UniProtKB - Q9Z257 (Q9Z257_MOUSE)
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Protein
P2X purinoceptor
Gene
P2rx4
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for ATP that acts as a ligand-gated ion channel.UniRule annotation
GO - Molecular functioni
- ATP binding Source: Ensembl
- cadherin binding Source: Ensembl
- copper ion binding Source: Ensembl
- extracellularly ATP-gated cation channel activity Source: Ensembl
- identical protein binding Source: Ensembl
- ligand-gated calcium channel activity Source: Ensembl
- purinergic nucleotide receptor activity Source: Ensembl
- receptor binding Source: Ensembl
- zinc ion binding Source: Ensembl
GO - Biological processi
- apoptotic signaling pathway Source: Ensembl
- cellular response to ATP Source: Ensembl
- membrane depolarization Source: Ensembl
- negative regulation of cardiac muscle hypertrophy Source: Ensembl
- neuronal action potential Source: Ensembl
- positive regulation of blood vessel endothelial cell migration Source: Ensembl
- positive regulation of calcium ion transport into cytosol Source: Ensembl
- positive regulation of calcium-mediated signaling Source: Ensembl
- positive regulation of endothelial cell chemotaxis Source: Ensembl
- protein homooligomerization Source: Ensembl
- regulation of blood pressure Source: Ensembl
- regulation of cardiac muscle contraction Source: Ensembl
- regulation of sodium ion transport Source: Ensembl
- relaxation of cardiac muscle Source: Ensembl
- response to fluid shear stress Source: Ensembl
- sensory perception of pain Source: Ensembl
Keywordsi
Molecular function | Ion channelUniRule annotation, ReceptorUniRule annotationImported |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-139853 Elevation of cytosolic Ca2+ levels R-MMU-418346 Platelet homeostasis |
Names & Taxonomyi
Protein namesi | Recommended name: P2X purinoceptorUniRule annotation |
Gene namesi | Name:P2rx4Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1338859 P2rx4 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 30 – 50 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 339 – 361 | HelicalUniRule annotationAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneInteractioni
GO - Molecular functioni
- cadherin binding Source: Ensembl
- identical protein binding Source: Ensembl
- receptor binding Source: Ensembl
Family & Domainsi
Sequence similaritiesi
Belongs to the P2X receptor family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
eggNOGi | ENOG410IFJF Eukaryota ENOG410XR0C LUCA |
GeneTreei | ENSGT00390000016028 |
HOVERGENi | HBG053086 |
OMAi | TMINVGS |
OrthoDBi | EOG091G0A2U |
TreeFami | TF328633 |
Family and domain databases
Gene3Di | 2.60.490.101 hit |
InterProi | View protein in InterPro IPR003047 P2X4_purnocptor IPR027309 P2X_extracellular_dom_sf IPR001429 P2X_purnocptor |
PANTHERi | PTHR10125 PTHR10125, 1 hit |
Pfami | View protein in Pfam PF00864 P2X_receptor, 1 hit |
PIRSFi | PIRSF005713 P2X_purinoceptor, 1 hit |
PRINTSi | PR01311 P2X4RECEPTOR PR01307 P2XRECEPTOR |
TIGRFAMsi | TIGR00863 P2X, 1 hit |
PROSITEi | View protein in PROSITE PS01212 P2X_RECEPTOR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Z257-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGCCSVLRA FLFEYDTPRI VLIRSRKVGL MNRVVQLLIL AYVIGWVFVW
60 70 80 90 100
EKGYQETDSV VSSVTTKAKG VAVTNTSQLG FRIWDVADYV VPAQEENSLF
110 120 130 140 150
IMTNMIVTVN QTQGTCPEIP DKTSICDSDA NCTLGSSDTH SSGIGTGRCV
160 170 180 190 200
PFNASVKTCE VAAWCPVEND AGVPTPAFLK AAENFTLLVK NNIWYPKFNF
210 220 230 240 250
SKRNILPNIT TSYLKSCIYN ARTDPFCPIF RLGQIVADAG HSFQEMAVEG
260 270 280 290 300
GIMGIQIKWD CNLDRAASHC LPRYSFRRLD TRDLEHNVSP GYNFRFAKYY
310 320 330 340 350
RDLAGNEQRT LTKAYGIRFD IIVFGKAGKF DIIPTMINVG SGLALLGVAT
360 370 380
VLCDVIVLYC MKKRYYYRDK KYKYVEDYEQ GLSGETDQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC115728 Genomic DNA No translation available. AF089751 mRNA Translation: AAC95601.1 |
RefSeqi | NP_035156.2, NM_011026.3 |
UniGenei | Mm.290884 Mm.463383 |
Genome annotation databases
Ensembli | ENSMUST00000031429; ENSMUSP00000031429; ENSMUSG00000029470 |
GeneIDi | 18438 |
UCSCi | uc008zlu.1 mouse |
Similar proteinsi
Entry informationi
Entry namei | Q9Z257_MOUSE | |
Accessioni | Q9Z257Primary (citable) accession number: Q9Z257 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 1999 |
Last sequence update: | May 1, 1999 | |
Last modified: | April 25, 2018 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |