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Protein

Claudin-7

Gene

Cldn7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-7
Gene namesi
Name:Cldn7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1859285. Cldn7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 8153ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 11917CytoplasmicSequence analysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST
Topological domaini141 – 16020ExtracellularSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Topological domaini182 – 21130CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apicolateral plasma membrane Source: UniProtKB
  • basolateral plasma membrane Source: MGI
  • bicellular tight junction Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • lateral plasma membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Claudin-7PRO_0000144751Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Z261.
PRIDEiQ9Z261.

PTM databases

PhosphoSiteiQ9Z261.

Expressioni

Tissue specificityi

Expressed predominantly in lung and kidney.1 Publication

Gene expression databases

BgeeiQ9Z261.
CleanExiMM_CLDN7.
ExpressionAtlasiQ9Z261. baseline and differential.
GenevisibleiQ9Z261. MM.

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. The phosphorylated form interacts with EPCAM (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9Z261. 1 interaction.
MINTiMINT-113113.
STRINGi10090.ENSMUSP00000018713.

Structurei

3D structure databases

ProteinModelPortaliQ9Z261.
SMRiQ9Z261. Positions 4-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni210 – 2112Interactions with TJP1, TJP2 and TJP3By similarity

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHPN. Eukaryota.
ENOG4111GPP. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z261.
KOiK06087.
OMAiYNPLVPM.
OrthoDBiEOG76HQ2T.
PhylomeDBiQ9Z261.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003552. Claudin7.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01381. CLAUDIN7.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANSGLQLLG FSMAMLGWVG LIASTAIPQW QMSSYAGDNI ITAQAMYKGL
60 70 80 90 100
WMECVTQSTG MMSCKMYDSV LALPGALQAT RALMVVSLVL GFLAMFVATM
110 120 130 140 150
GMKCTRCGGD DKAKKARIAM TGGIVFIVAG LAALVACSWI GHQIVTDFYN
160 170 180 190 200
PLTPMNVKYE FGPAIFIGWA GSALVLLGGA LLSCSCPGSE SKAAYRAPRS
210
YPKSNSSKEY V
Length:211
Mass (Da):22,359
Last modified:May 1, 1999 - v1
Checksum:i4FE87F3A57AC9F29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087825 mRNA. Translation: AAD09760.1.
AK002924 mRNA. Translation: BAB22460.1.
AK087296 mRNA. Translation: BAC39839.1.
AK145504 mRNA. Translation: BAE26475.1.
AK167250 mRNA. Translation: BAE39371.1.
AL596185 Genomic DNA. Translation: CAI35159.1.
BC008104 mRNA. Translation: AAH08104.1.
BC050007 mRNA. Translation: AAH50007.1.
CCDSiCCDS24925.1.
RefSeqiNP_001180548.1. NM_001193619.1.
NP_058583.1. NM_016887.6.
UniGeneiMm.281896.

Genome annotation databases

EnsembliENSMUST00000018713; ENSMUSP00000018713; ENSMUSG00000018569.
ENSMUST00000108597; ENSMUSP00000104238; ENSMUSG00000018569.
GeneIDi53624.
KEGGimmu:53624.
UCSCiuc007jtb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087825 mRNA. Translation: AAD09760.1.
AK002924 mRNA. Translation: BAB22460.1.
AK087296 mRNA. Translation: BAC39839.1.
AK145504 mRNA. Translation: BAE26475.1.
AK167250 mRNA. Translation: BAE39371.1.
AL596185 Genomic DNA. Translation: CAI35159.1.
BC008104 mRNA. Translation: AAH08104.1.
BC050007 mRNA. Translation: AAH50007.1.
CCDSiCCDS24925.1.
RefSeqiNP_001180548.1. NM_001193619.1.
NP_058583.1. NM_016887.6.
UniGeneiMm.281896.

3D structure databases

ProteinModelPortaliQ9Z261.
SMRiQ9Z261. Positions 4-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Z261. 1 interaction.
MINTiMINT-113113.
STRINGi10090.ENSMUSP00000018713.

PTM databases

PhosphoSiteiQ9Z261.

Proteomic databases

PaxDbiQ9Z261.
PRIDEiQ9Z261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018713; ENSMUSP00000018713; ENSMUSG00000018569.
ENSMUST00000108597; ENSMUSP00000104238; ENSMUSG00000018569.
GeneIDi53624.
KEGGimmu:53624.
UCSCiuc007jtb.2. mouse.

Organism-specific databases

CTDi1366.
MGIiMGI:1859285. Cldn7.

Phylogenomic databases

eggNOGiENOG410IHPN. Eukaryota.
ENOG4111GPP. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z261.
KOiK06087.
OMAiYNPLVPM.
OrthoDBiEOG76HQ2T.
PhylomeDBiQ9Z261.
TreeFamiTF331936.

Miscellaneous databases

ChiTaRSiCldn7. mouse.
NextBioi310365.
PROiQ9Z261.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z261.
CleanExiMM_CLDN7.
ExpressionAtlasiQ9Z261. baseline and differential.
GenevisibleiQ9Z261. MM.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003552. Claudin7.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01381. CLAUDIN7.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands."
    Morita K., Furuse M., Fujimoto K., Tsukita S.
    Proc. Natl. Acad. Sci. U.S.A. 96:511-516(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Mammary gland.
  5. "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins."
    Itoh M., Furuse M., Morita K., Kubota K., Saitou M., Tsukita S.
    J. Cell Biol. 147:1351-1363(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TJP1; TJP2 AND TJP3.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung and Pancreas.

Entry informationi

Entry nameiCLD7_MOUSE
AccessioniPrimary (citable) accession number: Q9Z261
Secondary accession number(s): Q3TJX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.