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Protein

Claudin-8

Gene

Cldn8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-8
Gene namesi
Name:Cldn8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1859286. Cldn8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 8153ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Topological domaini103 – 11715CytoplasmicSequence analysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Topological domaini139 – 16628ExtracellularSequence analysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Topological domaini188 – 22538CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apicolateral plasma membrane Source: UniProtKB
  • basolateral plasma membrane Source: MGI
  • bicellular tight junction Source: UniProtKB
  • endoplasmic reticulum Source: MGI
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Claudin-8PRO_0000144754Add
BLAST

Proteomic databases

PaxDbiQ9Z260.
PRIDEiQ9Z260.

PTM databases

iPTMnetiQ9Z260.
PhosphoSiteiQ9Z260.

Expressioni

Tissue specificityi

Expressed primarily in lung and kidney.1 Publication

Gene expression databases

BgeeiQ9Z260.
CleanExiMM_CLDN8.
ExpressionAtlasiQ9Z260. baseline and differential.
GenevisibleiQ9Z260. MM.

Interactioni

Subunit structurei

Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-113530.
STRINGi10090.ENSMUSP00000051887.

Structurei

3D structure databases

ProteinModelPortaliQ9Z260.
SMRiQ9Z260. Positions 30-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni224 – 2252Interactions with TJP1, TJP2 and TJP3By similarity

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJK4. Eukaryota.
ENOG410YQQY. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z260.
KOiK06087.
OMAiKCTRCTG.
OrthoDBiEOG76HQ2T.
PhylomeDBiQ9Z260.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003926. Claudin8.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF24. PTHR12002:SF24. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Z260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYALQMAA LVLGGVGMVG TVAVTIMPQW RVSAFIESNI VVFENRWEGL
60 70 80 90 100
WMNCMRHANI RMQCKVYDSL LALSPDLQAS RGLMCAASVL AFLAFMTAIL
110 120 130 140 150
GMKCTRCTGD DENVKSRILL TAGIIFFITG LVVLIPVSWV ANSIIRDFYN
160 170 180 190 200
PLVDVALKRE LGEALYIGWT TALVLIAGGA LFCCVFCCTE RSNSYRYSVP
210 220
SHRTTQRSFH AEKRSPSIYS KSQYV
Length:225
Mass (Da):24,947
Last modified:May 1, 1999 - v1
Checksum:i12BB3C460F23D876
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087826 mRNA. Translation: AAD09761.1.
BC003868 mRNA. Translation: AAH03868.1.
CCDSiCCDS28296.1.
RefSeqiNP_061248.1. NM_018778.3.
UniGeneiMm.25836.

Genome annotation databases

EnsembliENSMUST00000049697; ENSMUSP00000051887; ENSMUSG00000050520.
GeneIDi54420.
KEGGimmu:54420.
UCSCiuc007zuz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087826 mRNA. Translation: AAD09761.1.
BC003868 mRNA. Translation: AAH03868.1.
CCDSiCCDS28296.1.
RefSeqiNP_061248.1. NM_018778.3.
UniGeneiMm.25836.

3D structure databases

ProteinModelPortaliQ9Z260.
SMRiQ9Z260. Positions 30-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-113530.
STRINGi10090.ENSMUSP00000051887.

PTM databases

iPTMnetiQ9Z260.
PhosphoSiteiQ9Z260.

Proteomic databases

PaxDbiQ9Z260.
PRIDEiQ9Z260.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049697; ENSMUSP00000051887; ENSMUSG00000050520.
GeneIDi54420.
KEGGimmu:54420.
UCSCiuc007zuz.2. mouse.

Organism-specific databases

CTDi9073.
MGIiMGI:1859286. Cldn8.

Phylogenomic databases

eggNOGiENOG410IJK4. Eukaryota.
ENOG410YQQY. LUCA.
GeneTreeiENSGT00760000118928.
HOGENOMiHOG000220937.
HOVERGENiHBG000643.
InParanoidiQ9Z260.
KOiK06087.
OMAiKCTRCTG.
OrthoDBiEOG76HQ2T.
PhylomeDBiQ9Z260.
TreeFamiTF331936.

Miscellaneous databases

NextBioi311292.
PROiQ9Z260.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Z260.
CleanExiMM_CLDN8.
ExpressionAtlasiQ9Z260. baseline and differential.
GenevisibleiQ9Z260. MM.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003926. Claudin8.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF24. PTHR12002:SF24. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands."
    Morita K., Furuse M., Fujimoto K., Tsukita S.
    Proc. Natl. Acad. Sci. U.S.A. 96:511-516(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins."
    Itoh M., Furuse M., Morita K., Kubota K., Saitou M., Tsukita S.
    J. Cell Biol. 147:1351-1363(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TJP1; TJP2 AND TJP3.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney and Pancreas.

Entry informationi

Entry nameiCLD8_MOUSE
AccessioniPrimary (citable) accession number: Q9Z260
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.