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Protein

Claudin-7

Gene

Cldn7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-7
Gene namesi
Name:Cldn7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1859285 Cldn7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 81ExtracellularSequence analysisAdd BLAST53
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 119CytoplasmicSequence analysisAdd BLAST17
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 160ExtracellularSequence analysisAdd BLAST20
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 211CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447511 – 211Claudin-7Add BLAST211

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Z261
PaxDbiQ9Z261
PRIDEiQ9Z261

PTM databases

iPTMnetiQ9Z261
PhosphoSitePlusiQ9Z261

Expressioni

Tissue specificityi

Expressed predominantly in lung and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000018569
CleanExiMM_CLDN7
ExpressionAtlasiQ9Z261 baseline and differential
GenevisibleiQ9Z261 MM

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (PubMed:10601346). The phosphorylated form interacts with EPCAM (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9Z261, 2 interactors
MINTiQ9Z261
STRINGi10090.ENSMUSP00000018713

Structurei

3D structure databases

ProteinModelPortaliQ9Z261
SMRiQ9Z261
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni210 – 211Interactions with TJP1, TJP2 and TJP3By similarity2

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHPN Eukaryota
ENOG4111GPP LUCA
GeneTreeiENSGT00760000118928
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ9Z261
KOiK06087
OMAiNTKYEFG
OrthoDBiEOG091G0MX2
PhylomeDBiQ9Z261
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003552 Claudin7
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01381 CLAUDIN7
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSGLQLLG FSMAMLGWVG LIASTAIPQW QMSSYAGDNI ITAQAMYKGL
60 70 80 90 100
WMECVTQSTG MMSCKMYDSV LALPGALQAT RALMVVSLVL GFLAMFVATM
110 120 130 140 150
GMKCTRCGGD DKAKKARIAM TGGIVFIVAG LAALVACSWI GHQIVTDFYN
160 170 180 190 200
PLTPMNVKYE FGPAIFIGWA GSALVLLGGA LLSCSCPGSE SKAAYRAPRS
210
YPKSNSSKEY V
Length:211
Mass (Da):22,359
Last modified:May 1, 1999 - v1
Checksum:i4FE87F3A57AC9F29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087825 mRNA Translation: AAD09760.1
AK002924 mRNA Translation: BAB22460.1
AK087296 mRNA Translation: BAC39839.1
AK145504 mRNA Translation: BAE26475.1
AK167250 mRNA Translation: BAE39371.1
AL596185 Genomic DNA No translation available.
BC008104 mRNA Translation: AAH08104.1
BC050007 mRNA Translation: AAH50007.1
CCDSiCCDS24925.1
RefSeqiNP_001180548.1, NM_001193619.1
NP_058583.1, NM_016887.6
UniGeneiMm.281896

Genome annotation databases

EnsembliENSMUST00000018713; ENSMUSP00000018713; ENSMUSG00000018569
ENSMUST00000108597; ENSMUSP00000104238; ENSMUSG00000018569
GeneIDi53624
KEGGimmu:53624
UCSCiuc007jtb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCLD7_MOUSE
AccessioniPrimary (citable) accession number: Q9Z261
Secondary accession number(s): Q3TJX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health