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Protein

Claudin-6

Gene

Cldn6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-6
Alternative name(s):
Skullin
Gene namesi
Name:Cldn6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1859284. Cldn6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 116CytoplasmicSequence analysisAdd BLAST14
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 163ExtracellularSequence analysisAdd BLAST26
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 219CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

  • apicolateral plasma membrane Source: UniProtKB
  • bicellular tight junction Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447491 – 219Claudin-6Add BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei201PhosphoserineBy similarity1
Modified residuei203PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei211PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z262.
PRIDEiQ9Z262.

PTM databases

iPTMnetiQ9Z262.
PhosphoSitePlusiQ9Z262.

Expressioni

Tissue specificityi

Expressed mostly in embryonic tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000023906.
CleanExiMM_CLDN6.
ExpressionAtlasiQ9Z262. baseline and differential.
GenevisibleiQ9Z262. MM.

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-113590.
STRINGi10090.ENSMUSP00000024699.

Structurei

3D structure databases

ProteinModelPortaliQ9Z262.
SMRiQ9Z262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni218 – 219Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z262.
KOiK06087.
OMAiGSSHYMA.
OrthoDBiEOG091G0MMR.
PhylomeDBiQ9Z262.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003925. Claudin6.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF41. PTHR12002:SF41. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01445. CLAUDIN6.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z262-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTGLQILG IVLTLLGWVN ALVSCALPMW KVTAFIGNSI VVAQMVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVVTLLI VLLGLLVYLA
110 120 130 140 150
GAKCTTCVED RNSKSRLVLI SGIIFVISGV LTLIPVCWTA HSIIQDFYNP
160 170 180 190 200
LVADAQKREL GASLYLGWAA SGLLLLGGGL LCCACSSGGT QGPRHYMACY
210
STSVPHSRGP SEYPTKNYV
Length:219
Mass (Da):23,388
Last modified:May 1, 1999 - v1
Checksum:i00CF687FAB687E1F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → T in AAK02012 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087824 mRNA. Translation: AAD09759.1.
AF125305 mRNA. Translation: AAK02012.1.
AK010560 mRNA. Translation: BAB27028.1.
AK010682 mRNA. Translation: BAB27114.1.
BC005718 mRNA. Translation: AAH05718.1.
CCDSiCCDS28457.1.
RefSeqiNP_061247.1. NM_018777.4.
XP_006524704.1. XM_006524641.1.
UniGeneiMm.86421.

Genome annotation databases

EnsembliENSMUST00000024699; ENSMUSP00000024699; ENSMUSG00000023906.
GeneIDi54419.
KEGGimmu:54419.
UCSCiuc008asw.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087824 mRNA. Translation: AAD09759.1.
AF125305 mRNA. Translation: AAK02012.1.
AK010560 mRNA. Translation: BAB27028.1.
AK010682 mRNA. Translation: BAB27114.1.
BC005718 mRNA. Translation: AAH05718.1.
CCDSiCCDS28457.1.
RefSeqiNP_061247.1. NM_018777.4.
XP_006524704.1. XM_006524641.1.
UniGeneiMm.86421.

3D structure databases

ProteinModelPortaliQ9Z262.
SMRiQ9Z262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-113590.
STRINGi10090.ENSMUSP00000024699.

PTM databases

iPTMnetiQ9Z262.
PhosphoSitePlusiQ9Z262.

Proteomic databases

PaxDbiQ9Z262.
PRIDEiQ9Z262.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024699; ENSMUSP00000024699; ENSMUSG00000023906.
GeneIDi54419.
KEGGimmu:54419.
UCSCiuc008asw.3. mouse.

Organism-specific databases

CTDi9074.
MGIiMGI:1859284. Cldn6.

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z262.
KOiK06087.
OMAiGSSHYMA.
OrthoDBiEOG091G0MMR.
PhylomeDBiQ9Z262.
TreeFamiTF331936.

Miscellaneous databases

PROiQ9Z262.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023906.
CleanExiMM_CLDN6.
ExpressionAtlasiQ9Z262. baseline and differential.
GenevisibleiQ9Z262. MM.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003925. Claudin6.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF41. PTHR12002:SF41. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01445. CLAUDIN6.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.