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Protein

Claudin-6

Gene

Cldn6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-6
Alternative name(s):
Skullin
Gene namesi
Name:Cldn6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1859284. Cldn6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 8153ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 11614CytoplasmicSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Topological domaini138 – 16326ExtracellularSequence analysisAdd
BLAST
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Topological domaini185 – 21935CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apicolateral plasma membrane Source: UniProtKB
  • bicellular tight junction Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Claudin-6PRO_0000144749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei201 – 2011PhosphoserineBy similarity
Modified residuei203 – 2031PhosphoserineBy similarity
Modified residuei207 – 2071PhosphoserineBy similarity
Modified residuei211 – 2111PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z262.
PRIDEiQ9Z262.

PTM databases

iPTMnetiQ9Z262.
PhosphoSiteiQ9Z262.

Expressioni

Tissue specificityi

Expressed mostly in embryonic tissues.1 Publication

Gene expression databases

BgeeiQ9Z262.
CleanExiMM_CLDN6.
ExpressionAtlasiQ9Z262. baseline and differential.
GenevisibleiQ9Z262. MM.

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-113590.
STRINGi10090.ENSMUSP00000024699.

Structurei

3D structure databases

ProteinModelPortaliQ9Z262.
SMRiQ9Z262. Positions 4-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni218 – 2192Interactions with TJP1, TJP2 and TJP3By similarity

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z262.
KOiK06087.
OMAiGSSHYMA.
OrthoDBiEOG79KPGQ.
PhylomeDBiQ9Z262.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003925. Claudin6.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF41. PTHR12002:SF41. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01445. CLAUDIN6.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z262-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTGLQILG IVLTLLGWVN ALVSCALPMW KVTAFIGNSI VVAQMVWEGL
60 70 80 90 100
WMSCVVQSTG QMQCKVYDSL LALPQDLQAA RALCVVTLLI VLLGLLVYLA
110 120 130 140 150
GAKCTTCVED RNSKSRLVLI SGIIFVISGV LTLIPVCWTA HSIIQDFYNP
160 170 180 190 200
LVADAQKREL GASLYLGWAA SGLLLLGGGL LCCACSSGGT QGPRHYMACY
210
STSVPHSRGP SEYPTKNYV
Length:219
Mass (Da):23,388
Last modified:May 1, 1999 - v1
Checksum:i00CF687FAB687E1F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341A → T in AAK02012 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087824 mRNA. Translation: AAD09759.1.
AF125305 mRNA. Translation: AAK02012.1.
AK010560 mRNA. Translation: BAB27028.1.
AK010682 mRNA. Translation: BAB27114.1.
BC005718 mRNA. Translation: AAH05718.1.
CCDSiCCDS28457.1.
RefSeqiNP_061247.1. NM_018777.4.
XP_006524704.1. XM_006524641.1.
UniGeneiMm.86421.

Genome annotation databases

EnsembliENSMUST00000024699; ENSMUSP00000024699; ENSMUSG00000023906.
GeneIDi54419.
KEGGimmu:54419.
UCSCiuc008asw.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087824 mRNA. Translation: AAD09759.1.
AF125305 mRNA. Translation: AAK02012.1.
AK010560 mRNA. Translation: BAB27028.1.
AK010682 mRNA. Translation: BAB27114.1.
BC005718 mRNA. Translation: AAH05718.1.
CCDSiCCDS28457.1.
RefSeqiNP_061247.1. NM_018777.4.
XP_006524704.1. XM_006524641.1.
UniGeneiMm.86421.

3D structure databases

ProteinModelPortaliQ9Z262.
SMRiQ9Z262. Positions 4-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-113590.
STRINGi10090.ENSMUSP00000024699.

PTM databases

iPTMnetiQ9Z262.
PhosphoSiteiQ9Z262.

Proteomic databases

PaxDbiQ9Z262.
PRIDEiQ9Z262.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024699; ENSMUSP00000024699; ENSMUSG00000023906.
GeneIDi54419.
KEGGimmu:54419.
UCSCiuc008asw.3. mouse.

Organism-specific databases

CTDi9074.
MGIiMGI:1859284. Cldn6.

Phylogenomic databases

eggNOGiENOG410IIJR. Eukaryota.
ENOG410YA61. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z262.
KOiK06087.
OMAiGSSHYMA.
OrthoDBiEOG79KPGQ.
PhylomeDBiQ9Z262.
TreeFamiTF331936.

Miscellaneous databases

PROiQ9Z262.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z262.
CleanExiMM_CLDN6.
ExpressionAtlasiQ9Z262. baseline and differential.
GenevisibleiQ9Z262. MM.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003925. Claudin6.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF41. PTHR12002:SF41. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01445. CLAUDIN6.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands."
    Morita K., Furuse M., Fujimoto K., Tsukita S.
    Proc. Natl. Acad. Sci. U.S.A. 96:511-516(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Skullin: a novel membrane molecule marks formation of epithelium."
    Troy T., Wisco V., Turksen K.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryonic stem cell.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins."
    Itoh M., Furuse M., Morita K., Kubota K., Saitou M., Tsukita S.
    J. Cell Biol. 147:1351-1363(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TJP1; TJP2 AND TJP3.

Entry informationi

Entry nameiCLD6_MOUSE
AccessioniPrimary (citable) accession number: Q9Z262
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.