Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9Z262 (CLD6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Claudin-6
Alternative name(s):
Skullin
Gene names
Name:Cldn6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.

Subunit structure

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Ref.5

Subcellular location

Cell junction › tight junction. Cell membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Expressed mostly in embryonic tissues. Ref.1

Sequence similarities

Belongs to the claudin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Claudin-6
PRO_0000144749

Regions

Topological domain1 – 77Cytoplasmic Potential
Transmembrane8 – 2821Helical; Potential
Topological domain29 – 8153Extracellular Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 11614Cytoplasmic Potential
Transmembrane117 – 13721Helical; Potential
Topological domain138 – 16326Extracellular Potential
Transmembrane164 – 18421Helical; Potential
Topological domain185 – 21935Cytoplasmic Potential
Region218 – 2192Interactions with TJP1, TJP2 and TJP3 By similarity

Amino acid modifications

Modified residue2011Phosphoserine By similarity
Modified residue2031Phosphoserine By similarity
Modified residue2071Phosphoserine By similarity
Modified residue2111Phosphoserine By similarity

Experimental info

Sequence conflict341A → T in AAK02012. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Z262 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 00CF687FAB687E1F

FASTA21923,388
        10         20         30         40         50         60 
MASTGLQILG IVLTLLGWVN ALVSCALPMW KVTAFIGNSI VVAQMVWEGL WMSCVVQSTG 

        70         80         90        100        110        120 
QMQCKVYDSL LALPQDLQAA RALCVVTLLI VLLGLLVYLA GAKCTTCVED RNSKSRLVLI 

       130        140        150        160        170        180 
SGIIFVISGV LTLIPVCWTA HSIIQDFYNP LVADAQKREL GASLYLGWAA SGLLLLGGGL 

       190        200        210 
LCCACSSGGT QGPRHYMACY STSVPHSRGP SEYPTKNYV

« Hide

References

« Hide 'large scale' references
[1]"Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands."
Morita K., Furuse M., Fujimoto K., Tsukita S.
Proc. Natl. Acad. Sci. U.S.A. 96:511-516(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"Skullin: a novel membrane molecule marks formation of epithelium."
Troy T., Wisco V., Turksen K.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryonic stem cell.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins."
Itoh M., Furuse M., Morita K., Kubota K., Saitou M., Tsukita S.
J. Cell Biol. 147:1351-1363(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TJP1; TJP2 AND TJP3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF087824 mRNA. Translation: AAD09759.1.
AF125305 mRNA. Translation: AAK02012.1.
AK010560 mRNA. Translation: BAB27028.1.
AK010682 mRNA. Translation: BAB27114.1.
BC005718 mRNA. Translation: AAH05718.1.
IPIIPI00130548.
RefSeqNP_061247.1. NM_018777.4.
UniGeneMm.489762.
Mm.86421.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

MINTMINT-113590.
STRING10090.ENSMUSP00000024699.

PTM databases

PhosphoSiteQ9Z262.

Proteomic databases

PRIDEQ9Z262.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000024699; ENSMUSP00000024699; ENSMUSG00000023906.
GeneID54419.
KEGGmmu:54419.

Organism-specific databases

CTD9074.
MGIMGI:1859284. Cldn6.

Phylogenomic databases

eggNOGNOG45113.
GeneTreeENSGT00700000104125.
HOGENOMHOG000220937.
HOVERGENHBG000643.
InParanoidQ9Z262.
KOK06087.
OMARGPSEYP.
OrthoDBEOG45490V.

Gene expression databases

ArrayExpressQ9Z262.
BgeeQ9Z262.
CleanExMM_CLDN6.
GenevestigatorQ9Z262.
GermOnlineENSMUSG00000023906. Mus musculus.

Family and domain databases

InterProIPR006187. Claudin.
IPR003925. Claudin6.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF41. PTHR12002:SF41. 1 hit.
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01077. CLAUDIN.
PR01445. CLAUDIN6.
PROSITEPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311288.
SOURCESearch...

Entry information

Entry nameCLD6_MOUSE
AccessionPrimary (citable) accession number: Q9Z262
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: April 3, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents