASTA24326,916
        10         20         30         40         50         60 
MAKVEQVLSL EPQHELKFRG PFTDVVTTNL KLGNPTDRNV CFKVKTTAPR RYCVRPNSGV 

        70         80         90        100        110        120 
IDAGASLNVS VMLQPFDYDP NEKSKHKFMV QSMFAPPDTS DMEAVWKEAK PEDLMDSKLR 

       130        140        150        160        170        180 
CVFELPAENA KPHDVEINKI MPTSASKTEA PVAAKPLTSP LDDAEVKKVM EECRRLQGEV 

       190        200        210        220        230        240 
QRLREESRQL KEEDGLRARK ALPSNSPMAA LAASGKEEGL SARLLALVVL FFIVGVIIGK 


IAL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins."
Nishimura Y., Hayashi M., Inada H., Tanaka T.
Biochem. Biophys. Res. Commun. 254:21-26(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Lubec G., Kang S.U.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 176-182, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF086631 mRNA. Translation: AAD13580.1.
BC065576 mRNA. Translation: AAH65576.1.
RefSeqNP_068619.1. NM_021847.3.
UniGeneRn.52500.

3D structure databases

ProteinModelPortalQ9Z269.
SMRQ9Z269. Positions 1-134.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9Z269. 2 interactions.
MINTMINT-4566897.
STRING10116.ENSRNOP00000007554.

Proteomic databases

PaxDbQ9Z269.
PRIDEQ9Z269.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000007554; ENSRNOP00000007554; ENSRNOG00000005331.
GeneID60431.
KEGGrno:60431.
UCSCRGD:68326. rat.

Organism-specific databases

CTD9217.
RGD68326. Vapb.

Phylogenomic databases

eggNOGCOG5066.
GeneTreeENSGT00390000006947.
HOGENOMHOG000293182.
HOVERGENHBG028551.
InParanoidQ9Z269.
KOK10707.
OMAGLRMRKA.
OrthoDBEOG7CK389.
PhylomeDBQ9Z269.
TreeFamTF317024.

Gene expression databases

GenevestigatorQ9Z269.

Family and domain databases

Gene3D2.60.40.360. 1 hit.
InterProIPR000535. MSP_dom.
IPR008962. PapD-like.
IPR016763. Vesicle-associated_membrane.
[Graphical view]
PfamPF00635. Motile_Sperm. 1 hit.
[Graphical view]
PIRSFPIRSF019693. VAMP-associated. 1 hit.
SUPFAMSSF49354. SSF49354. 1 hit.
PROSITEPS50202. MSP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio612154.
PROQ9Z269.

Entry information

Entry nameVAPB_RAT
AccessionPrimary (citable) accession number: Q9Z269
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families