P2rx4

Functionⁱ

Receptor for ATP that acts as a ligand-gated ion channel.UniRule annotation

GO - Molecular functionⁱ

ATP binding Source: Ensembl
cadherin binding Source: Ensembl
copper ion binding Source: Ensembl
drug binding Source: Ensembl
extracellular ATP-gated cation channel activity Source: Ensembl
purinergic nucleotide receptor activity Source: Ensembl
receptor binding Source: Ensembl
zinc ion binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

apoptotic signaling pathway Source: Ensembl
cellular response to ATP Source: Ensembl
membrane depolarization Source: Ensembl
negative regulation of cardiac muscle hypertrophy Source: Ensembl
neuronal action potential Source: Ensembl
positive regulation of blood vessel endothelial cell migration Source: Ensembl
positive regulation of calcium ion transport into cytosol Source: Ensembl
positive regulation of calcium-mediated signaling Source: Ensembl
positive regulation of endothelial cell chemotaxis Source: Ensembl
protein homooligomerization Source: Ensembl
regulation of blood pressure Source: Ensembl
regulation of cardiac muscle contraction Source: Ensembl
regulation of sodium ion transport Source: Ensembl
relaxation of cardiac muscle Source: Ensembl
response to fluid shear stress Source: Ensembl
sensory perception of pain Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	Ion channelUniRule annotation, ReceptorUniRule annotationImported
Biological process	Ion transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-139853. Elevation of cytosolic Ca2+ levels. R-MMU-418346. Platelet homeostasis.

Reactomeⁱ

R-MMU-139853. Elevation of cytosolic Ca2+ levels.
R-MMU-418346. Platelet homeostasis.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: P2X purinoceptorUniRule annotation
Gene namesⁱ	Name:P2rx4Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:1338859. P2rx4.

Subcellular locationⁱ

Membrane
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU000681
; Multi-pass membrane protein
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU000681

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	30 – 50	HelicalUniRule annotationAdd BLAST		21
Transmembraneⁱ	339 – 361	HelicalUniRule annotationAdd BLAST		23

GO - Cellular componentⁱ

cell junction Source: Ensembl
dendritic spine Source: Ensembl
extracellular exosome Source: Ensembl
integral component of plasma membrane Source: Ensembl
lysosomal membrane Source: Ensembl
neuronal cell body Source: Ensembl
perinuclear region of cytoplasm Source: Ensembl
postsynaptic density Source: Ensembl
terminal bouton Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000029470.

Bgeeⁱ

ENSMUSG00000029470.

Interactionⁱ

GO - Molecular functionⁱ

cadherin binding Source: Ensembl
receptor binding Source: Ensembl

Complete GO annotation...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the P2X receptor family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IFJF. Eukaryota. ENOG410XR0C. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016028.
HOVERGENⁱ	HBG053086.
OMAⁱ	TMINVGS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A2U.
TreeFamⁱ	TF328633.

Family and domain databases

Gene3Dⁱ	2.60.490.10. 1 hit.
InterProⁱ	View protein in InterPro IPR003047. P2X4_purnocptor. IPR027309. P2X_extracellular_dom. IPR001429. P2X_purnocptor.
PANTHERⁱ	PTHR10125. PTHR10125. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00864. P2X_receptor. 1 hit.
PIRSFⁱ	PIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSⁱ	PR01311. P2X4RECEPTOR. PR01307. P2XRECEPTOR.
TIGRFAMsⁱ	TIGR00863. P2X. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01212. P2X_RECEPTOR. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9Z257-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGCCSVLRA FLFEYDTPRI VLIRSRKVGL MNRVVQLLIL AYVIGWVFVW 
        60         70         80         90        100
EKGYQETDSV VSSVTTKAKG VAVTNTSQLG FRIWDVADYV VPAQEENSLF 
       110        120        130        140        150
IMTNMIVTVN QTQGTCPEIP DKTSICDSDA NCTLGSSDTH SSGIGTGRCV 
       160        170        180        190        200
PFNASVKTCE VAAWCPVEND AGVPTPAFLK AAENFTLLVK NNIWYPKFNF 
       210        220        230        240        250
SKRNILPNIT TSYLKSCIYN ARTDPFCPIF RLGQIVADAG HSFQEMAVEG 
       260        270        280        290        300
GIMGIQIKWD CNLDRAASHC LPRYSFRRLD TRDLEHNVSP GYNFRFAKYY 
       310        320        330        340        350
RDLAGNEQRT LTKAYGIRFD IIVFGKAGKF DIIPTMINVG SGLALLGVAT 
       360        370        380 
VLCDVIVLYC MKKRYYYRDK KYKYVEDYEQ GLSGETDQ

Length:388

Mass (Da):43,492

Last modified:May 1, 1999 - v1

Checksum:ⁱ46569A39F76FAB9A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC115728 Genomic DNA. No translation available. AF089751 mRNA. Translation: AAC95601.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_035156.2. NM_011026.3.
UniGeneⁱ	Mm.290884. Mm.463383.

Genome annotation databases

Ensemblⁱ	ENSMUST00000031429; ENSMUSP00000031429; ENSMUSG00000029470.
GeneIDⁱ	18438.
UCSC genome browser More...UCSCⁱ	uc008zlu.1. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC115728 Genomic DNA. No translation available. AF089751 mRNA. Translation: AAC95601.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_035156.2. NM_011026.3.
UniGeneⁱ	Mm.290884. Mm.463383.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000031429; ENSMUSP00000031429; ENSMUSG00000029470.
GeneIDⁱ	18438.
UCSC genome browser More...UCSCⁱ	uc008zlu.1. mouse.

Organism-specific databases

CTDⁱ	5025.
MGIⁱ	MGI:1338859. P2rx4.

Phylogenomic databases

eggNOGⁱ	ENOG410IFJF. Eukaryota. ENOG410XR0C. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016028.
HOVERGENⁱ	HBG053086.
OMAⁱ	TMINVGS.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A2U.
TreeFamⁱ	TF328633.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-139853. Elevation of cytosolic Ca2+ levels. R-MMU-418346. Platelet homeostasis.

Reactomeⁱ

R-MMU-139853. Elevation of cytosolic Ca2+ levels.
R-MMU-418346. Platelet homeostasis.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029470.

Bgeeⁱ

ENSMUSG00000029470.

Family and domain databases

Gene3Dⁱ	2.60.490.10. 1 hit.
InterProⁱ	View protein in InterPro IPR003047. P2X4_purnocptor. IPR027309. P2X_extracellular_dom. IPR001429. P2X_purnocptor.
PANTHERⁱ	PTHR10125. PTHR10125. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00864. P2X_receptor. 1 hit.
PIRSFⁱ	PIRSF005713. P2X_purinoceptor. 1 hit.
PRINTSⁱ	PR01311. P2X4RECEPTOR. PR01307. P2XRECEPTOR.
TIGRFAMsⁱ	TIGR00863. P2X. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01212. P2X_RECEPTOR. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q9Z257_MOUSE
Accessionⁱ	Q9Z257Primary (citable) accession number: Q9Z257
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 1, 1999
	Last sequence update:	May 1, 1999
	Last modified:	July 5, 2017
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Z257 (Q9Z257_MOUSE)

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P2X purinoceptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ